Clinical trials: Knee Rheumatism
Osteoarthritis, Knee
The Comparison of Two Crosslinked Hyaluronate for the Treatment of Osteoarthritis Pain
The aim of this study is to compare the safety and effectiveness between two BDDE-crosslinked hyaluronate, HYAJOINT Plus and Durolane, for the Treatment of Knee Osteoarthritis Pain.
- Trial name
- NCT04000204
- Testing
- HYAJOINT Plus, Durolane
- Where
- Taiwan
- Volunteers
- 142 people
- Sponsor
- SciVision Biotech Inc.
Osteoarthritis of Knee
A Clinical Trial to Evaluate the Safety and Efficacy of Retreatment With Intra-articular LBSA0103 Injections in the Patients With Osteoarthritis of the Knee
To assess the safety and efficacy of LBSA0103 (BDDE cross-linked sodium hyaluronate gel) when it is administered for the second time 26 weeks after its first administration in patients with osteoarthritis of the knee.
- Trial name
- NCT02122601
- Testing
- LBSA0103 (BDDE cross-linked sodium hyaluronate gel)
- Where
- South Korea
- Volunteers
- 174 people
- Sponsor
- LG Life Sciences
Osteoarthritis, Knee, Traumatic Arthritis
Physica System Total Knee Replacement Registry Study
The primary objective of this study is to obtain long-term implant survivorship (out to 10 years) and to assess clinical, patient-reported outcome measures, and radiographic data for the commercially available Physica system.
- Conditions
- Osteoarthritis, Knee, Traumatic Arthritis, Avascular Necrosis, Degenerative Joint Disease of Knee
- Trial name
- NCT03048201
- Testing
- Physica Kinematic Retaining Knee System, Physica Cruciate Retaining Knee System, Physica Posterior Stabilized Knee System
- Where
- 5 sites in United States
- Volunteers
- 800 people
- Sponsor
- Limacorporate S.p.a
Osteoarthritis, Knee
Comparative Study of Two Hyaluronic Acid Formulation in the Management of Knee Osteoarthritis
The objective of this randomized, double-blind, active-controlled, non-inferiority study is to compare the effectiveness and safety of a single injection of Hymovis ONE®, a sodium hyaluronate formulation, to Monovisc™, another…
- Trial name
- NCT06528600
- Testing
- Hymovis ONE, Monovisc
- Where
- 19 sites in Italy
- Volunteers
- 350 people
- Sponsor
- Fidia Farmaceutici s.p.a.
Knee Osteoarthritis
Exploratory Non Comparative Study to Evaluate the Efficacy of Highly Bioavailable Curcumin (Flexofytol) in Patients With Knee Osteoarthritis
The purpose of this study is to evaluate the efficacy of bio-optimized curcumin(Flexofytol) during a 90-days period in knee ostearthritis patients on the serum levels of specific biomarkers of osteoarthritis and on the evaluation…
- Trial name
- NCT01909037
- Testing
- Flexofytol (bio-optimized curcumin)
- Where
- Belgium
- Volunteers
- 22 people
- Sponsor
- Tilman S.A.
Osteoarthritis, Knee
JOURNEY™ II CR Total Knee System
The purpose of this study is to evaluate the safety and effectiveness of the JOURNEY™ II CR Total Knee System in subjects with degenerative joint disease (DJD) requiring primary total knee replacement.
- Trial name
- NCT02440672
- Testing
- JOURNEY™ II CR Total Knee System (J II CR TKS)
- Where
- 9 sites in United States, Spain and 1 more
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Smith & Nephew, Inc.
Osteoarthritis, Knee
Umbilical Cord Derived Wharton's Jelly for Knee Osteoarthritis
The purpose of this study is to determine the safety and efficacy of intraarticular injection of umbilical cord derived Wharton's Jelly for treatment of knee osteoarthritis symptoms.
- Trial name
- NCT04719793
- Testing
- Umbilical Cord-derived Wharton's Jelly
- Volunteers
- 12 people
- Sponsor
- BioIntegrate
Osteoarthritis Knee
Gel-One Treatment in Knee Osteoarthritis
The purpose of this study is to determine whether Gel-One demonstrates a superior effectiveness in osteoarthritis (OA) knee pain compared with phosphate buffered saline (PBS) injections.
- Trial name
- NCT01934218
- Testing
- Gel-One, PBS
- Where
- 41 sites in United States
- Volunteers
- 814 people
- Sponsor
- Seikagaku Corporation
Osteoarthritis, Knee
Study to Evaluate the Safety and Tolerability of FX201 in Patients With Osteoarthritis of the Knee
This two-part study will be conducted in male and female patients, 30 - 80 years of age with painful OA of the index knee with Kellgren-Lawrence (K-L) Grade 2, 3 or 4.
- Trial name
- NCT04119687
- Testing
- FX201
- Where
- 6 sites in United States
- Volunteers
- 72 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Knee Osteoarthritis
A Clinical Study to Evaluate the Safety, Tolerability and Efficacy of BBM-A101 in the Treatment of Knee Osteoarthritis.
The purpose of the study is to evaluate the safety, tolerability, and efficacy of BBM-A101 to treat participants with knee osteoarthritis.
- Trial name
- NCT07198555
- Testing
- BBM-A101
- Where
- 2 sites in China
- Volunteers
- 81 people
- Sponsor
- Belief BioMed (Beijing) Co., Ltd
Osteoarthritis, Knee, Joint Instability
Combined Prospective and Retrospective Post-Market Follow Up of the 'BPK-S Integration' UC as Primary Implant in the Variant CoCr
Patients who received a total knee endoprosthesis BPK-S Integration between 2011 and 2013 will be invited to participate in this PMCF study provided sufficient source data documentation is available regarding preoperative…
- Trial name
- NCT03406637
- Testing
- BPK-S Integration
- Where
- 2 sites in Belgium
- Volunteers
- 62 people
- Sponsor
- Peter Brehm GmbH
Osteoarthritis
Retrospective Follow-up of Synvisc® in Active Patients With Knee Osteoarthritis
Retrospective collection of data, aimed at a better knowledge of the context of use of Synvisc® among the patients practising a regular activity (professional/leisure), and at evaluating the different practices and their results.
- Trial name
- NCT02195492
- Testing
- Synvisc®
- Volunteers
- 41 people
- Sponsor
- Boehringer Ingelheim
Knee Osteoarthritis
Safety and Effectiveness Study of a Non-Crosslinked HA Alkylamide HYADD(TM) 4 Hydrogel for Osteoarthritis of the Knee
The purpose of this study is to determine whether intra-articular hyaluronic acid provides symptomatic relief of osteoarthritis of the knee.
- Trial name
- NCT02187549
- Testing
- HYMOVIS
- Where
- 21 sites in United States
- Volunteers
- 332 people
- Sponsor
- Fidia Farmaceutici s.p.a.
Osteoarthritis
The Influence Of a Natural Anti-Inflammatory Product On Levels Of Inflammatory Markers In Cases With Osteoarthritis Of Knee
This is a randomized, placebo controlled study. The first subject is expected to be enrolled in July 2014, and the last subject is expected to complete the study by July 2015.
- Trial name
- NCT02333084
- Testing
- PRN Joint Health Formula, PRN Flex Omega Benefits® combination
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Physician Recommended Nutriceuticals
Osteoarthritis, Knee, Pain
New Hydroxyethyl Cellulose Hydrogel for the Treatment of the Pain of Knee Arthrosis
Prospective, multicenter study, unmasked, single-arm, to study the safety and efficacy of a new hydroxyethyl cellulose hydrogel for the treatment of the knee pain caused by osteoarthritis.
- Trial name
- PROMGEL-OA (NCT04061733)
- Testing
- Hydrogel injection
- Where
- 3 sites in Argentina
- Volunteers
- 50 people
- Sponsor
- Promedon
Rheumatoid Vasculitis With Rheumatoid Arthritis of Knee, Unilateral Post-Traumatic Osteoarthritis of Knee
JOURNEY II XR Safety and Effectiveness PMCF
This study was designed to demonstrate the safety and performance of the JOURNEY II XR total knee system by evaluating implant survival rates at 10 years using Kaplan-Meier analysis.
- Conditions
- Rheumatoid Vasculitis With Rheumatoid Arthritis of Knee, Unilateral Post-Traumatic Osteoarthritis of Knee, Knee Osteoarthritis, Degenerative Arthritis Peripheral Joint
- Trial name
- NCT03136887
- Testing
- JOURNEY II XR Total Knee System
- Where
- 14 sites in United States
- Volunteers
- 176 people
- Sponsor
- Smith & Nephew, Inc.
Osteoarthritis
Safety and Efficacy of the Buprenorphine Transdermal Delivery System in Subjects With Osteoarthritis Pain.
The objective of this study is to assess the safety and efficacy of the buprenorphine transdermal system (5, 10, and 20 mg) in comparison to placebo transdermal system in subjects with osteoarthritis pain.
- Trial name
- NCT00314652
- Testing
- Buprenorphine transdermal delivery system
- Where
- 22 sites in United States
- Volunteers
- 260 people
- Sponsor
- Purdue Pharma LP
Osteoarthritis of Knee
Study to Assess the Effect of E-OA-07 on Acute Pain Response in Subjects Suffering From Knee OA
The repetitive motions associated with active life and many sports can increase the wear and tear to the joints that leads to decrease in flexibility and joint pain finally heading its way to osteoarthritis.
- Trial name
- Osteolanc (NCT02417506)
- Testing
- E-OA-07 (Lanconone), Ibuprofen
- Where
- India
- Volunteers
- 72 people
- Sponsor
- Vedic Lifesciences Pvt. Ltd.
Osteoarthritis, Knee, Osteoarthritis, Hip
Phase II Study of CG100649 for Primary Osteoarthritis in Male Subjects
The primary objective of this study is to evaluate the safety and efficacy of 3 loading and maintenance dose levels of CG100649 administered for 21 days in the treatment of osteoarthritis pain.
- Trial name
- NCT00530452
- Testing
- CG100649, Silicified microcrystalline cellulose + talc
- Where
- Germany
- Volunteers
- 240 people
- Sponsor
- CrystalGenomics, Inc.
Osteoarthritis
A Comparative Study of Tramadol Hydrochloride Plus Acetaminophen Tablets Maintenance Versus Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Maintenance in Participants With Knee Osteoarthritis
The purpose of this study is to compare the effectiveness of tramadol hydrochloride 37.5 milligram (mg) plus acetaminophen 325 mg maintenance with that of non-steroidal anti-inflammatory drugs (NSAIDs) maintenance in participants…
- Trial name
- NCT00635349
- Testing
- Meloxicam, Aceclofenac, Tramadol Hydrochloride Plus Acetaminophen
- Volunteers
- 143 people
- Sponsor
- Janssen Korea, Ltd., Korea
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