Clinical trials: Lactation
Breast Milk Expression
Early Initiation of Milk Expression in Mothers of Very Low Birth Weight Infants
Compelling evidence exists that breast milk helps protect very premature infants from prematurity-specific morbidities. Unfortunately, mothers of premature infants often exhibit delayed lactogenesis stage II (when the milk "comes…
- Trial name
- NCT01892085
- Testing
- Early initiation, Intermediate expression, Late initiation
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- University of Florida
HIV Infections
Using Nevirapine to Prevent Mother-to-Child HIV Transmission During Breastfeeding
The many benefits of breastfeeding are well documented. However, because of the risk of mother-to-child transmission (MTCT) of HIV from an HIV infected mother to her infant, there is considerable concern over the practice…
- Trial name
- NCT00074412
- Testing
- Nevirapine
- Where
- 5 sites in South Africa, Tanzania and 2 more
- Volunteers
- 2,026 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Fabry Disease, Alpha Galactosidase A Deficiency
Study of the Effects of Fabrazyme Treatment on Lactation and Infants
The study was planned for up to 2 years (24 months). Planned full participation for both mother and infant was 24 months, planned full participation of mother and development of infant was 24 months, while planned full…
- Trial name
- NCT00230607
- Testing
- agalsidase beta
- Where
- 5 sites in United States, Austria and 1 more
- Volunteers
- 7 people
- Sponsor
- Genzyme, a Sanofi Company
Breast Feeding, Analgesia Obstetrical
Intravenous Dexmedetomidine for Cesarean Section
Nervous, anxiety, fear and other psychological reactions always appears in parturients during cesarean section. This study intends to investigate the effectiveness and safety of dexmedetomidine combined with butorphanol tartrate…
- Conditions
- Breast Feeding, Analgesia Obstetrical, Postoperative Pain
- Trial name
- NCT03065530
- Testing
- Normal Saline, Dexmedetomidine 0.03ug/kg/h, Dexmedetomidine 0.05ug/kg/h
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Obstetric Pain, Postpartum Depression
Ketamine to Improve Recovery After Cesarean Delivery - Part 1
The objective of this study is evaluate the breastmilk transfer and pharmacokinetics (Part 1) and effectiveness (Part 2) of a post-cesarean delivery intravenous ketamine bolus-and-infusion strategy, as a preventive analgesic…
- Conditions
- Obstetric Pain, Postpartum Depression, Breastfeeding, Pain, Acute
- Trial name
- KINETIC (NCT04037085)
- Testing
- Ketamine
- Where
- 2 sites in United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Grace Lim, MD, MS
Lactation Suppressed
Cabergoline for Lactation Inhibition After Second-Trimester Abortion or Loss
This research study investigates the use of a drug, cabergoline, given immediately after second-trimester abortion or perinatal loss to decrease breast engorgement.
- Trial name
- LISTA (NCT04701333)
- Testing
- Cabergoline 1 MG
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- Stanford University
Exclusive Breastfeeding, Co-production of Health in Communities
A Mobile-health Pilot Experiment Targeting Mothers With Newborns in Rural Areas of San Juan Sacatepequez, Guatemala
The purpose of this study was to determine whether exposure to m-health platforms promoting recommended breastfeeding practices was effective in transmitting the exclusive breastfeeding message to participant mothers, and in…
- Trial name
- NCT02263118
- Testing
- Uni-directional SMS, Feature phone, Virtual communities
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Universidad Francisco Marroquín
Osteoporosis, Obesity
Breastfeeding and Exercise for Healthy Infants and Postpartum Moms Too!
Approximately 8 million American women suffer from osteoporosis, and one out of every two women over the age of 50 will have an osteoporotic-related fracture in their lifetime (42).
- Conditions
- Osteoporosis, Obesity, Weight Loss
- Trial name
- BEHIP (NCT00966381)
- Testing
- Exercise and weight loss intervention
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Greensboro
Contraception, Postpartum Depression
Timing of Postpartum Depot Medroxyprogesterone Acetate Administration on Breastfeeding, Contraceptive Continuation, and Depression
The investigators plan to enroll 184 women who are planning to breastfeed and use DMPA after delivery to find out whether the timing of postpartum administration of DMPA (prior to hospital discharge or 4-6 weeks after delivery)…
- Conditions
- Contraception, Postpartum Depression, Lactation
- Trial name
- DEPO-ABCD (NCT01463202)
- Testing
- Depot medroxyprogesterone acetate
- Where
- United States
- Volunteers
- 184 people, healthy volunteers welcome
- Sponsor
- Beatrice Chen
Breast Discharge Infected, Intraductal Papilloma of Breast
Feasibility and Therapeutic Efficacy of Ductoscopic Papilloma Extraction in Patients With Pathologic Nipple Discharge
In this prospective clinical trial, patients who sign an approved informed consent for ductoscopy to assess etiology of Pathologic nipple discharge (PND) will be enrolled in the study.
- Trial name
- NCT01901562
- Testing
- Ductoscopic papillectomy
- Where
- 2 sites in United States
- Volunteers
- 9 people
- Sponsor
- Montefiore Medical Center
HIV, Pregnancy
Safety and Pharmacokinetics of Dolutegravir in Pregnant HIV Mothers and Their Neonates: A Pilot Study
Aim: To evaluate dolutegravir (DTG) pharmacokinetics in pregnant HIV-infected women Rationale: In developing countries many women present with a new HIV diagnosis in late pregnancy, and are at high risk of transmitting infection…
- Trial name
- DolPHIN1 (NCT02245022)
- Testing
- Dolutegravir 50mg od, Standard of Care
- Where
- 2 sites in South Africa, Uganda
- Volunteers
- 60 people
- Sponsor
- University of Liverpool
Pain
Caring for Babies During the Newborn Screening Blood Test
Newborn infants have blood work procedures in their first days of life that cause pain, distress and physiological changes. Breastfeeding (BF), skin to skin care (SSC), or giving sweet solutions (sucrose or glucose) has been…
- Trial name
- NCT02608892
- Testing
- BSweet2Babies video
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Eastern Ontario
Breastfeeding
The Impact of Telelactation Services on Breastfeeding Outcomes
This project will assess the impact of a novel breastfeeding support intervention ("telelactation"), delivered via video calls on personal devices including mobile phones and tablets.
- Trial name
- NCT04856163
- Testing
- Telelactation support
- Where
- United States
- Volunteers
- 2,108 people, healthy volunteers welcome
- Sponsor
- RAND
Breast Feeding, Breast Feeding, Exclusive
Alive & Thrive Evaluation in Burkina Faso
The time between birth and age 24 months provides a unique opportunity to impact the long-term health and development of children through improved infant and young child feeding practices.
- Trial name
- NCT02435524
- Testing
- A&T infant and young child feeding intervention
- Where
- 2 sites in Burkina Faso
- Volunteers
- 4,541 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Lactation
Recombinant Human Prolactin for Lactation Induction
The purpose of the study is to assess the safety and determine the effects of the hormone prolactin on lactation (breast milk production).
- Trial name
- NCT00181623
- Testing
- Recombinant Human Prolactin
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Massachusetts General Hospital
Human Milk Microbiome, Bacterial Growth
Milk in Life Conditions (MiLC): Bacterial Composition of Human Milk Pumped and Stored in "Real-Life" Conditions
The MiLC trial is a randomized control trial of two different breast pump set-ups: mother's own and sterile. The objective of this trial is to investigate the bacterial composition of human milk pumped and stored in "real-life"…
- Trial name
- MiLC (NCT03123874)
- Testing
- Sterile pump set-up, Mother's Own pump set-up
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Cornell University
Health Education, Sudden Infant Death
Study of the Impact of Parental Note Taking on the Effectiveness of Anticipatory Guidance
The delivery of anticipatory guidance is an essential component of pediatric practice. Given the large amount of information to be shared during each encounter and the limited time available, there is a need for an effective and…
- Trial name
- NCT01014169
- Testing
- Note taking
- Where
- United States
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Boston Medical Center
Parenting, Breastfeeding
Evaluating a Coparenting Breastfeeding Support Intervention
The purpose of this trial is to evaluate the effectiveness of a Coparenting Breastfeeding Support Intervention with first time parents on exclusive breastfeeding rates at 12 weeks postpartum.
- Trial name
- COSI (NCT01536119)
- Testing
- Coparenting Breastfeeding Support Intervention
- Where
- Canada
- Volunteers
- 428 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Jaundice, Breastfeeding
Breastfeeding Support Intervention in Jaundiced Infants
Breastfeeding decreases the risk of many infantile infectious diseases and certain types of cancers in women. It strengthens the bond between mothers and babies and decreases the health care cost to society by making children…
- Trial name
- NCT00966719
- Testing
- Lactation Consultant support
- Where
- Canada
- Volunteers
- 99 people
- Sponsor
- Children's Hospital of Eastern Ontario
Breastfeeding, Weight Loss
Breastfeeding Support and Weight Management for Black Women
This study, in African American mothers in Detroit, will test an intervention that combines home visiting by experienced peer counselors with a smart phone-based weight control program.
- Trial name
- MamaBear (NCT03480048)
- Testing
- Breastfeeding and weight loss support
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Michigan State University