Clinical trials: Labor Epidural Analgesia
Emesis
High Protein Intake to Decrease Emesis and Promote Patient Satisfaction in Labor
The purpose of our study is to determine if the incidence of emesis can be lowered with the addition of a high protein drink during labor.
- Trial name
- NCT01414478
- Testing
- Protein Shake
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Labor, Second Stage
Urinary Catheterization and Second Stage of Labor
Labor is divided into three stages: the first stage is from labor onset until full dilation, second stage is from full dilation until delivery of the baby, and the third stage from the delivery of the baby until the delivery of…
- Trial name
- cath2stage (NCT02198157)
- Testing
- urinary catheterization
- Where
- Israel
- Volunteers
- 184 people, healthy volunteers welcome
- Sponsor
- Raed Salim
Pregnancy, Atelectasis
Evaluation of Regional Distribution of Ventilation During Labor With or Without Epidural Analgesia
With an efficient epidural analgesia the physiological effects of pain are disabled during labor. Pain may cause an increase of minute volume, oxygen consumption and a decrease of paCO2 (Arterial CO2 pressure).
- Trial name
- NCT02523755
- Testing
- Epidural analgesia Ropivacaine, Absence of epidural analgesia
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- Universitair Ziekenhuis Brussel
Analgesia, Labor Pain
Efficacy and Safety of Hydromorphone-ropivacaine Versus Sufentanil-ropivacaine for Epidural Labor Analgesia
The purpose of this study is to compare the effects of three different doses of hydromorphone combined with ropivacaine and sufentanil combined with ropivacaine in epidural labor analgesia through prospective clinical trials, so…
- Trial name
- NCT06036797
- Testing
- Hydromorphone, Sufentanil, Ropivacaine
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Maternal and Child Health Hospital of Hubei Province
Anesthesia, Analgesia
Conversion of Labor Analgesia for Intrapartum Cesarean Delivery: DPE v CSE v Epidural
As the dural puncture epidural (DPE) is increasing in popularity for labor analgesia, it is important to understand how it impacts outcomes in parturients.
- Trial name
- NCT05514431
- Testing
- Epidural, Dural Puncture Epidural (DPE) technique, Combined Spinal-Epidural (CSE) technique
- Where
- 2 sites in United States, Canada
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Labor Pain, Obstetric Pain
Comparison of Intrathecal Versus Epidural Fentanyl on Fetal Bradycardia in Labor Combined Spinal Epidural Analgesia
There have been studies reporting that combined spinal-epidural (CSE) with fentanyl and bupivacaine produce fetal bradycardia, (M.Kuczkowski, 2004) (Abrão K, 2009 ).
- Trial name
- NCT03623256
- Testing
- Spinal fentanyl, Spinal bupivacaine, Spinal Fentanyl and Bupivacaine
- Where
- United States
- Volunteers
- 558 people
- Sponsor
- Augusta University
Administration Methods of Labor Analgesia
Epidural Loading Prior to Catheter Insertion
This study explores the potential for a more rapid onset of pain relief when drug administration is performed through the epidural needle, a technique of epidural loading that provides a rapid and reliable level of labor…
- Trial name
- NCT02883283
- Testing
- Epidural loading dose, Epidural catheter, Epidural needle
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Ohio State University
Pregnancy Related
Effectiveness of Clonidine, Dexmedetomidine, and Fentanyl Adjuncts for Labor Epidural Analgesia
The purpose of this randomized controlled trial is to compare the effectiveness of epidural clonidine, dexmedetomidine, or fentanyl adjuncts for labor analgesia.
- Trial name
- NCT05487196
- Testing
- Clonidine, Dexmedetomidine, Fentanyl
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Grace Lim, MD, MS
Labor Pain
A Comparison of Epidural Analgesia: Continuous Infusion Versus Programmed Intermittent Boluses
The analgesic approach in labor can be done in different ways, among which the neuraxial approach has shown the best analgesic results and fetal outcomes.
- Trial name
- NCT02510287
- Testing
- Bupivacaine and Fentanyl Initial Dose, Bupivacaine and Fentanyl: Continuous Epidural Infusion, Bupivacaine and Fentanyl: Programmed Intermittent Epidural Bolus
- Where
- Colombia
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Fundación Santa Fe de Bogota
Labor Pain
Labor Analgesia With Ropivacaine and Clonidine
The aim of the present study was to examine, for pain relief during labor, the efficacy of two pharmacological approaches - the 0.125% ropivacaine alone and the 0.0625% ropivacaine added to 75 ug clonidine, both by epidural…
- Trial name
- LA (NCT00626977)
- Testing
- ropivacaine, ropivacaine and clonidine
- Where
- Brazil
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- UPECLIN HC FM Botucatu Unesp
Pregnancy
PIEB vs CEI for Labor Analgesia: An MLAC Study
Utilizing a 'minimal local analgesic concentration (MLAC) study' design to first determine the relative potency of Programmed Intermittent Epidural Bolus (PIEB) compared to Continuous Epidural Infusion (CEI) and secondly to…
- Trial name
- NCT02573597
- Testing
- Bupivacaine, Sufentanil
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Stanford University
Labour Pain
Combined Spinal-Epidural Versus Traditional Labor Epidural
The purpose of this study to compare the use of spinal-epidural versus traditional labor epidural on maternal and fetal effects.
- Trial name
- NCT00151346
- Testing
- Bupivacaine and Fentanyl (for CSE), Bupivacaine and Fentanyl (for traditional epidural)
- Where
- United States
- Volunteers
- 127 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Epidural Anesthesia, Labor Pain
Epidural Dexmedetomidine vs Nalbuphine for Labor Analgesia
The aim of this study is to compare epidural dexmedetomidine vs nalbuphine added to bupivacaine in labor analgesia and determine the privilege of one over the other and to compare the effect of both analgesics after delivery.
- Trial name
- NCT05327088
- Testing
- Dexmedetomidine, Nalbuphine
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- Ain Shams University
Labor Epidural Analgesia
Comparative Study of the Combination of Different Modes of Administration of Local Anesthetics in Labor Analgesia
The investigators have design an observational study to know the anesthetic consumption in terms of rescue analgesia (Patient Controlled Epidural Analgesia (PCEA) and manual boluses) of the combination of different modes of…
- Trial name
- NCT03839056
- Testing
- IC+PIEB+PCEA high flow, PIEB+PCEA high flow, PIEB+PCEA standar flow
- Where
- Spain
- Volunteers
- 151 people
- Sponsor
- Marian Daras
Labor Pain
Assessment of Catheter Flow Direction Using Color Flow Doppler in Labor Epidurals
Epidural analgesia is commonly used for pain relief in labor and involves placement of a catheter in the epidural space. Failure of epidural analgesia may occur in 12-16% of epidural catheter placements.
- Trial name
- NCT05126745
- Testing
- color flow Doppler ultrasonography
- Where
- Canada
- Volunteers
- 45 people
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Cesarean Section
Preoperative Epidural Labor Analgesia and Postoperative Pain
Parturients who undergo emergency Cesarean section (C-sec) after experiencing labor pain are likely to develop pain-induced central sensitization.
- Trial name
- NCT03381690
- Testing
- Epidural labor analgesia
- Where
- South Korea
- Volunteers
- 222 people
- Sponsor
- Seoul National University Bundang Hospital
Labor Pain
Use of Standardized Algorithm for the Management of Epidural Analgesia for Labor and Delivery
Programmed Intermittent Epidural Bolus (PIEB) has become a standard technique for labour analgesia in many departments of anesthesia.
- Trial name
- NCT04814199
- Testing
- Algorithm
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Pregnant Women
Interest of the Injection of Morphine, in Addition to a Local Anesthetic When Performing a Combined Spinal-epidural for Labor Analgesia
The addition of morphine to a local anesthetic when performing an epidural analgesia during labor analgesia has improved the efficiency and the action duration of analgesia.
- Trial name
- MASEA (NCT02868944)
- Testing
- experimental group : sequential combined spinal epidural with local anesthetic injection (chirocaine) associated with morphine (sufentanil)., control group : sequential combined spinal epidural with local anesthetic injection (chirocaine) alone.
- Where
- France
- Volunteers
- 144 people
- Sponsor
- CHU de Reims
Labor Pain
Dural Puncture Epidural Versus Combined Spinal Epidural With Epidural Volume Extension in Labor Analgesia
Labor is the process where the cervix is prepared to allow the baby to pass from the uterine cavity to the outside world. In the ordinary course, it ends with spontaneous or instrumental vaginal delivery or cesarean section.
- Trial name
- NCT04234178
- Testing
- Epidural, Intrathecal+Epidural
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ataturk University
Labor Pain
Agreement Between Laterality of Tsui Test and Laterality of Color Flow Doppler Signals During Labor Epidural Analgesia
Epidural analgesia for relief of labor pain is a very common, safe and reliable technique that requires placement of a catheter in the epidural space.
- Trial name
- NCT05281991
- Testing
- Doppler ultrasonography, Tsui test
- Where
- Canada
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital