Clinical trials: Labor Complications
Prematurity, Respiratory Distress Syndrome
CPAP vs.Unsynchronized NIPPV at Equal Mean Airway Pressure
This study seeks to determine if standard continuous positive airway pressure, known as CPAP is as effective as a more complicated approach that generates intermittent increases in airway pressure applied to the nostrils via a…
- Conditions
- Prematurity, Respiratory Distress Syndrome, Apnea of Prematurity
- Trial name
- NICA (NCT03670732)
- Testing
- continuous positive airway pressure, nasal intermittent positive pressure ventilation
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Women and Infants Hospital of Rhode Island
Premature Rupture of Membranes at Term
Comparison of Misoprostol and PGE2 Gel for Induction of Labour in Women With Premature Rupture of Membranes at Term
Induction of labour with vaginal misoprostol, in women with premature rupture of membranes at term, results in significant shortening of induction to delivery time in comparison to vaginal PGE2 gel induction.
- Trial name
- NCT00355966
- Testing
- Misoprostol, PGE2 gel
- Where
- India
- Volunteers
- 212 people
- Sponsor
- Nilratan Sircar Medical College
Preterm Birth
What is the Future of Vulnerable New-borns
The aim of this data base is to know exactly the future of a "vulnerable newborns" cared in Pontoise Hospital (In the neonatology service) and compare the information with the national data of preterm birth.
- Trial name
- DNNV (NCT04021654)
- Testing
- Data collection
- Where
- France
- Volunteers
- 257 people
- Sponsor
- Hôpital NOVO
Postpartum Hemorrhage
TRAnexamic Acid for Preventing Postpartum Hemorrhage Following a Cesarean Delivery
The aim is to assess the impact of tranexamic acid (TXA) for preventing postpartum hemorrhage (PPH) following a cesarean section (CS).
- Trial name
- TRAAP2 (NCT03431805)
- Testing
- Tranexamic Acid Injectable Solution, Sodium Chloride 0.9%
- Where
- 26 sites in France
- Volunteers
- 4,574 people
- Sponsor
- University Hospital, Bordeaux
Preterm Birth
Direct Measurements of Cervical Remodeling for Predicting Preterm Birth
Racism and health care system distrust are potent stressors and may be associated with preterm birth (PTB). Additionally, cervical shortening is a common pathway leading to PTB.
- Trial name
- NCT01175551
- Where
- 2 sites in United States
- Volunteers
- 1,207 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Preterm Birth
Progesterone Vaginal Pessary for Prevention of Preterm Twin Birth
Multiple pregnancies accounted for 1 - 6 % of all births in UK during 2007. More than 98% of these multiple births being twin births .
- Trial name
- PPPTP (NCT02350231)
- Testing
- The progesterone vaginal pessary, Tonics group
- Volunteers
- 100 people
- Sponsor
- Assiut University
Respiratory Distress Syndrome, Premature Birth
nCPAP Versus High-Flow Nasal Cannula in Preterm Infants With RDS
This randomized controlled trial aims to compare the efficacy and safety of nasal continuous positive airway pressure versus high-flow nasal cannula as initial non-invasive respiratory support in preterm infants with respiratory…
- Trial name
- NCT07869719
- Testing
- Non-invasive respiratory support
- Volunteers
- 94 people
- Sponsor
- Assiut University
Respiratory Distress Syndrome, Newborn
NIPPV vs.nCPAP During LISA Procedure
The goal of this randomized controlled study is to compare the efficacy of using NIPPV versus NCPAP during the LISA procedure in very preterm infants.
- Trial name
- NIPAL (NCT05796128)
- Testing
- Nasal Intermittent Positive Pressure Ventilation (NIPPV), Nasal continuous positive airway pressure (NCPAP)
- Where
- Italy
- Volunteers
- 202 people
- Sponsor
- University of Florence
Infant, Premature
Impact of Oropharyngeal Administration of Colostrum in the First 48 Hours of Life Term Premature Newborn ≤ 32 Weeks of Amenorrhea
Colostrum is the first milk secreted by the mother when the tight junctions of mammary epithelium open, allowing the cellular transport of a multitude of components and immunological protective derivatives of the maternal…
- Trial name
- COLOSTRUM (NCT02650167)
- Testing
- Colostrum feeding, formula for preterm infants
- Where
- France
- Volunteers
- 140 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Preterm Birth, Twin Pregnancy With Antenatal Problem
Emergency Cerclage in Twin Pregnancies at Imminent Risk of Preterm Birth: an Open-Label Randomised Controlled Trial
Twin pregnancies are at an increased risk of early delivery. One of the reasons for this may be due to a weakened neck of the womb (cervix). There are 2 main ways to manage a weakened cervix in pregnancy.
- Conditions
- Preterm Birth, Twin Pregnancy With Antenatal Problem, Twin to Twin Transfusion Syndrome
- Trial name
- ENCIRCLE (NCT03818867)
- Testing
- Insertion of cervical cerclage
- Where
- United Kingdom
- Volunteers
- 31 people
- Sponsor
- St George's, University of London
Infant, Newborn, Infant, Low Birth Weight
Early-Onset Sepsis Surveillance Study
In this observational study, the NICHD Neonatal Research Network (NRN) is conducting surveillance of all infants born at NRN centers to identify all newborns who are diagnosed with early-onset sepsis (EOS) and/or meningitis.
- Conditions
- Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, Premature
- Trial name
- EOS (NCT00874367)
- Where
- 19 sites in United States
- Volunteers
- 615 people, healthy volunteers welcome
- Sponsor
- NICHD Neonatal Research Network
Preterm Delivery, Pregnant Women
Study of Antenatal Model to Prevent Preterm Delivery
The purpose of this study is to determine whether antenatal model in vaginosis are effective in preventing vaginal infection and preterm delivery
- Conditions
- Preterm Delivery, Pregnant Women, Antenatal Care Model
- Trial name
- AACP (NCT01232192)
- Testing
- antenatal model
- Where
- Indonesia
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Showa University
Neonatal, Premature Birth
Extending CPAP Therapy in Stable Preterm Infants to Increase Lung Growth and Function
This is a study to see if an extra 2 weeks of continuous positive airway pressure (CPAP) in stable preterm infants in the neonatal intensive care unit (NICU) can cause increased lung growth and lung function in the infants as…
- Conditions
- Neonatal, Premature Birth, Respiratory Distress Syndrome
- Trial name
- NCT04295564
- Testing
- Additional 2 weeks of CPAP
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Cynthia McEvoy
Apnea of Prematurity
Effect of Three-Stair-Position on Improvement of Apnea of Prematurity
The purpose of this study is evaluating the effectiveness of three-stair-position (TSP) on the rate of Apnea of Prematurity (AOP), the feeding performance and the vital signs.
- Trial name
- NCT02346864
- Testing
- Three-stair-position, Head elevated tilt position group
- Volunteers
- 144 people
- Sponsor
- Children's Hospital of Fudan University
Prematurity, Nephrocalcinosis
Preterm Infants and Nephrocalcinosis
Nephrocalcinosis (NC), defined as calcification of renal tissue, has been reported to occur in 7-41% of premature infants. Causes of NC are likely multi-factorial, and infants born prematurely and with very low birth weight…
- Conditions
- Prematurity, Nephrocalcinosis, Hypercalciuria
- Trial name
- NC (NCT02438267)
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- University of Utah
Metabolic Bone Disease
Physical Therapy to Prevent Osteopenia in Preterm Infants
To determine whether reflex locomotion therapy is effective for the prevention of osteopenia in preterm infants and compare its effectiveness over other physiotherapeutic methods like passive joint mobilizations and massage
- Trial name
- NCT04356807
- Testing
- Reflex Locomotion Therapy, Passive Joint Mobilizations, Massage
- Where
- 3 sites in Spain
- Volunteers
- 101 people
- Sponsor
- Galaad Torró Ferrero
Placenta Previa
Management Of Placenta Previa Cases And Determination Of Hospitalization Criteria
Placenta previa cases are one of the difficult groups of patients to manage in modern obstetrics. When the literature is evaluated extensively, no clear information can be seen especially in terms of hospitalization time.
- Trial name
- NCT04264234
- Testing
- Vaginal Ultrasonography, Magnetic Resonance Imaging
- Where
- Turkey (Türkiye)
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Ege University
Bottle Feeding, Preterm İnfant
The Effect of Breast Milk Odor on Feeeding in Preterm Infants
This study was conducted as a randomized controlled experiment to assess the impact of breast milk odor, applied before the first oral feeding of preterm infants transitioning to oral feeding, on their feeding performance.
- Trial name
- NCT06563973
- Testing
- Milk odor, Pacifier
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Orogastric Tube Insertion
Pain Perception Associated With Orogastric Tube Insertion in Preterm Infants
This study is a randomized controlled experimental study designed to examine the effect of white noise and swaddling methods in reducing the pain caused by orogastric tube insertion in preterm infants.
- Trial name
- NCT04678570
- Testing
- White Noise, Swaddling Method
- Where
- Turkey (Türkiye)
- Volunteers
- 132 people
- Sponsor
- Afyonkarahisar Health Sciences University
Preterm Birth
Antenatal Azithromycin to Prevent Preterm Birth in Pregnant Women With Vaginal Cerclage
In women with indicated vaginal cerclage, this study aims to assess the efficacy of antenatal prophylactic Azithromycin in preventing preterm labor.
- Trial name
- NCT04278937
- Testing
- Azithromycin Tablets
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Ain Shams Maternity Hospital
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