Clinical trials: Labor Delivery, open to volunteers
Preterm Labor, Preterm Birth
Cervical Stiffness in Women With Threatened Preterm Labor
Women giving birth prematurely due to spontaneous preterm labor may exhibit signs and symptoms of preterm labor (PTL) which are mostly nonspecific.
- Trial name
- CZECH-TPTL (NCT07840235)
- Testing
- Pregnolia System
- Where
- Czechia
- Volunteers
- 100 people
- Sponsor
- Pregnolia AG
Prematurity
Study of the Interprofessional Reproducibility of a Clinical Observation Scale for the Development of Very Premature Infants
The research concerns the study of the interprofessional reproducibility of a grid for observing the development of premature infants from 1 to 6 months corrected age.
- Trial name
- SPIN-NA (NCT07169110)
- Testing
- SPIN-NA Developmental Observation Grid Assessment via Home-Based Standardized Video Recording
- Where
- France
- Volunteers
- 35 people
- Sponsor
- University Hospital, Toulouse
Labor Induction
COOKACUPAIN 2 : Impact of Acupuncture on Delay of Delevery During Induced Labor With Cook's Balloon at the Beaumont Maternity in Roubaix
In France, labor induction rate is above 25.8%. Labor induction with Cook's balloon is a non-hormonal mechanical method. At Roubaix's maternity, midewifes can adminitred acupuncture therapy to help to manage this labor induction.
- Trial name
- COOKACUPAIN 2 (NCT07774442)
- Testing
- Acupuncture therapy
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Centre Hospitalier de Roubaix
Fetal Growth Restriction (FGR), Preterm Birth
Enhancing Prediction of Adverse Pregnancy Outcomes in Africa Through Partnerships and Innovation
Pregnancy complications such as pre-eclampsia (high blood pressure during pregnancy), poor fetal growth, unexplained stillbirth, and spontaneous preterm birth are major causes of illness and death for mothers and babies in…
- Conditions
- Fetal Growth Restriction (FGR), Preterm Birth, Still Births, Abruptio Placentae
- Trial name
- EPAPOA (NCT07844876)
- Where
- 2 sites in Uganda
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Makerere University
Postpartum Hemorrhage, Uterine Atony
Exteriorization Versus In Situ Hysterotomy Repair During Cesarean: Effects on Uterine Tone
During standard cesarean deliveries, there are two ways that obstetricians repair the incision on the uterus (hysterotomy after delivery of the baby.
- Conditions
- Postpartum Hemorrhage, Uterine Atony, Uterine Atony With Hemorrhage, Cesarean Section
- Trial name
- NCT07606846
- Testing
- Test Intervention: In Situ Repair, Comparator Intervention: Exteriorization
- Volunteers
- 60 people
- Sponsor
- Stanford University
Infant, Premature
Automated Oxygen Control in Preterms on Non-invasive Ventilation
This randomised controlled trial aims to investigate the effectiveness of closed-loop automated oxygen control (CLAC) in preterm infants receiving non-invasive respiratory support and determine if it reduces the duration of…
- Conditions
- Infant, Premature, Airway Morbidity
- Trial name
- NCT07622563
- Testing
- Closed loop automated oxygen control
- Where
- United Kingdom
- Volunteers
- 76 people
- Sponsor
- King's College Hospital NHS Trust
Pregnancy, Prematurity
Vaginal Probiotics During Pregnancy After Premature (24-32 Weeks of Gestation) Preterm Rupture of Membranes
The goal of this clinical trial is to evaluate the feasibility of the randomized controlled trial (RCT). Secondary objectives include comparing the microbiota of preterm babies born after premature rupture of membranes across…
- Conditions
- Pregnancy, Prematurity, PPROM
- Trial name
- PROB-PROM (NCT06965049)
- Testing
- Probiotic
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Perinatal and Neonatal Outcomes in Pregnancies With Type 2 Diabetes Mellitus (T2DM)
Antenatal Myo-inositol Supplementation in Pre-existing Diabetes
This feasibility pilot study aims to gather data that can guide the design of a larger, more comprehensive trial to establish the effects of myo-inositol supplementation on supporting healthy outcomes in pregnancies complicated…
- Trial name
- AMulet (NCT07241221)
- Testing
- Myo-inositol and folic acid supplement, Folic acid supplement
- Where
- Singapore
- Volunteers
- 182 people
- Sponsor
- National University Hospital, Singapore
Lymphedema, Premature Birth
Infant Massage for Lymphedema and Comfort in Preterm Newborns
This randomized controlled trial investigates the effectiveness of infant massage in reducing symptoms of immobilization-related lymphedema and improving comfort in preterm newborns hospitalized in the Neonatal Intensive Care…
- Conditions
- Lymphedema, Premature Birth, Edema, Immobilization
- Trial name
- NCT07418814
- Testing
- Infant Massage Group
- Volunteers
- 40 people
- Sponsor
- Erzurum Technical University
Pain Management, Birth
Combined Intravenous Tramadol and Paracetamol Versus Intramuscular Pethidine for Pain Relief During the First Stage of Labor. Compare the Efficacy and Adverse Effects
The goal of this intervention study is to compare the efficacy and adverse effects of pain relief during the first stage of labor using 75 mg IM pethidine versus the combination of IV 100 mg tramadol and 1000 mg paracetamol.
- Trial name
- NCT07264309
- Testing
- pethidine, Tramadol, Paracetamol 1 g
- Where
- Israel
- Volunteers
- 140 people
- Sponsor
- Zohar Nachum
Skin Injury, Premature Birth
Cohesive Bandage Fixation of Pulse Oximeter Probes and Skin Condition in Preterm Neonates
Pulse oximeter probes are used to continuously monitor oxygen levels in newborn babies in intensive care. These probes are usually attached to the baby's hand or foot with adhesive tape and must be moved to a new site every few…
- Conditions
- Skin Injury, Premature Birth, Medical Adhesive Related Skin Injury
- Trial name
- NCT07864298
- Testing
- Cohesive bandage fixation of pulse oximeter probe, Standard adhesive fixation of pulse oximeter probe
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Uskudar University
Intrauterine Growth Retardation (IUGR), Lung Function Tests
Early Lung Function Trajectories: Comparison Between Infants With and Without Intrauterine Growth Restriction.
During intrauterine life, some babies are smaller or grow less than expected. This fetal growth abnormality, called fetal growth restriction (FGR), can be diagnosed by ultrasound.
- Conditions
- Intrauterine Growth Retardation (IUGR), Lung Function Tests, Preterm Infant, Respiratory Monitoring
- Trial name
- ELFIGO (NCT06919757)
- Testing
- fetal ultrasound to assess lungs, heart and diaphragm
- Where
- Italy
- Volunteers
- 54 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Pregnancy Related
Patient Centered Simulation For Labor and Delivery
Patient satisfaction is an important outcome in the evaluation and development of healthcare services. Studies have identified tools that successfully measure women's childbirth experiences, and have shown that multidimensional…
- Trial name
- NCT03654079
- Testing
- Simulation
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Wake Forest University Health Sciences
Third Stage of Delivery
Maternal Outcomes Following Manual Lysis of the Placenta.
Comparison of maternal outcomes following manual lysis of placenta 15 vs 30 minutes after delivery. A primary outcome of the drop in hemoglobin will be compared between the two groups.
- Trial name
- NCT03626844
- Testing
- Manual Lysis of Placenta after 15 minutes (Intervention), Manual Lysis of Placenta after 30 minutes (Control)
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Holy Family Hospital, Nazareth, Israel
Growth Failure, Preterm Birth
Impact of Colostrum Oropharyngeal Immunotherapy on Postnatal Growth in Preterm Infants
The goal of this clinical trial is to ascertain whether oropharyngeal administration of colostrum contributes to postnatal growth in very preterm infants (those born before 32 weeks of gestation).
- Conditions
- Growth Failure, Preterm Birth, Microbiota
- Trial name
- IOCOIOPGIPI (NCT07082881)
- Testing
- Colostrum, Normal Saline
- Volunteers
- 220 people
- Sponsor
- Suqian First Hospital
Prematurity, Iron-deficiency
Darbe Plus IV Iron to Decrease Transfusions While Maintaining Iron Sufficiency in Preterm Infants
In this phase II trial, the investigators overarching goal is to demonstrate the feasibility and potential benefit of darbepoetin (Darbe) plus slow-release intravenous (IV) iron to decrease transfusions, maintain iron sufficiency…
- Conditions
- Prematurity, Iron-deficiency, Iron Deficiency Anemia, Iron Malabsorption
- Trial name
- DIVI (NCT05340465)
- Testing
- Darbepoetin Alfa, Low Molecular Weight Iron Dextran, Ferumoxytol injection
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Washington
Attention-Deficit/Hyperactivity Disorder (ADHD), Autism Spectrum Disorder
Home Play-based Intervention for Parents and Infants
The goal of this clinical trial is to learn whether a 12-week home-based intervention (Sociometric Play-based Remediation of Individual Neurodevelopmental Trajectories (SPRINT)) helps support parenting and the development of…
- Conditions
- Attention-Deficit/Hyperactivity Disorder (ADHD), Autism Spectrum Disorder, Premature Birth, Global Developmental Delay
- Trial name
- SPRINT (NCT07716072)
- Testing
- SPRINT Intervention, Waitlist Protocol
- Where
- Singapore
- Volunteers
- 120 people
- Sponsor
- Nanyang Technological University
Prematurity
Evaluating Wearable Smart Sensors for Continuous Measurement of Vital Signs in ICU Patients
The purpose of this study is to develop biocompatible wireless electronic devices that will allow continuous, non-invasive hemodynamic and physiology measurements in the ICU.
- Trial name
- NCT04723654
- Testing
- Wireless Wearable Vital Sign Monitor
- Where
- 2 sites in United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Preterm Infant
Clinical Impact of Non-invasive Neurally Adjusted Ventilatory Assist in Very Preterm Infants
This is a prospective observational study investigating the impact of NIV-NAVA on short-term clinical outcomes and long-term neurodevelopment in very preterm infants.
- Trial name
- NCT06786039
- Testing
- Non-invasive NAVA
- Where
- 2 sites in South Korea
- Volunteers
- 80 people
- Sponsor
- Korea University Anam Hospital
Bronchopulmonary Disease
Preterm Lung Patient Registry
The goal of the Preterm Lung Patient Registry is to collect data on individuals with neonatal lung disease to better understand the illness and ultimately improve their care and survival.
- Trial name
- NCT00951366
- Testing
- Patient Registry
- Where
- United States
- Volunteers
- 1,500 people
- Sponsor
- Boston Children's Hospital