Clinical trials: Labyrinthitis
Vertigo, Peripheral
Non Inferiority of Meclin® (Meclizine Chlorhydrate) Versus Dramin® (Dimenhydrinate) in Control of Acute Vertigo Symptoms From Peripheral Origin
Evaluation of the non inferiority of Meclin (meclizine) versus Dramin (Dimenhydrinate) to treat the symptoms of acute vertigo from peripheral origin after up to 4 weeks of treatment; Evaluation of impact on quality of life in…
- Trial name
- NCT02112578
- Testing
- Meclizine, Dimenhydrinate
- Where
- 7 sites in Brazil
- Volunteers
- 292 people
- Sponsor
- Apsen Farmaceutica S.A.
Meniere's Disease
SPI-1005 for the Treatment of Patients With Meniere's Disease
This study will evaluate the safety, efficacy, and Pharmacokinetics (PK) of two dose levels of SPI-1005 administered for 28 days compared to placebo in patients with Meniere's disease.
- Trial name
- NCT03325790
- Testing
- 200mg SPI-1005 BID, 400mg SPI-1005 BID
- Where
- 13 sites in United States
- Volunteers
- 149 people
- Sponsor
- Sound Pharmaceuticals, Incorporated
Inner Ear Diseases
A Single Dose PK Study of SENS-218 in Healthy Volunteers
This study is to aid the development for the use of SENS-218 outside its marketed therapeutic indications. SENS-218 is available in Asia and is marketed as an anti-emetic (Anti-sickness) drug often prescribed after exposure to…
- Trial name
- NCT02772796
- Testing
- SENS-218
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Simbec Research
Meniere's Disease, Meniere Disease
Expanded Access Protocol for SPI-1005
The purpose of this protocol is to facilitate expanded access ("compassionate use") of SPI-1005 to Meniere's disease (MD) or sudden sensorineural hearing loss (SSNHL) patients who cannot gain access through ongoing clinical…
- Conditions
- Meniere's Disease, Meniere Disease, Meniere´s Disease, Meniere's Disease Aggravated
- Trial name
- NCT07873281
- Testing
- Ebselen
- Sponsor
- Sound Pharmaceuticals, Incorporated
Vestibular Diseases, Gait Disorders
Safety and Efficacy Study of BrainPort® Balance Device in Peripheral Vestibular Dysfunction.
The purpose of this study is to assess the safety and efficacy of the BrainPort balance device in improving balance and gait as measured by clinically accepted standardized balance assessments in subjects with peripheral…
- Trial name
- NCT00768378
- Testing
- Training with the BrainPort balance device
- Where
- 17 sites in United States
- Volunteers
- 147 people
- Sponsor
- Wicab
Vertigo, Autonomic Dysfunction
Efficacy and Safety of Vespireit, Prolonged-release Tablets, in Patients With Autonomic Dysfunction Syndrome Accompanied by Functional Vertigo
This study aims to evaluate the efficacy and safety of Vespireit, prolonged-release tablets, 15 mg (Valenta Pharm JSC, Russia) in comparison with Arlevert, tablets, 40 mg + 20 mg (Menarini International Operations Luxembourg…
- Trial name
- NCT06321341
- Testing
- Vespireit, Arlevert
- Where
- 4 sites in Russia
- Volunteers
- 160 people
- Sponsor
- Valenta Pharm JSC
Meniere's Disease
Study of OTO-104 in Subjects With Unilateral Meniere's Disease
The purpose of this study is to evaluate the effectiveness of OTO-104 for the treatment of Meniere's disease.
- Trial name
- AVERTS-1 (NCT02612337)
- Testing
- OTO-104
- Where
- United States
- Volunteers
- 166 people
- Sponsor
- Otonomy, Inc.
Ototoxicity
SPI-1005 for Prevention and Treatment of Tobramycin Induced Ototoxicity
The primary objective of this study is to determine the safety and efficacy of SPI-1005 treatment in CF patients with active pulmonary exacerbation that are receiving an IV course of tobramycin, determined by comparing hearing…
- Trial name
- NCT02819856
- Testing
- SPI-1005 Ebselen 200mg Capsule x1, SPI-1005 Ebselen 200mg Capsule x2, SPI-1005 Ebselen 200mg Capsule x3
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Sound Pharmaceuticals, Incorporated
Brain Concussion, Vestibular Disorder
Portable Mixed Reality-based Platform for Assessment of Progress in Multisensory Rehabilitation Strategies Post-TBI
The goal of this comparative pilot study is to provide evidence that Praxis, a portable testbed with low-cost wearable sensors and a mixed reality environment, can deliver effective multisensory rehabilitation exercises with…
- Conditions
- Brain Concussion, Vestibular Disorder, Cognition Disorder, Mild Traumatic Brain Injury
- Trial name
- Praxis (NCT06314464)
- Testing
- Praxis, Supervised cardiovascular exercise
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- BlueHalo
Meniere's Disease
Sildenafil For Meniere's Disease
Meniere's disease affects a person's sense of balance. An attack can last 20 minutes to 2 hours or longer. Symptoms include rotational vertigo, hearing loss, tinnitus and a sensation of fullness in the affected ear and may be…
- Trial name
- NCT00145483
- Testing
- Sildenafil
- Where
- 4 sites in Australia
- Volunteers
- 163 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Meniere's Disease
Isobide Solution and Meniace Tablets Compared to Monotherapy With Meniace Tablets
A multicenter, randomized, open-label clinical study with a concurrent control group to assess the effectiveness and safety of combined therapy with Isobide solution and Meniace tablets compared to monotherapy with Meniace…
- Trial name
- NCT02718846
- Testing
- Meniace, Isobide
- Volunteers
- 220 people
- Sponsor
- Alvogen Korea
Vestibular Disorder, Dizziness
Head-Mounted Vibrotactile Prosthesis for Patients With Chronic Postural Instability
The goal of this study is to evaluate a tactile prosthesis that provide individuals who have demonstrated chronic imbalance with help to maintain a correct sense of orientation with respect to the gravity and improve posture…
- Trial name
- BALCAP (NCT03330262)
- Testing
- BALCAP prosthesis
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Barron Associates, Inc.
Vertigo
Effectiveness of Betaserc® (Betahistine Dihydrochloride) in Patients With Vestibular Vertigo in Routine Practice
The purposes of this international post-marketing observational program is to investigate effectiveness of betahistine dihydrochloride (Betaserc®) tablets and assess the course of vestibular vertigo after treatment…
- Trial name
- VIRTUOSO (NCT01759251)
- Where
- 24 sites in Russia, Ukraine
- Volunteers
- 309 people
- Sponsor
- Abbott
Meniere Disease
Phase 3 Study of OTO-104 in Subjects With Unilateral Meniere's Disease
The purpose of this study is to evaluate the effectiveness of OTO-104 for the treatment of Meniere's disease.
- Trial name
- NCT03664674
- Testing
- OTO-104
- Where
- 65 sites in United States, Belgium and 6 more
- Volunteers
- 148 people
- Sponsor
- Otonomy, Inc.
Meniere's Disease
Effects of Betaserc on Vestibular Compensation in Patients Suffering From Disabling Meniere's Disease and Having Undergone Vestibular Neurotomy
This study is to compare the effects of Betaserc 24mg and placebo on compensation of postural and locomotor deficits (static and dynamic posturography) after vestibular neurotomy in patients suffering from disabling Menière's…
- Trial name
- NCT00160238
- Testing
- Betahistine 24 mg bid (Betaserc)
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Solvay Pharmaceuticals
Benign Paroxysmal Positional Vertigo
Automated Robotic Maneuvering System (RMS) vs Manual Reposition Maneuver in Treatment of Benign Paroxysmal Positional Vertigo (BPPV)
Comparison of treatment efficacy of an automated robotic maneuvering system (RMS) repositioning chair versus manual positioning maneuvers in Benign Paroxysmal Positional Vertigo.
- Trial name
- NCT05352555
- Testing
- Automated vertigo repositioning chair, Canalith Reposition Maneuver
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Stratejik Yenilikci Girisimler Ltd.
Meniere's Disease
Study to Evaluate SPI-1005 in Adults With Meniere's Disease
This study will evaluate the safety and efficacy of three dose levels of SPI-1005 compared to placebo on vertigo, tinnitus and sensorineural hearing loss in 40 adults with Meniere's disease.
- Trial name
- NCT02603081
- Testing
- SPI-1005
- Where
- 5 sites in United States
- Volunteers
- 40 people
- Sponsor
- Sound Pharmaceuticals, Incorporated
Meniere's Disease
Open Label Study of OTO-104 in Subjects With Meniere's Disease
This is a 1-year, multicenter, Phase 2, open-label safety study in subjects with unilateral Meniere's disease. Subjects will receive 1 intratympanic (IT) injection of 12 mg OTO-104 at 3-month intervals for a total of 4 injections…
- Trial name
- NCT02740387
- Testing
- OTO-104
- Where
- Canada
- Volunteers
- 34 people
- Sponsor
- Otonomy, Inc.
Meniere Disease, Vertigo
Safety of APSLXR in Patients Presenting Vertigo of Vestibular Origin or Meniere's Disease
The purpose of this study is to evaluate the safety of APSLXR in participants with Meniere's disease or other Verigo of vestibular origin. Pharmacokinetics will also be evaluated in a small group.
- Conditions
- Meniere Disease, Vertigo, Vertigo Vestibular
- Trial name
- NCT04674735
- Testing
- APSLXR
- Sponsor
- Apsen Farmaceutica S.A.
Vestibular Disorder, Balance; Distorted
Individualized Vestibular Rehabilitation for Elderly With Self-Management and Gaming Elements
The aim of this study is to test whether when using the Vestibular Rehabilitation App older patients perform rehabilitation in a similar manner as when directly instructed by a clinician.
- Conditions
- Vestibular Disorder, Balance; Distorted, Vestibular Diseases
- Trial name
- NCT05436067
- Testing
- Vestibular rehabilitation app, Traditional Physical Therapy
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- CFD Research Corporation