Clinical trials: Knee Surgery
Knee Osteoarthritis
A Randomized Trial Comparing High Tibial Osteotomy Plus Non-Surgical Treatment and Non-Surgical Treatment Alone
The purpose of this study is to compare patients with knee osteoarthritis (OA) receiving optimized non-surgical treatment plus surgical realignment of the tibia, or optimized non-surgical treatment only.
- Trial name
- NCT02003976
- Testing
- Medial Opening Wedge High Tibial Osteotomy (HTO), Non-Surgical Treatment Program
- Where
- Canada
- Volunteers
- 71 people
- Sponsor
- Western University, Canada
Prosthesis-related Infections
European Prosthetic Joint Infection Cohort Study- Hip, Knee and Shoulder Prosthetic Joint Infection
The purpose of the study is to compare different approaches for the treatment of prosthetic joint revisions and to optimize the outcomes in patients with prosthetic joint infections (PJI) by improving the treatment concept of PJI.
- Trial name
- EPJIC (NCT02424903)
- Where
- Germany
- Volunteers
- 5,000 people
- Sponsor
- Pro-Implant Foundation
Infection, Surgical Site Infection
Changing of Dressing for Periprosthetic Joint Infection in Total Knee Arthroplasty
The primary aim of the study is to compare two methods for a relationship with total knee infection: regular changing of dressings and not changing dressings.
- Conditions
- Infection, Surgical Site Infection, Prosthetic Infection, Wound Infection
- Trial name
- NCT04346875
- Testing
- Regularly changing of dressing, No application
- Volunteers
- 842 people
- Sponsor
- Bezmialem Vakif University
Stress
The SENSE Study: Surgical ENvironment Stress Evaluation
Surgical procedures such as total hip and knee arthroplasty require a complex set of physical and cognitive skills, expert execution, and inevitably place a high stress load on the surgeon.
- Trial name
- SENSE (NCT07506330)
- Testing
- total joint arthroplasty
- Where
- United Kingdom
- Volunteers
- 6 people
- Sponsor
- University College, London
Knee Arthroscopy Surgery
Ultrasound Plus Nerve Stimulator Versus Nerve Stimulator Guided Lumbar Plexus Block
Ultrasound imaging, an effective tool to localize peripheral nerves, may facilitate block performance. It allows direct visualization of nerve structures, needle guidance in real-time to the target, and observation of local…
- Trial name
- NCT02020096
- Testing
- Ultrasound and nerve stimulator guided lumbar plexus block, Nerve stimulator guided lumbar plexus block
- Where
- China
- Volunteers
- 48 people
- Sponsor
- Huazhong University of Science and Technology
Wound Heal, Wound of Skin
Aesthetic Outcome of Complex Linear Closure vs Second Intention Healing: Below the Knee
The purpose of this study is to determine whether complex linear closure vs second intention healing for cutaneous wounds below the knee affects esthetic outcomes (primary outcome).
- Trial name
- NCT05074212
- Testing
- Factorial Assignment
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of California, Davis
Quadriceps Atrophy, ACL Reconstruction
Does Blood Flow Restriction Training Improve Quadriceps Function After Arthroscopic Knee Surgery?
The purpose of this study is to evaluate the effectiveness of physical therapy (PT) plus BFR training compared to PT alone (without BFR training) after ACL reconstruction in patients who require extended limited weight bearing…
- Trial name
- NCT03096366
- Testing
- Blood flow restriction, Physical therapy
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- The University of Texas Health Science Center, Houston
Postoperative Analgesia, Morphine and Dexmedetomidine
Compare Morphine and Dexmedetomidine as Adjuvants to Bupivacaine in Ultrasound-guided ACB for Postoperative Analgesia After Knee Surgeries
This study aims to compare morphine and dexmedetomidine as adjuvants to bupivacaine in ultrasound-guided ACB for postoperative analgesia after knee surgeries
- Trial name
- NCT07240402
- Testing
- Adductor Canal Block (ACB) Only
- Volunteers
- 15 people
- Sponsor
- Kafrelsheikh University
Osteoarthritis, Blood Loss, Surgical
Non-inferiority Trial of Oral Tranexamic Acid vs. Intravenous Tranexamic Acid in Joint Replacement Surgery
The purpose of this research is to determine if the oral form of a medication (tranexamic acid) to reduce bleeding can be used in place of an intravenous (IV) form, to learn the best way to give tranexamic acid: either a pill by…
- Conditions
- Osteoarthritis, Blood Loss, Surgical, Blood Loss, Postoperative
- Trial name
- NCT02438566
- Testing
- Tranexamic Acid (Oral), Tranexamic Acid (Intravenous)
- Where
- United States
- Volunteers
- 118 people
- Sponsor
- The New England Baptist Hospital
Knee Ligament Injury, PCL - Posterior Cruciate Ligament Rupture
Evaluation of Clinical and Radiographic Outcomes of Surgically Treated Multiligamentous Knee Injuries
Multiligament knee injuries are typically caused by high-energy mechanisms and are classified according to the number of ligaments involved using Schenk's classification (Knee Dislocation) into KD 1, KD 2, KD 3, and KD 4.
- Conditions
- Knee Ligament Injury, PCL - Posterior Cruciate Ligament Rupture, PROMs
- Trial name
- MULTI-LIG (NCT06522659)
- Where
- Italy
- Volunteers
- 42 people
- Sponsor
- Istituto Ortopedico Rizzoli
Anterior Cruciate Ligament Injuries
Individualized Anterior Cruciate Ligament Versus Conventional Reconstruction
A randomised prospective control trial comparing the efficiency of a more individualized approach in ACL reconstruction with the help of neuromuscular computer models with traditional ACL reconstruction practices.
- Trial name
- IACLR (NCT04366362)
- Testing
- Individualised ACL reconstruction, Conventional ACL reconstruction
- Where
- Greece
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Larissa University Hospital
Postoperative Pain Management During Rehabilitation in Patients Undergoing Total Knee Arthroplasty
A Clinical Trial to Evaluate the Safety and Effectiveness of OLIZ, a Photobiomodulation Medical Device for Surgical Site Pain Relief in Patients After Total Knee Arthroplasty
A Clinical Trial to Evaluate the Safety and Effectiveness of OLIZ, a Photobiomodulation Medical Device for Surgical Site Pain Relief in Patients After Total Knee Arthroplasty
- Trial name
- NCT07091773
- Testing
- OLIZ Photobiomodulation Device
- Volunteers
- 68 people
- Sponsor
- LTBIO Co., Ltd.
Pain, Postoperative, Arthroplasty, Replacement, Knee
Reducing Postoperative Side Effect of Pregabalin
The purpose of this study was to determine 1) if pregabalin, when given 37.5 mg twice on the day before surgery, would be effective in reducing the early postoperative side effects including dizziness, nausea, vomiting and…
- Conditions
- Pain, Postoperative, Arthroplasty, Replacement, Knee, Arthroplasty, Replacement, Hip
- Trial name
- NCT04599894
- Testing
- 37.5mg Pregabalin + 75mg Pregabalin, 75mg Pregabalin
- Where
- China
- Volunteers
- 58 people
- Sponsor
- The First Hospital of Jilin University
Obese, Limb Deformities
Longitudinal Changes in Lower Extremity Alignment and Mechanical Axis Parameters After Bariatric Surgery in Patients With Morbid Obesity: A Prospective Observational Study
The goal of this prospective observational study is to understand whether major weight loss after bariatric surgery is associated with changes in the alignment of the lower limbs in adults with morbid obesity.
- Conditions
- Obese, Limb Deformities, Arthritis
- Trial name
- BARILIMBSALIGN (NCT07794566)
- Testing
- Obese.
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Marmara University
Old Age, Knee Replacement Surgery
Mini-dose Dexmedetomidine-Esketamine Infusion and Perioperative Sleep Quality
Sleep disturbances are prevalent in older patients with osteoarthrosis or fracture who are scheduled for knee or hip replacement surgery.
- Conditions
- Old Age, Knee Replacement Surgery, Hip Replacement Surgery, Dexmedetomidine
- Trial name
- NCT05950646
- Testing
- Dexmedetomidine, Esketamine, Normal saline
- Where
- 2 sites in China
- Volunteers
- 154 people
- Sponsor
- Peking University First Hospital
Knee Surgery, Shoulder Surgery
Changes in Anthropometry Following Ambulatory Orthopaedic Surgery
The purpose of this research is to study changes in weight, body mass index, and percentage of fat following orthopaedic knee or shoulder surgery.
- Trial name
- CAS (NCT02435251)
- Testing
- dual energy X-ray absorptiometry
- Where
- United States
- Sponsor
- State University of New York at Buffalo
Knee Arthritis, Anesthesia, Local
The Effect of PPB Using 10, 20 and 30 ml of Lidocaine, Study on Volunteers
The aim of this study is to evaluate the Popliteal Plexus Block (PPB) effect on motor nerve branches of the sciatic and femoral nerve, when using different volumes of local anesthetics for PPB.
- Conditions
- Knee Arthritis, Anesthesia, Local, Post Surgical Pain
- Trial name
- NCT05464862
- Testing
- Popliteal Plexus Block with 10 ml, Popliteal Plexus Block with 20 ml, Popliteal Plexus Block with 30 ml
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Charlotte Runge
Knee Arthroscopy
Assessing the Effects of Sublingual Sufentanil 30 µg on Postoperative Recovery
A pilot study to evaluate the effect of incorporating sublingual sufentanil into our perioperative opioid regimen for ambulatory orthopedic surgery.
- Trial name
- NCT04561375
- Testing
- Sufentanil, Fentanyl
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- The Cleveland Clinic
Pain Management, Function
Evaluation of Post Hospital Administration of Celecoxib Following Minimally Invasive Knee Replacement Surgery
This study will evaluate the benefits of continuing celecoxib through six weeks of total knee arthroplasty recovery. This is a randomized, double blind study with a group of approximately 130 primary total knee patients.
- Conditions
- Pain Management, Function, Minimally Invasive Total Knee Arthroplasty, Celecoxib
- Trial name
- NCT00474773
- Testing
- Celecoxib
- Where
- United States
- Volunteers
- 107 people
- Sponsor
- St. Louis Joint Replacement Institute
Knee Arthroplasty, Total, Knee Arthritis, Osteoarthritis
The Perioperative Outcome of Epinephrine Infusion and Tranexamic Acid in Knee Arthroplasty Surgery
The aim of this clinical trial is to evaluate the effect of administering low-dose epinephrine and tranexamic acid on perioperative blood loss, thromboembolic complications, and hospitalization duration in patients undergoing…
- Conditions
- Knee Arthroplasty, Total, Knee Arthritis, Osteoarthritis, Total Knee Anthroplasty, Blood Loss
- Trial name
- NCT07089251
- Testing
- low-dose epinephrine and tranexamic acid, Tranexamic Acid (TXA) treatment
- Where
- Saudi Arabia
- Volunteers
- 80 people
- Sponsor
- King Abdullah International Medical Research Center