Clinical trials: Labour,Induced
Labor, Induced, Cervical Ripening
Labor Induction With a Combined Method (Pharmacologic and Mechanical): Randomized Controlled Trial
Labor induction is a common pregnancy procedure worldwide. Both mechanical and pharmacologic agents are used for induction of labor. These agents reduce the incidence of cesarean delivery in women undergoing induction.
- Trial name
- NCT03928600
- Testing
- Cervical Foley combined with Misoprostol, Dinoprostone 10mg insert OR, Misoprostol
- Where
- Portugal
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Centro Hospitalar De São João, E.P.E.
Prelabour Rupture of Membranes at Term
A Pilot RCT on the Management of Term Prelabour Rupture of Membranes
This is a pilot study that will eventually result in a main randomised controlled trial that will look at what management is associated with a higher rate of normal birth and a lower rate of chorioamnionitis (maternal infection)…
- Trial name
- NCT02872883
- Testing
- Expectant management, Minimal Vaginal examinations (only when necessary), Active management
- Where
- United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Central Lancashire
Labor; Forced or Induced, Affecting Fetus or Newborn
The Comparison of Oxytocin Induced Labor and Cook Balloon Induced Labor
Currently, the study about intervention on the induced abortion at trimester is so little. So, the investigators want to compare the safety and effectiveness of different induced labor.
- Trial name
- NCT02202083
- Testing
- Cook Balloon
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- West China Second University Hospital
Labour Induction
Impact of Early Versus Late Amniotomy on Labour Induction in Nulliparous Women After Vaginal Misoprostol
Investigation the effect of timing of amniotomy (early versus delayed) after vaginal misoprostol in induced labor. Condition: induction of labour intervention: eary versus late amniotomy on labour induction after vaginal…
- Trial name
- RCT (NCT04514770)
- Testing
- Misoprostol
- Where
- Egypt
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Menoufia University
Labour, Induced
Comparative Bioavailability Study of Two Misoprostol Formulations
The purpose of this study is to compare pharmacokinetics of two formulations of misoprostol following single dose administration in adult women being given misoprostol for cervical ripening and induction of labour.
- Trial name
- NCT02516631
- Testing
- Angusta™, Cytotec®
- Where
- Sweden
- Volunteers
- 72 people
- Sponsor
- Region Skane
Induced Vaginal Delivery
Dinoprostone Versus Vaginal Misoprostol for Induction of Labour
This randomized controlled study was carried out on 370 pregnant women with gestational age ≥ 40 weeks of different ages and parities at El-Shatby Maternity University Hospital after approval of ethical committee of Alexandria…
- Trial name
- NCT06560515
- Testing
- Vaginal Dinoprostone
- Where
- Egypt
- Volunteers
- 370 people
- Sponsor
- University of Alexandria
Premature Rupture of Fetal Membranes
Evaluation of CRB in PROM Patients
The CRB study is designed to study the safety and effectiveness of the Cook Cervical Ripening Balloon (CRB) for the induction of labor in term and near-term patients with premature rupture of membranes (PROM).
- Trial name
- NCT01736852
- Testing
- CRB, Pitocin
- Where
- 4 sites in United States
- Volunteers
- 129 people
- Sponsor
- Cook Group Incorporated
Obstetric Labour, Premature
A Study to Evaluate the Pharmacokinetics, Safety and Tolerability of Retosiban (GSK221149) When Dosed With Efavirenz (EFZ)
This will be a randomized single sequence open label study. This study is designed to determine if chronic dosing with efavirenz (EFZ) will have an effect on the pharmacokinetics (PK) of intravenously-administered retosiban in…
- Trial name
- NCT01867996
- Testing
- Retosiban, EFZ 600 mg
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Pregnancy, Labor; Forced or Induced, Affecting Fetus or Newborn
Outpatient Labor Induction With the Transcervical Foley Balloon
This study represents the first randomized trial comparing traditional inpatient induction with a transcervical foley catheter versus outpatient induction with immediate removal of a transcervical foley catheter.
- Trial name
- NCT02210598
- Testing
- inpatient Foley balloon induction, outpatient Foley balloon induction, Oxytocin
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- University of Southern California
Labor, Induced, Cervical Ripening
Prehospital Cervical Ripening Before Induction and the Maternal Experience
This is a randomized study evaluating the impact of pre-hospital cervical ripening with a transcervical Foley balloon before labor induction in full-term pregnancies on the length of inpatient labor induction and maternal…
- Trial name
- "PRIME" (NCT01641601)
- Testing
- Outpatient transcervical Foley balloon
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of California, San Francisco
Induced Labor, Cervical Ripening
Low-dose Vaginal Misoprostol Versus Vaginal Dinoprostone Insert for Induction of Labor
Purpose: To compare the efficacy and safety of low-dose protocol of vaginal misoprostol and vaginal dinoprostone insert for induction of labor in women with post-term pregnancies.
- Conditions
- Induced Labor, Cervical Ripening, Obstetric Labor, Pregnancy
- Trial name
- MADUTER (NCT03744364)
- Testing
- Misoprostol 25 mcg, Dinoprostone 10mg
- Volunteers
- 198 people, healthy volunteers welcome
- Sponsor
- Hospital Miguel Servet
Labor, Induced, Term Pregnancy
Comparison of Vaginal PGE2 (Dinoprostone) and Vaginal Misoprostol for Induction of Labour in Primigravid Term Pregnancy
This randomized controlled trial was conducted to compare vaginal misoprostol and vaginal PGE2 (dinoprostone) for induction of labour in primigravid women with term pregnancy.
- Conditions
- Labor, Induced, Term Pregnancy, Cervical Ripening
- Trial name
- NCT07559812
- Testing
- Misoprostol, Dinoprostone 3 mg
- Where
- Pakistan
- Volunteers
- 240 people
- Sponsor
- Mayo Hospital Lahore
Failed Induction of Labor
A Novel Protocol for Labour Induction
The use of foley catheter was tested many times and proved to be effective for induction of labour.
- Trial name
- NCT01506388
- Testing
- foley catheter, Misoprostol, Vaginal IMN
- Where
- 2 sites in Egypt
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Cairo University
Labor Induction
Effect of Dexamethasone on Labour Induction in Term Pregnancies
The aim of the study is to assess the effect of dexamethasone on labour induction in term pregnancies. Primary outcome: The interval between initiation of induction and beginning of the active phase of labour.
- Trial name
- NCT07109258
- Testing
- Dexamethasone (Decadron) 8mg IM injection, Misoprostol 25 mcg, Both Misoprostol 25 mcg & Dexamethasone 8mg IM injection
- Where
- Egypt
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Cairo University
Premature Rupture of Fetal Membranes
Intravenous Papaverine for Term Prelabor Rupture of Membranes
This randomized, double-blind, placebo-controlled trial evaluates whether intravenous papaverine, administered as an adjunct to oxytocin, shortens the time to delivery in women with term premature rupture of membranes (PROM).
- Trial name
- NCT07826533
- Testing
- Papaverine
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Wolfson Medical Center
Epidural, Labor Pain
Improving Labour Induction Analgesia: Epidural Fentanyl Bolus at Epidural Initiation for Induction of Labour
Labour pain can be intensified for labour inductions and women undergoing inductions often have earlier and more frequent requests for analgesia.
- Conditions
- Epidural, Labor Pain, Induction of Labor Affected Fetus / Newborn, Obstetric Anesthesia Problems
- Trial name
- NCT04011098
- Testing
- Epidural Fentanyl Bolus, Standard Epidural Group
- Where
- Canada
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Saskatchewan
Macrosomia, Induction of Labour
Induction of Labour for LGA fœtus in Women Without Insulin-treated Diabetes.
A french study published in 2015 (DAME) showed a decrease of shoulder dystocia and an increase of spontaneous vaginal delivery when the non insulin-treated diabetes patients with large-for-date fetus were induced.
- Conditions
- Macrosomia, Induction of Labour, Non-insulin-dependent Diabetes
- Trial name
- NCT03355040
- Testing
- induction of labour
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Montpellier
Labor, Induced, Amniotomy
Early Versus Late Amniotomy During Labor Induction in Women With Bishop's Score of ≥ 6
Labor induction is the stimulation of uterine contractions during pregnancy, before labor begins on its own to achieve a vaginal birth.
- Trial name
- NCT04731896
- Testing
- Amniotomy
- Where
- Tunisia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Tunis El Manar
Maternal Obesity
Balloon to Induce Labor in Generous Women.
The rate of obesity increases continuously in France as in many developing countries.The risk of cesarean delivery is increased in obese compared to normal-weight women and postpartum complications as infections, thromboembolic…
- Trial name
- BIGW (NCT03435458)
- Testing
- Balloon catheter + oral misoprostol, Oral misoprostol alone
- Where
- 18 sites in France, Martinique
- Volunteers
- 429 people
- Sponsor
- University Hospital, Toulouse
Gestational Diabetes Mellitus (GDM)
The Feasibility Of Expectant Management Versus Induction At 38 Weeks Among Individuals With Gestational Diabetes Mellitus: A Randomized Controlled Pilot Trial (EAGER Pilot Trial)
The EAGER pilot trial is designed to assess the feasibility of a Canadian, multicentre prospective randomized open-label blinded end-point (PROBE) clinical trial addressing whether induction of labour (IOL) at 38 weeks' gestation…
- Trial name
- EAGER Pilot (NCT06641141)
- Testing
- Induction of Labour
- Where
- Canada
- Volunteers
- 260 people
- Sponsor
- Ottawa Hospital Research Institute