Clinical trials: Knee Pathology
Postoperative Pain, Knee Osteoarthritis
Preop Cooled Radiofrequency Ablation for Total Knee Replacement
Total knee replacement surgery is commonly performed for patients suffering from severe knee osteoarthritis. However, 20% of patients continue to experience pain after surgery.
- Trial name
- NCT03893292
- Testing
- Total knee replacement, COOLIEF
- Where
- United States
- Sponsor
- Hospital for Special Surgery, New York
Osteoarthritis, Pain
Norspan® Patches Versus Tramadol in Subjects With Chronic, Moderate to Severe Osteoarthritis Pain in the Hip Knee and/or Lumbar Spine
The primary objective of this equivalence study is to evaluate the efficacy of Norspan® patches versus Tramadol in subjects with chronic, moderate to severe osteoarthritis pain of the hip, knee and/or lumbar spine.
- Trial name
- NCT00426647
- Testing
- Buprenorphine, Tramadol
- Where
- Finland
- Volunteers
- 120 people
- Sponsor
- Norpharma A/S
Postoperative Pain
Dose-Ranging Study for Prolonged Postoperative Analgesia in Subject Undergoing Total Knee Arthroplasty
Dose-ranging study for prolonged postoperative analgesia in subjects undergoing total knee arthroplasty
- Trial name
- TKA (NCT00485693)
- Testing
- Bupivacaine HCl, SKY0402
- Where
- 9 sites in United States, Czechia
- Volunteers
- 138 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Knee Arthropathy, Postoperative Pain
IPACK Block After Total Knee Arthroplasty
Adductor canal block (ACB) is a peripheral nerve blockade technique that provides good pain control in patients undergoing total knee arthroplasty (TKA) which however does not relieve posterior knee pain.
- Trial name
- NCT04295421
- Testing
- adductor canal block, IPACK block
- Where
- Tunisia
- Volunteers
- 88 people
- Sponsor
- University Tunis El Manar
Total Knee Replacement, Post-operative Nausea and Vomiting
Aromatherapy in Total Knee Replacement
The purpose of this pilot randomized controlled trial is to investigate the effects of aromatherapy on postoperative anxiety and pain in total knee replacement patients.
- Conditions
- Total Knee Replacement, Post-operative Nausea and Vomiting, Opioid Use, Anxiety
- Trial name
- NCT06045078
- Testing
- Elequil Lavender-peppermint Aromatabs, Elequil Almond-Oil Aromatabs
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Hospital for Special Surgery, New York
Osteoarthritis
A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Osteoarthritis (OA) of the Knee
The GZPT master protocol will support two independent studies, J2A-MC-GZT1 and J2A-MC-GZT2. Each study will see how well and safely orforglipron works in people with obesity or overweight who have osteoarthritis (OA) of the knee…
- Trial name
- ATTAIN-OA PAIN (NCT07153471)
- Testing
- Orforglipron
- Where
- 88 sites in United States, Canada and 5 more
- Volunteers
- 800 people
- Sponsor
- Eli Lilly and Company
Osteo Arthritis Knee
Effectiveness of Pain Science Education in People With Symptomatic Knee Osteoarthritis
The aim of this study is to determine the effectiveness of the program integrated with pain science education for people with painful knee osteoarthritis (OA).
- Trial name
- NCT05649995
- Testing
- Pain science education driven physiotherapy program, Biomedical education driven physiotherapy program
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Marmara University
Necrosis of Femoral Head, Knee Osteoarthritis
Probiotics Attenuate Postoperative Cognition Decline
The aim of this study was to evaluate whether perioperative probiotics can reduce the incidence of postoperative cognitive dysfunction and postoperative delirium.
- Conditions
- Necrosis of Femoral Head, Knee Osteoarthritis, Fracture of Neck of Femur, Lumbar Disc Herniation
- Trial name
- NCT04017403
- Testing
- Bifidobacterium triple live capsule
- Where
- 3 sites in China
- Volunteers
- 220 people
- Sponsor
- RenJi Hospital
Knee Pain Chronic
Genicular RFT vs Phenol Management in Patients With Knee Osteoarthritis
The aim of this study was to compare the efficacy of phenol and radiofrequency ablation for genicular nerve neurolysis in severe knee pain.
- Trial name
- NCT05908942
- Testing
- Nerve ablation
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Diskapi Teaching and Research Hospital
Cerebrovascular Accident, Post-polio Syndrome
Nomad P-KAFO Study
The goal of this clinical trial is to evaluate the impact of using the Nomad powered KAFO in people who have had a musculoskeletal or neurological injury that has affected their ability to walk.
- Conditions
- Cerebrovascular Accident, Post-polio Syndrome, Spinal Cord Injuries, Multiple Sclerosis
- Trial name
- NCT05644522
- Testing
- Indego Nomad® Powered Knee-Ankle-Foot Orthosis (P-KAFO) (Parker Hannifin Corp., Cleveland, OH)
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Shirley Ryan AbilityLab
Osteoarthritis, Gonarthrosis
Photobiomodulation Therapy to Reduce Pain and Inflammation in Patients With Gonarthrosis
Osteoarthritis (OA) is one of the main causes of chronic pain and physical disability, which directly impacts the quality of life of patients.
- Trial name
- NCT05975957
- Testing
- Photomodulation Therapy with the Light-Aid system, Control
- Where
- Brazil
- Volunteers
- 238 people
- Sponsor
- D'Or Institute for Research and Education
Acute Pain
Dexamethasone in Pain Control After Total Knee Replacement
The primary aims of total knee replacement are improvement in functional activities and reduce pain due to degenerated knee joints.
- Trial name
- NCT02767882
- Testing
- Dexamethasone, Saline
- Where
- Hong Kong
- Volunteers
- 138 people
- Sponsor
- The University of Hong Kong
Osteo Arthritis Knee
Measurement of Osteoarthritic Patient Pain Through Electrodermal Activity Signals
This pilot study aims to investigate the viability of using a smartwatch-based electrodermal activity (EDA) sensor to capture enough EDA signal to quantitatively assess pain in osteoarthritis subjects and test the feasibility of…
- Trial name
- NCT06701461
- Testing
- Electrodermal Activity signal
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Knee Osteoarthritis, Total Knee Arthroplasty
Improved Pain Management in Knee Osteoarthritis-related Surgeries
In recent years, pain management coordinated with enhanced recovery after surgery (ERAS) has been widely applied and rapidly developed in orthopedics, showing promising prospects.
- Conditions
- Knee Osteoarthritis, Total Knee Arthroplasty, Unicompartmental Knee Arthroplasty, High Tibial Osteotomy
- Trial name
- NCT06124170
- Testing
- Preoperative pain managment, Intraoperative pain managment, Postoperative pain managment
- Where
- China
- Volunteers
- 714 people
- Sponsor
- Peng Liu
Frailty Syndrome, Prehabilitation
Multimodal Prehabilitation of Frail Patients Undergoing Elective Knee or Hip Replacement
Background: Frailty is a geriatric syndrome of reduced physiologic reserve that increases surgical risk and is common among older adults undergoing hip or knee replacement.
- Conditions
- Frailty Syndrome, Prehabilitation, Arthroplasties, Knee Replacement, Arthroplasties, Hip Replacement
- Trial name
- NCT07465159
- Testing
- Multimodal Prehabilitation
- Where
- Iceland
- Volunteers
- 50 people
- Sponsor
- University of Iceland
Pain Postoperative, Total Knee Anthroplasty
Comparative Analgesic Effect After Total Knee Arthroplasty Between Intraosseous and Peri-articular Injection
The goal of this RCT is to compare analgesic effect after total knee arthroplasty between intraosseous multimodal analgesic agent injection versus periarticular injection.
- Conditions
- Pain Postoperative, Total Knee Anthroplasty, Functional Outcomes
- Trial name
- NCT06800846
- Testing
- Intraosseous Morphine, Periarticular Injection
- Where
- Thailand
- Volunteers
- 90 people
- Sponsor
- Thammasat University Hospital
Knee Osteoarthritis
Effectiveness and Safety of Intra-Articular Hyaluronic Acid Conjugated With Fibrinogen in Knee Osteoarthritis
This study aims to evaluate the effectiveness and safety of intra-articular injections of hyaluronic acid conjugated with fibrinogen in patients with knee osteoarthritis.
- Trial name
- NCT07323342
- Testing
- Intra-articular hyaluronic acid conjugated with fibrinogen
- Where
- Vietnam
- Volunteers
- 31 people
- Sponsor
- Cao Kim Xoa
Anterior Knee Pain Syndrome, Proprioceptive Disorders
Joint Position Sense in Individuals With Anterior Knee Pain
Introduction Anterior knee pain (AKP) commonly affects physically active as well as sedentary individuals and the aetiology remains unknown.
- Trial name
- NCT03998241
- Testing
- No intervention was provided
- Where
- South Africa
- Volunteers
- 25 people
- Sponsor
- University of Stellenbosch
Knee Osteoarthritis (Knee OA)
Exercise-induced Irisin in Individuals With Knee Osteoarthritis.
The goal of this prospective randomised controled study is to investigate the effect of 8-weeks brisk walking exercise on irisin levels, physical and psychosocial parameters in individuals with knee osteoarthritis, and the…
- Trial name
- Osteoarthritis (NCT06758388)
- Testing
- home exercise program, home exercise program + brisk walking exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people
- Sponsor
- Ümmahani Kuş
Knee Osteoarthritis
Clinical Evaluation of the Levitation Knee Brace
Osteoarthritis (OA) is a debilitating disease affecting approximately 1/3 of Canadians over the age of 25. Knee OA typically involves at least 2 of 3 compartments in the knee joint.
- Trial name
- NCT05543486
- Testing
- Levitation 2 Tri-Compartment Offloader (TCO) knee brace, Knee sleeve
- Where
- Canada
- Volunteers
- 26 people
- Sponsor
- University of Calgary