Clinical trials: Labor Stage, First
Postpartum Depression
EEG Alterations of Uterine Contractions in the First Stage of Labor Predicting Postpartum Depression
Severe uterine contractions in labor can trigger emotional disorders including postpartum depression in women during the puerperium.
- Trial name
- NCT05217251
- Testing
- frontal alpha asymmetry in EEG
- Where
- China
- Volunteers
- 330 people
- Sponsor
- Zhujiang Hospital
Labor Pain, Induced; Birth
Spinal Fentanyl or Epidural Analgesia in the Early First Phase of Induced Labor
A total of 60 parturients undergoing induction of labour will be consented to participate in the study where they will be randomized to receive either spinal fentanyl (20 µg) or epidural analgesia (fentanyl 100µg and lidocaine 80…
- Trial name
- NCT04645823
- Testing
- Fentanyl Citrate, Lidocaine 1% Injectable Solution
- Where
- Finland
- Volunteers
- 60 people
- Sponsor
- Women's Hospital HUS
Pregnancy Related
Epidural Versus Low-dose Spinal for Analgesia of Late First Stage of Labor
The aim of this study is to compare the effect of epidural analgesia versus low-dose spinal analgesia in parturient in the late first stage of labor regarding time needed to perform the block, duration of the intra- and…
- Trial name
- NCT05056142
- Testing
- Epidural Anesthesia, Spinal Analgesia
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Ain Shams University
Advanced Solid Tumors
A Trial to Find Out How Safe REGN7075 is and How Well it Works in Combination With Cemiplimab for Adult Participants With Advanced Cancers
This study is researching an investigational drug called marlotamig (REGN7075) by itself and in combination with cemiplimab with or without chemotherapy.
- Trial name
- COMBINE-EGFR-1 (NCT04626635)
- Testing
- REGN7075, Cemiplimab, Platinum-based doublet chemotherapy
- Where
- 54 sites in United States, France and 5 more
- Volunteers
- 548 people
- Sponsor
- Regeneron Pharmaceuticals
Geographic Atrophy Secondary to Age-related Macular Degeneration
An Optimised GA Interventional Trial (Opti-GAIN) to Test if Treatment With CTx001 is Safe and Works for People With Geographic Atrophy (GA)
This is a clinical study to evaluate the safety, tolerability and efficacy of CTx001, administered via a single subretinal injection, for GA (secondary to AMD).
- Trial name
- Opti-GAIN (NCT07392255)
- Testing
- CTx001
- Where
- 8 sites in United States, United Kingdom
- Volunteers
- 75 people
- Sponsor
- Complement Therapeutics
Labor Onset and Length Abnormalities, First Birth
Use of Cinnamomum Verum for Induction of Labor. Double Blind Randomized Clinical Trial
The purpose of the research protocol is to evaluate the effectiveness of Cinnamomum verum extract for the initiation of labor. Cinnamaldehyde ((E)-3-Phenylprop-2-enal) is an α, β unsaturated aromatic aldehyde, derived from…
- Trial name
- CINNALAB (NCT06164613)
- Testing
- Cinnamomum Verum oil extract
- Where
- Honduras
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Universidad Nacional Autonoma de Honduras
Melanoma, Clear-Cell Renal-Cell Carcinoma (ccRCC)
A First-In Human (FIH) Study to Find Out How Well REGN10597 Medicine Given Alone or in Combination With Cemiplimab Works in Adult Participants Who Have Cancer With Tumors That Have Spread in Their Body
This study is researching an experimental drug called REGN10597 alone or in combination with another drug called cemiplimab (called "study drug(s)").
- Conditions
- Melanoma, Clear-Cell Renal-Cell Carcinoma (ccRCC), Advanced Solid Tumors
- Trial name
- BrILliance (NCT06413680)
- Testing
- REGN10597, Cemiplimab
- Where
- 11 sites in United States
- Volunteers
- 240 people
- Sponsor
- Regeneron Pharmaceuticals
Vaginal Delivery
Effect of Intravenous Hyoscine Butylbromide Injection on First Stage Labour in Primigavidae
A case control study conducted on 120 women coming to Cairo University Maternity Hospital .Patients who meet the inclusion criteria were asked to participate in the study and a verbal consent was obtained from each patient.
- Trial name
- NCT02824679
- Testing
- hyoscine butylbromide, saline
- Volunteers
- 200 people
- Sponsor
- Ahmed M Maged, MD
Cancers With HER2 Expression
A First in Human Study of BAY2701439 to Look at Safety, How the Body Absorbs, Distributes and Excretes the Drug, and How Well the Drug Works in Participants With Advanced Cancer Expressing the HER2 Protein
In this study, researchers want to learn about the safety of drug BAY2701439 and how well the drug works in patients with advanced cancer that has the protein HER2 (Human Epidermal growth factor Receptor 2) and cannot be cured by…
- Trial name
- NCT04147819
- Testing
- BAY2701439
- Where
- 6 sites in United States, United Kingdom
- Volunteers
- 14 people
- Sponsor
- Bayer
Labor, Pregnancy
The Effects of Warm Showers Application in Birth on Birth Pain, Birth Satisfaction and Birth Results
The use of non-pharmacological methods in labor pain is very important in order to improve the birth process, increase comfort and provide relaxation.
- Conditions
- Labor, Pregnancy, First Stage of Labor
- Trial name
- NCT05335681
- Testing
- Warm Showers Application
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Gulhane School of Medicine
Labor Pain
Effects of Ambulation During First Stage of Labour on Maternal and Neonatal Outcomes
This study investigates the effect of ambulation (walking) during first stage of labour on maternal and neonatal outcomes. In the intervention group women will be encouraged to ambulate and women in the control group will receive…
- Trial name
- NCT03447015
- Testing
- ambulation
- Where
- Jordan
- Volunteers
- 290 people, healthy volunteers welcome
- Sponsor
- Mutah University
Vaginal Delivery
Measurement of the Fetal Occiput-spine Angle During the First Stage of Labor as Predictor of the Outcome of Labor
2D trans abdominal ultrasound was done during the first stage of labor. If fetal position is occiput anterior and fetal presentation is vertex, two dimensional sagittal picture of the fetal head and upper spine was acquired and…
- Trial name
- NCT03264599
- Testing
- transabdominal ultrasound
- Where
- Egypt
- Volunteers
- 400 people
- Sponsor
- Cairo University
Neonatal Morbidity
Reducing Neonatal Morbidity by Discontinuing Oxytocin During the Active Phase of 1st Stage of Labor
The purpose of this study is to measure the impact of a discontinuous administration of oxytocin during the active phase of the 1st stage of labor on the neonatal morbidity rate.
- Trial name
- STOPOXY (NCT03991091)
- Testing
- discontinuation of oxytocin administration, continuation of oxytocin administration
- Where
- France
- Volunteers
- 2,459 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Labor Onset and Length Abnormalities, 37 or More Completed Weeks of Gestation
Comparative Study Between Using WHO Labour Care Guide & Modified WHO Partograph
This randomized clinical trial is based on comparing the efficiency of modified WHO partographs vs. the new WHO labour care guide in monitoring and assessing the outcome of labour.
- Conditions
- Labor Onset and Length Abnormalities, 37 or More Completed Weeks of Gestation, First Birth
- Trial name
- NCT06537089
- Testing
- Supportive care measures, LCG guided labour interference
- Where
- Egypt
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Hend Mahmoud Abdelghany
Healthy
A Trial to Learn if REGN7999 is Safe and Well Tolerated, and How it Works in the Body of Healthy Participants
The primary objective of the study is to evaluate the safety and tolerability of single ascending intravenous (IV) and subcutaneous (SC) doses of REGN7999 in healthy adult participants.
- Trial name
- NCT05481333
- Testing
- REGN7999
- Where
- Belgium
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Regeneron Pharmaceuticals
Pregnancy Related
The Effect of Hot Perfoming on the Soles of the Feet in the First Stage of Labor on Labor
This research was conducted to determine the effect of applying heat to the soles of the feet during the active phase (5-10 cm dilation) of the first stage of labor. It is a randomized controlled experimental study.
- Trial name
- NCT06518772
- Testing
- hot application
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Cumhuriyet University
Labor Pain
Labor Analgesia in the Latent Phrase
Painless labor is an essential part in woman's health care. Labor analgesia in the active phrase is in popular use currently. However, parturients are still haunted by the labor delivery pain in the latent phrase up to 7-8 hours…
- Trial name
- LALP (NCT00647725)
- Testing
- Active phrase epidural analgesia, Latent phrase epidural analgesia
- Where
- China
- Volunteers
- 15,000 people
- Sponsor
- Nanjing Medical University
Hepatocellular Carcinoma
A First-in-human Study to Learn About the Safety of BAY 3547926 and How Well it Works in Participants With Advanced Liver Cancer
In this study, researchers want to learn about the safety of a new drug, BAY 3547926, and how well the drug works in people with a type of liver cancer called advanced hepatocellular carcinoma (HCC), which has a special protein…
- Trial name
- BANTAM-01 (NCT06764316)
- Testing
- BAY 3547926, BAY 3547922, BAY 3713391
- Where
- 36 sites in United States, Belgium and 7 more
- Volunteers
- 148 people
- Sponsor
- Bayer
Failed Labor
Prediction of Delivery With Transperineal Ultrasound in Women With Prolonged Labour. Multicentre Study
Objectives 1. To assess if head-perineum distance and angle of progression measured with transperineal ultrasound by the obstetrician on call can predict delivery mode in primiparous women with prolonged first stage of labour. 2.
- Trial name
- NCT01610453
- Testing
- ultrasound examination
- Where
- 6 sites in Denmark, Norway and 2 more
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Helse Stavanger HF