Clinical trials: Language
Learning Disorders, Dyslexia
Efficacy of a Two-Year Intensive Reading Intervention for Middle School English Learners With Reading Difficulties
This study investigates the efficacy of a reading comprehension intervention for English learners in Grades 6 and 7 with reading difficulties.
- Trial name
- TCLD (NCT03695068)
- Testing
- RISE Intervention
- Where
- 2 sites in United States
- Volunteers
- 840 people
- Sponsor
- University of Houston
Emergency Medicine, Diagnostic Errors
Diagnostic Accuracy of Two Large Language Models in Turkish Emergency Department Anamnesis Notes
This retrospective diagnostic accuracy study evaluates two large language models - GPT-4.1 (gpt-4.1-2025-04-14; OpenAI) and Claude Sonnet 4.6 (claude-sonnet-4-6; Anthropic) - as retrospective coding-quality instruments applied to…
- Conditions
- Emergency Medicine, Diagnostic Errors, Artificial Intelligence (AI) in Diagnosis
- Trial name
- LLM-ED-DX-TR (NCT07632859)
- Where
- Turkey (Türkiye)
- Volunteers
- 600 people
- Sponsor
- Marmara University Pendik Training and Research Hospital
Aphasia, Stroke
Balancing Effortful and Errorless Learning in Naming Treatment for Aphasia
Aphasia is a language disorder caused by stroke and other acquired brain injuries that affects over two million people in the United States and which interferes with life participation and quality of life.
- Trial name
- NCT05653440
- Testing
- Accuracy-maximized condition, Effort-maximized condition, Effort-accuracy balanced condition
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Pittsburgh
AI-Assisted Diagnosis, Large Language Models
Improving AI-Assisted Medical Diagnosis and Triage by the General Public
This study is a randomized controlled trial (RCT) investigating whether access to a new LLM interface can improve medical triage and diagnostic accuracy for laypeople compared to access to a standard LLM interface.
- Trial name
- NCT07728513
- Testing
- new GPT-4o Interface, Control
- Where
- Pakistan
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Lahore University of Management Sciences
Developmental Dyslexia
Using fMRI to Evaluate Instructional Programs for Children With Developmental Dyslexia
Dyslexia is a common reading disorder. Specialized instructional programs can improve reading ability in children with dyslexia.
- Trial name
- NCT00068835
- Testing
- Lindamood-Bell training for dyslexia
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Medulloblastoma, Childhood, Healthy Volunteers
Child's Study of the Impact of PF Lesion on Motor Skills, Language, Cognitive Functioning and Social Cognition
One of the major complications of posterior fossa surgery is Posterior Fossa Syndrome (PFS). This syndrome is due to a possible complication of surgical excision of a tumor of the cerebellum (4th ventricle) and is characterized…
- Conditions
- Medulloblastoma, Childhood, Healthy Volunteers, Fossa Posterior Tumor, Low-grade Glioma
- Trial name
- CervIRM (NCT04174820)
- Testing
- Functional Magnetic Resonance Imaging (fMRI)
- Where
- 5 sites in France
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Alzheimer's Disease, Aphasia
Effect of Repetitive Transcranial Magnetic Stimulation on Language in Alzheimer's Disease
The investigators wish to investigate the efficacy of targeted repetitive transcranial magnetic stimulation (rTMS) on expressive language in patients with Alzheimer's disease (AD).
- Conditions
- Alzheimer's Disease, Aphasia, Dementia
- Trial name
- NCT00814697
- Testing
- Repetitive Transcranial Magnetic Coil Stimulation (rTMS)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- The New York Memory Services
Amyotrophic Lateral Sclerosis
Multimodal Brain Imaging Study
To explain the key brain network nodes and their brain mechanisms of ALS language cognitive impairment and decline, reveal the neural mechanism of the association between ALS language cognitive impairment and motor executive…
- Trial name
- NCT04960540
- Testing
- MRI,
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Peking University Third Hospital
Healthy, Artificial Intelligence (AI)
Large Linguistic Model for Clinical Reaoning of Physical Therapy Students
Clinical reasoning is a fundamental skill for physical therapy students, enabling them to collect and interpret patient information to make accurate diagnoses and treatment decisions.
- Trial name
- NCT06809634
- Testing
- Large Language Model, Conventional
- Where
- Spain
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Neuron, Spain
Autism Spectrum Disorder, Early Developmental Impairment
Multicenter Validation Study on Autism Screening Using a Machine-assisted System
The goal of this observational study is to assess the effectiveness of a machine-assisted system for early screening of autism. The main questions it aims to answer are: Does the machine-assisted system including 5 main…
- Conditions
- Autism Spectrum Disorder, Early Developmental Impairment, Language Development Disorders
- Trial name
- NCT07006948
- Testing
- Autism Diagnostic Observation Schedule, the 2nd edition(ADOS-2), Griffiths Developmental Scales, Chinese edition(GDS-C)
- Where
- 10 sites in China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Fudan University
Diabetes
SUPREME-DM (Diabetes Mellitis) Treatment Study
This multisite pragmatic clinical trial was designed to assess the effectiveness of a single scripted telephone call to diabetes patients who (a) were currently above recommended clinical goals for glucose, blood pressure, or…
- Trial name
- NCT02192255
- Testing
- Intervention Phone Call
- Where
- United States
- Volunteers
- 2,378 people
- Sponsor
- HealthPartners Institute
Complete Blood Count Review
Multi-center Validation Study of a Large Language Model-based Intelligent Agent for Blood Cell Analysis
I. Study Background: Currently, in most medical institutions, the review of blood cell analysis still heavily relies on manual verification by laboratory staff.
- Trial name
- NCT07607184
- Testing
- LLM-Assisted Review Group
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Huashan Hospital
Preterm Birth, Developmental Dyslexia
Reading-FREE Markers for Early Detection of Developmental Dyslexia
This study aims to identify early signs of developmental dyslexia (DD) and other reading difficulties in children born preterm, using behavioral, cognitive, and brain imaging data collected before reading problems typically…
- Trial name
- FREE-DD (NCT07072104)
- Testing
- Multidomain Neuropsychological and Reading-Free Screening Tool (RSFT) Assessment Battery - Grade 2, MRI - Grade 2, Multidomain Neuropsychological and Reading-Free Screening Tool (RSFT) Assessment Battery - Grade 3
- Where
- Italy
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Università Vita-Salute San Raffaele
Ophthalmic Disease, Artifical Intelligence
Evaluating AI-Generated Plain Language Summaries on Patient Comprehension of Ophthalmology Notes Among English-Speaking Patients
This clinical trial is testing whether plain language summaries made by artificial intelligence help people understand their eye doctor's notes better.
- Conditions
- Ophthalmic Disease, Artifical Intelligence, Large Language Model
- Trial name
- NCT06859216
- Testing
- AI-Generated Plain Language Summaries
- Where
- United States
- Volunteers
- 460 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Congenital and Acquired Developmental Disabilities
Tele-rehabilitation in Subjects With Congenital and Acquired Developmental Disabilities
The COVID-19 emergency has led to the complete closure of all rehabilitation services, both public and/or private, across Italy, including the region of Tuscany.
- Trial name
- TABLETOSCANA (NCT06219447)
- Testing
- VRRS Home Tablet or Medico Amico Kids APP
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Giovanni Cioni
Epilepsy, Temporal Lobe
Language and Emotional Function in Patients With Temporal Lobe Epilepsy
This study uses functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) to examine how the brain processes tasks involving language and emotion in normal volunteers and in patients with epilepsy.
- Trial name
- NCT00081432
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Primary Progressive Aphasia
Semantic Rehabilitation for Patients With Primary Progressive Semantic Aphasia
This project aims to measure the effect of a semantic rehabilitation protocol for patients with primary progressive semantic aphasia and using the SCED methodology.
- Trial name
- SCED-APPvs (NCT04957537)
- Testing
- semantic therapy and semantic re-education
- Where
- France
- Volunteers
- 15 people
- Sponsor
- University Hospital, Toulouse
Epilepsy, Temporal Lobe
Language Localization Using Repetitive Transcranial Magnetic Stimulation (rTMS) in Patients With Epilepsy
Repetitive transcranial magnetic stimulation (rTMS) may be able to provide a moderately detailed localization of language functions in the brain.
- Trial name
- NCT00001672
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Speech, Psychiatric Disorder
Speech-based Digital Biomarker for Psychiatric Disease
The general objectives of this study are to build a proof-of-concept, speech-based, digital biomarker for identifying the presence and tracking the severity of psychiatric disease.
- Conditions
- Speech, Psychiatric Disorder, Language
- Trial name
- NCT04851912
- Testing
- Winterlight Apps
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Winterlight Labs
Inactivity
Developing a Text-Message Enhanced Physical Activity Intervention for Latino Men
The aim of this study is to build upon our tailored print intervention by developing new text-delivered intervention materials to complement our print-based physical activity (PA) intervention.
- Trial name
- NCT02512419
- Testing
- Text-Enhanced Physical Activity Intervention Arm, Health Education Control Arm, Actigraph GT3X
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego