Clinical trials: Large Vessel Occlusion
Collateral Circulation, Large-artery Occlusion
Study of Collateral Circulation in Patients With Symptomatic Intracranial Anterior Circulation Occlusion
Intracranial artery stenosis is the leading cause of stroke onset or recurrence in Asian. Multiple studies have shown that anterior circulation is most common in intracranial artery stenosis, especially the middle cerebral artery…
- Conditions
- Collateral Circulation, Large-artery Occlusion, Cerebral Infarction
- Trial name
- NCT04091412
- Testing
- Butylphthalide Soft Capsules
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- The Second Hospital of Hebei Medical University
Stroke, Acute, Ischemic
PeRfusiOn Post tHrombEcTomy (PROPHET)
Endovascular mechanical thrombectomy is the standard of care for treating patients with a large-vessel occlusion acute ischemic stroke.
- Trial name
- PROPHET (NCT06691230)
- Where
- 2 sites in Switzerland
- Volunteers
- 279 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
AIS, Stroke
Endovascular Treatment for Acute Large Vessel Occlusion With Ultra-Large Ischemic Core
an investigator initiated, prospective, multicenter, randomized, open-label, blinded endpoint trial (PROBE)
- Trial name
- LARGE CORE-MT (NCT07791810)
- Testing
- Patients assigned to the EVT group should undergo EVT as soon as possible, followed by BMM according to the current EVT guidelines., The medical group receives BMM alone. EVT is not performed in the medical group.
- Where
- China
- Volunteers
- 450 people
- Sponsor
- First Affiliated Hospital of Harbin Medical University
Acute Stroke
SEACOAST 1- SEdAtion With COllAteral Support in Endovascular Therapy for Acute Ischemic Stroke
SEACOAST 1 is a prospective, randomized, blinded endpoint trial comparing collateral vigor and clinical outcomes, with different forms of GA in patients with acute ischemic stroke due to anterior circulation large vessel…
- Trial name
- SEACOAST (NCT03737786)
- Testing
- Tight control of end-tidal CO2 levels
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of California, Los Angeles
Ischemic Stroke
Extending the Time Window for Tenecteplase by Effective Reperfusion in Patients with Large Vessel Occlusion
Patients presenting to the emergency department with an acute ischemic stroke due to a large vessel occlusion eligible for thrombectomy and target mismatch on computed tomography perfusion imaging within 24 hours of onset will be…
- Trial name
- ETERNAL-LVO (NCT04454788)
- Testing
- Tenecteplase, Standard Care (which may include intravenous Alteplase)
- Where
- 7 sites in Australia
- Volunteers
- 242 people
- Sponsor
- University of Melbourne
Acute Ischemic Stroke, Endovascular Thrombectomy
A Multicenter, Randomized Controlled Clinical Investigation to Evaluate the Safety and Effectiveness of the Super-Bore 8/7F Aspiration Catheters in the Treatment of Acute Intracranial Large Vessel Occlusion
To Evaluate the Safety and Efficacy of the Super-Bore 8/7F Thrombosis Aspiration Catheter in the Treatment of Acute Intracranial Large Vessel Occlusion.
- Trial name
- NCT06559475
- Testing
- Super-Bore Thrombosis Aspiration Catheter treatment group, Conventional thrombectomy device treatment group
- Where
- China
- Volunteers
- 360 people
- Sponsor
- The First Affiliated Hospital of University of Science and Technology of China
Coronary Artery Disease, Drug-coated Balloon
Long-term Efficacy of Drug-coated Balloon Versus Drug-eluting Stent in Large de Novo Coronary Lesions
To evaluate the efficacy of drug-coated balloon versus drug-eluting stent for the treatment of large de novo coronary lesions(RVD=2.75~4.0mm).
- Trial name
- NCT05101005
- Testing
- Drug-Coated Balloon, Sirolimus-Eluting Stent
- Volunteers
- 400 people
- Sponsor
- Lepu Medical Technology (Beijing) Co., Ltd.
Stroke
PREhospital Routage of Acute STroke Patients With Suspected Large Vessel Occlusion: Mothership Versus Drip and Ship
Background: The outcome of ischemic stroke is related to the brain lesion volume and this volume of infarction is directly related to the time to reperfusion, which therefore depends on the time to initiation of therapy.
- Trial name
- PRESTO-F (NCT04121013)
- Testing
- mothership
- Where
- France
- Volunteers
- 800 people
- Sponsor
- University Hospital, Caen
Acute Stroke With Large Vessel Occlusion
Stent Thrombosis After Tandem Lesions Thrombectomy
The aim is to describe the rate of delayed stent thrombosis after endovascular management of consecutive tandem lesions, in a patient series with systematic follow-up of stent patency.
- Trial name
- DST-TANDEM (NCT03588780)
- Where
- France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Strasbourg, France
Acute Ischemic Stroke, Mild Neurocognitive Disorder
Endovascular Therapy Versus Best Medical Treatment for Acute Large Vessel Occlusion Stroke With Low NIHSS
Patients presenting with mild symptoms of acute ischemic stroke are common and account for approximately half of all acute ischemic stroke. About 30% of patients with minor stroke have a 90-day functional disability.
- Conditions
- Acute Ischemic Stroke, Mild Neurocognitive Disorder, Thrombectomy
- Trial name
- NCT06143488
- Testing
- Endovascular therapy, Best medical management
- Where
- China
- Volunteers
- 264 people
- Sponsor
- First Affiliated Hospital of Wannan Medical College
Ischemic Stroke
Thrombectomy REvascularization of Large Vessel Occlusions in Acute Ischemic Stroke (TREVO)
To determine the revascularization rate of the CE-marked Trevo device in large vessel occlusions in ischemic stroke patients. Revascularization, defined as at least TICI 2a in the vascular territory treated at end of the neuro…
- Trial name
- TREVO (NCT01088672)
- Testing
- Mechanical Thrombectomy
- Where
- 7 sites in Austria, Germany and 2 more
- Volunteers
- 60 people
- Sponsor
- Stryker Neurovascular
Stroke, Ischemic, Stroke, Acute
Efficacy of Intravenous Tissue-type Plasminogen Activator on Acute Ischemic Stroke Patients With Large Vessel Occlusions
This is an observational prospective study about the reperfusion rate of intravenous thrombolysis on ischemic stroke patients with large vessel occlusions and predictor factors of successful recanalization.
- Trial name
- NCT04170647
- Testing
- Plasminogen Activators
- Where
- Vietnam
- Volunteers
- 81 people
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Acute Ischemic Stroke
Adjunctive Use of Intra-Arterial TNK and Albumin Following Thrombectomy
The purpose of this study is to investigate the feasibility and efficacy of intra-arterial TNK and albumin for patients with acute ischemic stroke after successful thrombectomy and whether there is a synergistic effect between…
- Trial name
- NCT06113848
- Testing
- Intra-Arterial TNK and Albumin, Intra-Arterial TNK, Intra-Arterial Albumin
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Tianjin Huanhu Hospital