Clinical trials: Knee Rheumatism
Knee Osteoarthritis
Estimation of the MCID for Patients With Knee Osteoarthritis
Background: The effect of exercise on knee osteoarthritis (OA) is often evaluated with patient-reported scales. The Minimal Clinically Important Difference (MCID) values of these scales are needed to understand the change in…
- Trial name
- NCT06034665
- Testing
- Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 94 people
- Sponsor
- Istanbul University
Necrosis of Femoral Head, Knee Osteoarthritis
Ketamine Prevent POCD
Previous study demonstrated that neuroinflammation induced by surgery is the main cause of the postoperative cognitive dysfunction. As an agonist of NMDA receptor, ketamine is proved to be an anti-inflammation agent.
- Trial name
- KPPOCD (NCT02220400)
- Testing
- Ketamine
- Where
- 3 sites in China
- Volunteers
- 484 people
- Sponsor
- RenJi Hospital
Osteoarthritis, Knee
Steroids, Hyaluronic Acid or Platelet Rich Plasma Versus Placebo for the Knee Osteoarthritis
This study investigates clinical outcome and imaging outcome parameters after intraarticular injection of steroids, platelet-rich-plasma (prp), hyaluronic acid or placebo in patients with early osteoarthritis of the knee joint.
- Trial name
- KIT (NCT02776514)
- Testing
- Triamcort, Platelet-rich-plasma, Suplasyn1
- Where
- Switzerland
- Volunteers
- 120 people
- Sponsor
- Balgrist University Hospital
Meniscal Degeneration, Osteoarthritis, Knee
Comparing Different Types of Physical Therapy for Treating People With a Meniscal Tear and Osteoarthritis
Knee osteoarthritis is a disabling problem affecting over 15 million adults in the United States. Many people who have knee arthritis also experience painful meniscal tears.
- Trial name
- TeMPO (NCT03059004)
- Testing
- TeMPO Home Exercise Program, Motivational SMS Messages, In-Clinic Topical Therapy
- Where
- 4 sites in United States
- Volunteers
- 879 people
- Sponsor
- Brigham and Women's Hospital
Osteo Arthritis Knee, Osteoarthritis, Knee
OA Optimization Program Pilot Trial
Total joint replacement is a highly successful treatment option for people affected by severe osteoarthritis (OA), however, the mismatch between resources and demand for this surgery means that many patients face long wait times…
- Conditions
- Osteo Arthritis Knee, Osteoarthritis, Knee, Osteoarthritis, Hip, Osteoarthritis
- Trial name
- NCT05389371
- Testing
- Alberta Healthy Living Program, Alberta Obesity Centre Program, Osteoarthritis advice
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- University of Calgary
Sedentary Lifestyle, Knee Osteoarthritis
NEAT!2 Sedentary Behavior Reduction for Individuals With Past or Present Knee Symptoms, Injuries, or Surgeries
This study will evaluate the effectiveness of an mHealth sedentary reduction program over a 6-month period of time in adults with past or present knee symptoms, injuries, or surgeries.
- Conditions
- Sedentary Lifestyle, Knee Osteoarthritis, Knee Injuries, Knee Pain Chronic
- Trial name
- NCT03987932
- Testing
- NEAT!2, NEAT!2+Calls, Delayed NEAT!2
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of South Carolina
Knee Osteoarthritis
A Study Evaluating the Safety and Efficacy of a Second Course of TPX-100 in Subjects Who Previously Received TPX-100 for Patellar Osteoarthritis Involving Both Knees
The purpose of this study is to evaluate the safety, tolerability, and preliminary efficacy of a second course of TPX-100 administered by intra-articular injection to subjects with osteoarthritis of the knee who participated in…
- Trial name
- NCT02837900
- Testing
- TPX-100 200 mg 4 times weekly for 4 weeks
- Volunteers
- 14 people
- Sponsor
- OrthoTrophix, Inc
Osteoarthritis, Knee
Comparison of Different Insoles as Conservative Treatment for Medial Knee Osteoarthritis
In patients with early to mid-stage knee osteoarthritis (OA), a conservative treatment is indicated. In medial knee OA (when mainly the medial compartment of the knee is affected by OA), lateral wedge insoles have been promoted…
- Trial name
- NCT04967339
- Testing
- Foot deformity correcting insoles, Lateral wedge insoles
- Where
- Switzerland
- Volunteers
- 25 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Osteoarthritis
A Comparison of Fixation Method in Total Knee Arthroplasty - Low Viscosity Versus High Viscosity Bone Cement
The purpose of this study is to compare the early migration and periprosthetic bone changes of two total knee arthroplasties fixated with two different type bone cement.
- Trial name
- NCT00175162
- Testing
- Osteopal G vs. Refobacin-Palacos R bone cement
- Where
- Denmark
- Sponsor
- University of Aarhus
Knee Osteoarthritis
Ultrasonographic Evaluation of Osteoarthritis.
Assessment of the effectiveness of ultrasonography in correlation to conventional imaging for the detection of the definite grading of knee osteoarthritis.
- Trial name
- NCT07001761
- Testing
- Ultrasound/ x rays
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Sohag University
Osteoarthritis of the Knee
Study of FX006 in Patients With Osteoarthritis of the Knee
The purpose of this study was to evaluate the safety, efficacy and pharmacokinetics of FX006 in patients with osteoarthritis of the knee.
- Trial name
- NCT01487161
- Testing
- FX006, TCA IR
- Where
- 21 sites in United States, Australia and 1 more
- Volunteers
- 229 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Osteoarthritis (OA) of the Knee
2ccPA Study in Patients With Symptomatic Knee Osteoarthritis
This clinical trial is designed to determine safety and tolerability as well as the MTD of a single-dose 2ccPA and PK data in symptomatic knee OA.
- Trial name
- NCT04229394
- Testing
- 2ccPA
- Where
- 5 sites in Taiwan
- Volunteers
- 40 people
- Sponsor
- Orient Europharma Co., Ltd.
Knee Osteoarthritis
Ambulatory Continuous Adductor Canal Block to Facilitate Same Day Discharge Following Total Knee Arthroplasty: A Pilot Study
Patients scheduled to undergo total knee arthroplasty will receive motor sparing knee blocks with continuous adductor canal block along with multimodal analgesia started pre-operatively and continued into the postoperative…
- Trial name
- NCT02228759
- Testing
- Adductor canal block
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Musculoskeletal Pain, Knee Osteoarthritis
Impact of Mesenchymal Stem Cells in Knee Osteoarthritis
Many patients with osteoarthritis of the knee fail non-operative measures and elect to have knee arthroplasty to improve their quality of life.
- Conditions
- Musculoskeletal Pain, Knee Osteoarthritis, Cartilage Injury, Cartilage Degeneration
- Trial name
- NCT03477942
- Testing
- Autologous Mesenchymal Stem Cells
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Knee Osteoarthritis
Evaluation of an Educational Program Associated With Exercises (EDEX) Before Total Knee Arthroplasty
The purpose of this study is to determine whether a standardized education and exercise program proposed before a total knee replacement for knee osteoarthritis is effective in functional recovery after surgery.
- Trial name
- EDEX (NCT01671917)
- Testing
- Educational and exercise program, Usual care
- Where
- France
- Volunteers
- 262 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Osteoarthritis, Knee
Effects of Low Impact Elliptical Training on Knee Osteoarthritis Outcomes.
This research study is determined to see the effects of low-impact elliptical training on knee osteoarthritis outcomes.
- Trial name
- NCT05977374
- Testing
- experimental and conventional group
- Where
- Pakistan
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Osteoarthritis, Pain Assessment
A Study to Evaluate the Effectiveness and Safety of Multiple Doses of Tapentadol(CG5503) in Patients Awaiting Joint Replacement Surgery
The purpose of this study is to evaluate in patients who are eligible for elective primary total or partial joint replacement of the hip or knee due to chronic osteoarthritis the efficacy (level of pain control) of CG5503 over 5…
- Conditions
- Osteoarthritis, Pain Assessment, Arthralgia
- Trial name
- NCT00361582
- Testing
- CG5503 IR; tapentadol
- Volunteers
- 669 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Osteoarthritis, Knee
How Does Platelet Dose Impact Clinical Outcomes After PRP Treatment?
The purpose of this study is to determine which platelet rich plasma (PRP) injection dosage provides the most improvement in a patient's knee pain level at 26 weeks post-injection.
- Trial name
- NCT05330689
- Testing
- PRP injection dose (<5 billion platelets), PRP injection dose (between 5 and <10 billion platelets), PRP injection dose (between 10 and <20 billion platelets)
- Where
- United States
- Sponsor
- Vanderbilt University Medical Center
Osteochondritis Dissecans, Osteoarthritis
ACI-C Versus AMIC. A Randomized Trial Comparing Two Methods for Repair of Cartilage Defects in the Knee
ACI-C versus AMIC: A controlled randomized trial comparing Autologous Chondrocyte Implantation ( ACI) and Autologous Matrix Induced Chondrogenesis (AMIC) for repair of cartilage defects in the knee.
- Conditions
- Osteochondritis Dissecans, Osteoarthritis, Cartilage Injury, Osteonecrosis
- Trial name
- NCT01458782
- Testing
- Treatment of cartilage defects in the knee
- Where
- Norway
- Volunteers
- 41 people
- Sponsor
- University Hospital of North Norway
Osteoarthritis, Knee, Knee Osteoarthritis
Baseline Predictors of Response to Radial Pressure Wave Therapy in Knee Osteoarthritis
This observational study aims to identify baseline factors that predict clinical response at six months in patients with knee osteoarthritis treated with radial pressure wave therapy (rESWT).
- Trial name
- PRE-RPWT-OA (NCT07531160)
- Testing
- Radial Pressure Wave Therapy
- Where
- Mexico
- Volunteers
- 62 people
- Sponsor
- Hospital Civil de Guadalajara