Clinical trials: Knee Replacement Arthroplasty
Acute Pain, Chronic Pain
The Use of Venlafaxine in Reducing Pain in Primary Total Knee Replacement
Patients experience pain after their knee replacement surgery - and some may continue to experience persistent pain long after their knee replacement surgery.
- Conditions
- Acute Pain, Chronic Pain, Knee Pain Chronic, Neuropathic Pain
- Trial name
- NCT05023278
- Testing
- Venlafaxine 37.5 MG
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Analgesia
Safety of F14 Following Total Knee Replacement
Open-label single-arm study in which all subjects receive F14 as part of a scheduled TKR and multimodal analgesia
- Trial name
- NCT04860635
- Testing
- F14 (sustained release celecoxib)
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Arthritis Innovation Corporation
Total Knee Arthroplasty, Revision Total Knee Arthroplasty
Multigen Plus CCK and AMF TT Cones Follow Up Study
This study is aimed to provide a clinical and radiographic evaluation of 68 condylar-constrained Total Knee Arthroplasty (TKA) using a single type of prosthesis (Multigen Plus CCK configuration), alone or involving the AMF TT…
- Trial name
- NCT05314491
- Testing
- Multigen Plus CCK, AMF TT cones
- Where
- 3 sites in Portugal, Slovakia and 1 more
- Volunteers
- 68 people
- Sponsor
- Limacorporate S.p.a
Knee Replacement, Hip Replacement
Perioperative Hyperglycaemia in Primary Total Hip and Knee Replacement
The purpose of this study is to analyze how common stress hyperglycaemia (abnormally high blood glucose) is in primary hip and knee replacement surgeries and which factors predispose to hyperglycaemia.
- Conditions
- Knee Replacement, Hip Replacement, Hyperglycemia
- Trial name
- HyTe-1 (NCT01021826)
- Where
- Finland
- Volunteers
- 193 people
- Sponsor
- Coxa, Hospital for Joint Replacement
Osteoarthritis, Rheumatoid Arthritis
PS150 Total Knee Arthroplasty Outcomes Registry
This registry is intended to evaluate the clinical outcomes of the DePuy P.F.C. Sigma PS150 RP Total Knee System. 200 participants will be enrolled prospectively or retrospectively and the follow up period will be 5 years.
- Trial name
- NCT02319291
- Testing
- P.F.C. Sigma PS150 RP Total Knee System
- Where
- 4 sites in Australia, South Korea
- Volunteers
- 175 people
- Sponsor
- DePuy Orthopaedics
Pain, Postoperative
Safety and Efficacy Study of KAI-1678 to Treat Subjects With Postoperative Pain
The purpose of this study is to determine whether KAI-1678 is effective in the treatment of postoperative pain following total hip or total knee replacement.
- Trial name
- NCT01015235
- Testing
- KAI-1678, Ketorolac Tromethamine
- Where
- New Zealand
- Volunteers
- 90 people
- Sponsor
- KAI Pharmaceuticals
Unicompartmental Knee Replacement
Fast-Track vs Conventional for UKA
The purpose of this study is to see if it is possible to discharge patient undergoing a UKA 1 day postoperatively
- Trial name
- NCT00284635
- Testing
- Fast track vs conventional
- Where
- Denmark
- Sponsor
- Frederiksberg University Hospital
Total Knee Arthroplasty, Osteoarthritis
Kinematic and Mechanical Alignment Randomized Trial
Knee replacement surgery is the second most common surgery in Canada. People who have very painful knee arthritis usually receive a knee replacement where the surgeon aims to make everyone's knee as straight as possible (called…
- Trial name
- KMART (NCT06787417)
- Testing
- Restricted Kinematically-aligned Arthroplasty, Mechanically-Aligned Arthroplasty
- Where
- Canada
- Volunteers
- 260 people
- Sponsor
- McMaster University
Total Knee Replacement
Effectiveness of Acupuncture as an Adjunct to Rehabilitation After Knee Arthroplasty
No randomized trials have tested the effectiveness of acupuncture as a supplement to rehabilitation after total knee replacement.
- Trial name
- NCT00935155
- Testing
- Acupuncture, exercises
- Where
- Denmark
- Volunteers
- 170 people
- Sponsor
- Back and Rehabilitation Center, Copenhagen
Postoperative Anemia, Osteoarthritis, Knee
Comparing Intravenous and Oral Iron in Postoperative Anemia
Postoperative anaemia are common in patients undergoing major orthopaedic surgery. The main consequence of perioperative anaemia is an increased risk of red blood cell (RBC) transfusions.
- Trial name
- NCT01913808
- Testing
- Ferric carboxymaltose, ferrous glycine sulphate
- Where
- Spain
- Volunteers
- 122 people
- Sponsor
- Parc de Salut Mar
Multimodal Analgesia, Nonsteroidal Anti-inflammatory Drugs
NSAID vs. Narcotics
This will be a single-center, prospective observational study. The study will compare post-operative pain scores and narcotic consumption between two groups of patients - one cohort will receive ibuprofen (Motrin) and Percocet…
- Trial name
- NCT02915055
- Testing
- Ibuprofen 600 mg, standard oxycodone/acetaminophen
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Knee Arthroplasty, Total, Anesthesia, Regional
Continuous Adductor Canal Block in Outpatient Total Knee Arthroplasty
Total knee arthroplasty (TKA) is a frequent performed surgery. Many institutions are implementing outpatient programs for this surgery and adequate pain management is an important feature.
- Conditions
- Knee Arthroplasty, Total, Anesthesia, Regional, Acute Pain
- Trial name
- NCT05100706
- Testing
- Continuous adductor canal block (CACB)
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University of Toronto
Total Knee Arthroplasty, Osteoarthritis
Computer Assisted Total Knee Replacement
The purpose of this study is to determine whether intraoperative computer-assisted navigation improves prosthetic implant positioning as compared to conventional intraoperatve instrumentation in Total Knee Arthroplasty (TKA).
- Trial name
- NCT00279838
- Testing
- Computer Assisted Navigation Knee Replacement
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Mayo Clinic
Primary Osteoarthritis of Knee Nos
A Prospective Study to Evaluate Robot Assisted Total Knee Replacement Outcomes
This study aims to see if outcomes for patients that receive the traditional total knee replacement surgical technique are different than the outcomes for patients that receive robot-assisted total knee replacement.
- Trial name
- NCT03523897
- Testing
- Robot Assisted Total Knee Replacement, Traditional Total Knee Replacement
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Virtua Health, Inc.
Venous Thromboembolism
Evaluation of AVE5026 as Compared to Enoxaparin for the Prevention of Thromboembolism in Patients Undergoing Elective Knee Replacement Surgery
The primary objective was to compare the efficacy of Semuloparin sodium (AVE5026) with Enoxaparin for the prevention of Venous Thromboembolic Events [VTE] in patients undergoing elective knee replacement surgery.
- Trial name
- SAVE-KNEE (NCT00718224)
- Testing
- Semuloparin sodium, Enoxaparin
- Where
- 17 sites in United States, Argentina and 15 more
- Volunteers
- 1,150 people
- Sponsor
- Sanofi
Genu Varum, Knee Osteoarthritis
Effect of RO On GB During TKR Severe Varus Deformity
Effect Of Reduction Osteotomy On Gap Balancing During Total Knee Replacement For Severe Varus Deformity
- Trial name
- NCT03065738
- Testing
- tibial reduction osteotomy in total knee replacement
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Assiut University
Post Operative Pain
Methadone in TKA for Post-op Pain and Opioid Reduction
This randomized, double-blind controlled trial investigates whether intraoperative IV methadone (0.15 mg/kg based on ideal body weight) reduces acute postoperative pain and opioid consumption in patients undergoing elective total…
- Trial name
- NCT07226076
- Testing
- Methadone Hydrochloride
- Where
- United States
- Volunteers
- 162 people
- Sponsor
- Medical University of South Carolina
Total Knee Replacement
The Clinical Observation on Taping After Total Knee Replacement
The investigators will conduct a single-blind, randomized controlled trial of 100 patients with total knee replacement. Patients will be randomly assigned into a control group and an intervention group.Both groups received same…
- Trial name
- taping (NCT03340584)
- Testing
- the Nine Castle Net Format Taping, traditional rehabilitation
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Osteo Arthritis Knee, Arthroplasty, Replacement, Knee
Sharp Dissection Versus Monopolar Electrocautery in Primary Total Knee Arthroplasty Performed Under Tourniquet
This study compares the use of sharp dissection with diathermy for the approach to a total knee replacement. Half of the patients will be randomly assigned each intervention.
- Trial name
- NCT03559478
- Testing
- Sharp dissection with scalpel plus electrocautery to vessels, Electrocautery for all dissection
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- Royal Infirmary of Edinburgh
Acute Pain, Postoperative, Chronic Pain
Effect of Rebound Pain on Chronic Postsurgical Pain After Total Knee Arthroplasty
This prospective observational study aims to evaluate whether rebound pain after peripheral nerve block is associated with the development of chronic postsurgical pain following elective total knee arthroplasty.
- Conditions
- Acute Pain, Postoperative, Chronic Pain, Arthroplasty, Replacement, Knee
- Trial name
- NCT07511985
- Where
- Turkey (Türkiye)
- Volunteers
- 220 people
- Sponsor
- Konya City Hospital
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