Clinical trials: Knee Replacement, open to volunteers
Knee Osteoarthritis
Survival Study of the Genutech® Total Knee Arthroplasty
Prospective cohort sudy of patients undergoing a Genutech® total knee arthroplasty
- Trial name
- NCT06899932
- Where
- Spain
- Volunteers
- 500 people
- Sponsor
- Hospital de Sant Rafael
Total Knee Arthroplasty
Oral Tranexamic Acid After Total Knee Arthroplasty
This is a prospective, double-blind, randomized controlled trial evaluating the efficacy of oral tranexamic acid (TXA) in total knee arthroplasty (TKA).
- Trial name
- NCT06894719
- Testing
- tranexamic acid Oral-Short Arm, tranexamic acid Oral-Long Arm
- Volunteers
- 351 people
- Sponsor
- Rush University Medical Center
Knee Replacement Surgery, Osteoarthritis, Knee
Cannabidiol for Postoperative Opioid Reduction in Primary Total Knee Arthroplasty
The goal of this study is to better understand how daily treatment with cannabidiol (CBD) affects the need for opioid pain medication, as well as pain, inflammation and other related symptoms, after knee replacement surgery.
- Trial name
- CORK (NCT06234631)
- Testing
- Epidiolex oral solution
- Where
- 2 sites in United States
- Volunteers
- 380 people
- Sponsor
- Chad Brummett
Joint Diseases
EVOLUTION® Revision STEMMED CS Post Market Clinical Follow-up Study Protocol
MicroPort (MPO) is conducting this PMCF study to evaluate the safety and effectiveness of its EVOLUTION® Revision Tibial System and EVOLUTION® Revision STEMMED CS Femur with the EVOLUTION® MP CS Tibial Insert.
- Trial name
- NCT06142669
- Testing
- EVOLUTION® Revision Tibial System and EVOLUTION® Stemmed CS Femur with the EVOLUTION® MP CS Tibial Insert
- Where
- Italy
- Volunteers
- 45 people
- Sponsor
- MicroPort Orthopedics Inc.
Total Knee Anthroplasty, Epidural Analgesia
Programmed Intermittent Epidural Bolus Versus Continuous Epidural Infusion for Postoperative Analgesia After Total Knee Arthroplasty
The goal of this clinical trial is to compare two different epidural analgesia delivery methods for pain control after total knee arthroplasty in adults undergoing elective surgery.
- Trial name
- NCT07605208
- Testing
- Programmed intermittent epidural bolus 6 ml, continuous epidural infusion
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Sakarya University
Knee Osteoarthritis
SII Levels Following iPACK Block With Adductor Canal Block in Knee Arthroplasty
This randomized controlled trial evaluates the effect of ultrasound-guided iPACK block with Adductor Canal Block (ACB) on the Systemic Immune-Inflammation Index (SII) in elderly patients undergoing total hip arthroplasty under…
- Trial name
- NCT07449442
- Testing
- sodium Chloride, Ropivacaine Hydrocloride
- Where
- Poland
- Volunteers
- 60 people
- Sponsor
- Poznan University of Medical Sciences
Joint (Knee or Hip Replacement)
The Impact of Extending Sleep Before Joint-replacement Surgery on Post-surgical Pain
This study will evaluate the impact of sleep banking on joint replacement surgery recovery.
- Trial name
- NCT07383584
- Testing
- Sleep banking
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Defense and Veterans Center for Integrative Pain Management
Knee Osteoarthristis
Sleep TO Prevent Post-surgical Pain
This research study is being done to compare different methods of addressing sleep problems before total knee replacement surgery. These methods include Cognitive Behavioral Therapy and light exposure.
- Trial name
- STOPPP (NCT06976138)
- Testing
- Cognitive-Behavioral Therapy for Insomnia, Bright Light therapy via the Re-Timer®, Negative Ion exposure via IonMi Device
- Where
- 2 sites in United States
- Volunteers
- 252 people
- Sponsor
- Johns Hopkins University
Hip Osteoarthritis, Knee Osteoarthritis
The WHERE Study: Waiting for Hip and KneE REplacement
Total hip and knee replacements (TJR) for osteoarthritis are common orthopaedic procedures performed in Canada. Waits for these procedures are already common and lengthy, and the COVID-19 pandemic has resulted in the further of…
- Trial name
- WHERE (NCT06074900)
- Testing
- prospective cohort study
- Where
- Canada
- Volunteers
- 3,008 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Knee Osteoarthritis, Knee Arthropathy
Improving Total Knee Arthroplasty Dissatisfaction Through a Personalized Approach Focusing on PROMs Phenotypes
This study is a randomized controlled trial to assess whether the implementation of a TKA Personalized Outcome Prediction Tool to set expectation, in addition to targeted interventions to address patients with poor baseline…
- Conditions
- Knee Osteoarthritis, Knee Arthropathy, Surgery
- Trial name
- NCT06298721
- Testing
- Personalized outcome prediction tool + targeted interventions, Standard of Care TKA
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- The Cleveland Clinic
Total Knee Arthroplasty, Knee Replacement
Investigating Patient Satisfaction With Smart Knee Implants
The main goal of this study is to see if there is a connection between the social and economic resources available in a patient's neighborhood (measured by the Area Deprivation Index, ADI) and their recovery after knee…
- Conditions
- Total Knee Arthroplasty, Knee Replacement, Knee Replacement Arthroplasty, Knee Osteoarthritis
- Trial name
- NCT06968143
- Testing
- Smart Knee Implant
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Joint Contractures, Total Knee Anthroplasty
Knee Flexionater to Avoid Motion Restoring Surgery
The goal of this clinical trial is to learn whether adding a stretching device to standard physical therapy can help people regain knee bending after total knee replacement surgery.
- Conditions
- Joint Contractures, Total Knee Anthroplasty, Knee Arthrofibrosis
- Trial name
- NCT07454356
- Testing
- Hydraulic high Intensity Stretch Device, Standard Physical Therapy
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Ermi LLC
Inflammation, Osteoarthritis
Photobiomodulation Therapy in Patients Receiving Total Knee Arthroplasty
Photobiomdoulation is the use of near-infrared light to relieve pain, stimulate healing and reduce inflammation. Swelling and inflammation is a common condition after orthopedics surgeries over extremity and spine.
- Conditions
- Inflammation, Osteoarthritis, Post Operative Pain
- Trial name
- NCT06426251
- Testing
- Photobiomodulation
- Where
- Taiwan
- Volunteers
- 15 people
- Sponsor
- National Taiwan University Hospital Hsin-Chu Branch
Knee Osteoarthritis, Total Knee Arthroplasty\(TKA\)
Comparison of Image Based Robotic Total Knee Arthroplasty vs Imageless Augmented Reality Assisted Total Knee Arthroplasty
This study compares the accuracy of two different techniques in placing a total knee replacement. In one technique, accurate instrument placement is facilitated by a robot, and in the other technique, augmented reality is used…
- Conditions
- Knee Osteoarthritis, Total Knee Arthroplasty\(TKA\), Total Knee Replacement Surgery
- Trial name
- RobAR (NCT06891807)
- Testing
- Robotics Assisted TKA, Augmented Reality assisted TKA
- Where
- Belgium
- Volunteers
- 250 people
- Sponsor
- Medisch Centrum Latem
Total Knee Arthroplasty, Postoperative Recovery
Effects of Different Bispectral Index Target Depths on Early Postoperative Recovery Quality in Elderly Patients Undergoing Total Knee Arthroplasty
This is a prospective, single-center, randomized, double-blind controlled trial. The purpose of this study is to determine whether depth-controlled anesthesia with ciprofol guided by Bispectral Index (BIS) can improve early…
- Trial name
- NCT07906457
- Testing
- BIS-guided light-depth anesthesia management (BIS target 50-65), BIS-guided deep-depth anesthesia management (BIS target 35-50)
- Where
- China
- Volunteers
- 130 people
- Sponsor
- General Hospital of Ningxia Medical University
Knee Arthropathy
Influence of Different Prostheses on Postoperative Clinical Function in Total Knee Arthroplasty
Exploring differences in knee function after surgery with different types of prostheses(Cruciate ligament retaining(CR) VS. posterior stabilizing(PS))
- Trial name
- NCT06617819
- Testing
- CR prosthesis, PS prosthesis
- Where
- China
- Volunteers
- 40 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Postoperative Pain After a Total Knee Arthroplasty
Post-operative Analgesic Effect of Oral Nefopam
Primary knee arthroplasty by total prosthesis is a painful surgery, performed on patients with advanced gonarthrosis (stage III), thus already presenting hyperalgesia and hyperalgesia and allodynia.
- Trial name
- NefPO (NCT04576078)
- Testing
- Oral nefopam
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Hospices Civils de Lyon
Pain, Postoperative, Osteoarthritis, Knee
Analgesic Efficacy of Pre-operative Dose of Ketorolac and Gabapentin
Evaluation of the analgesic efficacy of a pre-operative dose of ketorolac and gabapentin in reducing post-operative pain scores in patients undergoing TKA
- Trial name
- NCT07047040
- Testing
- Ketorolac Tromethamine 30 MG/ML Prefilled Syringe, Gabapentin, Empty Medication Capsules
- Where
- Egypt
- Volunteers
- 86 people
- Sponsor
- Assiut University
Osteoarthritis, Knee, Postoperative Pain
A Randomized Comparison of the Efficacy of the IPACK Block Versus the Popliteal Plexus Block for Posterior Knee Analgesia, in Patients Undergoing a Total Knee Arthroplasty and Receiving a Continuous Distal Femoral Triangle Block
Total knee arthroplasty (TKA) is commonly associated with significant postoperative pain, including pain arising from the posterior aspect of the knee.
- Trial name
- NCT07876310
- Testing
- Ultrasound-Guided iPACK Block, Ultrasound-Guided Popliteal Plexus Block, Ultrasound-Guided Continuous Femoral Triangle Block
- Volunteers
- 136 people
- Sponsor
- Clinica Santa Maria
Postoperative Wound Care After TKA
Evaluation of Ioband Coverage Waterproof Dressing Versus Isolated Waterproof Dressing After Primary Total Knee Arthroplasty
Title: Evaluation of Ioband® Coverage Waterproof Dressing in Post-Operative Total Knee Arthroplasty (TKA) Goal: To evaluate the effectiveness of Ioband® coverage waterproof dressing compared to standard waterproof dressing in…
- Trial name
- Wound coverage (NCT06943053)
- Testing
- Isolate waterproof dressing (Opsite), Ioban coverage group
- Where
- 2 sites in Thailand
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Thammasat University Hospital