Clinical trials: Knee Pain
Patellofemoral Pain Syndrome
Comparing Rehabilitation Programs for Patellofemoral Pain Syndrome
Patellofemoral pain syndrome (PFPS) is a common knee disorder affecting physically active people. Despite the growing base of support for the early introduction of hip strengthening exercises into the rehabilitation of PFPS…
- Trial name
- NCT00445224
- Testing
- Hip Progressive Resistive Exercise, Quad Progressive Resistive Exercises
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Timothy Uhl
Pain, Osteo Arthritis Knee
Clinical Trial to Evaluate the Efficacy and Safety of LEVI-04 in Patients With Osteoarthritis of the Knee
This is a phase 2, randomized, double-blind, placebo-controlled trial of multiple doses and multiple administrations of LEVI-04 for the treatment of pain due to osteoarthritis of the knee.
- Conditions
- Pain, Osteo Arthritis Knee, Knee Osteoarthritis, Arthritis
- Trial name
- NCT05618782
- Testing
- LEVI-04
- Where
- 13 sites in Czechia, Denmark and 3 more
- Volunteers
- 518 people
- Sponsor
- Levicept
Osteoarthritis, Knee
A Study to Assess the Safety and Efficacy of a Single Dose of UBX0101 in Patients With Osteoarthritis of the Knee
A study to assess efficacy, safety, and tolerability of a single-dose intra-articular administration of UBX0101 in patients with moderate to severe painful knee osteoarthritis (OA).
- Trial name
- NCT04129944
- Testing
- UBX0101
- Where
- 20 sites in United States
- Volunteers
- 183 people
- Sponsor
- Unity Biotechnology, Inc.
Knee Injuries, Knee Osteoarthritis
Gait Modification Treatments for Knee Pathology
The objective of this study is complete a longitudinal cross-over clinical study to investigate the effect of treatments for knee pathology, including cutaneous stimulation (skin vibration and soft knee brace), on locomotion…
- Trial name
- NCT03116230
- Testing
- Cutaneous Stimulation, Knee Sleeve
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Stanford University
PAIN
Effect of Oral Pregabalin on Spinal Neurotransmitters in Patients Undergoing Knee Replacement
This study involves research. Pregabalin is a Food and Drug Administration (FDA) medication approved in the United States for the treatment of nerve pain related to diabetes and post-herpetic neuralgia "shingles", and for…
- Trial name
- NCT00729690
- Testing
- Pregabalin
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Asokumar Buvanendran
Osteoarthritis, Knee
Efficacy and Safety of G001 in Patients With Osteoarthritis (OA) of the Knee
Phase 2 multicenter, double-blind, randomized, parallel-group, vehicle-controlled study to evaluate the efficacy, safety, and local tolerability of G001 topical gel compared to matching Vehicle topical gel in patients with…
- Trial name
- NCT05007808
- Testing
- G001 Topical Gel, Vehicle
- Where
- 10 sites in Canada
- Volunteers
- 210 people
- Sponsor
- BUZZZ Pharmaceuticals Limited
Trigger Point Pain, Myofascial
Trigger Point Injection in Reducing Pain Following Total Knee Arthroplasty
This study will evaluate the ability of trigger point injections completed immediately following a total knee arthroplasty decrease pain scores and opioid use compared to sham injections.
- Trial name
- NCT06955923
- Testing
- Trigger point injection (lidocaine)
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- David Grant U.S. Air Force Medical Center
Anterior Cruciate Ligament Rupture
Liposomal Bupivacaine for Pain Control Following Anterior Cruciate Ligament Reconstruction
This study will consist of 80 patients ages 18 to 50 at the Emory Orthopaedic and Spine Center who are undergoing Anterior Cruciate Ligament (ACL) reconstruction with a quadriceps tendon autograft or bone patellar tendon bone…
- Trial name
- NCT02189317
- Testing
- Exparel
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Emory University
Knee Osteoarthritis, Knee Pain Chronic
Gabapentin Regimens and Their Effects on Opioid Consumption
The purpose of this study is to determine the best strategy of administering gabapentin in connection with our current approach to perioperative pain management.
- Conditions
- Knee Osteoarthritis, Knee Pain Chronic, Opioid Use, Opioid Dependence
- Trial name
- NCT03334903
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Post Operative Pain
OXN PR Compared to OXY PR in Subjects With Postoperative Pain After Knee Arthroplasty
The purpose of this study is to demonstrate that treatment with OXN PR tablets is non inferior to treatment with OXY PR tablets in terms of analgesic efficacy in patients with postoperative pain after knee arthroplasty based on…
- Trial name
- OXN4505 (NCT01083485)
- Testing
- Oxycodone/Naloxone PR 20/10mg or 10/5mg tablets, Oxycodone
- Where
- Finland
- Volunteers
- 137 people
- Sponsor
- Mundipharma Oy
Osteoarthritis, Knee
A Study to Compare the Effectiveness of Adductor Canal Pain Catheters Following Total Knee Arthroplasty
The purpose of this research is to study how well the adductor canal pain catheters works after a total knee arthroplasty or replacement of the knee joint.
- Trial name
- NCT05053087
- Testing
- Ropivacaine Continuous Infusion, Ropivacaine Intermittent Bolus
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Mayo Clinic
Pain, Osteoarthritis, Knee
A Dose-Finding Study to Evaluate the Efficacy and Safety of GSK3858279 in Adults With Knee Osteoarthritis (OA) Pain
This is dose-finding study of GSK3858279 in participants with moderate to severe knee osteoarthritis pain. The purpose of this study is to investigate and provide the data necessary to select the optimal effective and safe…
- Trial name
- MARS-17 (NCT05838742)
- Testing
- GSK3858279
- Where
- 93 sites in United States, Argentina and 11 more
- Volunteers
- 314 people
- Sponsor
- GlaxoSmithKline
Osteoarthritis of the Knee
A Phase 2 Study To Assess The Efficacy, Tolerability, And Safety OF NKTR-181 In Subjects With Chronic OA Knee Pain
NKTR-181 is being developed as an analgesic compound for the treatment of moderate to severe chronic pain - active as a mu agonist, but with inherent molecular properties designed to provide a unique clinical profile, including…
- Trial name
- NCT01619839
- Testing
- NKTR-181
- Where
- 34 sites in United States
- Volunteers
- 296 people
- Sponsor
- Nektar Therapeutics
Osteoarthritis of Knee
Pain Relief for OsteoArthritis Through Combined Treatment (PROACT)
This mechanistic clinical trial proposes to test whether a five-day course of mindfulness meditation training (MMT) and tDCS, and their combination, can enhance pain modulatory balance and pain-related brain function, reduce…
- Trial name
- PROACT (NCT03884374)
- Testing
- Focused Breathing and Attention Training (BAT), Standard Breathing and Attention Training (BAT), Transcranial Direct Current Stimulation (tDCS)
- Where
- 2 sites in United States
- Volunteers
- 317 people
- Sponsor
- University of Florida
Osteoarthritis, Knee
Study of Cingal® and Triamcinolone Hexacetonide for the Relief of Knee Osteoarthritis Pain
This is a multi-center, randomized, double-blind, parallel group, placebo controlled trial to compare the safety and effectiveness of a single injection of Cingal® to a single injection of Triamcinolone Hexacetonide (TH) to…
- Trial name
- NCT04231318
- Testing
- Cingal, Triamcinolone Hexacetonide (TH)
- Where
- 26 sites in United States
- Volunteers
- 231 people
- Sponsor
- Anika Therapeutics, Inc.
Knee Osteoarthritis
Combined Application of Electrical Stimulation and Volitional Contractions for Muscle Strengthening and Knee Pain Inhibition (Seated Study)
The purpose of this study is to assess the efficacy of a 12-week low-load neuromuscular electrical stimulation with volitional contraction (NMES-VC) training program to improve quadriceps strength and activation, while not…
- Trial name
- NCT02802878
- Testing
- Hybrid Training using Electrodes and Joint Motion Sensors, Isokinetic Training with Isokinetic Dynamometer
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- University of Kansas Medical Center
Osteoarthritis
A Study to Determine the Difference in Low Contact Stress (LCS) Duofix Versus Low LCS Porocoat Knee Systems
The primary objective of this investigation is to test the hypothesis that the Duofix Tibial component results in a reduction of immediate postoperative pain compared to the LCS Porocoat version.
- Trial name
- NCT00733499
- Testing
- LCS Complete Duofix, LCS Complete Porocoat
- Where
- Ireland
- Volunteers
- 206 people
- Sponsor
- DePuy International
Osteoarthritis, Knee, Osteoarthritis Knees Both
Astaxanthin for Management of Inflammation in Knee Osteoarthritis
Over 30 million Americans are currently affected by osteoarthritis (OA), with prevalence expected to increase 40% by 2025 as a result of the aging population and obesity epidemic.
- Conditions
- Osteoarthritis, Knee, Osteoarthritis Knees Both, Joint Inflammation
- Trial name
- NCT05138549
- Testing
- Astaxanthin
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Prisma Health-Midlands
Arthritis, Osteoarthritis
Tanezumab In Osteoarthritis Of The Knee (2)
The purpose of this study is to test the efficacy and safety of 2 doses of tanezumab compared with naproxen and placebo in patients with osteoarthritis.
- Trial name
- NCT00830063
- Testing
- tanezumab 10 mg, tanezumab 5 mg, naproxen
- Where
- 94 sites in United States
- Volunteers
- 832 people
- Sponsor
- Pfizer
Total Knee Arthroplasty (Postoperative Pain), Total Hip Arthroplasty(Postoperative Pain)
Dose Dependent Effects of tDCS on Post-Operative Pain
The proper control of acute and chronic pain is one of the most important areas in health care. Despite the profound advances in neuroscience over the past 20 years, the investigators still largely use opiate narcotics, much as…
- Trial name
- tDCS-TKA (NCT02241967)
- Testing
- 4 Real sessions of Transcranial Direct Current Stimulation, 2 Real Sessions of Transcranial Direct Current Stimulation, 1 Real Session of Transcranial Direct Current Stimulation
- Where
- United States
- Volunteers
- 119 people
- Sponsor
- VA Office of Research and Development