Clinical trials: Knee Rheumatism
Osteoarthritis of the Knee, Total Knee Replacement
Prophecy Guide Outcomes in Total Knee Replacement Surgery
This project aims to assess two different techniques used to position the knee replacement implant during surgery. The patients will be randomised to receive either the following: 1.
- Trial name
- NCT01163708
- Testing
- Prophecy Technique, Navigation System
- Where
- 2 sites in Australia
- Volunteers
- 188 people
- Sponsor
- Global Orthopaedic Technology
Osteoarthritis, Knee
The Impact of Procedural Awareness of Knee Injections for Osteoarthritis on Patient Perceptions of Effectiveness
The purpose of this study is to determine whether outcomes for patients receiving intra-articular platelet-rich plasma (PRP) injections for knee osteoarthritis are influenced by observation of the preparatory steps to the…
- Trial name
- NCT04111718
- Testing
- Platelet-rich plasma (PRP), Viewing of preparation
- Where
- Canada
- Volunteers
- 158 people
- Sponsor
- ArthroBiologix Inc.
Osteoarthritis, Knee
"CuraMed" and "Curamin" in Osteoarthritis
This randomized, placebo-controlled study evaluates the effects of CuraMed ® (BCM-95 ®) and Curamin ® in the treatment of osteoarthritis.
- Trial name
- NCT02390349
- Testing
- Curamin, CuraMed
- Where
- Armenia
- Volunteers
- 179 people
- Sponsor
- EuroPharma, Inc.
Osteoarthritis, Knee
Safety and Efficacy of Celecoxib Versus Naproxen in the 6-month Treatment of Knee Osteoarthritis
To compare the safety and efficacy of celecoxib versus naproxen for the treatment of knee osteoarthritis
- Trial name
- CLOAK (NCT00643799)
- Testing
- Celecoxib, Naproxen
- Where
- 51 sites in United States
- Volunteers
- 586 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Osteoarthritis
Safety and Effectiveness of Monovisc® Injection for Osteoarthritis of the Knee
The purpose of this study is to determine whether intra-articular injection of Monovisc® hyaluronic acid provides symptomatic relief of osteoarthritis of the knee.
- Trial name
- NCT00653432
- Testing
- Monovisc®, Saline
- Where
- 31 sites in United States, Canada
- Volunteers
- 369 people
- Sponsor
- Anika Therapeutics, Inc.
Osteoarthritis, Avascular Necrosis
Cementless Oxford Partial Knee Controlled Observational Study
The purpose of this study is to evaluate the safety and effectiveness of the Cementless Oxford Partial Knee System.
- Trial name
- GK10 (NCT02350049)
- Volunteers
- 391 people
- Sponsor
- Zimmer Biomet
Osteoarthritis, Knee
AMZ001 for the Treatment of Knee Osteoarthritis Symptoms
This is a multicenter, randomized, double-blind, placebo-controlled, parallel group, 4-week trial of a formulation of AMZ001 once or twice daily versus placebo twice daily, including a single-blind treatment group with a…
- Trial name
- NCT03691844
- Testing
- AMZ001, Comparator
- Where
- 7 sites in United States, Czechia and 1 more
- Volunteers
- 444 people
- Sponsor
- Amzell
Osteoarthritis, Knee
A Phase 2b/3a Study to Evaluate the Efficacy and Safety of JointStem in Patients Diagnosed as Knee Osteoarthritis
This study is a double-blind, randomized, placebo controlled, multi-center, superiority study to evaluate the efficacy and safety of JointStem, autologous adipose tissue derived mesenchymal stem cells (AdMSC), in patients…
- Trial name
- NCT04368806
- Testing
- JointStem
- Where
- 9 sites in United States, South Korea
- Volunteers
- 173 people
- Sponsor
- Nature Cell Co. Ltd.
Chronic Pain
A Double-blind Study of Controlled Release OROS Hydromorphone Compared to Placebo in Patients With Chronic Osteoarthritis (OA) Pain
To evaluate the efficacy of OROS Hydromorphone in reducing moderate to severe chronic pain in patients with Osteoarthritis (OA) Pain
- Trial name
- NCT00631319
- Testing
- OROS hydromorphone
- Volunteers
- 343 people
- Sponsor
- Mallinckrodt
Osteoarthritis, OA Knee Pain
Open-label Extension Study Of RN624
Study RN624-CL007 is planned to be an open-label protocol to enroll subjects who have previously participated in Study No. RN624-CL006. In this study, subjects will receive RN624 on an open-label basis.
- Conditions
- Osteoarthritis, OA Knee Pain, Arthritis
- Trial name
- NCT00399490
- Testing
- RN624 (PF-04383119)
- Where
- 36 sites in United States
- Volunteers
- 287 people
- Sponsor
- Pfizer
Osteoarthritis, Knee
A Study of the Efficacy and Safety of EUFLEXXA™ for Treatment of Painful Osteoarthritis of the Knee
This multicenter, randomized, double-blind study will be performed in approximately 600 subjects with chronic idiopathic osteoarthritis (OA) of the knee. An open-label safety extension will follow.
- Trial name
- NCT00379236
- Testing
- EUFLEXXA™
- Where
- United States
- Volunteers
- 588 people, healthy volunteers welcome
- Sponsor
- Ferring Pharmaceuticals
Osteoarthritis, Knee
Preliminary Evaluation of Safety, Tolerability, and Efficacy of XT-150 for the Treatment of Osteoarthritic Pain
Preliminary Evaluation of Safety, Tolerability, and Efficacy of XT-150 for the Treatment of Osteoarthritic Pain - Dose escalation
- Trial name
- NCT03282149
- Testing
- XT-150
- Where
- Australia
- Volunteers
- 24 people
- Sponsor
- Xalud Therapeutics, Inc.
Osteoarthritis, Knee
A Study Of The Safety And Efficacy Of PF-04191834 In Patients With Osteoarthritis Of The Knee
PF-04191834 works in animal models by inhibiting one of the enzymes, 5-lipoxygenasein which is involved in the pathway that causes inflammation and pain.
- Trial name
- NCT01147458
- Testing
- PF-04191834, Naproxen
- Where
- 31 sites in United States, Canada and 1 more
- Volunteers
- 190 people
- Sponsor
- Pfizer
Osteoarthritis, Knee
Extract of Curcuma Longa Complexed With Phosphatidilcholine(Motore®)in the Treatment of Adults With Knee Osteoarthritis
Prospective, multicenter, phase IV, open, randomized, parallel, controlled, in which 288 (two hundred and eighty-eight) participants of both sexes, aged between 40 and 75 years will be randomly allocated to one of two treatment…
- Trial name
- NCT02409381
- Testing
- Motore, Alivium
- Where
- Brazil
- Volunteers
- 288 people
- Sponsor
- Ache Laboratorios Farmaceuticos S.A.
Osteoarthritis, Knee, Osteo Arthritis Knee
OrthoCor Advanced Trial for Knee Osteoarthritis
The objective of this clinical trial is to show that PEMF therapy, heat, recovery metrics, and compliance data provided by the OrthoCor Advanced System improves pain and quality of life for patients with osteoarthritis.
- Trial name
- NCT06475677
- Testing
- OrthoCor Advanced System
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Caerus Corporation
Osteoarthritis
Effectiveness Of Single Doses Of Ibuprofen In Patients With Osteoarthritis Of The Knee
To demonstrate that new drugs work, many complex multidose studies are often required. The intent of this study is to use Ibuprofen as an example of a marketed pain relief drug to validate a simpler single dose model for future…
- Trial name
- NCT00372801
- Testing
- Ibuprofen
- Where
- Australia
- Volunteers
- 36 people
- Sponsor
- GlaxoSmithKline
Osteoarthritis
Safety of BTDS in Subjects With Osteoarthritic (OA) Pain of Hip or Knee: A 6-Month Open-label Extension Phase
The purpose of the extension phase is to evaluate the long-term safety and tolerability of buprenorphine transdermal system (BTDS).
- Trial name
- NCT01141283
- Testing
- Buprenorphine transdermal patch
- Where
- 42 sites in United States
- Volunteers
- 290 people
- Sponsor
- Purdue Pharma LP
Osteoarthritis, Knee, Osteoarthritis, Hip
Minimal Clinically Important Changes in Osteoarthritis Treatment
To assess minimal clinically important change, cut-offs for treatment failure and patient acceptable symptom state for pain and patient-reported function and quality of life in persons with hip or knee osteoarthritis…
- Trial name
- NCT05316194
- Testing
- Digital treatment for hip and knee osteoarthritis
- Where
- Sweden
- Volunteers
- 11,708 people
- Sponsor
- Joint Academy
Knee Osteoarthritis
Exploratory Non Comparative Study to Evaluate the Efficacy of Highly Bioavailable Curcumin (Flexofytol) in Patients With Knee Osteoarthritis
The purpose of this study is to evaluate the efficacy of bio-optimized curcumin(Flexofytol) during a 90-days period in knee ostearthritis patients on the serum levels of specific biomarkers of osteoarthritis and on the evaluation…
- Trial name
- NCT01909037
- Testing
- Flexofytol (bio-optimized curcumin)
- Where
- Belgium
- Volunteers
- 22 people
- Sponsor
- Tilman S.A.
Knee Osteoarthritis
A Multicenter, Open-Label, Single-Arm Extension Study to Evaluate the Safety and Efficacy of FURESTEM-OA-Kit Inj. in Knee Osteoarthritis Patients Who Received Placebo in the K0701 Phase 2a Trial
A Multicenter, Open-Label, Single-Arm Extension Study to Evaluate the Safety and Efficacy of FURESTEM-OA-Kit Inj. in Knee Osteoarthritis Patients Who Received Placebo in the K0701 Phase 2a Trial
- Trial name
- NCT07754175
- Where
- 2 sites in South Korea
- Volunteers
- 36 people
- Sponsor
- Kang Stem Biotech Co., Ltd.
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