Clinical trials: LUTS
Benign Prostatic Hyperplasia (BPH)
Safety and Initial Efficacy Study of the Vortx Rx for Treatment of Benign Prostatic Hyperplasia (US)
The HistoSonics' Histotripsy BPH Device, the Vortx Rx, is a portable ultrasound therapy device. The purpose of this study is to assess and monitor the performance of the Vortx Rx for initial safety and efficacy for the treatment…
- Trial name
- NCT01896973
- Testing
- Vortx Rx - Histotripsy BPH Device
- Where
- 2 sites in United States
- Volunteers
- 28 people
- Sponsor
- HistoSonics, Inc.
Prostate Cancer
Study to Evaluate the Presence of Lower Urinary Tract Symptoms (LUTS) in Prostate Cancer Patients Scheduled to Receive Luteinizing Hormone Releasing Hormone (LHRH) Analogues
The intention of this study is to investigate how many patients with prostate cancer, planned to be treated with LHRH analogues without history of surgery or radiotherapy, are suffering from LUTS.
- Trial name
- ANALUTS (NCT02542501)
- Where
- 32 sites in Portugal, Spain
- Volunteers
- 470 people
- Sponsor
- Ipsen
Benign Prostatic Hyperplasia (BPH), Minimal Invasive Surgery
Minimally Invasive Prostate Interventions Registry (MIST Study)
This study is a multicenter prospective patient registry designed to evaluate clinical, functional, and safety outcomes after minimally invasive prostate interventions (MIST) performed for benign prostatic obstruction (BPO)…
- Conditions
- Benign Prostatic Hyperplasia (BPH), Minimal Invasive Surgery, LUTS
- Trial name
- MIST (NCT07242807)
- Testing
- No intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 2,000 people
- Sponsor
- Necmettin Erbakan University
Lower Urinary Tract Predominant Storage Symptoms
Treatment of Symptoms in Male Patients With Lower Urinary Tract Symptoms (LUTS) Predominant Storage Symptoms (Overactive Bladder Syndrome)
This study is a non interventional study where no investigational medicine is provided. Procedures and examination will follow the institution standard of care practice.
- Trial name
- VENICE (NCT01799902)
- Testing
- Solifenacin
- Where
- 15 sites in Belgium
- Volunteers
- 86 people
- Sponsor
- Astellas Pharma Europe B.V.
Prostatic Hyperplasia, Benign, Prostatic Hypertrophy, Benign
Clinical Trial of Prostatic Arterial Embolization Versus a Sham Procedure to Treat Benign Prostatic Hyperplasia
The purpose of this study is to determine whether prostatic arterial embolization (PAE) compared is an effective and safe treatment for benign prostatic hyperplasia in patients with severe lower urinary tract symptoms not…
- Conditions
- Prostatic Hyperplasia, Benign, Prostatic Hypertrophy, Benign, Genital Diseases, Male, Lower Urinary Tract Symptoms
- Trial name
- NCT02074644
- Testing
- Prostatic Arterial Embolization
- Where
- Portugal
- Volunteers
- 80 people
- Sponsor
- João Martins Pisco
Benign Prostatic Hyperplasia, Lower Urinary Tract Symptoms
Ultrasound IPP to Predict Response to Medical Therapy in LUTS/BPH
This prospective cohort study evaluated whether transabdominal ultrasound measurement of intravesical prostatic protrusion predicts symptom severity and response to medical therapy in men aged 50 years or older with lower urinary…
- Conditions
- Benign Prostatic Hyperplasia, Lower Urinary Tract Symptoms, Bladder Outlet Obstruction
- Trial name
- NCT07306767
- Testing
- Transabdominal ultrasound measurement of intravesical prostatic protrusion, Alpha-adrenergic blocker, 5-alpha reductase inhibitor
- Where
- Egypt
- Volunteers
- 130 people
- Sponsor
- Ain Shams University
Bladder Cancer, LUTS
Protoves M1® Syrup in Controlling Adverse Event During HIVEC® Instillations
100 patients with bladder cancer whose underwent Hyperthermic Intravesical Chemotherapy (HIVEC®) will be randomized in two groups (Group A: PROTOVES M1 SYRUP, Group B: NO TREATMENT).
- Conditions
- Bladder Cancer, LUTS, Pain
- Trial name
- NCT04148677
- Testing
- Protoves M1®
- Volunteers
- 100 people
- Sponsor
- Cardarelli Hospital
HIV Seropositivity, Lower Urinary Tract Symptoms
Lower Urinary Tract Symptoms in Males Living With HIV
The primary aim of this study is to learn whether the frequency of lower urinary tract symptoms differ between the males with seronegativity for HIV and males living with HIV.
- Trial name
- NCT05964803
- Testing
- Questionnaires
- Where
- Turkey (Türkiye)
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Koç University
Benign Prostatic Hyperplasia
A Pumpkin Seed, Isoflavonoid and Cranberry Mix in LUTS/BPH
The aim is to assess the efficacy of a mix of Pumpkin Seed Extract, Soy Germ Isoflavonoids and Cranberry (Novex®) in the management of mild to moderate LUTS in BPH patients.
- Trial name
- NCT04146103
- Testing
- Novex
- Where
- Lebanon
- Volunteers
- 163 people
- Sponsor
- Saint-Joseph University
Benign Prostatic Hyperplasia, Lower Urinary Tract Symptoms
Prostatic Artery Embolization for the Treatment of Symptomatic Benign Prostatic Hyperplasia (BPH)
This is a single center, prospective, investigational study to evaluate the safety and efficacy of prostatic artery embolization (PAE) for the treatment of moderate to severe lower urinary tract symptoms (LUTS) due to benign…
- Trial name
- NCT04563221
- Testing
- Prostatic artery embolization
- Where
- United States
- Sponsor
- Andrew Picel
Benign Prostatic Hyperplasia
Study of PRX302 for Lower Urinary Tract Symptoms Due to Benign Prostatic Hyperplasia (BPH)
The purpose of this study is to evaluate the safety, tolerability and efficacy of a single treatment of PRX302 for the treatment of Benign Prostatic Hyperplasia (BPH) as compared to placebo.
- Trial name
- NCT01454349
- Testing
- PRX302
- Where
- 15 sites in United States
- Volunteers
- 40 people
- Sponsor
- Sophiris Bio Corp
Male Sexual Function
A Prospective Randomized Trial Comparing the Effects of Anti-reflux Versus Standard Ureteral Stents on Male Sexual Function
Objective: To compare the effectiveness of anti-reflux ureteral stents on improving erectile function and quality of life of patients with ureteral stents.
- Trial name
- NCT07415993
- Testing
- Routine laser lithotripsy
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Rong Wang
Lower Urinary Tract Symptoms
Double j Stent Related Symptoms
In urology, ureteral stents are used to treat obstructive diseases. Hematuria (54%), fever, discomfort, and lower urinary system symptoms are the predominant symptoms related to ureteral stent.
- Trial name
- NCT07447518
- Testing
- Tadalafil 5mg, solidosin, Solfenacin
- Where
- Egypt
- Volunteers
- 535 people
- Sponsor
- Kafrelsheikh University
Safety, Efficacy
Tamsulosin Monotherapy Versus Combination Therapy With Tadalafil (2.5 mg vs 5 mg) in Managing Male LUTS Secondary to BPH
This study aims to evaluate the short-term impact and clinical outcomes of tamsulosin monotherapy versus combination therapy with tamsulosin plus tadalafil (2.5 mg vs.
- Conditions
- Safety, Efficacy, Tamsulosin, Monotherapy
- Trial name
- NCT07722884
- Testing
- Tamsulosin 0.4 mg + Tadalafil 2.5 mg, Tamsulosin 0.4 mg + Tadalafil 5 mg, Tamsulosin 0.4 mg
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Ain Shams University
Prostatic Hyperplasia, Benign, Enlarged Prostate With Lower Urinary Tract Symptoms
Prostate Artery Embolization for the Treatment of Symptomatic Benign Prostatic Hyperplasia
Investigator-initiated study to evaluate the safety and efficacy of prostate artery embolization for the treatment lower urinary tract symptoms in patients with benign prostatic hyperplasia
- Trial name
- NCT03055624
- Testing
- Embosphere microparticles for prostate artery embolization
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of California, San Diego
Benign Prostatic Hyperplasia (BPH)
Safety and Initial Efficacy Study of the Vortx Rx for Treatment of Benign Prostatic Hyperplasia (Canada)
The HistoSonics' Histotripsy BPH Device, the Vortx Rx, is a portable ultrasound therapy device. The purpose of this study is to assess and monitor the performance of the Vortx Rx for initial safety and efficacy for the treatment…
- Trial name
- NCT01775488
- Testing
- Vortx Rx - Histotripsy BPH Device
- Sponsor
- HistoSonics, Inc.
Benign Prostatic Hyperplasia (BPH)
Laser Ablation a Salvage Treatment for Obstructive Benign Prostatic Hyperplasia
Benign prostatic hyperplasia (BPH) is a common condition affecting aging men, often leading to lower urinary tract symptoms (LUTS).
- Trial name
- ECHOLASER (NCT07016620)
- Testing
- Transperineal Laser Ablation (TPLA)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- The Cleveland Clinic
Benign Prostatic Hyperplasia
MCS in Treating Lower Urinary Tract Symptoms (LUTS) Suggestive of Benign Prostatic Hyperplasia
Phase III, Randomized, double-blind, parallel placebo-controlled study. Two arms: MCS (30mg/day) vs. placebo. Subproject MCS-2: alpha-blocker naïve subjects Subproject MCS-3: subjects responding poorly to alpha-blocker
- Trial name
- NCT00501371
- Testing
- MCS
- Where
- 5 sites in Taiwan
- Volunteers
- 85 people
- Sponsor
- Health Ever Bio-Tech Co., Ltd.
BPH
Global Post-Market Registry Using Waterjet Ablation Therapy for Endoscopic Resection of Prostate Tissue
The purpose of this study is to evaluate the efficacy of the AQUABEAM System for the treatment of Lower Urinary Tract Symptoms (LUTS) resulting from Benign Prostatic Hyperplasia (BPH).
- Trial name
- OPEN WATER (NCT02974751)
- Testing
- Aquablation
- Where
- 5 sites in Australia, Germany and 3 more
- Volunteers
- 178 people
- Sponsor
- PROCEPT BioRobotics
Benign Prostatic Hyperplasia With Lower Urinary Tract Symptoms
Registry of MIUS for Benign Prostatic Obstruction
This national, multicenter, prospective registry aims to collect standardized perioperative and follow-up data on patients undergoing minimally invasive surgical management for benign prostatic obstruction (BPO) in Turkey.
- Trial name
- ReMIUS-BPO (NCT07159165)
- Testing
- Minimally invasive surgical treatment for benign prostatic obstruction
- Where
- Turkey (Türkiye)
- Volunteers
- 10,000 people
- Sponsor
- Ondokuz Mayıs University