Clinical trials: Labor Delivery
Miscarriage, Preterm Birth
Progesterone for the Prevention of Miscarriage and Preterm Birth in Women With First Trimester Bleeding: PREEMPT Trial
Miscarriages and preterm births are common and serious events affecting women, families, and healthcare systems on many levels. One of the risk factors for miscarriage and preterm birth is bleeding in the first trimester of…
- Trial name
- NCT02145767
- Testing
- Progesterone
- Where
- 7 sites in Canada
- Volunteers
- 850 people, healthy volunteers welcome
- Sponsor
- Sir Mortimer B. Davis - Jewish General Hospital
Premature Birth, Respiratory Distress Syndrome
Non-invasive Ventilation in Preterm Infants
This is a prospective, observational cohort study. For the study part on noninvasive neurally adjusted ventilatory assist (NIV-NAVA) the design is interventional.
- Conditions
- Premature Birth, Respiratory Distress Syndrome, Ventilator Lung; Newborn
- Trial name
- NCT05987800
- Testing
- Titration procedure, Electrical impedance tomography, Lung and diaphragm ultrasound
- Where
- Belgium
- Volunteers
- 136 people
- Sponsor
- Universitair Ziekenhuis Brussel
Intraoperative Pain
Management of Indwelling Labor Epidural Catheters for Cesarean Delivery
This is a prospective observational study that will survey patients who had an indwelling labor epidural catheter and subsequently underwent cesarean delivery.
- Trial name
- NCT07366307
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Baylor Research Institute
Premature Infants, Intracranial Hemorrhages
Effect of Erythropoietin in Premature Infants on White Matter Lesions and Neurodevelopmental Outcome
Preterm and very preterm infants are at risk of developing encephalopathy of prematurity and long-term neurodevelopmental delay.
- Conditions
- Premature Infants, Intracranial Hemorrhages, Periventricular Leukomalacia, Cerebral Palsy
- Trial name
- NCT03110341
- Testing
- Erythropoietin, Normal saline
- Where
- China
- Volunteers
- 400 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Delivery Uterine
Comparison Between 25 µg Vaginal Misoprostol vs Slow Release Pessary PGE2
For about 10% of pregnancies, it is necessary to induce delivery for medical reasons. Prostaglandins alone can be used to perform cervical ripening in cases of immature cervix.
- Trial name
- CYTOPRO (NCT01765881)
- Testing
- Misoprostol, Dinoprostone
- Where
- 4 sites in France
- Volunteers
- 1,700 people
- Sponsor
- University Hospital, Toulouse
Pain, Acute, Premature
Can Warm Skin Disinfection Reduce the Pain Peripheral Central Catheter Application in Premature Babies?
Peripheral central catheter application, especially in extremely low birth weight premature babies, is an intensive care follow-up procedure.
- Trial name
- w-pi (NCT04458441)
- Testing
- warm group/cold group
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Zekai Tahir Burak Women's Health Research and Education Hospital
Patent Ductus Arteriosus
Early Treatment Versus Expectative Management of PDA in Preterm Infants
Much controversy exists about the optimal management of a patent ductus arteriosus (PDA) in preterm infants, especially in those born at a gestational age <28 weeks and/or a birth weight ≦1000 grams due to a lack of evidence for…
- Trial name
- BeNeDuctus (NCT02884219)
- Testing
- Ibuprofen, Expectative Management, Indomethacin
- Where
- 13 sites in Belgium, Netherlands
- Volunteers
- 273 people
- Sponsor
- Radboud University Medical Center
Childbirth Experience, Urinary Retention
Analgesia in the Second Stage of Labour
This study investigates efficacy, safety and childbirth experience in women receiving pudendal block during the final stage of delivery. It is an observational study and half of included primarous women recieve a pudendal block.
- Conditions
- Childbirth Experience, Urinary Retention, Satisfaction, Personal, Pain, Obstetric
- Trial name
- ASL (NCT04391075)
- Testing
- Pudendal nerve block
- Volunteers
- 1,007 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Placenta Previa
Progesterone in Patients With Placenta Previa
This study evaluates the efficacy of prophylactic vaginal progesterone administration in reducing of the episodes of antepartum hemorrhage and subsequent prevention of preterm delivery in women with placenta previa.
- Trial name
- NCT03633175
- Testing
- Vaginal progesterone
- Where
- Egypt
- Volunteers
- 74 people
- Sponsor
- Ain Shams University
Post Partum Hemorrhage
Sublingual Oxytocin for the Prevention of Post-partum Hemorrhage
An open-label, randomized, single-center, dose ascending trial will be conducted to evaluate the efficacy and safety of sublingual oxytocin for the prevention of post-partum hemorrhage caused by uterine atony in term pregnant…
- Trial name
- NCT06968481
- Testing
- Oxytocin sublingual, Oxytocin IM
- Where
- Nigeria
- Volunteers
- 330 people
- Sponsor
- Insud Pharma
Postpartum Hemorrhage, Neonatal Asphyxia
Saving Lives at Birth in Uganda: Building and Sustaining Capacity of Frontline Health Workers - A Program Evaluation
The study aims are to evaluate the impact of supportive follow-up strategies for a novel twinned training and capacity-sustaining program among frontline health workers (providers) attending facility-based births in remote and…
- Trial name
- NCT03254628
- Testing
- Helping Mothers Survive - Bleeding After Birth training, Helping Babies Breathe, Mentor
- Volunteers
- 3,440 people
- Sponsor
- Jhpiego
Preterm Delivery
Factors Associated With Post-Traumatic Stress Disorder in Patients With After Preterm Delivery
Each year in France, between 50,000 and 60,000 children are born prematurely (< 37 weeks of amenorrhea). Literature has shown that preterm deliveries can be associated with the development of PTSD (Post-Traumatic Stress Disorder)…
- Trial name
- PTSD-preterm (NCT03344471)
- Testing
- Passation of questionnaires
- Where
- France
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Pregnancy, Delivery Care
Effects of Massage and Shower on Birth Experience and Breastfeeding
Study Design This study is a quasi-experimental research designed to examine the effects of massage and warm shower-used as non-pharmacological methods during labor-on birth satisfaction, maternal comfort, and breastfeeding…
- Trial name
- NCT07151144
- Testing
- Massage, Shower
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Sakarya University
Preterm Birth, Twin Pregnancy With Antenatal Problem
Prophylactic Cerclage for Twin Pregnancy With Shortened Cervix
This randomized controlled trial is aimed to evaluate pregnancy and neonatal outcomes in twin pregnancies, in which a cervical cerclage is placed due to the shortening of the cervix with or without visible fetal membranes.
- Conditions
- Preterm Birth, Twin Pregnancy With Antenatal Problem, Cervical Shortening
- Trial name
- NCT05338164
- Testing
- cervical cerclage
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Meditation
Meditation in Early Labor: Impact on Self-Efficacy and Childbirth Fear in First-Time Mothers
Aim-Introduction: The feeling of uncertainty about what will happen during labor, and the mother's perception of inadequacy regarding childbirth, can lead to anxiety and stress in some pregnant women, resulting in fear of…
- Trial name
- NCT07201220
- Testing
- meditation
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Seyhan District Health Directorate, Adana
Quality Improvement, Breast-feeding
To Improve the Rate of Mother's Own Milk Feeding of Premature Infants in NICU
Thirteen hospitals in China will participate in the study, which objectives of this study is to improve the rate of mother's own milk feeding of premature infants in neonatal intensive care unit(NICU), evaluate the effectiveness…
- Conditions
- Quality Improvement, Breast-feeding, Premature Infant
- Trial name
- NCT04383379
- Testing
- Experimental: Intervention group
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- Nanjing Medical University
Prematurity, Respiratory Distress Syndrome,Hypoxemia
Follow-up at School-age of Children Who Participated in the Efficacy Study of Nitric Oxide for Premature Infants
Our previous data demonstrated that premature infants treated with inhaled nitric oxide at birth had improved neurodevelopmental outcomes at two years corrected age.
- Trial name
- NCT00152542
- Testing
- Inhaled nitric oxide
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- University of Chicago
Labor Pain, Induced; Birth
Spinal Fentanyl or Epidural Analgesia in the Early First Phase of Induced Labor
A total of 60 parturients undergoing induction of labour will be consented to participate in the study where they will be randomized to receive either spinal fentanyl (20 µg) or epidural analgesia (fentanyl 100µg and lidocaine 80…
- Trial name
- NCT04645823
- Testing
- Fentanyl Citrate, Lidocaine 1% Injectable Solution
- Where
- Finland
- Volunteers
- 60 people
- Sponsor
- Women's Hospital HUS
Preterm Birth, Low Birthweight Neonate
Xylitol and the Prevention of Periodontal Disease and Preterm Birth Trial
The ground-breaking Prevention of Prematurity and Xylitol (PPaX) cluster randomized controlled clinical trial was conducted in Lilongwe, Malawi and enrolled approximately 10,069 pregnant individuals seeking to evaluate the impact…
- Conditions
- Preterm Birth, Low Birthweight Neonate, Periodontitis, Gingivitis
- Trial name
- XaPPP (NCT07424846)
- Testing
- Xylitol Chewing gum, Sorbitol chewing gum
- Where
- Malawi
- Volunteers
- 6,000 people
- Sponsor
- University of Washington
Preterm Birth, Mother-Infant Interaction
Continuous Delivery Room Skin-to-skin-study for Moderate and Late Preterm Infants
The goal of this randomized controlled trial is to compare the effect of direct skin-to-skin contact in moderate and late preterm infants.
- Conditions
- Preterm Birth, Mother-Infant Interaction, Infant Development
- Trial name
- COSY (NCT05975203)
- Testing
- skin-to-skin contact
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- University of Cologne
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