Clinical trials: L-PRF
PRF, Gingival Recession
Clinical Evaluation of Platelet Rich Fibrin Membrane With or Without Hyaluronic Acid Along With Coronally Advanced Flap in the Treatment of Rt1 Gingival Recession
Gingival recession is a common mucogingival deformity that may result in root hypersensitivity, esthetic concern, plaque accumulation, and difficulty in oral hygiene maintenance.
- Conditions
- PRF, Gingival Recession, Hyaluronic Acid
- Trial name
- NCT07662447
- Testing
- root coverage with multilayered PRF, root coverage with multilayered PRF and hyaluronic acid
- Where
- United Arab Emirates
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Gulf Medical University
Dental Implants
Augmentation of Peri-implant Keratinized Mucosa Using a Combination of Free Gingival Graft Strip With Platelet-Rich Fibrin
This clinical trial aims to evaluate the clinical effectiveness of combining a strip free gingival graft (sFGG) with Platelet-Rich Fibrin (PRF) for increasing keratinized mucosa around dental implants.
- Trial name
- NCT07346391
- Testing
- Combining a strip free gingival graft (sFGG) with Platelet-Rich Fibrin (PRF) to increase keratinized mucosa around dental implants, Conventional Free Gingival Graft (FGG) to increase keratinized mucosa around dental implants
- Where
- Vietnam
- Volunteers
- 22 people
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Diabetic Foot Ulcer, Type 1 Diabetes Mellitus
Evaluate Use of Tropocells(R) Autologous Platelet-rich Fibrin (PRF) for Wagner Grade 1 and Grade 2, Mild to Mod Neuroischemic Plantar Diabetic Foot Ulcer Wound Care.
The goal of this investigational study is to evaluate the safety and clinical performance of Tropocells Autologous Platelet-rich Fibrin (PRF) for wound care for both males and females, ages 18-80 years old, with Grade 1 and 2…
- Conditions
- Diabetic Foot Ulcer, Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus (T2DM), Neuroischemic Foot Ulcer
- Trial name
- NCT06810726
- Testing
- Platelet Rich Plasma
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Estar Medical dba Medical Technologies, LTD
Growth Factors, Combined Defect of, Gingival Recession
Growth Factors in the Treatment of the Multiple Gingival Recessions
The purpose of this study was to compare and evaluate the clinical effects of Concentrated Growth Factor (CGF) and Advanced Platelet-Rich Fibrin (A-PRF) applied together with Coronally Advanced Flap (CAF) technique using a…
- Trial name
- NCT05319938
- Testing
- CAF only, CAF+CGF, CAF+A-PRF
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Bulent Ecevit University
Palatal Donor Site Wound Healing, Platelet Rich Fibrin
Characterizing the Effects of Platelet-Rich Fibrin (PRF) as a Palatal Wound Dressing on Quality of Life and Sleep Following Mucogingival Surgery. Study Was Conducted at the Air Force Post Graduate Dental School. All HIPPA Consents and Research Informed Consents Are Located at JBSA-Lackland.
The goal of this clinical trial (2-arm) is to determine if the application of platelet rich fibrin (PRF) to palatal donor sites influence patients quality of life, sleep efficiency, and healing following mucogingival surgery.
- Conditions
- Palatal Donor Site Wound Healing, Platelet Rich Fibrin, Sleep Quality, Pain
- Trial name
- NCT07637838
- Testing
- Platelet rich fibrin, Control Group: collagen matrices or oxidized cellulose membrane
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- 59th Medical Wing
Bone Loss, Alveolar
Evaluation of Vertical Bone Gain After Ridge Augmentation With APRF & Xenograft Vs Collagen Membrane & Xenograft. RCT
Comparative study for evaluation of vertical bone gain after one stage ridge augmentation with advanced platelet rich fibrin (A-PRF) and xenograft versus guided bone regeneration using collagen membrane and xenograft.
- Trial name
- NCT03855852
- Testing
- Xenograft and Collagen membrane, Xenograft and APRF
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Cairo University
Liquid-PRF, A-PRF Plus
Effects of Recurrent Application of Liquid-PRF on Hard and Soft Tissues
Procedure: Tooth is extracted, then A-PRF+ is placed inside the socket. After that the ridge dimensions is asses clinically at the baseline) in addition to clinical assessment of the gingival biotype at the baseline.
- Trial name
- Liquid-PRF (NCT05492357)
- Testing
- Liquid platelet-rich fibrin, Advanced Platelet-rich fibrin plus
- Where
- Palestinian Territories
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cezar Edward Lahham
Bone Loss
Release Kinetics in PRF Versus GEM21S With and Without Bone Substitutes: An In Vitro Analysis
This study is seeking to evaluate that platelet-derived growth factor-BB (PDGF-BB) is a proven wound healing and osteogenic protein that plays a critical role in wound healing and previous research has demonstrated a non-linear…
- Trial name
- NCT04964466
- Testing
- Amount of PDGF-BB in PRF preparation vs. GEM21, Amount of PDGF-BB available in PRF + bone substitutes vs. rhPDGF-BB+ bone substitutes following preparation, Release kinetics of PDGF-BB in PRF + bone substitutes vs. rhPDGF-BB + bone substitutes
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Periodontitis
Evaluation of Advanced PRF Combined With Nano-crystalline Hydroxyapatite for Management of Grade II Furcation Defects
this study is to evaluate the use of advanced platelet rich fibrin (A-PRF) + nano-crystalline hydroxyapatite bone substitute combined with open flap debridement (OPD) versus open flap debridement alone in the management of…
- Trial name
- NCT03804086
- Testing
- Advanced PRF (A-PRF) + nano-crystalline hydroxyapatite bone substitute combined with open flap debridement, Open flap debridement
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Hadeer Ashraf Hassan Roushdy
Platelet-rich Fibrin, Bone Substitutes
Horizontal Bone Augmentation of Alveolar Ridge
The objective of this randomized controlled clinical trial was to evaluate the effects of particulate xenogeneic bone grafts associated with autogenous bone graft or Leukocyte-and-Platelet-Rich Fibrin (L-PRF) for horizontal…
- Conditions
- Platelet-rich Fibrin, Bone Substitutes, Atrophic Maxilla, Cone-beam Computed Tomography
- Trial name
- NCT06420713
- Testing
- Horizontal Bone Augmentation of Alveolar Ridge, Groups, Dental Implants
- Where
- Brazil
- Volunteers
- 28 people
- Sponsor
- University of Sao Paulo
Temporomandibular Joint Disorders
Evaluation Of Efficacy Of Liquid Platelet Rich Fibrin In Temporomandibular Joint Disorders
This randomized clinical trial aims to evaluate the efficacy of liquid platelet-rich fibrin administration at different Wilkes stages.
- Trial name
- NCT04317560
- Testing
- Arthrocentesis, injectable platelet rich fibrin injection
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Aydin Adnan Menderes University
Class II Division 1 Malocclusion
The Effect of Autologous Platelet Concentrations on Orthodontic Treatment Time
60 patients needed therapeutic extraction of the maxillary first premolars with subsequent retraction of the maxillary canines were divided to randomly three groups: (1) PRP group: Received PRP injections, (2) I-PRF group…
- Trial name
- NCT05335824
- Testing
- The platelet-rich plasma (PRP), The injectable platelet-rich fibrin (I-PRF) group, The control group
- Where
- Syria
- Volunteers
- 60 people
- Sponsor
- Damascus University
Melasma, Facial Melasma
Injectable Platelet-Rich Fibrin Versus Intradermal Tranexamic Acid for Melasma
Melasma is a chronic acquired hyperpigmentation disorder that commonly affects the face and has a significant impact on quality of life.
- Trial name
- NCT07540702
- Testing
- Injectable Platelet-Rich Fibrin, Tranexamic acid 100 mg/mL (Kapron)
- Where
- Egypt
- Volunteers
- 21 people
- Sponsor
- Kasr El Aini Hospital
Chronic Periodontitis, Intrabony Periodontal Defect
The Effectiveness of Titanium-Prepared Platelet-Rich Fibrin on Angiogenic Biomarkers in Gingival Crevicular Fluid
This study investigates the effect of titanium-prepared platelet-rich fibrin (T-PRF) treatment on the angiogenic biomarkers in gingival crevicular fluid (GCF) in infrabony defects of patients with chronic periodontitis.
- Trial name
- T-PRF (NCT02692079)
- Testing
- T-PRF, Allograft
- Volunteers
- 25 people
- Sponsor
- Kırıkkale University
Rate of Canine Retraction, Root Resorption
The Effect of Injectable PRF Vs LLL on Orthodontic Tooth Movement
The purpose of the present study is to compare the effect of injectable platelet fibrin and Low Level LASER therapy on the rate of upper canine retraction, and on root resorption of the canine
- Trial name
- NCT06520761
- Testing
- Injectable platelet rich fibrin, Low Level LASER
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Faculty of Dental Medicine for Girls
Impacted Third Molar Tooth, Postoperative Pain
Effects of Platelet-Rich Fibrin and Kinesio Taping on Postoperative Recovery in Oral Surgery
This study investigates the effectiveness of Platelet-Rich Fibrin (PRF) and Kinesio Taping in reducing postoperative pain, edema, and improving recovery following impacted third molar surgery.
- Conditions
- Impacted Third Molar Tooth, Postoperative Pain, Postoperative Edema
- Trial name
- PRFKTOralSur (NCT06900894)
- Testing
- Platelet-Rich Fibrin (PRF), Kinesio Taping, Standard Postoperative Care
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people
- Sponsor
- Mustafa Kemal University
Pain, Postoperative, Trismus
Comparison of the Effect of A-PRF and L-PRF on Outcomes After Removal of Impacted Mandibular Third Molar
In this study, it was aimed to investigating and comparing the postoperative effects of leukocyte- and platelet-rich fibrin (L-PRF) and advanced platelet-rich fibrin (A-PRF) in terms of pain, swelling on the cheek, and trismus…
- Conditions
- Pain, Postoperative, Trismus, Swelling
- Trial name
- NCT03672669
- Testing
- Advanced Platelet Rich Fibrin (A-PRF), Leukocyte- and platelet-rich fibrin (L-PRF)
- Where
- Turkey (Türkiye)
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Near East University, Turkey
Chronic Periodontitis
Platelet-rich Fibrin With 1.2% Rosuvastatin in Chronic Periodontitis Treatment
The present study is designed to evaluate the combined efficacy of Platelet Rich Fibrin (PRF) and 1.2% Rosuvastatin (RSV) with open flap debridement (OFD) in treatment of intrabony defects in chronic periodontitis patients
- Trial name
- NCT02645227
- Testing
- Open flap debridement (OFD), OFD with Platelet rich fibrin (PRF), OFD with PRF and 1.2% Rosuvastatin
- Where
- India
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Government Dental College and Research Institute, Bangalore
Immediate Implant Placement, Gap Filling With e-PRF
Extended Platelet Rich Fibrin Versus Allograft as Space Filling Material
Twenty-eight patients seeking prosthetic replacement of non-restorable single rooted maxillary teeth by dental implant will be selected from the outpatient Clinic of Oral and Maxillofacial Surgery Department, Faculty of…
- Conditions
- Immediate Implant Placement, Gap Filling With e-PRF, Gap Filling With Allograft
- Trial name
- NCT07445776
- Testing
- Allograft, e-PRF
- Where
- Egypt
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Socket Preservation
Study on Platelet-Rich Fibrin for Preserving Jawbone After Tooth Extraction Using CBCT Imaging in Adults
The goal of this clinical trial is to learn if platelet-rich fibrin (PRF), a substance made from a person's own blood, helps preserve the bone in the jaw after tooth extraction in adults.
- Trial name
- NCT07022860
- Testing
- Platelet-rich fibrin (PRF)
- Where
- Iran
- Volunteers
- 12 people
- Sponsor
- Zahedan University of Medical Sciences