Clinical trials: Knee Replacement Arthroplasty
Primary Knee Replacement Surgery
Does Supplementing of Quadriceps Strength With Exoskeleton After Total Knee Arthroplasty in High Risk Population Reduce Transfer to Extended Care Facility (ECF)
This study involves an exoskeleton which is believed to increase quadriceps muscle strength in the rehabilitation phase after TKA and reduce the discharge the such patients in Extended care facility (ECF) .
- Trial name
- NCT03762603
- Testing
- Robotic exoskeleton device
- Where
- United States
- Sponsor
- Stanford University
Periprosthetic Knee Infection
One-stage Versus Two-stage Revision of the Infected Knee Arthroplasty
This study investigates functional outcome and safety after one-stage versus two-stage revision of the infected knee arthroplasty.
- Trial name
- NCT03435679
- Testing
- one-stage, two-stage
- Where
- 9 sites in Denmark
- Volunteers
- 97 people
- Sponsor
- Odense University Hospital
Knee Osteoarthritis
Validity and Reliability of 30SFPW Test Patients With TKA
Walking speed after total knee arthroplasty (TKA) can be used as a simple tool to monitor postoperative recovery. There are different protocols for gait assessment in patients with TKA.
- Trial name
- NCT06202170
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people
- Sponsor
- Dokuz Eylul University
Acupuncture Analgesia, Acupuncture
ACU_Knee: Role of Acupuncture in Knee Prosthetic Surgery
Post-operative analgesia after total knee arthroplasty (TKA) has always been a challenge in the anesthesiological setting, having to combine good pain control and the need for early mobilization, both factors that can affect the…
- Conditions
- Acupuncture Analgesia, Acupuncture, Acupuncture Therapy, Total Knee Anthroplasty
- Trial name
- ACU_Knee (NCT07123805)
- Testing
- Acupuncture group
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Knee Osteoarthritis
FAldini Sport Total Joint Arthroplasty-Knee II
The majority of patients undergoing total knee arthroplasty are elderly individuals with low functional demands, aiming to alleviate pain.
- Trial name
- FAST-K II (NCT06383936)
- Testing
- intensive rehabilitation after uncemented TKA
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Istituto Ortopedico Rizzoli
Pain, Hispanics
Efficacy of NSAID and Acetaminophen in the Control of Post-Operative Pain in Patients Undergoing Total Knee Replacement
An alternate perioperative pain control protocol composed of intravenous ketorolac and oral acetaminophen for patients who underwent total knee replacement was designed with the aim to determine its efficacy when compared to pain…
- Conditions
- Pain, Hispanics, Opioid Use, Multimodal Analgesia
- Trial name
- NCT05393414
- Testing
- Opioid based protocol, Opioid sparing protocol
- Where
- Puerto Rico
- Volunteers
- 81 people
- Sponsor
- University of Puerto Rico
Neuromuscular Blockade, Arthroplasty, Replacement, Hip
Reversal of Neuromuscular Blockade With Sugammadex or Usual Care in Hip Fracture Surgery or Joint (Hip/Knee) Replacement (P07038)
This study will assess the effect of reversal of neuromuscular blockade with sugammadex compared with reversal according to usual care (neostigmine or spontaneous reversal) on the incidence of post-surgical bleeding events and on…
- Conditions
- Neuromuscular Blockade, Arthroplasty, Replacement, Hip, Arthroplasty, Replacement, Knee, Blood Coagulation
- Trial name
- NCT01422304
- Testing
- Sugammadex, neostigmine and glycopyrrolate or atropine
- Volunteers
- 1,198 people
- Sponsor
- Merck Sharp & Dohme LLC
Knee Osteoarthritis, Total Knee Arthroplasty
Robotic-Assisted Total Knee Arthroplasty: Cruciate-Retaining Versus Bi-Cruciate Stabilized
The global prevalence of osteoarthritis of the knee with total knee arthroplasty performed is projected to substantially rise in the near future.
- Trial name
- NCT06838663
- Testing
- Robotic assisted Cruciate-Retaining (CR) TKA procedures, Robotic assisted Bi-Cruciate Stabilized (BCS) TKA procedures
- Where
- Hong Kong
- Volunteers
- 60 people
- Sponsor
- Chinese University of Hong Kong
Post-surgical Pain
Study to Evaluate Safety/Efficacy of a Single Preop Dose of AYX1 Injection to Treat Pain After Knee Replacement Surgery
The objectives of this study are to evaluate the safety and analgesic efficacy of a single preoperative intrathecal administration of AYX1 Injection in patients undergoing unilateral total knee arthroplasty.
- Trial name
- NCT02807428
- Testing
- AYX1 Injection 660 mg/6 mL
- Where
- 9 sites in United States
- Volunteers
- 210 people
- Sponsor
- Adynxx, Inc.
Acute Pain, Urinary Retention
Incidence of Urinary Retention in Patients Undergoing Unilateral Total Knee Arthroplasty- Comparison Between Continuous Epidural Analgesia and Single Shot Femoral Nerve Block- a Randomized Controlled Study (UriKANE)
This study aims to compare the incidence of urinary retention and requirement of bladder catheterization in patients undergoing total knee arthroplasty while receiving either continuous epidural analgesia or single shot femoral…
- Conditions
- Acute Pain, Urinary Retention, Post Operative Pain
- Trial name
- UriKANE (NCT02689011)
- Testing
- Femoral Nerve Block, Epidural
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Aga Khan University
Acute Pain, Chronic Pain
Dexamethasone and Pain Following Total Knee Arthroplasty
The purpose of the study is three fold. First to determine the ideal dose of dexamethasone intraoperatively that will reduce acute pain and opioid consumption.
- Trial name
- NCT02271698
- Testing
- Dexamethasone
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Duke University
Pain, Postoperative
Efficiency Study About the Effect of Acupuncture on Postoperative Pain After Total Knee Arthroplasty
The purpose of this study is to evaluate the use of needle acupuncture in comparison to a conventional postoperative pain management in terms of reducing pain and pain medication use in an interdisciplinary setting in a…
- Trial name
- APOPKA (NCT02456116)
- Testing
- acupuncture/PCA/NSAID, PCA/NSAID
- Where
- Austria
- Volunteers
- 90 people
- Sponsor
- Medical University of Vienna
Tantalum, Bone Loss
Allograft and Tantalum Cone Reconstruction in TKA Revision
A new surgical technique of reconstruction for bone loss in TKA revision using tantalum cone and allograft. Study of radiological and clinical outcomes.
- Conditions
- Tantalum, Bone Loss, Allograft
- Trial name
- NCT05510011
- Where
- France
- Volunteers
- 76 people
- Sponsor
- University Hospital, Montpellier
Osteoarthritis, OA
Comparing X-3 To N2vac Polyethylene With the Triathlon Total Knee System
Methodology: This study will be a randomized, multi-center evaluation comparing N2vac polyethylene inserts and patellas with X3 inserts and patellas when used in the Triathlon PS total knee system.
- Trial name
- NCT00665964
- Testing
- X-3 polyethylene, N2Vac polethylene
- Where
- Canada
- Sponsor
- Dalhousie University
Arthroplasties, Replacement, Knee
Stryker Triathlon Total Knee System for Total Knee Arthroplasty Implanted Using Shapematch Cutting Guides:Sub-Study A
This is a prospective, non-randomized, study of the clinical outcomes of participants that receive the Stryker Triathlon® Total Knee System for Total Knee Arthroplasty implanted using ShapeMatch® Cutting Guides.
- Trial name
- NCT02516163
- Testing
- Shapematch Cutting Guides
- Volunteers
- 55 people
- Sponsor
- Stryker South Pacific
Osteoarthritis
Comparison of Total Knee Arthroplasties With Oxidized Zirconium and Cobalt Chromium Femoral Components
The purpose of this study is to determine if there are any clinical or radiographic differences in cemented total knee arthroplasty with an oxidized zirconium and a cobalt-chromium femoral knee component.
- Trial name
- NCT01336595
- Testing
- Zirconium (Zirconium Genesis II), Cobalt-Chrome (Cobalt Chrome Genesis II)
- Where
- South Korea
- Volunteers
- 331 people
- Sponsor
- Ewha Womans University
Venous Thromboembolism
BIBR 1048 Dose Range Finding Study in Prevention of Venous Thromboembolism in Patients With Primary Elective Total Hip or Knee Replacement Surgery
The primary objective of this study is to establish the dose-response relationship with regard to efficacy and safety of BIBR 1048 (50 mg bis in die(b.i.d), 150 mg b.i.d, 225 mg b.i.d.
- Trial name
- NCT01225822
- Testing
- Enoxaparin, BIBR 1048
- Where
- 59 sites in Austria, Belgium and 10 more
- Volunteers
- 1,973 people
- Sponsor
- Boehringer Ingelheim
Thromboembolism
SALTO - Epidemiological Study on Compliance and Treatment Satisfaction
Patients that are on total knee/hip replacement initiate prophylaxis treatment on the hospital ground. Once they leave the hospital, as outpatients they continue with the treatment at least during two consecutive weeks.
- Trial name
- SALTO (NCT00911001)
- Testing
- No Drug
- Where
- Spain
- Volunteers
- 480 people
- Sponsor
- Bayer
Total Knee Arthroplasty (Postoperative Pain)
Phase 2B Study Assessing Pain Relief After Replacement of the Knee
The goal of the ATX101-TKA-004 clinical trial aims to evaluate the efficacy and safety of ATX101 1,500 mg in participants undergoing primary unilateral total knee arthroplasty.
- Trial name
- SPARK2 (NCT06799845)
- Testing
- ATX101, bupivacaine hydrochloride
- Where
- 11 sites in United States
- Volunteers
- 226 people
- Sponsor
- Allay Therapeutics, Inc.
Total Knee Arthroplasty
The Health Impact of Mindfulness Based Stress Reduction on Total Knee Arthroplasty
Despite surgical success of total knee arthroplasty (TKA), reports of dissatisfaction and poor outcomes including increased pain, reduced function for daily activities, and compromised psychological health are common.
- Trial name
- NCT03228745
- Testing
- Pre-operative MBSR
- Where
- Canada
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
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