Clinical trials: Knee Rheumatism
Knee Osteoarthritis, Knee Pain Chronic
Lyophilized and Micronized Particulate Human Amniotic and Umbilical Cord (TTAX03) for KL Grade 3-4 Knee OA
It is hypothesized that a single Intra-articular Injection of TTAX03, 100mg in 2mL of saline, will have more benefit with respect to the proportion of responders 12 weeks post-injection than an equal volume of saline, based on…
- Conditions
- Knee Osteoarthritis, Knee Pain Chronic, Knee Arthritis
- Trial name
- NCT05079035
- Testing
- TTAX03, Saline
- Where
- 10 sites in United States
- Volunteers
- 90 people
- Sponsor
- BioTissue Holdings, Inc
Knee Osteoarthritis
A Study to Compare Levels of Capsaicin After Intra-Articular Injection and Topical Application in Patients With Painful Knee Osteoarthritis
This is a Phase 1b, open-label, two-period, randomized crossover study in adult male and female participants with painful knee osteoarthritis.
- Trial name
- NCT03576508
- Testing
- CNTX-4975-05, Qutenza, Lidocaine (without epinephrine)
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Centrexion Therapeutics
Osteoarthritis
Osteoarthritis Bedside Testing Kit
Develop and test a bedside testing kit for evaluating pain and symptoms of osteoarthritis
- Trial name
- NCT00794651
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Analgesic Solutions
Osteoarthritis, Knee
A Study To Investigate Whether PF-04457845 Is Effective In Treating Pain, Is Safe And Tolerable In Patients With Osteoarthritis Of The Knee
Inactivation of the FAAH (Fatty Acid Amide Hydrolase) enzyme has been shown to relieve pain and inflammation in animal studies. PF-04457845 has been shown to inactivate the FAAH enzyme in animals and healthy human volunteers.
- Trial name
- NCT00981357
- Testing
- PF-04457845, Naproxen
- Where
- 7 sites in United States, Canada and 1 more
- Volunteers
- 76 people
- Sponsor
- Pfizer
Osteoarthritis of the Knee
Irritation and Sensitization Study of HP-5000 Topical System
This study will assess skin irritation and sensitization for HP-5000 patch in healthy subjects.
- Trial name
- NCT04882319
- Testing
- HP-5000 Topical Patch, Saline Patch
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Noven Pharmaceuticals, Inc.
Knee Osteoarthritis
Comparison Between Mobithron® and Crystalline Glucosamine Sulphate in Patients With Knee Osteoarthritis
Knee osteoarthritis is a common degenerative joint disorder that causes pain, functional limitation, and reduced quality of life.
- Trial name
- NCT07717957
- Testing
- Mobithron®, Crystalline Glucosamine Sulphate
- Where
- Malaysia
- Volunteers
- 34 people
- Sponsor
- BREGO Life Sciences
Osteoarthritis, Knee
An Exploratory Clinical Study to Investigate the Effect of autoSTEM-OA and alloSTEM-OA in Participants With Knee Osteoarthritis
A phase 1 exploratory clinical study to investigate safety, tolerance and efficacy of a single intra-articular injection of autoSTEM-OA or alloSTEM-OA in participants with mild to moderate knee osteoarthritis
- Trial name
- NCT05789719
- Testing
- STEM-OA
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- StemMedical A/S
Knee Osteoarthritis
Phase 1b Clinical Trial to Evaluate PEP and EUFLEXXA for Knee Osteoarthritis (KOA)
Evaluate the safety and exploratory efficacy of single intra-articular injections of PEP reconstituted with 0.9% Normal Saline at a low dose (one vial PEP) and high dose (two vials PEP), with and without EUFLEXXA, for the…
- Trial name
- NCT06463132
- Testing
- PEP/Euflexxa, PEP
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Rion Inc.
Knee Osteoarthritis
Initial Pilot Study to Evaluate the Safety and Temporary Symptom Improvement Efficacy of CKD-981
The purpose of this study is to prove that the temporary symptom improvement effect on knee osteoarthritis using CKD-981
- Trial name
- NCT06954766
- Testing
- CKD-981(1), CKD-981(2), Reference Drug
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Chong Kun Dang Pharmaceutical
Osteoarthritis, Knee
A Single Time-Point Study to Evaluate the ConforMIS iTotal (PS) Knee Replacement System Versus Off-the-Shelf
This study is designed to compare outcome data for patients who have recently undergone surgery with the iTotal® Posterior Stabilizing (PS) Knee Replacement System (hereafter referred to as the "iTotal") versus those who have…
- Trial name
- NCT03146819
- Testing
- iTotal PS Knee Replacement System, Off-the-Shelf Knee Replacement System
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Restor3D
Osteoarthritis, Knee
A Study of the Efficacy and Safety of EUFLEXXA™ for Treatment of Painful Osteoarthritis of the Knee
This multicenter, randomized, double-blind study will be performed in approximately 600 subjects with chronic idiopathic osteoarthritis (OA) of the knee. An open-label safety extension will follow.
- Trial name
- NCT00379236
- Testing
- EUFLEXXA™
- Where
- United States
- Volunteers
- 588 people, healthy volunteers welcome
- Sponsor
- Ferring Pharmaceuticals
Gonarthrosis
Management of Joint Pain Associated With Osteoarthritis of the Knee With Association of Plant Extracts.
The aim of the study is to evaluate at 3 months the effect of a supplementation with extracts of Curcuma longa, Boswellia serrata and Porphyra umbilicalis on the acceptability of pain for patients suffering from gonarthritic pain.
- Trial name
- NCT02977936
- Testing
- Cartimotil Fort
- Where
- France
- Volunteers
- 126 people
- Sponsor
- PiLeJe
Osteoarthritis
Prospective Clinical Study Evaluating Tibiofemoral Rotational Alignment Using Intraoperative Sensing During Total Knee Arthroplasty (TKA)
The objectives of the study are twofold: 1) Evaluate how intra-operative sensing may assist the surgeon with tibiofemoral rotational alignment by testing the precision and variability of setting tray rotation to the mid-third of…
- Trial name
- NCT02286739
- Testing
- TKA with "Verasense", TKA without "Verasense"
- Where
- 6 sites in United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Orthosensor, Inc.
Knee Osteoarthritis
Post Market Clinical Follow-Up Study- EVOLUTION® Revision CCK
Sponsor is conducting this post market clinical follow-up (PMCF) study to evaluate the safety and efficacy of its EVOLUTION® Revision CCK Tibia and EVOLUTION® Revision CCK Femur with EVOLUTION® CCK Tibial inserts.
- Trial name
- NCT04145401
- Testing
- Revision Knee implants
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- MicroPort Orthopedics Inc.
Osteoarthritis
A Study of the Efficacy and Safety of Synvisc® in Chinese Subjects With Symptomatic Osteoarthritis of the Knee(s)
Primary Objective: To evaluate the change of Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) A1 subscore (walking pain) at 26 weeks compared to the Baseline score To evaluate the safety using the incidence…
- Trial name
- NCT01586338
- Testing
- Hylan G-F 20
- Where
- China
- Volunteers
- 237 people
- Sponsor
- Sanofi
Osteoarthritis, Knee
Prospective Post-Market Data Collection on Patients With Knee OA and Treated With nSTRIDE APS
This study will document treatment effects, changes in quality of life, procedure complications, adverse events, healthcare resource utilization, and further needed intervention(s) following treatment with nSTRIDE autologous…
- Trial name
- PROGRESS III (NCT02580643)
- Testing
- APS
- Where
- United Kingdom
- Volunteers
- 78 people
- Sponsor
- Zimmer Biomet
Knee Osteoarthritis
Evaluation of the Safety and Effectiveness of the Kinamed Gem Ceramic Femoral Component for Total Knee Replacement
The aim of this study is to provide evidence that the safety and effectiveness of the ceramic femoral component of the Gem Total Knee System is similar to FDA approved implants used in total knee replacement surgery.
- Trial name
- NCT00743717
- Testing
- zirconia femoral component, cobalt chrome femoral component
- Volunteers
- 4 people
- Sponsor
- Kinamed Incorporated
Osteoarthritis
Meloxicam SoluMatrix® Capsules vs Meloxicam Tablets to Treat Osteoarthritis Pain
The purpose of this study is to evaluate the safety and efficacy of a low dose and a high dose of Meloxicam SoluMatrix® Capsules versus Meloxicam Tablets for the treatment of pain due to osteoarthritis of the knee or hip.
- Trial name
- NCT02405793
- Testing
- Meloxicam Test Capsules, Meloxicam Tablets
- Sponsor
- Iroko Pharmaceuticals, LLC
Osteoarthritis (OA) of the Knee
To Assess the Safety and Effectiveness of Hyruan ONE Versus a Comparator for the Treatment of Knee Osteoarthritis in Europe
To Assess the Safety and Effectiveness of Hyruan ONE versus a Comparator for the Treatment of Knee Osteoarthritis in Europe
- Trial name
- NCT04732793
- Testing
- Hyruan ONE®, Durolane®
- Where
- Poland
- Volunteers
- 284 people
- Sponsor
- LG Chem
Knee Osteoarthritis
Fasitibant Intra-articular Injection in Patients With Symptomatic Osteoarthritis of the Knee
This study is designed as a double-blind, randomised, placebo-controlled, four parallel arm, dose-finding study, to be conducted in approximately 26 sites, to evaluate the efficacy, safety, tolerability, and pharmacokinetics of…
- Trial name
- ALBATROSS-3 (NCT02205814)
- Testing
- Fasitibant- low dose, Fasitibant- intermediate dose, Fasitibant- high dose
- Where
- 25 sites in United States, Czechia and 2 more
- Volunteers
- 436 people
- Sponsor
- Menarini Group