Clinical trials: Labour Induction, open to volunteers
Labor, Induced
Topical Anesthesia During Catheter Insertion for Cervical Ripening (TOLERANCE)
The goal of this RCT is to learn if application of topical anesthetic cream to the perineum and posterior wall of vagina prior to balloon catheter insertion as part of labor induction will reduce pain levels experienced by…
- Trial name
- TOLERANCE (NCT07288021)
- Testing
- Topical Analgesia with Lidocaine-Prilocaine cream
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Bnai Zion Medical Center
Preterm PROM (Pregnancy)
Oxytocin/Foley vs. Oxytocin for Induction in Patients With PPROM
Data on the optimal mode of labor induction after preterm prelabor rupture of membranes (PPROM) is lacking. Studies have shown no difference between oxytocin and misoprostol use for labor induction in this cohort (1).
- Trial name
- NCT07119398
- Testing
- Oxytocin plus Foley Catheter, Oxytocin
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Eastern Virginia Medical School
Cervical Ripening, Unfavorable Cervix
Oxytocin vs Prostaglandins for Labor Induction of Women With an Unfavorable Cervix After 24h of Cervical Ripening
Twenty-two percent of deliveries in France are induced. In cases where labor is induced and cervix is unfavorable, cervical ripening prior oxytocin administration is advised in order to reduce the risk of cesarean delivery.
- Trial name
- OPIC (NCT04949633)
- Testing
- Prostaglandins, Oxytocin
- Where
- 14 sites in France
- Volunteers
- 1,494 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Fetal Growth Restriction
Prostaglandins Versus Trans-cervical Balloon for Induction of Labor in Fetal Growth Restriction (PROBIN)
The goal of this randomized trial is to compare two methods of induction in a fetal growth restriction population. The main question it aims to answer is: Is trans-cervical balloon superior to prostaglandins in reducing the…
- Trial name
- PROBIN (NCT05674487)
- Testing
- Trans-cervical balloon, Misoprostol
- Where
- France
- Volunteers
- 774 people
- Sponsor
- University Hospital, Bordeaux
Infections
Azithromycin Before Induction
This is a double blinded randomized control trial involving administration of 2 grams prophylactic azithromycin in third trimester patients undergoing induction of labor at our institution to demonstrate reduction in maternal and…
- Trial name
- NCT06543290
- Testing
- Azithromycin Pill
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Arrowhead Regional Medical Center
Intrapartum Fetal Distress
Prediction of Intrapartum Fetal Compromise After Elective Induction of Labour
Each fetus has a different metabolic capacity at the onset of labor, and in cases of an imbalance between fetal demands and placental oxygen supply, fetal hypoxia occurs.
- Trial name
- NCT07881744
- Volunteers
- 182 people
- Sponsor
- Ain Shams Maternity Hospital
Labor Induction, Cesarean Birth
Implementation of a Disparities in Labor Outcomes Dashboard
This proposal will determine if a Disparities in Labor Outcomes dashboard can be used as an implementation strategy to increase compliance to an evidence-based set of interventions for labor induction in a two-site…
- Trial name
- NCT07756424
- Testing
- Disparities in Labor Outcomes Dashboard
- Where
- United States
- Volunteers
- 2,300 people
- Sponsor
- University of Pennsylvania
Induction of Labor Affected Fetus / Newborn
Cervical Ripening as an Outpatient Method Using the Foley (COMFORT)
A multicenter pragmatic randomized trial of nulliparous women undergoing a term (≥37 weeks) induction of labor wherein the provider intends to use a Foley catheter for cervical ripening.
- Trial name
- COMFORT (NCT05759988)
- Testing
- Outpatient Foley catheter
- Where
- 6 sites in United States
- Volunteers
- 2,300 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Induced; Birth
Outcome of Concurrent Versus Sequential Method of Induction of Labour in Term Pregnancy
This randomized controlled trial will compare two methods of induction of labour in women with term pregnancy: concurrent use of a Foley catheter and PGE2 vaginal pessary versus sequential use of the two methods.
- Trial name
- NCT07821099
- Testing
- Foley Catheter, PGE2 Vaginal Pessary
- Where
- Pakistan
- Volunteers
- 128 people
- Sponsor
- Khyber Medical University Peshawar
Pregnancy Related
Oxytocin in Multiparous Women
This is a randomized controlled trial investigating whether continuous oxytocin infusion in multiparous women shortens time to delivery, without altering maternal or neonatal outcomes, in augmented deliveries, compared to…
- Trial name
- NCT06372522
- Testing
- Pitocin Injectable Product
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Delivery, Obstetric, Cesarean Section
Comparison Between Two Medical Devices for Labor Induction After Previous C-section
The objective of the study ist to compare the Dilapan-S and the Cook Ballon device for the mechanical induction of labour in women with a previous C-section.
- Conditions
- Delivery, Obstetric, Cesarean Section, Obstetric Delivery
- Trial name
- DiBal (NCT06506721)
- Testing
- Double ballon device, Cook, Hygroscopic cervix dilators, Dilapan-S
- Where
- Switzerland
- Volunteers
- 137 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Induction of Labor, Cervical Ripening
Combined Nipple Stimulation and Foley Balloon for Cervical Ripening
Labor induction rates have increased substantially worldwide, and successful cervical ripening remains a key determinant of induction outcomes.
- Trial name
- NCT07317674
- Testing
- Foley balloon catheter with nipple stimulation, Mechanical cervical ripening with Foley catheter
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Western Galilee Hospital-Nahariya
Labor, Induced
Mifepristone Outpatient Labour Induction
The number of women having an induction of labour is increasing and is currently used in 33% of pregnancies for a range of medical reasons.
- Trial name
- MOLI (NCT05177510)
- Testing
- Mifepristone
- Where
- United Kingdom
- Volunteers
- 400 people
- Sponsor
- Chelsea and Westminster NHS Foundation Trust
Ophthalmic Artery, Labor and Delivery
The Ophthalmic Artery Doppler Evaluation Prior to Labor Induction and Adverse Intrapartum Fetal Outcomes
The ophthalmic artery Doppler has been recently proposed as a potential "soft marker" for placental insufficiency in retrospective and observational studies, with similar clinical significance with respect to Uterine Artery (UA)…
- Conditions
- Ophthalmic Artery, Labor and Delivery, Induction of Labor, Intrapartum Fetal Distress
- Trial name
- OPHELIA (NCT07846137)
- Testing
- Ophthalmic Artery Doppler
- Volunteers
- 1,477 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Induction of Childbirth
3-hour Versus 12-hour Double-balloon Catheter for Labor Induction
This study aims to demonstrate that a 3-hour ultra-short cervical ripening protocol using a double-balloon catheter significantly reduces the induction-to-birth interval by at least 6 hours compared to the standard 12-hour…
- Trial name
- BAL3H (NCT07492186)
- Testing
- Cook® double-balloon catheter
- Where
- France
- Volunteers
- 280 people
- Sponsor
- Centre Hospitalier de PAU
Induction of Labour
Women's Knowledge About Induction of Labour and Its Association With Their Experience
Induction of labour (IOL) is a common procedure to initiate childbirth, around one in three pregnant women having their labour induced in the UK.
- Trial name
- INFORM (NCT07616765)
- Testing
- Survey and Interview-Based Assessment
- Volunteers
- 112 people
- Sponsor
- Imperial College London
Premature Rupture of Fetal Membranes, Labor, Induced
PGE2 Followed by Oxytocin vs Oxytocin in Term PROM (POXY-PROM)
This study is being done to learn more about the best way to start labor for pregnant women whose water breaks at term before labor begins, a condition called term prelabor rupture of membranes (term PROM).
- Conditions
- Premature Rupture of Fetal Membranes, Labor, Induced, Cervical Ripening
- Trial name
- POXY-PROM (NCT07366359)
- Testing
- Sequential Induction: Dinoprostone Followed by Oxytocin, Immediate Oxytocin Induction
- Where
- Vietnam
- Volunteers
- 450 people
- Sponsor
- National Hospital of Obstetrics and Gynecology
Gestational Diabetes Mellitus (GDM)
The Feasibility Of Expectant Management Versus Induction At 38 Weeks Among Individuals With Gestational Diabetes Mellitus: A Randomized Controlled Pilot Trial (EAGER Pilot Trial)
The EAGER pilot trial is designed to assess the feasibility of a Canadian, multicentre prospective randomized open-label blinded end-point (PROBE) clinical trial addressing whether induction of labour (IOL) at 38 weeks' gestation…
- Trial name
- EAGER Pilot (NCT06641141)
- Testing
- Induction of Labour
- Where
- Canada
- Volunteers
- 260 people
- Sponsor
- Ottawa Hospital Research Institute
Pruritis, Hypotension Drug-Induced
Incidence of Pruritus Using Intrathecal Fentanyl Versus Epidural Fentanyl to Initiate Labour Analgesia.
The purpose of this study is to investigate the effect of neuraxial analgesia initiation on the incidence of pruritus in laboring women.
- Conditions
- Pruritis, Hypotension Drug-Induced, Urinary Retention, Fetal Bradycardia During Labor
- Trial name
- NCT07187427
- Testing
- Spinal analgesia, Epidural Analgesia
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- St. Justine's Hospital
Labor, Induced, Labor, Obstetric
Maternal Informing on Labor Induction: Impact on Childbirth Experience
The aim of this study is to explore the information provided to mothers about labor induction and its connection to their childbirth experience.
- Conditions
- Labor, Induced, Labor, Obstetric, Pregnancy, Humans
- Trial name
- NCT07272785
- Where
- Finland
- Volunteers
- 50 people
- Sponsor
- Turku University Hospital