Clinical trials: LARS - Low Anterior Resection Syndrome, open to volunteers
Low Anterior Resection Syndrome, Rectal Carcinoma
A Bowel Management Program (Retrograde Rectal Enema) for the Treatment of Low Anterior Resection Syndrome in Rectal Cancer Patients
This clinical trial studies if a bowel management program with a retrograde rectal enema (RRE) for the treatment of low anterior resection syndrome (LARS) in rectal cancer patients is better than medical management alone.
- Trial name
- NCT06424522
- Testing
- Dietary Fiber, Enema Administration, Loperamide Hydrochloride
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
LARS - Low Anterior Resection Syndrome
5-HT3 Receptor Antagonist (Ramosetron) vs Loperamide for the Treatment of Low Anterior Resection Syndrome(RALARS)
Safety \& Efficacy of 5-HT3 Receptor Antagonist (Ramosetron) versus Loperamide for the Treatment of Low Anterior Resection Syndrome (RALLARS): Multicenter Randomized Controlled Trial
- Trial name
- RaLARS (NCT05577845)
- Testing
- Ramosetron
- Where
- South Korea
- Volunteers
- 212 people
- Sponsor
- Seoul National University Hospital
Low Anterior Resection Syndrome (LARS)
Evaluating the Optimal Timing of Trans-Anal Irrigation for Low Anterior Resection Syndrome Post-rectal Cancer Surgery
This study aims to evaluate the optimal timing of trans-anal irrigation (TAI) for participants with low anterior resection syndrome (LARS) who have undergone surgery for rectal cancer.
- Trial name
- EARLY-TAI (NCT07696689)
- Testing
- Water-based transanal irrigation system
- Volunteers
- 250 people
- Sponsor
- Simona Ascanelli
Low Anterior Resection Syndrome, Rectal Cancer
Comparison of Transanal Irrigation and Glycerol Suppositories in Treatment of Low Anterior Resection Syndrome
The study is a multicentre randomized controlled trial with the objective to compare the effect of transanal irrigation with glycerol suppositories in patients suffering from major Low Anterior Resection Syndrome (LARS).
- Trial name
- NCT04087421
- Testing
- Qufora Irrisedo Cone System, Glycerol "OBA"
- Where
- Denmark
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Low Anterior Resection Syndrome (LARS)
Early Implementation of Sacral Neuromodulation in Patients With Low Anterior Resection Syndrome.
A randomized, prospective, multicenter, open-label, pragmatic pilot study of patients with Low Anterior Resection Syndrome treated early (<120 days after discharge following intestinal bypass reconstruction) with sacral nerve…
- Trial name
- NCT07761884
- Testing
- Sacral neuromodulation
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Low Anterior Resection Syndrome, Rectal Cancer Surgery
Transanal Irrigation for Low Anterior Resection Syndrome
The preservation surgery of the anal sphincter muscle has become the standard procedure in the treatment of rectal cancer and, thanks to advancements in surgical techniques, can now be performed for tumors located closer to the…
- Conditions
- Low Anterior Resection Syndrome, Rectal Cancer Surgery, Insomnia
- Trial name
- TraLARS (NCT06796296)
- Testing
- Transanal Irrigation (TAI)
- Where
- South Korea
- Volunteers
- 94 people
- Sponsor
- Seoul National University Hospital
Rectal Adenocarcinoma, LARS - Low Anterior Resection Syndrome
ProLARS Trial: Prospective Longitudinal Follow-up of Low Anterior Resection Syndrome (LARS) and COREFO Score After Rectum Surgery in Patients Undergoing Upfront Surgery or Different Neo-adjuvant Treatment Regimens
OBJECTIVE Low anterior resection syndrome (LARS) is a term for functional bowel complaints occurring after low anterior resection.
- Conditions
- Rectal Adenocarcinoma, LARS - Low Anterior Resection Syndrome, Rectal Resection, Low Anterior Resection
- Trial name
- ProLARS (NCT07339904)
- Testing
- Questionnaire
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- University Hospital, Antwerp
Rectal Cancer, Fecal Incontinence and Constipation
Aerobic Exercise and Guided Imagery in Low Anterior Resection Syndrome
Low Anterior Resection Syndrome (LARS) is a common complication after sphincter-preserving rectal cancer surgery and may negatively affect bowel function and quality of life.
- Conditions
- Rectal Cancer, Fecal Incontinence and Constipation, Aerobic Exercise, Guided Imagery Exercise
- Trial name
- NCT07732894
- Testing
- Exercise, guided imagery
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Biruni University
Rectal Cancer, LARS - Low Anterior Resection Syndrome
Personalized Care Pathways for Bowel Symptoms in Rectal Cancer patients_development of E-diary
Colorectal cancer is the 2nd and 3rd most common cancer in respectively women and men, of which about 40% is located in the rectum.
- Trial name
- Treatable (NCT06274190)
- Testing
- bowel e-diary
- Where
- Belgium
- Volunteers
- 158 people
- Sponsor
- KU Leuven
Ovarian Cancer, Low Anterior Resection Syndrome
Assessment of Quality of Life After Low Anterior Resection During Cytoreductive Surgery for Advanced Ovarian Cancer
This study aims to evaluate the incidence of low anterior resection syndrome and quality of life after cytoreductive surgery for advanced ovarian cancer patients.
- Conditions
- Ovarian Cancer, Low Anterior Resection Syndrome, Quality of Life
- Trial name
- LAPSODY (NCT05431530)
- Testing
- Cytoreductive surgery
- Where
- South Korea
- Volunteers
- 108 people
- Sponsor
- Seoul National University Hospital
Low Anterior Resection Syndrome, Rectal Cancer
The Safety and Efficacy of Transanal Irrigation in Patients With Sleep Disturbance From Low Anterior Resection Syndrome After Rectal Cancer Surgery (TraLARS)
The preservation surgery of the anal sphincter muscle has become the standard procedure in the treatment of rectal cancer and, thanks to advancements in surgical techniques, can now be performed for tumors located closer to the…
- Conditions
- Low Anterior Resection Syndrome, Rectal Cancer, Insomnia, Sleep Disorder
- Trial name
- TraLARS (NCT06222255)
- Testing
- Transanal Irrigation (TAI)
- Where
- South Korea
- Volunteers
- 52 people
- Sponsor
- Seoul National University Hospital
Gastroenterology, LARS - Low Anterior Resection Syndrome
A Randomised Clinical Investigation to Assess Efficacy of Low Volume Transanal Irrigation by Qufora® IrriSedo MiniGo Versus Conservative Treatment for Low Anterior Resection Syndrome Patients
The purpose of this post-market clinical follow up study is to assess the efficacy on clinical symptoms of LARS of low volume Transanal Irrigation by MiniGo in conjunction with conservative treatment versus conservative treatment…
- Conditions
- Gastroenterology, LARS - Low Anterior Resection Syndrome, Rectal Cancer
- Trial name
- MINIGO (NCT06923150)
- Where
- 9 sites in France
- Volunteers
- 78 people
- Sponsor
- Qufora A/S
LARS - Low Anterior Resection Syndrome, Rectal Cancer Surgery
Improving Functional Outcomes and Quality of Life in Patients With Rectal Cancer After Surgery With Intensified Follow-up & Surveillance
The goal of this clinical study is to gain further insights into the treatment of patients with Low Anterior Resection Syndrome (LARS) symptoms after rectal resection.
- Conditions
- LARS - Low Anterior Resection Syndrome, Rectal Cancer Surgery, Rectal Cancer, Quality of Life (QOL)
- Trial name
- iRECOVER (NCT06936774)
- Testing
- Intensified follow-up program
- Where
- 5 sites in Switzerland
- Volunteers
- 140 people
- Sponsor
- University Hospital, Basel, Switzerland
Rectal Cancer, LARS - Low Anterior Resection Syndrome
Personalized Care Pathways for Bowel Symptoms in Rectal Cancer Patients_contributing Factors (Treatable)
Colorectal cancer is the 2nd and 3rd most common cancer in respectively women and men, of which about 40% is located in the rectum.
- Conditions
- Rectal Cancer, LARS - Low Anterior Resection Syndrome, Active Surveillance
- Trial name
- Treatable (NCT06914245)
- Testing
- Electronic bowel diary, Faecal Incontinence Quality of Life questionnaire (FIQL), EuroQoL 5 dimensions, 5 levels (EQ-5D-5L)
- Where
- Belgium
- Volunteers
- 150 people
- Sponsor
- KU Leuven
Low Anterior Resection Syndrome, Fecal Microbiota Transplantation
Fecal Microbiota Transplantation in the Treatment of Major LARS
Randomized trial to assess FMT efficacy in improving bowel function for major LARS patients. 40 subjects, blinded, randomized to FMT or probiotics.
- Trial name
- FMT-LARS (NCT06475430)
- Testing
- fecal microbiota transplantation, Formulated probiotic supplements
- Volunteers
- 40 people
- Sponsor
- Peking University People's Hospital
Rectal Cancer, Low Anterior Resection Syndrome
The Effects of Kegel Exercise Combined With Biofeedback Therapy on Bowel Function Recovery, Emotional Distress, and Quality of Life in Patients Following Low Anterior Resection for Rectal Cancer
This randomized controlled trial aims to evaluate the effects of combining Kegel exercise with a single biofeedback session on bowel function, emotional distress, and quality of life in patients who have undergone low anterior…
- Conditions
- Rectal Cancer, Low Anterior Resection Syndrome, LARS - Low Anterior Resection Syndrome
- Trial name
- BFT in LARS (NCT07253298)
- Testing
- Kegel Exercise with Biofeedback, Kegel Exercise Only
- Where
- Taiwan
- Volunteers
- 66 people
- Sponsor
- National Taiwan University Hospital
Low Anterior Resection Syndrome (LARS), Rectal Neoplasm Malignant
Efficacy and Safety of Transcutaneous Posterior Tibial Nerve Stimulation on Fecal Continence in Patients Undergoing Surgery for Rectal Neoplasia
Rectal neoplasia is one of the most prevalent cancers in Spain, and the treatment of choice is total mesorectal excision (TME), as it has demonstrated significant oncological improvements.
- Conditions
- Low Anterior Resection Syndrome (LARS), Rectal Neoplasm Malignant, Quality of Life (QOL), Fecal Incontinence (FI)
- Trial name
- NCT07632196
- Testing
- Posterior tibial nerve stimulation intervention group, Control group
- Where
- 2 sites in Spain
- Volunteers
- 84 people
- Sponsor
- Althaia Xarxa Assistencial Universitària de Manresa
Rectal Neoplasm
Knowledge-enhanced Digital Intervention to Prevent Low Anterior Resection Syndrome
Low anterior resection syndrome refers to changes in bowel habits such as frequent defecation, urgent defecation, and fecal incontinence, which result in decreased bowel function.
- Trial name
- NCT07041515
- Testing
- Mobile app, standard
- Volunteers
- 320 people
- Sponsor
- National Cancer Center, Korea
Faecal Incontinence With Faecal Urgency, Rectal Cancer
Efficacy of a Novel High Intensive Percutaneous Tibial Nerve Stimulation on Faecal Incontinence in Patients With Low Anterior Resection Cancer Syndrome After Rectal Cancer Surgery
This study aims to assess and evaluate the clinical efficacy of an intensified form of Percutaneous tibial nerve stimulation (PTNS) compared to standard conservative treatment for low anterior resection syndrome (LARS).
- Conditions
- Faecal Incontinence With Faecal Urgency, Rectal Cancer, Radiotherapy Side Effects, Low Anterior Resection Syndrome (LARS>20)
- Trial name
- HiPLARS (NCT07862673)
- Testing
- Percutaneous Tibial Nerve Stimulation
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Region Skane
Rectal Disorders, Low Anterior Resection Syndrome
Impact of Early Postoperative Treatment With Posterior Tibial Nerve Stimulation on the Incidence and Duration of Low Anterior Rectal Resection Syndrome
The treatment of rectal cancer is currently based on surgical resection of the rectum with total excision of the mesorectum, associated with neoadjuvant radiochemotherapy.
- Conditions
- Rectal Disorders, Low Anterior Resection Syndrome, Low Anterior Resection
- Trial name
- LARS (NCT05368168)
- Testing
- Posterior tibial nerve stimulation (PTNS)
- Where
- Spain
- Volunteers
- 114 people
- Sponsor
- Innovacion en Cirugía Vigo