Clinical trials: Labour, Induced
Induced Labor, Cervical Ripening
Low-dose Vaginal Misoprostol Versus Vaginal Dinoprostone Insert for Induction of Labor
Purpose: To compare the efficacy and safety of low-dose protocol of vaginal misoprostol and vaginal dinoprostone insert for induction of labor in women with post-term pregnancies.
- Conditions
- Induced Labor, Cervical Ripening, Obstetric Labor, Pregnancy
- Trial name
- MADUTER (NCT03744364)
- Testing
- Misoprostol 25 mcg, Dinoprostone 10mg
- Volunteers
- 198 people, healthy volunteers welcome
- Sponsor
- Hospital Miguel Servet
Obesity Complicating Childbirth, Obesity
The MODE Trial: Planned Caesarean Section Versus Induction of Labour for Women With Class III Obesity
Canadian guidelines recommend that women with a pre-pregnancy body mass index (BMI) at or above 40 kg/m2 deliver by their due date.
- Conditions
- Obesity Complicating Childbirth, Obesity, Labor Onset and Length Abnormalities, Pregnancy, High Risk
- Trial name
- MODE (NCT03985618)
- Testing
- Caesarean section, Induction of Labour
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Ottawa Hospital Research Institute
Pregnancy Related
Artificial Induction of Labour in Full-term Singleton Pregnancy : Comparative Randomized Trial of Two Strategies
Labour induction is an obstetrical procedure, which artificially starts the process of cervix dilation, in order to induce labour.
- Trial name
- BESTWAY (NCT04452747)
- Testing
- Vaginal Dinoprostone system (Propess®), Dilatation balloon
- Where
- 2 sites in France
- Volunteers
- 450 people
- Sponsor
- University Hospital, Montpellier
Cervix; Pregnancy
Comparative Study Between Only Vaginal Misoprostol and Vaginal Misoprostol and Estradiol Cream
To compare the safety and effectiveness of vaginal misoprostol with combined vaginal misoprostol and estradiol for induction of labour in unfavorable cervix
- Trial name
- NCT05306405
- Testing
- Vaginal Tablet
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Epidural, Labor Pain
Improving Labour Induction Analgesia: Epidural Fentanyl Bolus at Epidural Initiation for Induction of Labour
Labour pain can be intensified for labour inductions and women undergoing inductions often have earlier and more frequent requests for analgesia.
- Conditions
- Epidural, Labor Pain, Induction of Labor Affected Fetus / Newborn, Obstetric Anesthesia Problems
- Trial name
- NCT04011098
- Testing
- Epidural Fentanyl Bolus, Standard Epidural Group
- Where
- Canada
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Saskatchewan
Prelabor Rupture of Membranes, Labor (Obstetrics)--Complications
Early V/S Delayed Induction of Labour in Patients With Prelabour Rupture of Membranes
To compare the effects of early V/s delayed induction of labour and its outcomes in patients presenting with PROM without labour.
- Conditions
- Prelabor Rupture of Membranes, Labor (Obstetrics)--Complications, Induction of Labor
- Trial name
- PROM (NCT07261332)
- Testing
- 0.5mg PGE2 gel
- Where
- Pakistan
- Volunteers
- 88 people
- Sponsor
- Laiba Qamar
Labour, Induced
Comparative Bioavailability Study of Two Misoprostol Formulations
The purpose of this study is to compare pharmacokinetics of two formulations of misoprostol following single dose administration in adult women being given misoprostol for cervical ripening and induction of labour.
- Trial name
- NCT02516631
- Testing
- Angusta™, Cytotec®
- Where
- Sweden
- Volunteers
- 72 people
- Sponsor
- Region Skane
Macrosomia, Induction of Labour
Induction of Labour for LGA fœtus in Women Without Insulin-treated Diabetes.
A french study published in 2015 (DAME) showed a decrease of shoulder dystocia and an increase of spontaneous vaginal delivery when the non insulin-treated diabetes patients with large-for-date fetus were induced.
- Conditions
- Macrosomia, Induction of Labour, Non-insulin-dependent Diabetes
- Trial name
- NCT03355040
- Testing
- induction of labour
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Montpellier
Gestational Diabetes Mellitus (GDM)
The Feasibility Of Expectant Management Versus Induction At 38 Weeks Among Individuals With Gestational Diabetes Mellitus: A Randomized Controlled Pilot Trial (EAGER Pilot Trial)
The EAGER pilot trial is designed to assess the feasibility of a Canadian, multicentre prospective randomized open-label blinded end-point (PROBE) clinical trial addressing whether induction of labour (IOL) at 38 weeks' gestation…
- Trial name
- EAGER Pilot (NCT06641141)
- Testing
- Induction of Labour
- Where
- Canada
- Volunteers
- 260 people
- Sponsor
- Ottawa Hospital Research Institute
Pre-Eclampsia
qMOLI- A Qualitative Assessment of Misoprostol or Oxytocin for Labour Induction
Q MOLI is an alongside qualitative study, for the 'Misoprostol or Oxytocin for Labour Induction' (MOLI) pragmatic, open-label, randomised controlled trial, comparing a misoprostol/misoprostol regime vs the standard…
- Trial name
- qMOLI (NCT04037683)
- Testing
- Misoprostol Oral Tablet, Oxytocin
- Where
- India
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- University of Liverpool
Intrapartum Fetal Distress
Prediction of Intrapartum Fetal Compromise After Elective Induction of Labour
Each fetus has a different metabolic capacity at the onset of labor, and in cases of an imbalance between fetal demands and placental oxygen supply, fetal hypoxia occurs.
- Trial name
- NCT07881744
- Volunteers
- 182 people
- Sponsor
- Ain Shams Maternity Hospital
Labor Onset and Length Abnormalities
Misoprostol Versus Oxytocin for Induction of Labour in Parturients With Spontaneous Rupture of Fetal Membranes at Term
Intravenous oxytocin titration has a prime position as a choice agent for induction of labour following term PROM as it has been shown to be efficacious for such purpose.
- Trial name
- NCT06343480
- Testing
- Labour Induction
- Where
- 2 sites in Nigeria
- Volunteers
- 120 people
- Sponsor
- Federal Teaching Hospital Abakaliki
Labor, Induced, Cervical Ripening
Membrane Stripping for Cervical Ripening
The goal of this interventional study is to evaluate the effectiveness of membrane stripping in cervical ripening compared to double balloon catheter induction. The study population consists of women undergoing labor induction.
- Conditions
- Labor, Induced, Cervical Ripening, Balloon Induction, Membrane Stripping
- Trial name
- Stripping (NCT06591247)
- Testing
- Double Baloon Catheter, Membrane Stripping, PGE2
- Where
- Israel
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Labor, Induced, Cervix Uteri-Diseases
Comparing Outpatient to Inpatient Cervical Ripening Using Dilapan-S®
The target population for our study is women who present for induction of labor. If there is a decision by the obstetrical team to place a mechanical dilator for cervical ripening, the obstetrical team will notify the research…
- Trial name
- HOMECARE (NCT03665688)
- Testing
- Outpatient Dilapan-S, Inpatient Dilapan-S
- Where
- 2 sites in United States
- Volunteers
- 338 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Premature Rupture of Membranes at Term, Induction of Labour
Propess Versus Prostin for Induction of Labour in Women With Term PROM
Premature rupture of membranes (PROM) at term is a rupture that occurs at term (> 37 weeks) before the start of labor. The purpose of the study was to compare the safety and efficacy of two agents used in induction of labor in…
- Trial name
- PESTIBOR (NCT04743297)
- Testing
- Prostaglandin E2 (Propess), Prostaglandin E2 (Prostin)
- Volunteers
- 526 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Maribor
Induction of Birth, Cervical Ripening
Evaluation of the INGA Sensor System for Fetal and Uterine Monitoring During Cervical Ripening
The goal of this clinical trial is to learn about the safety and performance of the INGA Sensor System when used with the INGA balloon catheter during cervical ripening for labor induction in pregnant individuals at term.
- Conditions
- Induction of Birth, Cervical Ripening, Cervical Ripening and Induction of Labor, Balloon Catheter for Labor Induction
- Trial name
- INGA-SEN (NCT07432282)
- Testing
- Cervical ripening, labor Induction, uterus and fetal monitoring
- Sponsor
- Aalto University
Obesity, Labor, Induced
Oxytocin Dosage to Decrease Induction Duration
This is a randomized controlled trial in which women are allocated either 'high dose' or 'low dose' oxytocin infusions for induction of labour. The randomization is stratified by maternal body mass index.
- Conditions
- Obesity, Labor, Induced, Oxytocin
- Trial name
- OPS (NCT03140488)
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- University of Arizona
Pain
Preventive Analgesia in Multiparas Undergoing Induction of Labour
Our study is about providing a better birthing experience by placing and initiating epidural for labour pain before the contractions start.
- Trial name
- NCT00465231
- Testing
- bupivacaine, fentanyl, preservative free saline
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Induced; Birth, Pregnancy
Comparison of Patient Satisfaction With Home Induction and In-patient Induction.
Induced labour is a medical intervention designed to initiate or accelerate the childbirth process when clinically indicated. Induced labour concerns 25.8% of pregnant women in France, according to the latest National Perinatal…
- Trial name
- NCT06272591
- Testing
- Preliminary search in the patient's file, A posteriori research in the patient's file, First questionnaire : choice of induction method reason for choice
- Where
- France
- Volunteers
- 187 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Fetal Membranes, Premature Rupture, Induced Labor
Intracervical Catheters for Induction of Labour in Women With Prelabour Rupture of Membranes at Term
The purpose of this study is to examine the feasibility of using intracervical balloon catheters for cervical ripening as part of labour induction in healthy, GBS-negative women with prelabour rupture of membranes at term.
- Trial name
- IC-PROM (NCT00890630)
- Testing
- Intracervical Balloon Catheter, Oxytocin
- Where
- Canada
- Volunteers
- 5 people
- Sponsor
- McMaster University