Clinical trials: Labour Analgesia, Epidural Anaesthesia
Primigravida in Labour Pains
Dosing Strategies for Automated Mandatory Intermittent Boluses Technique for Epidural Labour Analgesia
The purpose of this study is to determine how manipulation of the programmed intermittent time interval and volume influences total drug use, quality of analgesia, and patient satisfaction during maintenance of labor analgesia.
- Trial name
- NCT01205360
- Testing
- Bupivacaine-Fentanyl Mixture
- Volunteers
- healthy volunteers welcome
- Sponsor
- Pravara Institute of Medical Sciences University
Labour Pain
Combined Spinal-Epidural Versus Traditional Labor Epidural
The purpose of this study to compare the use of spinal-epidural versus traditional labor epidural on maternal and fetal effects.
- Trial name
- NCT00151346
- Testing
- Bupivacaine and Fentanyl (for CSE), Bupivacaine and Fentanyl (for traditional epidural)
- Where
- United States
- Volunteers
- 127 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Labour
Systematic Clonidine for Epidural Analgesia in Labour
In a prospective randomised study involving primiparous women in spontaneous uncomplicated labour with cervical dilatation < 5 cm, epidural analgesia will be given with an initial volume of 20 mL anaesthetic solution, followed by…
- Trial name
- NCT00983125
- Testing
- Clonidine
- Where
- France
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Analgesia, Epidural
Comparison of Safety and Efficacy Between PIEB and CEI for Labour Epidural Analgesia
The goal of this clinical trial is to compare safety and efficacy of programmed intermittent epidural bolus (PEIB) and continuous epidural infusion (CEI) in parturients during active phase of labour.
- Trial name
- NCT06889285
- Testing
- Continuos epidural infusion, Programmed intermittent epidural bolus
- Where
- Malaysia
- Volunteers
- 76 people
- Sponsor
- Hospital Universiti Sains Malaysia
Labour Analgesia
Prediction of Local Anaesthetic Dosing During Labour Epidural Analgesia
Epidural analgesia is the gold standard for controlling labour pain. However, labour pain happens during neuraxial analgesia, due to anaesthetic, obstetric, maternal factors.
- Trial name
- DIANA (NCT07614516)
- Testing
- Machine-learning prediction model
- Where
- Italy
- Volunteers
- 12,500 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Labor Pain, Labor; Prolonged, Second Stage
Remifentanil vs. Combined Spinal-epidural Analgesia for Labor Analgesia and Progress of Labor in Multiparous
Remifentanil may be an ideal drug for labor analgesia due to its pharmacodynamic and pharmacokinetic profile. As compared to epidural analgesia, it demonstrated satisfactory for pain relief at the beginning of labour with a…
- Conditions
- Labor Pain, Labor; Prolonged, Second Stage, Labor; Prolonged, First Stage
- Trial name
- NCT02963337
- Testing
- remifentanil, combined spinal-epidural analgesia
- Where
- Slovenia
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana
Breakthrough Pain
Comparison of Regimens MPIB, CIPCEA, PCEA
Epidural analgesia is the gold standard of pain relief for labour pain. Despite this, more than 50% of parturients continue to experience pain leading to suffering and increased caregiver workload.
- Trial name
- COLEUS (NCT02278601)
- Testing
- epidural delivery system, Ropivacaine, Fentanyl
- Where
- Singapore
- Volunteers
- 839 people
- Sponsor
- KK Women's and Children's Hospital
Obstetric Pain, Labor Pain
Dural Puncture Epidural VS Standard Epidural on Physician Top-ups During Labour Analgesia
The purpose of this prospective randomized controlled study is to compare the number of physician top-up interventions during the first stage of labour between two different neuraxial analgesia techniques : the dural puncture…
- Conditions
- Obstetric Pain, Labor Pain, Anesthesia
- Trial name
- DPE (NCT04728048)
- Testing
- Dural puncture epidural, Standard epidural
- Where
- Canada
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
Anesthesia, Obstetrical, Analgesia, Epidural
Epidural Analgesia During Labour
Randomized single blind trial based on comparing the way the local anesthetic is dosificated during labour. The pain control is evaluated and compared with both dosage techniques (PCEA vs PIEB)using levobupivacaine and fentanyl.
- Trial name
- PIEBvsPCEA (NCT03133091)
- Testing
- PIEB: Patient Intermittent Epidural Boluses, PCEA: Patient Controlled Epidural Analgesia
- Where
- Spain
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Hospital del Rio Hortega
Labor Pain
Quality of Labour Epidural Analgesia With Intrathecal Morphine as a Component of Combined Spinal Epidural
Neuraxial analgesia has shown to be the gold standard for effective labor pain relief, offering numerous benefits including enhanced pain control and maternal satisfaction.
- Trial name
- NCT06572241
- Testing
- Intrathecal morphine
- Where
- Canada
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Obstetric Pain, Analgesia
Study Comparing Dural Puncture Epidural With Epidural and Combined Spinal Epidural Anesthesia for Obstetric Analgesia.
This will be a prospective, randomized, double blind, controlled clinical trial. Epidural analgesia (EP) is currently the method of choice to ensure the comfort of the parturient during childbirth.
- Trial name
- NCT05196256
- Testing
- Dural puncture, Combined spinal epidural analgesia, Epidural analgesia
- Where
- Belgium
- Volunteers
- 90 people
- Sponsor
- Brugmann University Hospital
Labor Pain
Programmed Intermittent Epidural Bolus Versus Continuous Infusion in Labour Analgesia
This study aims to establish if programmed intermittent epidural bolus combined to patient controlled analgesia in labour analgesia will lower the hourly bupivacaine consumption when compared to continuous infusion combined with…
- Trial name
- NCT03730753
- Testing
- Programmed intermittent epidural bolus, Continuous infusion
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Pregnancy, Labour
Minimum Effective Dose (MED) & Epidural Bupivacaine
Local anaesthetics are highly toxic drugs. They can cause toxicity by an absolute overdose, accidental injection in a blood vessel or slow absorption from the area of injection.
- Conditions
- Pregnancy, Labour, Primigravida Labour, Epidural Block
- Trial name
- NCT02116842
- Testing
- 0.1% bupivacaine, 0.075% bupivacaine, 40 µg fentanyl
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- University of Leeds
Labouring Parturients Requiring/Requesting Epidural Analgesia as Part of Their Peri-partum Care
A Comparison Study Of Two Different Techniques For Identifying The Epidural Space In Parturients In Labour
The purpose of this study is to determine whether the use of the Epidrum device to identify the epidural space in labouring parturients reduces morbidity, when compared to standard loss of resistance techniques.
- Trial name
- NCT01574391
- Testing
- Epidrum
- Where
- Ireland
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- National Maternity Hospital, Ireland
Analgesia, Epidural
Levobupivacaine for Epidural Analgesia in Labour
In a prospective randomised study involving primiparous women in spontaneous uncomplicated labour with cervical dilatation > 7 cm, epidural analgesia will be given with an initial volume of 20 mL anaesthetic solution, followed by…
- Trial name
- NCT00929682
- Testing
- Randomization between two referenced treatments
- Volunteers
- 136 people
- Sponsor
- University Hospital, Clermont-Ferrand
Epidural Analgesia for Labour and Delivery
M-mode Ultrasonography for Epidural Catheter Identification and Confirmation of Correct Catheter Position
In France, 80% of women choose epidural analgesia for delivery and birth. The localization of the epidural space is classically achieved by loss of resistance to saline.
- Trial name
- ETEMERC (NCT05897814)
- Testing
- Location of the epidural analgesia catheter
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Epidural, Analgesia
Epidural Analgesia and Delivery of Second Twin
Over an 8-year period, 124 twin pregnancies at gestational age ≥32 weeks with both twins presenting as a vertex and eligible for vaginal delivery were reviewed.
- Conditions
- Epidural, Analgesia, Labor Pain
- Trial name
- Epidural (NCT04608006)
- Testing
- Bupivacaine-fentanyl
- Where
- Egypt
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Abdelrady S Ibrahim, MD
Epidural Analgesia, Obstetric
Impact of Low-Dose Epidural Analgesia on Labour Progression in Low-Risk Women
Aim of the study was to analyse data on cervical dilation and fetal descent patterns in low-risk women, who did or did not receive intermittent low-dose epidural analgesia (EA), and who had either a vaginal or a caesarean…
- Trial name
- NCT06987591
- Where
- Italy
- Volunteers
- 5,995 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Epidural Top-up, Labour
Labour Epidural Top-up With Warmed Ropivacaine
The purpose of this study is to determine weather using warmed (body temperature) 0.75% Ropivicaine to convert labour epidural analgesia to surgical anaesthesia, reduces the onset time of surgical block, compared to standard room…
- Conditions
- Epidural Top-up, Labour, Caesarian Section, Ropivacaine
- Trial name
- LETWR (NCT02838329)
- Testing
- warming of ropivacaine for BT, Ropivicaine
- Where
- United Kingdom
- Volunteers
- 90 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Labor Pain
Assessment of Sensory Block During Labour Epidural Analgesia in Patients Experiencing Pain During First Stage of Labour.
Epidural analgesia is the gold standard for pain control during labour and an essential component of delivering effective and safe epidural analgesia is the assessment of the epidural sensory block.
- Trial name
- NCT05881395
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital