Clinical trials: Language Development, open to volunteers
Child Language, Language Delay
Talk With Me Baby: Leveraging Well-Child Care to Enhance the Early Home Language Environment
Language-rich interactions with a parent or caregiver can serve as a protective factor for young children, by supporting their language development and other positive long-term outcomes, but existing interventions have not had…
- Conditions
- Child Language, Language Delay, Developmental Milestones
- Trial name
- TWMB (NCT07132411)
- Testing
- Patients in Talk With Me Baby Clinics, Patients in Care-As-Usual Clinics
- Where
- 2 sites in United States
- Volunteers
- 400 people
- Sponsor
- University of Kansas Medical Center
Developmental Language Disorder
Neuroimaging Reveals Treatment-related Changes in DLD
Children with developmental language disorders (DLD, aka specific language impairment), a prevalent pediatric disorder, experience hallmark grammar deficits with life-long impacts on educational and occupational outcomes.
- Trial name
- NCT05268341
- Testing
- My Sentence Builder
- Where
- 6 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Premature Baby, Neurocognition, Child
Longitudinal Assessment of Early Premature Infant Skills for Audiovisual Speech Perception
From birth, babies perceive speech face to face with their interlocutors in audiovisual situations (AV): in addition to hearing them (auditory speech), they will also, in most cases, be able to observe their speaking faces (ex…
- Trial name
- Pré-AV (NCT07245693)
- Testing
- Audiovisual association capability tests
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Grenoble
Bilateral Sensorineural Hearing Loss, Speech and Language Development Delay Due to Hearing Loss
Neural Prediction to Enhance Language
The language outcome of children receiving cochlear implantation to address bilateral sensorineural hearing loss is more variable than that of typical hearing children.
- Conditions
- Bilateral Sensorineural Hearing Loss, Speech and Language Development Delay Due to Hearing Loss, Social Communication
- Trial name
- NCT05962359
- Testing
- Parent-Implemented Communication Treatment
- Where
- United States
- Volunteers
- 700 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Preterm Birth, Developmental Dyslexia
Reading-FREE Markers for Early Detection of Developmental Dyslexia
This study aims to identify early signs of developmental dyslexia (DD) and other reading difficulties in children born preterm, using behavioral, cognitive, and brain imaging data collected before reading problems typically…
- Trial name
- FREE-DD (NCT07072104)
- Testing
- Multidomain Neuropsychological and Reading-Free Screening Tool (RSFT) Assessment Battery - Grade 2, MRI - Grade 2, Multidomain Neuropsychological and Reading-Free Screening Tool (RSFT) Assessment Battery - Grade 3
- Where
- Italy
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Università Vita-Salute San Raffaele
Autistic Disorder, Autism Spectrum Disorder
SQUED™ Series 28.1 Home-use and Treatment of Autowave Reverberator of Autism
Locomotor, transport and information functions in human body systems are carried out by active media in autowave regimes! Any living organism is a (micro-macro-mega) hierarchy of autowave subsystems-an ensemble of loosely coupled…
- Conditions
- Autistic Disorder, Autism Spectrum Disorder, Child Development Disorders, Pervasive, Neurodevelopmental Disorders
- Trial name
- SQUED™ (NCT03222375)
- Testing
- SQUED™ series 28.1 home-use
- Where
- 2 sites in United States, Ukraine
- Volunteers
- 80 people
- Sponsor
- American Federation of Medical Synergetics
Language Impairment, Autism
Pilot Evaluation of the Developed Syntactic-Semantic Visual Configuration Intervention for Children With Language Impairment
This study will pilot a newly developed Syntactic-Semantic Visual Configuration Intervention (SSVCI) designed to help Urdu-speaking children with language impairment improve their ability to understand and produce phrases and…
- Conditions
- Language Impairment, Autism, Hearing Impaired Children, Down Syndrome
- Trial name
- SSVC-PILOT (NCT07786545)
- Testing
- Syntactic-Semantic Visual Configuration Intervention (SSVCI)
- Where
- Pakistan
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Language Delay, Substance Use Disorders
Prevent Language Delays and Disorders Among Children of Caregivers With Substance Use Disorders With Community Groups and Individualized Services
The goal of this clinical trial is to test ways to improve early language development among young children of parents with substance use disorder (SUD).
- Conditions
- Language Delay, Substance Use Disorders, Language Disorders in Children, Language Development
- Trial name
- NCT07529327
- Testing
- Comilia Group, Interaction Review Enhancement, Practical Support Enhancement
- Where
- United States
- Volunteers
- 244 people
- Sponsor
- University of Oregon
Developmental Language Disorder
Language Outcomes, Mechanisms, and Trajectories in Adults With and Without Developmental Language Disorder
The investigators' overall objective is to characterize the long-term outcomes of Developmental Language Disorder (DLD) in adulthood and to identify specific cognitive mechanisms mediating these outcomes.
- Trial name
- NCT06898671
- Testing
- Eye-Tracking in Visual World Paradigm
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Dementia (Diagnosis), Alzheimer Dementia (AD)
Speech-Based Artificial Intelligence for Detection of Dementia in Danish Patients (DetectAI)
The goal of this observational study is to learn if an artificial intelligence (AI)-based speech analysis tool can identify which patients with memory problems need specialist evaluation at a memory clinic.
- Conditions
- Dementia (Diagnosis), Alzheimer Dementia (AD), Vascular Dementia (VaD), Lewy Body Dementia (LBD)
- Trial name
- DetectAI (NCT07200739)
- Testing
- Mini-mental State Examination, Addenbrooke's Cognitive Examination, Speech Task - Picture Description
- Where
- Denmark
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- Zealand University Hospital
Emergency Medicine
Development of a Natural Language Processing Tool to Enable Clinical Research in Emergency Medicine
The goal of this retrospective cohort study is to develop and validate a language model that can interpret the contents of emergency department electronic medical records and extract relevant information for research purposes in…
- Trial name
- NLP-DeVal (NCT06240572)
- Testing
- no intervention
- Where
- 8 sites in Italy
- Volunteers
- 300,000 people, healthy volunteers welcome
- Sponsor
- Mario Negri Institute for Pharmacological Research
Stuttering, Stuttering, Childhood
The Development of Stuttering in Young Children
The goal of this longitudinal research is to learn why some children "grow out" of stuttering, while others persist. Children who do and do not stutter aged 3-6 years are eligible to participate in our study.
- Conditions
- Stuttering, Stuttering, Childhood, Stuttering, Developmental
- Trial name
- NCT06578416
- Testing
- Standardized assessments of speech and language abilities
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Michigan State University
Autism Spectrum Disorder
Tool for Evaluating the Effectiveness of the DENVER Protocol
Early remediation of the communicative and social difficulties of children with autism spectrum disorders (ASD) is central. However, from the age of 6-8 months, children with ASD show a lack of attention to social stimuli such as…
- Trial name
- FACECOM (NCT06253793)
- Where
- 3 sites in France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Development Language Disorder
Promoting Motivation and Linguage in Developmental Language Disorder Through Interaction With the Humanoid Social Robot
Developmental Language Disorder (DLD) is a communication disorder that interferes with learning, understanding, and using language.
- Trial name
- NCT07426328
- Testing
- Nao assisted therapy, Standard therapeutic protocol
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- IRCCS Centro Neurolesi Bonino Pulejo
Stutter, Stuttering, Adult
Organization and Development of Motor Cortical Circuits for Speech Production in Stuttering
The overall objective of this study is to examine inter effector areas (IEAs) activity and functional connectivity during continuous speech production in stuttering adults.
- Conditions
- Stutter, Stuttering, Adult, Stuttering, Stuttering, Developmental
- Trial name
- NCT07180628
- Testing
- Speech Production During functional magnetic resonance imaging (MRI)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Michigan
Autism Spectrum Disorder, Depression - Major Depressive Disorder
Mental Health, Intellectual and Neurodevelopmental Disorder Detection With Artificial Intelligence Models
This study investigates whether AI-driven analysis of speech can accurately predict clinical diagnoses and assess risk for various mental or behavioral health conditions, including attention-deficit/hyperactivity disorder (ADHD)…
- Conditions
- Autism Spectrum Disorder, Depression - Major Depressive Disorder, Anxiety, Generalized, Bipolar Disorder (BD)
- Trial name
- MINDAIM (NCT06792175)
- Testing
- Solicue Machine Learning Models, Mercuria Machine Learning Models
- Where
- 2 sites in United States
- Volunteers
- 500 people
- Sponsor
- Psyrin Inc.
Language Disorders, Aphasia
Development and Validation of Language and Communication Assessment Scales
The aim of speech therapy for people with aphasia is to improve their ability to communicate in daily life. Traditional evaluations focus on linguistic tasks, but they do not fully address everyday communication skills, which are…
- Trial name
- SCALE_COM (NCT07518576)
- Testing
- conversational approach
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- IRCCS San Camillo, Venezia, Italy
Coronary Heart Disease (CHD), Artifical Intelligence
Construction and Validation of a Coronary Artery Disease-Specific Large Language Model and Its Evaluation Framework (CorAI)
Coronary artery disease (CAD) affects an estimated 11.39 million people in China, and mortality has continued to rise since 2012.
- Trial name
- CorAI (NCT07766551)
- Testing
- No Intervention: Observational Cohort
- Where
- 3 sites in China
- Volunteers
- 640 people
- Sponsor
- China National Center for Cardiovascular Diseases
Stuttering, Adult, Stuttering, Childhood
Transcranial Alternating Current Stimulation (tACS) in Stuttering
The purpose of this study is to investigate how mild, noninvasive electrical brain stimulation affects speech relevant brain areas, which may in turn affect speech fluency and speaking-related brain activity in people that…
- Conditions
- Stuttering, Adult, Stuttering, Childhood, Stuttering, Developmental
- Trial name
- NCT06740968
- Testing
- transcranial alternating current stimulation (tACS)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Michigan
Autism, Autism Spectrum Disorder
Word Learning From Parentese in Autistic Children
The overall objective of this research is to determine whether parentese delivered in the video format (Aim 1) and in live interaction (Aim 2) facilitates novel word learning in autistic children and to investigate if there are…
- Conditions
- Autism, Autism Spectrum Disorder, Neurodevelopmental Disorders
- Trial name
- NCT06649916
- Testing
- Parentese Speech, Adult Registered Speech
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The University of Texas at Dallas