Clinical trials: Knee Osteoarthrosis
Anterior Knee Pain
Comparison of Removing and Non-removing Patellofemoral Joint Osteophytes Following Medial Unicompartment Knee Arthroplasty
Background: Anterior knee pain (AKP) is a challenge following unicompartmental knee arthroplasty (UKA). Some surgeons remove patellofemoral joint (PFJ) osteophytes to reduce osteophyte impingement and AKP.
- Trial name
- NCT05367375
- Testing
- removing osteophyte at patellofemoral joint
- Volunteers
- 90 people
- Sponsor
- Thammasat University
Osteoarthritis, Knee
Comparison of Autologous Platelet-rich Plasma With Hyaluronic Acid for the Treatment of Osteoarthritis of the Knee Joint
The purpose of this study is to compare the efficacy of platelet-rich plasma versus hyaluronic acid intra-articular injections for the treatment of osteoarthritis of knee joint.
- Trial name
- NCT02211521
- Testing
- PRP, Hyaluronic acid
- Where
- South Korea
- Volunteers
- 110 people
- Sponsor
- Samsung Medical Center
Osteoarthritis, Knee
The Difference of Angle of Femoral Component Rotation in TKA With Gap Balance and Measured Resection Technique
Gap balance type and measured resection type total knee arthroplasty (TKA) have different influence on the rotation of femoral component.In this study, the rotation of patients received different type of TKA will be estimated and…
- Trial name
- NCT03358381
- Testing
- the gap balance type of total knee arthroplasty, the measured resection type of total knee arthroplasty
- Volunteers
- 50 people
- Sponsor
- Peking University People's Hospital
Knee Osteoarthritis
Effect of Core Stability Versus Ankle Foot Strengthening Exercise in the Management of Knee Osteoarthritis
Knee osteoarthritis (KOA) is a degenerative joint disease causing pain, stiffness, and reduced quality of life. While treatments often focus on drugs or surgery, noninvasive exercises like core stabilization and ankle/foot…
- Trial name
- NCT06766877
- Testing
- core stability exercise, foot-ankle strengthening exercise
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- Dow University of Health Sciences
Osteoarthritis, Knee, Meniscus; Degeneration
Knowledge Translation and Exercise for Degenerative Meniscal Tears and Early Osteoarthritis: KNEE-DEeP Study
Knee pain due to a degenerative meniscal tear (DMT) or early osteoarthritis (OA) is a frequent presentation in middle-aged and older adults.
- Trial name
- KNEE-DEeP (NCT06576557)
- Testing
- KNEE-DEeP intervention- Knowledge translation and exercise for early degenerative knee pain
- Where
- Ireland
- Volunteers
- 36 people
- Sponsor
- University of Limerick
Total Knee Replacement
Innovative Gait Training for People With Knee Osteoarthritis Using Dual Belt Treadmill
Knee osteoarthritis (OA) is the most common form of arthritis and is the leading cause of chronic musculoskeletal pain and functional disability. Gait assessment is essential for the rehabilitation of people with knee OA.
- Trial name
- NCT05958212
- Testing
- Gait training program, Conventional training only
- Where
- Hong Kong
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Osteoarthritis, Knee, Radiofrequency Ablation
The Effect of Radiofrequency Ablation on the Results of the Genicular Nerve Number in the Treatment of Knee Osteoarthritis
Knee osteoarthritis is a disease that increases in frequency with age and decreases the quality of life and physical activity by leading to a decrease in pain and joint range of motion.
- Conditions
- Osteoarthritis, Knee, Radiofrequency Ablation, Genicular Nerve
- Trial name
- NCT05447624
- Testing
- Radiofrequency ablation of genicular nerves
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Marmara University
Knee Osteoarthritis
Evaluation of the Evolution of Biological and Imaging Markers of Bone and Cartilage Degradation in Patients With Knee Osteoarthritis Receiving Intra-articular Injections of a Hyaluronan Derivative HYMOVIS®
This pilot study MOKHA is aimed to evaluate the beneficial effect of HYMOVIS® on cartilage of patients suffering of knee osteoarthritis as revealed by using scientifically sound, objective measurements of biological and MRI-based…
- Trial name
- MOKHA (NCT04293861)
- Testing
- HYMOVIS
- Where
- 8 sites in Belgium, France
- Volunteers
- 50 people
- Sponsor
- Fidia Farmaceutici s.p.a.
Osteoarthritis
Reduction of Pro-Inflammatory Synovial Fluid Biomarkers in Osteoarthritis of the Knee With Alpha-2 Macroglobulin
The purpose of the current study is to assess the ability of alpha-2-macroglobulin treatment to reduce the level of pro-inflammatory synovial fluid biomarkers in patients with osteoarthritis of the knee.
- Trial name
- NCT03656575
- Testing
- synovial fluid biomarker concentrations
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- NYU Langone Health
Osteoarthritis, Knee
Pilot Study: Geniculate Artery Embolization in Knee Osteoarthrosis.
Geniculate Artery Embolization (GAE) has recently been described and studied as a palliative treatment for osteoarthrosis-related knee pain in patients un-eligible for surgical intervention.
- Trial name
- NCT04113681
- Testing
- Geniculate Artery Embolization
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Maisonneuve-Rosemont Hospital
Knee Osteoarthritis, Blood Loss
Use of Tranexamic Acid in the Total Knee Arthroplasty.
Tranexamic acid is a medication used to treat or prevent excessive blood loss during surgery. Previous studies have shown tranexamic acid (TXA) reduces blood loss and post-operative blood transfusion rate without significant…
- Conditions
- Knee Osteoarthritis, Blood Loss, Blood Transfusion
- Trial name
- NCT05919615
- Testing
- Tranexamic Acid 100 MG/ML, Normal saline
- Where
- Syria
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Damascus University
Physical Therapy
SWT VERSUS EMFT IN KOA
The purpose of this study was to compare the effect of extracorporeal shock wave therapy and pulsed electromagnetic field in reducing pain, improving function, and increasing ROM in knee osteoarthritis patients.
- Trial name
- NCT07505368
- Testing
- Shock Wave Therapy, Electromagnetic Field Therapy, Conservative therapy
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Suez Canal University
Osteoarthritis, Knee
Study of Pain Catastrophizing-2 (SPAC-2)
This study experimentally manipulates pain catastrophizing in order to investigate the neural mechanisms by which pain catastrophizing influences the experience of pain in different ethnic groups among adults with knee…
- Trial name
- SPAC (NCT04805190)
- Testing
- Cognitive-Behavioral Intervention, Pain Education
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- University of Florida
Knee Osteoarthritis, Hip Osteoarthritis
Regional Anesthesia in Total Hip and Knee Arthroplasty
The purpose of this study is to test whether the use of Ropivacaine and Mepivacaine are better in terms of effectiveness, cost, and safety than Bupivacaine as regional anesthetics in elective hip or knee replacement surgery.
- Trial name
- NCT04257682
- Testing
- Bupivacaine, Ropivacaine, Mepivacaine
- Volunteers
- 135 people
- Sponsor
- Ottawa Hospital Research Institute
Knee Osteoarthristis
Medication vs. Meditation for Chronic Knee Osteoarthritis
The purpose of this research study is to improve pain management for individuals with chronic knee osteoarthritis pain. Specifically, we are comparing the effects of a mindfulness meditation practice with those of oral…
- Trial name
- NCT07837284
- Testing
- Oral diclofenac potassium 50 mg, Mindfulness meditation
- Volunteers
- 30 people
- Sponsor
- Florida State University
Total Knee Arthroplasty, Osteo Arthritis Knee
In Vivo Kinematics for Subjects Implanted With Klassic Total Knee Arthroplasty (TKA)
In vivo knee kinematics will be assessed for 20 subjects that have been implanted with a Total Joint Orthopedics Klassic knee system by Dr.
- Conditions
- Total Knee Arthroplasty, Osteo Arthritis Knee, Knee Implant, Knee Injuries
- Trial name
- TKA (NCT04113785)
- Testing
- Klassic Knee System
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- The University of Tennessee, Knoxville
Osteoarthritis, Knee
Outcomes of MAKOplasty Patellofemoral Arthroplasty in Younger Active Patients
The primary purpose of this investigation is to report the short-term clinical outcomes (2-3 years) of patellofemoral arthroplasty implanted using the MAKOplasty knee resurfacing system.
- Trial name
- NCT02738476
- Testing
- Patellofemoral arthroplasty
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Cincinnati Sportsmedicine Research and Education Foundation
Knee Osteoarthritis, Anxiety
Comparison of Music and Ambient Noise Cancellation in Patients Undergoing Total Knee Arthroplasty (TKA)
The aim of this clinical trial is to compare the effects of music and ambient noise cancellation during total knee arthroplasty and to analyse the effects on patients.
- Conditions
- Knee Osteoarthritis, Anxiety, Post Operative Pain, Noise Exposure
- Trial name
- TKA (NCT06401018)
- Testing
- No noise cancellation and no music playing, Noise cancelled but not allowed to listen to music, Music is played but noise is not cancelled
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Ankara City Hospital Bilkent
Osteoarthritis, TKA
Comparing Articular Noise and Its Perception Between Two Different Types of Individualized Total Knee Arthroplasty
Knee osteoarthritis is a degenerative joint disorder leading to pain and limited movement. Total knee arthroplasty (TKA) has transformed the treatment of knee osteoarthritis, resulting in long-term outcomes that enhance the…
- Trial name
- ANIKA (NCT07030049)
- Testing
- Postero-stabilized total knee replacement for knee osteoarthritis, Cruciate-retaining total knee replacement for knee osteoarthritis
- Volunteers
- 210 people
- Sponsor
- Clinique Trenel
Knee Osteoarthritis, Knee Pain Chronic
Effects of Internet / Web-based Exercises on the Population With Knee Arthritis
1. To test whether internet-based exercises reduce the pain in knee OA 2. To check whether internet-based exercises improve the physical activity in the patients with knee OA. 3.
- Conditions
- Knee Osteoarthritis, Knee Pain Chronic, Sleep Disturbance
- Trial name
- Knee OA (NCT03545048)
- Testing
- Internet based exercises
- Where
- United Kingdom
- Volunteers
- 105 people
- Sponsor
- University of Nottingham
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