Clinical trials: Knee Prosthesis, open to volunteers
Total Knee Arthroplasty, Knee Replacement
Investigating Patient Satisfaction With Smart Knee Implants
The main goal of this study is to see if there is a connection between the social and economic resources available in a patient's neighborhood (measured by the Area Deprivation Index, ADI) and their recovery after knee…
- Conditions
- Total Knee Arthroplasty, Knee Replacement, Knee Replacement Arthroplasty, Knee Osteoarthritis
- Trial name
- NCT06968143
- Testing
- Smart Knee Implant
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Prosthesis Durability
Evaluation of the Clinical Outcomes of the Total Knee ps Prosthesis Implanted With the Use of Inertial Sensors
evaluate the clinical outcome of the implantation of a specific primary TKA model implanted with the aid of inertial sensors for the execution of bone cuts through the administration of questionnaires for the calculation of…
- Trial name
- SYMPHO-EM (NCT06321042)
- Testing
- Knee arthroplasty
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Istituto Ortopedico Rizzoli
Knee Arthroscopy
Outpatient Total Knee Arthroscopy (TKA): Comparison of Postoperative Recovery Versus a Conventional Hospitalization
Outpatient TKA is a controversial topic due to concerns about its safety as an outpatient procedure, and remains a marginal procedure.
- Trial name
- PTG (NCT07276061)
- Where
- France
- Volunteers
- 440 people
- Sponsor
- University Hospital, Strasbourg, France
Transfemoral Amputation, Limb Loss
Effect of a Microprocessor-controlled Prosthetic Knee Joint on K2 Level Ambulators
Microprocessor-controlled knees (MPKs) automatically adjust resistance or damping in the joint to improve swing- and/or stance-phase control as appropriate for the prosthesis user during gait.
- Conditions
- Transfemoral Amputation, Limb Loss, Limb Absence
- Trial name
- MPK-K2 (NCT07103798)
- Testing
- College Park ICON, Conventional NMPK
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- VA Office of Research and Development
Knee Arthropathy
Influence of Different Prostheses on Postoperative Clinical Function in Total Knee Arthroplasty
Exploring differences in knee function after surgery with different types of prostheses(Cruciate ligament retaining(CR) VS. posterior stabilizing(PS))
- Trial name
- NCT06617819
- Testing
- CR prosthesis, PS prosthesis
- Where
- China
- Volunteers
- 40 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Hip Prosthesis Infection, Knee Prosthesis Infection
Proof of Concept Study to Assess Safety and Efficacy of Phage Therapy in Hip or Knee Prosthetic Joint Infections Due to Staphylococcus Aureus Treated by DAIR.
Total joint replacements are effective for chronic pain but can lead to Prosthetic Joint Infections (PJI), primarily caused by Staphylococcus aureus and resistant to antibiotics.
- Trial name
- GLORIA (NCT06605651)
- Testing
- Anti-Staphylococcus aureus Bacteriophages (PP1493 and PP1815) intra-articular injection with 0.9% NaCl solution, 0.9% NaCl solution
- Volunteers
- 100 people
- Sponsor
- Phagenix
Knee Pain Chronic, Knee Pain Swelling
Efficacy of Microparticle Geniculate Artery Embolization in Total Knee Prosthesis Patients With Pain Resistant to Medical Treatment. A Prospective Randomized Controlled Trial
The goal of this clinical investigation is to evaluate the effectiveness on pain of arterial occlusion (embolization) of neovessels by microparticle in a double-blind sham controlled randomised trial in patients with persistent…
- Trial name
- EPROGE (NCT06466330)
- Testing
- microparticles, embolization
- Where
- 11 sites in France
- Volunteers
- 112 people
- Sponsor
- Societe Francaise de Rhumatologie
Osteoarthritis, Knee, Genu Varum
Adductor Ratio in Severe Varus Gonarthrosis
The restoration of the joint line (JL) is essential for the proper functioning of Total Knee Arthroplasty (TKA). The exact position of JL can be determined using anatomical landmarks such as femoral condylar width (TEW), tibial…
- Conditions
- Osteoarthritis, Knee, Genu Varum, Joint Prosthesis; Complications
- Trial name
- NCT05936814
- Testing
- total knee arthroplasty
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people
- Sponsor
- Saglik Bilimleri Universitesi
Mutars, Modular Universal Tumor And Revision System
Metal-ions in Patients With the PEEK HD Coupling Mechanism of the Knee
The goal of this observational study is to evaluate the changes of serum metal ion (Cobalt and Chrome) levels at 0, 3-6, 12, and 24 months postoperative in patients receiving a MUTARS mega-prostheses of the knee with a PEEK HD…
- Conditions
- Mutars, Modular Universal Tumor And Revision System, Metal-ions, Tumor Prosthesis
- Trial name
- MIONS (NCT05893602)
- Testing
- Blood sample analysis
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Leiden University Medical Center
Periprosthetic Osteolysis
Assessment of Periprosthetic Bone Mineral Density in Patients Undergoing Total Knee Prosthesis of Different Design
compare changes in BMD via DXA at the level of the femoral and tibial periprosthetic bone between two groups of patients undergoing cemented TKA of different design (posterior stabilization vs posterior cruciate preservation)…
- Trial name
- DXA-TKA (NCT06309433)
- Testing
- dual energy x-ray absorptiometry
- Where
- 2 sites in Italy
- Volunteers
- 50 people
- Sponsor
- Istituto Ortopedico Rizzoli
Arthroplasty, Replacement
ORIGIN® vs. VANGUARD® PS Observational Study
The study objective is to assess patient satisfaction after the surgery with a patient match CE marked implant (ORIGIN®) versus off-the-shelf (VANGUARD PS) device, and to document the clinical and device performance outcomes of…
- Conditions
- Arthroplasty, Replacement, Knee
- Trial name
- NCT04728542
- Testing
- ORIGIN PS System, VANGUARD PS System
- Where
- Germany
- Volunteers
- 140 people
- Sponsor
- Symbios Orthopedie SA
Knee Prosthesis
Study of the Prognostic Value of the Coagulolytic Balance Dependent on Circulating Microvesicles in the Occurrence of Thrombotic Events After Total Knee Replacement in Orthopedic Surgery.
This is a prospective multicenter cohort study to evaluate the prognostic value of new biological markers in predicting thrombotic events after orthopedic surgery.
- Trial name
- MOTiVE (NCT05387694)
- Testing
- Thrombotic risk assessment
- Where
- France
- Volunteers
- 387 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Prosthesis Survival, Arthropathy of Knee
Evaluation of 5-year Survival and Clinical Outcomes in Patients Undergoing Total Knee Arthroplasty With a Polyethylene Tibial Component
Total knee arthroplasty (TKA) is one of the most successful procedures in orthopedic surgery for treating advanced knee osteoarthritis, providing pain relief, functional recovery, and improved quality of life.
- Trial name
- ALLPOLY-TKA (NCT07544264)
- Testing
- Total knee arthroplasty
- Where
- Italy
- Volunteers
- 78 people
- Sponsor
- Istituto Ortopedico Rizzoli
Infection of Total Hip Joint Prosthesis, Infection of Total Knee Joint Prosthesis
Topical Vancomycin for Infection Prophylaxis in TJA
11% of the general population undergo total hip arthroplasty (THA) in their lifetime and 7% undergo total knee arthroplasty (TKA), with these rates expected to rise up to 50% by 2026.
- Trial name
- NCT04993027
- Testing
- Vancomycin Powder
- Volunteers
- 100 people
- Sponsor
- Alberta Hip and Knee Clinic
Knee Arthropathy
Rate of Return to Sport After Total Knee Prosthesis: Comparison of Three Types of Prostheses
The purpose of the study is the rate of return to sport (regardless of the sport envisaged) after a minimum of 3 years after total knee prosthesis.
- Trial name
- TKA&RTS (NCT05928403)
- Testing
- total knee prosthesis
- Where
- 2 sites in France
- Volunteers
- 660 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Knee Osteoarthritis
Prospective Randomized Study Comparing the SpheriKA® (MEDACTA) and Origin® (SYMBIOS) Prostheses During Total Knee Replacement Using the Kinematic Alignment Technique
The traditional technique for implanting a total knee prosthesis, known as mechanical alignment, does not aim to preserve the original anatomy and laxity of the knee.
- Trial name
- KAOR (NCT06603103)
- Testing
- SPHERIKA prosthesis, ORIGIN prosthesis
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Clinique du Sport, Bordeaux Mérignac
Knee Osteoarthritis, Rheumatoid Arthritis (RA)
Comparative Study on the Medium- and Long-term Benefits of Prosthesis Selection in Total Knee Arthroplasty
This retrospective real-world study aims to compare the medium- and long-term clinical outcomes, safety, and economic benefits of different knee prosthesis brands used in primary unilateral total knee arthroplasty (TKA) at our…
- Trial name
- NCT07553871
- Volunteers
- 3,500 people
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Amputation of Lower Limb Below Knee, Amputation, Traumatic
REsistance and LOADing Exercise for Bone Health
Lower limb amputation, often resulting from military conflict and road traffic accidents, is associated with reduced hip bone mineral density (BMD) and increased risk of hip fractures.
- Conditions
- Amputation of Lower Limb Below Knee, Amputation, Traumatic, Amputation, Limb Loss
- Trial name
- RELOAD (NCT07817381)
- Testing
- Resistance and high-impact exercise training
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- Defence Medical Rehabilitation Centre, UK
Aseptic Loosening, Aseptic Loosening of Prosthetic Joint
DIGITAL-KNEE Study: Adequately Diagnosing Total Knee Arthroplasty Loosening by Evaluating the AtMoves Knee System in a Routine Clinical Setting
The goal of the clinical trial is to evaluate the efficacy of the AtMoves Knee System in the clinical diagnostic process of aseptic loosening in patients with a knee prosthesis.
- Conditions
- Aseptic Loosening, Aseptic Loosening of Prosthetic Joint, Aseptic Loosening of Orthopaedic Hardware, Knee Arthroplasty, Total
- Trial name
- DigitalKnee (NCT06839807)
- Testing
- AtMoves Knee System
- Where
- 7 sites in Netherlands
- Volunteers
- 124 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Transfemoral Amputation, Limb Loss
A Biomechanical Evaluation of the Ossur Power Knee in Persons With Transfemoral Amputation
Microprocessor-controlled knees (MPKs) do not typically utilize motors to power joint rotation, but they automatically adjust resistance or damping in the joint to improve swing- and/or stance-phase control as appropriate for the…
- Conditions
- Transfemoral Amputation, Limb Loss, Limb Absence
- Trial name
- OPKTFA (NCT06218238)
- Testing
- Powered prosthetic knee joint, Conventional microprocessor-controlled prosthetic knee joint
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- VA Office of Research and Development