Clinical trials: Labor Complications
Necrotizing Enterocolitis, Premature Birth
Cohort of Premature Newborns for Charaterization of the Digestive Microbiota in Ulcerative Necrotizing Enterocolitis in Premature Infants
Compare the bacterial digestive microbiota during the stay in neonatal intensive care between a group of premature newborns developing a NEC (necrotizing enterocolitis) and a group of newborns free from NEC.
- Trial name
- CortECS (NCT04972734)
- Testing
- premature newborns developing a NEC, premature newborns without NEC
- Where
- France
- Volunteers
- 297 people
- Sponsor
- University Hospital, Clermont-Ferrand
Preterm Birth
Interdisciplinary E-health Based Follow-up of Preterm Born Children
The aim of the study is to assess mental and somatic symptoms of preterm born children at the ages of 2, 5 and 10 by a multidisciplinary team and to evaluate an app that screens for these symptoms.
- Trial name
- NeoUp (NCT06345664)
- Testing
- Diagnostics and intervention recommendations
- Where
- Germany
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Premature Birth, Infant, Premature
Parent-Facilitated Early Oral-Sensory Experience in the NICU for Feeding Outcomes
The purpose of this study is to evaluate the feasibility, acceptability, and preliminary effects of the Parent-Facilitated Early Oral-Sensory Experience (PEOE) program for very preterm infants in the Neonatal Intensive Care Unit…
- Conditions
- Premature Birth, Infant, Premature, Infant, Very Premature
- Trial name
- NCT07883707
- Testing
- Parent-Facilitated Early Oral-Sensory Experience (PEOE)
- Volunteers
- 60 people
- Sponsor
- Boston College
Prelabor Rupture of Membranes
Induction of Labor in Pregnant Women With Prelabor Rupture of Membranes - Oxytocin or Misoprostol
The aim of study is to compare the efficacy and safety of oral misoprostol versus oxytocin in induction of labor in pregnant women with prelabor rupture of membranes at term.
- Trial name
- NCT05215873
- Testing
- Misoprostol, Syntocinon
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Ain Shams Maternity Hospital
Low Birth Weight Baby, Small for Gestational Age (SGA)
Biological Impacts of Rising Temperatures on Maternal, Fetal, and Newborn Health: A Cohort Study (BIRTH Cohort)
The goal of this study is to learn how being exposed to high environmental temperatures during pregnancy affects the health of pregnant women and their babies.
- Conditions
- Low Birth Weight Baby, Small for Gestational Age (SGA), Preterm Birth, Pregnancy Complications
- Trial name
- BIRTH (NCT06957769)
- Testing
- heat stress
- Where
- 3 sites in Pakistan
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
PPH - Postpartum Hemorrhage, Eclampsia
Comparing Simulated Patients and Manikin Based Simulation in Obstetrics
The aim of this randomized study is to compare a live, trained simulated patient with a high-fidelity manikin in obstetric emergency team training using two standardized scenarios.
- Trial name
- NCT07857551
- Testing
- Trained, standardized patient, MamaAnne Patient Simulator
- Where
- Austria
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Placenta Accreta Spectrum
Risk Factors, Prognosis and Prediction Models for Placenta Accreta Without Prior Cesarean Section
1. Identify the risk factors for Placenta accreta spectrum (PAS) disorders in women without prior caesarean section (CS). 2. Clarify the prognostic factors of the disease and explore individualized treatment options to improve…
- Trial name
- NCT06383923
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Growth, Body Composition
Effect of Target Fortified Human Milk on the Growth Quality of Very Preterm Infants (TargetFort)
It is reported that the standard method for fortification of human milk (HM) overestimates the energy and protein densities of HM (Macedo MHNP 2018), thus originating infant undernutrition (Macedo AJP 2018).
- Conditions
- Growth, Body Composition, Prematurity, Breast Milk Collection
- Trial name
- TargetFort (NCT04400396)
- Testing
- standard HM fortification, target HM fortification
- Where
- Portugal
- Volunteers
- 80 people
- Sponsor
- Centro Hospitalar de Lisboa Central
Post Partum Hemorrhage
Feasibility Clinical Investigation Using the InPress Device for the Treatment of Postpartum Hemorrhage
Feasibility trial of the InPress Device to treat postpartum hemorrhage (PPH).
- Trial name
- NCT04364386
- Testing
- InPress Device
- Where
- 2 sites in Indonesia
- Volunteers
- 10 people
- Sponsor
- Alydia Health
Prematurity
Repeatability and Feasibility of Infant Spirometry
This is a study examining repeatability and feasibility of a new method for measurement of lung function in babies. A flexible vest is placed around the torso of the baby, and changes in tidal volume and flow is measured.
- Trial name
- NCT01057472
- Where
- Norway
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Haukeland University Hospital
Microbial Colonization, Preterm Birth
Gastric Bacterial Colonization of Preterm Neonates
This prospective cohort study was conducted in the Christiana Care Health System Neonatal Intensive Care Unit. It occurred at two time periods: Time period 1 included infants admitted to the traditional, open bay NICU.
- Trial name
- NCT05385939
- Testing
- Observational
- Where
- United States
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Christiana Care Health Services
Cesarean Section Complications
Reducing Blood Loss During Cesarean Section by Topical Versus IV Tranexamic Acid
Tranexamic (TXA)acid is an inexpensive, antifibrinolytic drug long used to control bleeding due to surgery, menorrhagia, or trauma.
- Trial name
- NCT03706339
- Testing
- normal saline arm group, intravenous tranexamic acid, Topical tranexamic acid
- Where
- Egypt
- Volunteers
- 450 people
- Sponsor
- Aswan University Hospital
Facilitated Tucking, Non Nutritive Sucking
Efficacy of Facilitated Tucking During Pain Procedure in Preterm Infants
Preterm infants undergo very frequent painful procedures during neonatal care particularly during the first few days. The support for the pain of the preterm is a priority for nurses and neonatologists.
- Conditions
- Facilitated Tucking, Non Nutritive Sucking, Preterm, Pain Relief
- Trial name
- BABYDOUL (NCT02096822)
- Testing
- Facilitated tucking + non-nutritive sucking, non-nutritive sucking
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Prematurity
Effectiveness Of Osteopathic Manipulative Treatment In NICU: A Multicenter Clinical Trial
The use of complementary and alternative medicine in neonatal ward has been steadily rising during the last decade. This integrated medicine approach has been shown to be helpful to improve neonatal health care.
- Trial name
- NCT01645137
- Testing
- osteopathic manipulative treatment, Usual care
- Where
- 3 sites in Italy
- Volunteers
- 690 people, healthy volunteers welcome
- Sponsor
- European Institute for Evidence Based Osteopathic Medicine
Preterm Labor
Tocolysis for Preterm Labor
Preterm birth is the most common and costly complication in obstetrics. It complicates up to 11% of all pregnancies and it is responsible for 70% of sick babies.
- Trial name
- NCT00811057
- Testing
- 1 Magnesium Sulfate, Nifedipine, Indomethacin
- Where
- United States
- Volunteers
- 301 people
- Sponsor
- University of Mississippi Medical Center
Premature Lungs, Respiratory Distress Syndrome
Early Caffeine and LISA Compared to Caffeine and CPAP in Preterm Infants
This study is being conducted to determine whether prophylactic administration of surfactant by the Less Invasive Surfactant Administration (LISA) method reduces the need for mechanical ventilation in the first 72 hours of life…
- Conditions
- Premature Lungs, Respiratory Distress Syndrome, Surfactant Deficiency Syndrome Neonatal
- Trial name
- CaLI (NCT04209946)
- Testing
- Less Invasive Surfactant Administration LISA, Continuous Positive Airway Pressure CPAP
- Where
- 3 sites in United States
- Volunteers
- 180 people
- Sponsor
- Sharp HealthCare
Premature Birth
Initial Nutritional Strategy and Stature-level Growth During the Neonatal Period of Children Born Moderately Premature
The growth and nutrition of premature infants during the neonatal period is a concern of neonatology services; it impacts the child's health in the short and long term.
- Trial name
- EPIPAGE2 (NCT03662503)
- Where
- France
- Volunteers
- 2,000 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Placenta Accreta
Internal Iliac Artery Ligation During Management of Placenta Accreta Spectrum
Vessels ligation have been used as a part of conservative management in treatment of placenta accrete spectrum to decrease blood loss as uterine artery ligation and internal iliac artery ligation.
- Trial name
- NCT04593303
- Testing
- Internal iliac artery ligation with cervicoisthmic compression suture, Cervicoisthmic compression suture without Internal iliac artery ligation
- Where
- Egypt
- Volunteers
- 42 people
- Sponsor
- Mansoura University Hospital
Premature Birth, Obstetric Labor, Premature
Welch Emotional Connection Screen (WECS) in the NICU
The purpose of this study is to assess knowledge about emotional connection, attitude about relational health, and efficacy of Welch Emotional Connection Screen (WECS) training in the NICU.
- Trial name
- NCT04922242
- Testing
- Welch Emotional Connection Screen for Neonatal Intensive Care Unit, NICU WECS Training
- Where
- United States
- Volunteers
- 193 people, healthy volunteers welcome
- Sponsor
- Columbia University
Acute Kidney Injury, Drug Use
A Big Data Approach to Predict NEOnatal Acute Kidney Injury in Newborns expoSed to nephroTOxic Drugs (NeoAKI STOP)
This observational retrospective study aims to learn about the incidence of acute kidney (AKI) injury in newborns in infants exposed to nephrotoxic drugs with a big data approach.
- Conditions
- Acute Kidney Injury, Drug Use, Drug Interaction, Drug Toxicity
- Trial name
- NeoAKISTOP (NCT05851222)
- Where
- Italy
- Volunteers
- 4,200 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
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