Clinical trials: Large Language Model
Influenza, Human, Vaccine Hesitancy
Conversational AI for Adult Flu Vaccination Decisions
This randomized trial tests whether an online guide combining short evidence cards with an AI-guided conversation increases flu-vaccination intention among US adults who haven't decided whether to get a flu vaccine this season.
- Trial name
- NCT07896850
- Testing
- Flu vaccination guide, Accident safety guide
- Where
- United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Calypta Systems, Inc.
Clinical Decision Support, Clinical Decision-making
Generative AI-Assisted Clinical Decision Support for Medical Intensive Care Unit Physicians
This pilot study evaluated the feasibility and usefulness of generative artificial intelligence (AI) as a clinical decision-support tool for physicians working in a medical intensive care unit.
- Trial name
- NCT07708155
- Testing
- Generative AI-Assisted Clinical Decision Support, Usual Clinical Information Resources
- Where
- South Korea
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Critical Illness, Sepsis
Point-of-Care AI Assistance and Critical Care Outcomes: A Randomized Trial
This is a prospective, unmasked, randomized, multicenter clinical trial evaluating the impact of point-of-care large language model (LLM)-based decision support on diagnostic accuracy and clinical outcomes in adult medical…
- Conditions
- Critical Illness, Sepsis, Acute Respiratory Failure (ARF), Multi-organ Failure
- Trial name
- POC-AI-ICU (NCT07293078)
- Testing
- Point-of-care large language model decision support (ChatGPT-5)
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- MetroWest Artificial Intelligence Research Workgroup
Patient Health Information Seeking Behavior, Trust
Patient AI Trust Dynamics Before and After Orthopedic Consultation (ORTHO-OP-GPT)
Patients increasingly consult artificial intelligence (AI) chatbots such as ChatGPT for health information before clinical visits, yet the impact of an actual orthopedic consultation on patient trust in AI-derived information…
- Conditions
- Patient Health Information Seeking Behavior, Trust, Health Literacy, Orthopedics
- Trial name
- ORTHO-OP-GPT (NCT07631585)
- Where
- 2 sites in Cyprus
- Volunteers
- 350 people
- Sponsor
- Utku Gürhan
Ophthalmic Disease, Artifical Intelligence
Evaluating AI-Generated Plain Language Summaries on Patient Comprehension of Ophthalmology Notes Among English-Speaking Patients
This clinical trial is testing whether plain language summaries made by artificial intelligence help people understand their eye doctor's notes better.
- Conditions
- Ophthalmic Disease, Artifical Intelligence, Large Language Model
- Trial name
- NCT06859216
- Testing
- AI-Generated Plain Language Summaries
- Where
- United States
- Volunteers
- 460 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Bronchopulmonary Dysplasia
Early Prediction of Bronchopulmonary Dysplasia in Preterm Infants Using Clinical Data
Early Prediction of Bronchopulmonary Dysplasia in Preterm Infants Using Clinical Data from the First Three Postnatal Weeks with Large Language Models: A Retrospective Study This retrospective, observational study aims to evaluate…
- Trial name
- NCT07525167
- Testing
- Artificial Intelligence-Based Risk Prediction
- Where
- Turkey (Türkiye)
- Volunteers
- 108 people
- Sponsor
- Konya City Hospital
Patient Understanding of Ultrasound Reports
LLMs Improve Patient Understanding of Ultrasound Reports
This multicenter, patient-blinded, controlled evaluation assessed whether expert-reviewed artificial intelligence (AI)-simplified ultrasound reports improved patient- or guardian-reported understanding and reading experience…
- Trial name
- NCT07647536
- Testing
- Standard ultrasound report presentation, Expert-reviewed AI-simplified ultrasound report presentation
- Where
- China
- Volunteers
- 660 people
- Sponsor
- Lu Wang
Pediatric Advanced Life Support (PALS)
Comparing the Effectiveness of Large Language Model-Based and Video-Based Refresher Education on Knowledge Retention After Simulation-Based Pediatric Cardiopulmonary Resuscitation Training: A Six-Month Follow-Up Study
This study aims to compare the effectiveness of large language model (LLM)-based refresher education and video-based refresher education for maintaining knowledge and performance after simulation-based Pediatric Advanced Life…
- Trial name
- NCT07783932
- Testing
- LLM-Based Refresher Education, Video-Based Refresher Education
- Where
- South Korea
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Psychological Stress, Perceived Stress
A Persian AI-Based CBT Chatbot and Voice Analysis System for Managing Perceived Stress
This pilot randomized controlled trial aims to evaluate a Persian-language artificial intelligence (AI)-based cognitive behavioral therapy (CBT) chatbot designed to support adults in managing perceived stress.
- Trial name
- PersianAI-CBT (NCT07840469)
- Testing
- Persian AI-Based CBT Chatbot, Active Mental Health Content
- Where
- Iran
- Volunteers
- 120 people
- Sponsor
- Hamid Reza Marateb
Educational Assessment, Artifical Intelligence
Large Language Models Versus Human Examiners for Grading Physiotherapy Clinical Cases
This study evaluates whether large language models (LLMs) can reliably assess written clinical-reasoning case examinations completed by undergraduate physiotherapy students, compared with faculty assessment.
- Conditions
- Educational Assessment, Artifical Intelligence, Physical Therapy Education
- Trial name
- PACE-AI (NCT07677202)
- Testing
- LLM-based assessment, Faculty assessment (reference standard)
- Where
- Spain
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Neuron, Spain
Acute Respiratory Distress Syndrome, Pneumonia in Children
Using Artificial Intelligence To Improve Ventilator Settings For Intensive Care Patients
This observational study aims to determine whether an AI-assisted decision support system can improve clinical outcomes for mechanically ventilated pediatric patients (aged 1 month to 18 years) in the PICU, compared to standard…
- Conditions
- Acute Respiratory Distress Syndrome, Pneumonia in Children, Respiratory Failure (Pediatric Patients)
- Trial name
- NCT07592039
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Wu Rongzhou
Chest Pain
The Application of Large Language Model in Emergency Chest Pain Triage
This study will evaluate the accuracy and efficiency of large language model in emergency triage.
- Trial name
- ALERT (NCT06493175)
- Testing
- Application of large language model in emergency chest pain triage., According to the normal procedures to receive medical treatment
- Where
- China
- Volunteers
- 1,189 people
- Sponsor
- Peking University Third Hospital
Self-Directed Learning, Artificial Intelligence
ChatGPT Helping Advance Training for Medical Students: A Study on Self-Directed Learning Enhancement
The goal of this clinical trial is to evaluate the effect of LearnGuide, a custom GPT developed with ChatGPT for supporting self-directed learning (SDL) in medical students.
- Conditions
- Self-Directed Learning, Artificial Intelligence, Medical Education
- Trial name
- CHAT-MS (NCT06276049)
- Testing
- custom GPT supported self-directed learning
- Where
- China
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Wang Shalong
Acute Myocardial Infarction, Large Language Models
Acute Myocardial Infarction Clinical Intelligent Decision Support System
Acute Myocardial Infarction (AMI) remains the leading cause of cardiovascular mortality globally. In China, while the incidence of AMI is escalating at an annual rate of 5.2%, significant clinical challenges persist: diagnostic…
- Conditions
- Acute Myocardial Infarction, Large Language Models, Clinical Decision Support System
- Trial name
- AMI-CIDSS (NCT07367399)
- Where
- China
- Volunteers
- 15,000 people
- Sponsor
- Beijing Anzhen Hospital
Type 2 Diabetes Mellitus, Hypertension
LLM-Assisted Diabetes and Hypertension Management by Village Doctors
This is a prospective, assessor-blinded, randomized controlled study designed to evaluate whether large language model (LLM)-assisted decision support can improve village doctors' abilities in the comprehensive management of…
- Trial name
- NCT07678658
- Testing
- LLM
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Jiangsu Taizhou People's Hospital
Alcohol Use Disorder
A Feasibility and Acceptability Study of a Large Language Model-based Chatbot for Brief Alcohol Intervention Among Emerging Adults
American emerging adults (EAs; aged 18-29 years) have the highest rates of alcohol use disorder (AUD) and the lowest levels of treatment engagement of any age group.
- Trial name
- NCT07214831
- Testing
- Large language model-based chatbot brief alcohol intervention session
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Massachusetts General Hospital
Hypertension, Diabetes
LLM-CoManage: Large Language Model-Enabled Co-Management of Hypertension, Diabetes, and Dyslipidemia
This study aims to evaluate the effectiveness of a large language model (LLM)-supported, community-based integrated management model in improving cardiometabolic multimorbidity control among adults with hypertension and…
- Conditions
- Hypertension, Diabetes, Dyslipidemia
- Trial name
- LLM-CoManage (NCT07350486)
- Testing
- LLM-Enabled Co-management
- Where
- 6 sites in China
- Volunteers
- 6,800 people
- Sponsor
- First Hospital of China Medical University
Gastrointestinal Neoplasm Malignant
Treatment Recommendations for Gastrointestinal Cancers Via Large Language Models
This study will evaluate the utility of ChatGPT in recommending treatment plans for patients with gastrointestinal cancers, using both retrospective and prospective data.
- Trial name
- NCT06002425
- Testing
- Clinician-Directed Treatment Plan, ChatGPT-Assisted Treatment Plan
- Where
- 7 sites in United States, China and 2 more
- Volunteers
- 400 people
- Sponsor
- Chinese Academy of Sciences
Coronary Heart Disease (CHD)
Scalable Clinical Oversight of Large Language Models Via Uncertainty Triangulation
This prospective, multi-reader, randomized crossover trial evaluates SCOUT (Scalable Clinical Oversight via Uncertainty Triangulation), a model-agnostic meta-verification framework that selectively defers unreliable large…
- Trial name
- SCOUT (NCT07414966)
- Testing
- SCOUT-Assisted Review Workflow, Standard Manual Review Workflow
- Volunteers
- 7 people
- Sponsor
- China National Center for Cardiovascular Diseases
Nonsmall Cell Lung Cancer
Evaluating the Efficacy and Safety of AI Localization Models in Multidisciplinary Team Care for NSCLC
The goal of this clinical trial is to evaluate the effectiveness and safety of a locally deployed artificial intelligence (AI) decision-support model in the multidisciplinary team (MDT) process for patients with non-small cell…
- Trial name
- NCT07626736
- Testing
- Treat Regimen
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Wen-zhao ZHONG