Clinical trials: Lactic Acid/Metabolism
MELAS Syndrome, Lebers Hereditory Optic Neuropathy With Extra Ocular Symptoms (LHON-Plus)
A Basket Clinical Study to Assess Glycerol Tributyrate in Patients With Mitochondrial Encephalopathy, Lactic Acidosis, Stroke-like Episodes (MELAS) or Leber's Hereditary Optic Neuropathy-Plus (LHON-Plus)
This is a parallel arm non-randomized dose-escalation, open-label basket exploratory phase 1 clinical trial where Mitochondrial encephalopathy, lactic acidosis, stroke-like episodes (MELAS) and Leber's hereditary optic…
- Trial name
- NCT06792500
- Testing
- Glycerol Tributyrate
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- George Washington University
Nephrectomy / Methods, Intraoperative Hypothermia
Effect of Preoperative Prewarming on Serum Lactate Levels in Patients Undergoing Elective Nephrectomy
The goal of this observational study is to learn whether warming patients before surgery, called "prewarming," affects blood lactate levels (a marker of how well tissues are getting oxygen) and recovery in adults having planned…
- Conditions
- Nephrectomy / Methods, Intraoperative Hypothermia, Hyperlactatemia
- Trial name
- NCT07702487
- Testing
- Preoperative active warming (prewarming)
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people
- Sponsor
- Beyzanur Aydoğdu
Hypoglycemia
Lactate to Treat Hypoglycemia
Tight glucose control in intensive care has become a major concern, allowing a reduction in morbidity and mortality. However, its use is limited by the percentage of hypoglycemia which can have severe consequences on the brain.
- Trial name
- NCT01387477
- Testing
- Lactate, Glucose
- Where
- France
- Sponsor
- Institut d'Anesthesiologie des Alpes Maritimes
Metformin Associated Lactic Acidosis
Study of Metformin Overdose
The objective of the METINFO study is an observational single-center retrospective and descriptive study. The main objective is to estimate the real mortality rate associated to a Metformin overdose.
- Trial name
- METINFO (NCT04762966)
- Testing
- Metformin
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Central Hospital, Nancy, France
Hyperlactatemia, Brain Tumor
Hyperlactatemia During and After Tumorcraniotomy
This study aims to investigate the association between hyperlactatemia and neurological disability, length-of-stay and mortality in patients who undergo tumorcraniotomy.
- Conditions
- Hyperlactatemia, Brain Tumor, Surgery, Anesthesia
- Trial name
- NCT04410315
- Testing
- Serum-lactate < 2,2 mmol/L, Serum-lactate >/= 2,2 mmol/L
- Where
- Denmark
- Volunteers
- 450 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Heart Failure, Resistance Training
The Effect of the 3/7 vs 3X9 Method in Resistance Training on Metabolic Stress in Cardiac Rehabilitation
The study proposes to measure the effect of resitance training (RT) (3/7 method) on biological markers of muscle hypertrophy in a cardiac population.
- Conditions
- Heart Failure, Resistance Training, Coronary Artery Disease
- Trial name
- NCT05391620
- Testing
- Cardiac rehabilitation with 3/7 method, Cardiac rehabilitation with 3X9 method
- Where
- Belgium
- Volunteers
- 25 people
- Sponsor
- Université Libre de Bruxelles
Post-cardiac Surgery, Hyperlactatemia
Lactate Acidosis in Postoperative Hearts
This is a single-center, observational study. Investigators aim to characterize the metabolism of lactate in children over the first forty-eight hours following cardiac surgery. Blood samples will be obtained up to 12 timepoints.
- Trial name
- NCT03025659
- Testing
- Pyruvate levels
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- University of Florida
Healthy, Lactate Blood Increase
The Lactate Project: Investigating the Impact of Lactate to Preserve Vital Organ Blood Supply and Function in Heart and Brain
The aim of the proposed study is to investigate the effect of increased plasma lactate concentrations on the heart and brain's metabolism of other energy sources, primarily glucose in the brain and glucose and FFA in the heart.
- Trial name
- NCT06665763
- Testing
- Sodium Lactate Solution
- Where
- 2 sites in Denmark
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Plasmodium Falciparum Malaria
The Cytoadherence in Pediatric Malaria (CPM) Study
The purpose of this study is to determine the importance of key blood group molecules in the clinical outcome of Plasmodium falciparum malaria infection in children.
- Trial name
- CPM (NCT00707200)
- Where
- Uganda
- Volunteers
- 2,000 people
- Sponsor
- University Health Network, Toronto
Lipodystrophy, Emaciation
Clinical Trial to Determine the Efficacy of Sculptra™ Dermal Filler for the Correction of Contour Deformities Caused by Lipoatrophy
Lipoatrophy is a condition that affects certain individuals, most commonly those who are infected with the HIV virus. Lipoatrophy however can also affect individuals who suffer from recurrent systemic infections, those who have a…
- Trial name
- NCT00360139
- Testing
- Sculptra Injection
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Dermatology Cosmetic Laser Medical Associates of La Jolla, Inc.
Acute Kidney Injury
Hyperlactatemia in Critically Ill Patients With Acute Kidney Injury
The aim of the research is to determine the prevalence of patients with acute kidney injury in the intensive care unit, the role of dialysis treatment in the treatment of these patients.
- Trial name
- NCT06565403
- Where
- Slovenia
- Volunteers
- 250 people
- Sponsor
- University Medical Centre Maribor
Hematologic Tests
Interval Training and Plasma Volume Variation
The goal of this clinical trial is to to compare the effects of high (HIIWT) versus moderate-intensity interval walking training (MIIWT) on body composition, plasma volume variations (PVV), hematological parameters, muscle damage…
- Trial name
- NCT07019285
- Testing
- High intensity interval walking training, Moderate-intensity interval walking training
- Where
- Tunisia
- Volunteers
- 32 people
- Sponsor
- Wissal Abassi
PreDiabetes, Metabolic Syndrome
Does Co-administration of Lactate to an Oral Glucose Tolerance Test Lower the Glucose Response?
To investigate whether co-administration of lactate with a glucose load affects postprandial glucose levels/handling, gastrointestinal hormones, gastric emptying, and appetite sensations in individuals with pre-diabetes when…
- Conditions
- PreDiabetes, Metabolic Syndrome, Insulin Resistance
- Trial name
- NCT06265337
- Testing
- Lactate
- Where
- Denmark
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Cryotherapy Effect
Behaviour After Exercise of Biological, Clinical and Metabolic Variables as From Different Temperatures and Times of Immersion Cold Water Application
Introduction: immersion cold water is a recuperative strategy commonly used, however, are not yet fully understood the real effects of this technique on specific conditions.
- Trial name
- NCT02497495
- Testing
- immersion cold water
- Where
- Brazil
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Paulista University
Aging Well, Aging
The Role of Brain Lactate Metabolism in Neuroprotection During Healthy Aging
The brain's primary source of fuel is glucose. Unfortunately, the brain's ability to use glucose declines during normal aging. This decline in brain glucose metabolism makes it vulnerable to cognitive impairment and Alzheimer's…
- Trial name
- NCT07731451
- Testing
- Sodium lactate infusion, Exercise-induced hyperlactatemia
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Northern Arizona University
Blood Lactic Acid Increased, Hip Fractures
Optimal Blood Sampling Site for Point of Care Lactate Assessment
The study was to compare blood Lactate levels between ear lobe and finger against venous forearm blood sample using the electronic hand held lactate device in hip fracture patients with good cognitive function (AMT >/= 7)
- Trial name
- NCT04291989
- Testing
- Optimal Blood Sampling Site for Point of Care Lactate Assessment using the handled Lactate-Pro 2 device
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospitals, Leicester
Diabetes Mellitus, Lactic Acidosis
Safety of Continuing Metformin in Diabetic Patients With Normal Kidney Function Receiving Contrast Media
The purpose of this study is to determine whether metformin causes lactic acidosis in diabetic patients with preserved kidney function, undergoing coronary angiography or angioplasty with new contrast media.
- Trial name
- NCT01873859
- Testing
- Metformin
- Where
- Iran
- Volunteers
- 166 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
Metabolic Acidosis
Effect of Propofol and Sevoflurane on Lactate During Anesthesia for Pediatric Heart Catheterisation
Propofol is routinely used for general anesthesia during pediatric heart catheterisation. Propofol infusion syndrome (PRIS) is a rare, but often fatal complication mainly defined by bradycardia with progress to asystolia during…
- Trial name
- PRISCATHLAB (NCT01293266)
- Testing
- Propofol
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- University Hospital Schleswig-Holstein
Metabolic Acidosis
Value of Fetal Scalp Lactate Sampling During Labour in Cases of Abnormal Fetal Heart Rate
ST-analysis of the foetal ECG (STAN®) is another second line technique for intrapartum foetal monitoring. Combining ST-analysis with standard CTG interpretation aims to identify hypoxic foetuses more accurately than CTG alone.
- Trial name
- NCT05259202
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Montpellier
Mitochondrial Disorders, Mitochondrial Genetic Disorders
North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC)
The North American Mitochondrial Disease Consortium (NAMDC) maintains a patient contact registry and tissue biorepository for patients with mitochondrial disorders.
- Conditions
- Mitochondrial Disorders, Mitochondrial Genetic Disorders, Mitochondrial Diseases, Disorder of Mitochondrial Respiratory Chain Complexes
- Trial name
- NAMDC (NCT01694940)
- Where
- 17 sites in United States, Canada
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Columbia University