Clinical trials: Lactic Acid/Metabolism
Septic Shock, Hyperlactatemia
Early Goal Directed Therapy Using a Physiological Holistic View. The ANDROMEDA-SHOCK Study
Septic shock is a highly lethal condition associated with a mortality risk of 30 to 60%. Optimizing tissue perfusion and oxygenation is the aim to decrease mortality and morbidity in septic shock patients.
- Conditions
- Septic Shock, Hyperlactatemia, Peripheral Perfusion
- Trial name
- ANDROMEDA (NCT03078712)
- Testing
- Peripheral Perfusion guided resuscitation, Lactate guided resuscitation
- Where
- Chile
- Volunteers
- 424 people
- Sponsor
- Pontificia Universidad Catolica de Chile
HIV, Hepatitis B
EuroSIDA - Clinical and Virological Outcome of European Patients Infected With HIV
The EuroSIDA study is a prospective observational cohort study of 23,000+ patients followed in 100+ clinics in 35 European countries, Israel and Argentina.
- Conditions
- HIV, Hepatitis B, Hepatitis C, AIDS
- Trial name
- EuroSIDA (NCT02699736)
- Where
- 110 sites in Argentina, Austria and 34 more
- Volunteers
- 23,000 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Exercise Training
Impact of Exercise Intensity on Fitness, Extracellular Vesicles, Inflammation, and Metabolism
Introduction This study investigates the effects of different intensities of indoor cycling on various health measures. Participants will perform a maximal cycling test to determine their maximal fitness - a strong predictor of…
- Trial name
- CEX (NCT06398548)
- Testing
- Control Group, Moderate Intensity Continuous Training, Heavy Intensity Continuous Training
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
GLUT1 Deficiency Syndrome, GLUT1DS1
Sodium Lactate Infusion in GLUT1DS Patients
This study investigates the effect of lactate infusion on epileptic discharges on EEG and seizure frequency in glucose transporter 1 deficiency syndrome (GLUT1DS) patients.
- Conditions
- GLUT1 Deficiency Syndrome, GLUT1DS1, GLUT1DS2, Epilepsy
- Trial name
- NCT04112862
- Testing
- sodiumlactate
- Where
- Netherlands
- Volunteers
- 2 people
- Sponsor
- Radboud University Medical Center
Cardiac Complications, Cardiopulmonary Bypass
Fenoldopam and Splanchnic Perfusion During Cardiopulmonary Bypass
Cardiopulmonary bypass (CPB) for cardiac operations may be accompanied by different patterns of visceral underperfusion. This could result in clinical patterns of lactic acidosis but in the most severe cases there is the risk for…
- Trial name
- NCT00747331
- Testing
- Fenoldopam mesilate
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- IRCCS Policlinico S. Donato
Umbilical Cord Clamping
30-Second Versus Pulsation-Based Delayed Cord Clamping in Term Newborns
This randomized controlled trial aims to compare the effects of 30-second cord clamping and pulsation-based delayed cord clamping on neonatal metabolic adaptation in term newborns delivered vaginally.
- Trial name
- NCT07833059
- Testing
- Pulsation-Based Delayed Cord Clamping, 30-Second Cord Clamping
- Where
- Turkey (Türkiye)
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Tarsus University
Myelosuppression, Lactic Acidosis
Investigation of the Correlation Between Plasma Concentration of Linezolid Antibiotic and Treatment Response and Adverse Reactions
Linezolid is the second line agent in the treatment of MRSA and PRSP infections, and it is also the drug of choice for VRE infections.
- Conditions
- Myelosuppression, Lactic Acidosis, Peripheral Neuropathy
- Trial name
- NCT03126890
- Where
- Taiwan
- Volunteers
- 1,000 people
- Sponsor
- National Taiwan University Hospital
Metabolic Flexibility
Astaxanthin Reduces Exercising Heart Rate.
Briefly, this study involved 2 trials: baseline (Trial 1) and post-astaxanthin intervention (Trial 2). Both trials included participants completing a graded exercise test while connected to a metabolic cart, to measure…
- Trial name
- NCT05282355
- Testing
- Astaxanthin
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of North Alabama
Type 2 Diabetes, Obesity
Lactate and Glycerol Contribution to Gluconeogenesis
A major cause of increased blood glucose levels in type 2 diabetes (T2D) is increased hepatic gluconeogenesis (GNG), as the liver converts various substrates into glucose.
- Conditions
- Type 2 Diabetes, Obesity, Healthy
- Trial name
- NCT06955130
- Testing
- Glycerol, Lactate, Glucose
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Sepsis, Sepsis Bacterial
A Validation Study of the Lab Clasp Device: A Point of Care Sepsis Risk Monitor
The overall purpose of this study is to demonstrate the usability of a clinical-grade device in the form of a finger clasp similar to a pulse oximeter for monitoring lactate values, by comparing its performance in reading…
- Conditions
- Sepsis, Sepsis Bacterial, Lactate Blood Increase, Infectious Disease
- Trial name
- NCT04796285
- Testing
- Lab Clasp
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital