Clinical trials: Large Vessel Occlusion
Coronary Artery Disease, Myocardial Ischemia
Drug-Coated Balloon vs. Drug-Eluting Stent for Clinical Outcomes in Patients With Large Coronary Artery Disease
Prospective, randomised, open-label, international multicenter trial to evaluate the safety and efficacy of drug-coated balloon (DCB) treatment compared to drug-eluting stenting (DES) in patients with large coronary artery…
- Conditions
- Coronary Artery Disease, Myocardial Ischemia, Acute Coronary Syndrome, Coronary Stenosis
- Trial name
- REVERSE (NCT05846893)
- Testing
- SeQuent® Please NEO drug-coated balloon catheter, Current-generation drug-eluting stent
- Where
- 21 sites in Malaysia, Singapore and 2 more
- Volunteers
- 1,436 people
- Sponsor
- B. Braun Medical Industries Sdn. Bhd.
Acute Ischemic Stroke
Stimulation-Temperature-Oxygen-Positioning Multimodal Neuroprotection for Acute Ischemic Stroke (STOP)
Acute ischemic stroke may result in substantial disability despite timely reperfusion therapy because ischemic and reperfusion-related brain injury can continue before, during, and after restoration of blood flow.
- Trial name
- STOP (NCT07840794)
- Testing
- Stimulation-Temperature-Oxygen-Positioning (STOP) Multimodal Neuroprotective Strategy, Guideline-Based Reperfusion Therapy and Standard Stroke-Unit Care
- Volunteers
- 380 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Acute Ischemic Stroke
The Vesalio NeVa Stent Retriever Registry Study for Treatment of Large Vessel Occlusion Strokes
A prospective, open label, 90-day study designed to assess the safety, performance and efficacy of thrombus removal in subjects presenting with acute ischemic stroke with the NeVa stent retrievers.
- Trial name
- NCT03926988
- Testing
- NeVa Stent Retriever
- Where
- Spain
- Volunteers
- 400 people
- Sponsor
- Vesalio
Acute Ischemic Stroke, Large Vessel Occlusion
Evaluation of the CONDA Stent Retriever in Acute Ischemic Stroke
The goal of this study is to evaluate the safety and performance of the CONDA stent retriever in patients with acute ischemic stroke due to large vessel occlusion, treated within 24 hours of symptom onset.
- Trial name
- ARTEMIS (NCT07174505)
- Testing
- Mechanical Thrombectomy using the CONDA Stent Retriever
- Where
- 2 sites in Hungary, Spain
- Volunteers
- 50 people
- Sponsor
- Anaconda Biomed S.L.
Ischemic Stroke
Impact of Apixaban on Clinical Outcome of the Patients With Large Vessel Occlusion or Stenosis Trial
The aim of this study is to investigate the clinical events of the patients with acute cerebral large vessel occlusion or stenosis and atrial fibrillation, treated by apixaban within 14 days after onset.
- Trial name
- ALVO (NCT02818868)
- Testing
- apixisaban
- Where
- Japan
- Volunteers
- 700 people
- Sponsor
- Hyogo Medical University
Stroke, Occlusion, Cerebrovascular
Effect of Proximal Blood Flow Arrest During Endovascular Thrombectomy
Endovascular thrombectomy (EVT) has become the standard of care for large vessel occlusion in acute ischaemic stroke (AIS). During clot-retrieval, simultaneous balloon inflation within the internal carotid artery offers transient…
- Trial name
- ProFATE (NCT05020795)
- Testing
- Endovascular thrombectomy
- Where
- United Kingdom
- Volunteers
- 134 people
- Sponsor
- Nottingham University Hospitals NHS Trust
Cancer
Heparin or M-EDTA in Preventing Catheter-Related Infections and Blockages in Patients at High Risk for a Catheter-Related Infection
RATIONALE: Heparin or M-EDTA may prevent catheter-related infections and blockages in patients at high risk for a catheter-related infection.
- Trial name
- NCT00378781
- Testing
- Heparin, Minocycline-EDTA
- Sponsor
- M.D. Anderson Cancer Center
Acute Ischemic Stroke
Study of Endovascular Therapy in Acute Anterior Circulation Large Vessel Occlusive Patients With a Large Infarct Core
Endovascular therapy (EVT) was recommended as the primary treatment for patients with acute large vascular occlusion (LVO) in anterior circulation.
- Trial name
- ANGEL-ASPECT (NCT04551664)
- Testing
- Best medical management, Endovascular therapy
- Where
- China
- Volunteers
- 456 people
- Sponsor
- Beijing Tiantan Hospital
Acute Ischemic Stroke
The Vesalio NeVa Stent Retriever Study for Treatment of Large Vessel Occlusion Strokes
A prospective, open label, single-arm 90-day study designed to assess the safety, performance and efficacy of thrombus removal in subjects presenting with acute ischemic stroke with the NeVa stent retrievers.
- Trial name
- NCT03927001
- Testing
- NeVa Stent Retrievers
- Where
- Spain
- Volunteers
- 150 people
- Sponsor
- Vesalio
Acute Ischemic Stroke
Efficacy and Safety of Human Urinary Kallidinogenase Combined With Endovascular Therapy in Acute Ischemic Stroke With Large Vessel Occlusion
The purpose of this study is to evaluate the safety and efficacy of Human Urinary Kallidinogenase combined with endovascular therapy in acute ischemic stroke (AIS) patients with large vessel occlusion.
- Trial name
- HEAL (NCT06211712)
- Testing
- Experimental: Human Urinary Kallidinogenase
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Huashan Hospital
Ischemic Stroke, Acute
Intra-arterial Recombinant Human TNK Tissue-type Plasminogen Activator (rhTNK-tPA) Thrombolysis for Acute Large Vascular Occlusion After Successful Mechanical Thrombectomy Recanalization
The goal of this clinical trial is to evaluate whether intra-arterial (IA) rhTNK-tPA thrombolysis can improve neurological outcomes in acute large vessel occlusion patients after successful mechanical thrombectomy (MT)…
- Trial name
- ANGEL-TNK (NCT05624190)
- Testing
- Recombinant Human tenecteplase Tissue-type Plasminogen Activator (rhTNK-tPA), Best Medical Management
- Where
- China
- Volunteers
- 256 people
- Sponsor
- Beijing Tiantan Hospital
Coronary Artery Disease
DRUG RELEASING BALL vs. PHARMACOACTIVE STENT IN LARGE VESSELS: MORPHOLOGICAL ANALYSIS AND FUNCTION VASOMOTOR (DEBORA STUDY) IN LARGE VESSELS: MORPHOLOGICAL ANALYSIS AND FUNCTION VASOMOTOR (DEBORA STUDY)
Randomized, controlled, open and multicenter study that analyzes the vasomotor function 8 months after use of the drug-eluting balloon (DCB) vs. drug-eluting stent (DES) in vessels ≥ 3.5 mm
- Trial name
- NCT06448637
- Testing
- Drug Coated Balloon (DCB), Drug Eluting Stent (DES)
- Where
- 9 sites in Spain
- Volunteers
- 94 people
- Sponsor
- Fundación EPIC
Mechanical Thrombectomy, Large Ischemic Core
Randomized Controlled Trial of Endovascular Therapy for Acute Large Vessel Occlusion With Large Ischemic Core
RESCUE-Japan LIMIT(Recovery by Endovascular Salvage for Cerebral Ultra-acute Embolism Japan Large IscheMIc core Trial) is a prospective, open label, blinded endpoint (PROBE), Japanese, two-arm, randomized, controlled, post-market…
- Trial name
- NCT03702413
- Testing
- Endovascular treatment
- Where
- Japan
- Volunteers
- 203 people
- Sponsor
- Hyogo Medical University
Acute Stroke
Smartphone-App Based Prediction of Large Vessel Occlusion
The aim of this non-interventional study is to evaluate a German version of the triage stroke-score FAST-ED performed by ambulance service personnel in a pre-hospital setting using a smartphone app (Join-Triage, Allm).
- Trial name
- NCT04404504
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- University Hospital, Essen
Vertebrobasilar Stroke
A Randomized Trial Of Endovascular Treatment For Acute Posterior Large Vessel Occlusion
The aim of this trial is to investigate whether endovascular treatment can improve the 90-day functional outcome of acute large vessel occlusion in the posterior circulation.
- Trial name
- BASILAR-2 (NCT04743076)
- Testing
- Endovascular treatment, Standard medical treatment
- Where
- 16 sites in China
- Volunteers
- 386 people
- Sponsor
- Xinqiao Hospital of Chongqing
Acute Ischemic Stroke
Comparison of Solitaire to Embotrap to Treat Large Vessel Occlusion in Acute Ischemic Stroke (SOLTRAP Study)
The primary aim of this study is to assess if there is a difference in first pass reperfusion between the two devices. This is a randomized prospective study to assess if there is a difference in first pass reperfusion at two…
- Trial name
- NCT05518240
- Testing
- Stent Retrievers, Stent Retriever
- Where
- 2 sites in United States
- Volunteers
- 418 people
- Sponsor
- WellStar Health System
Stroke, Ischemic
HeadPulse Large Vessel Occlusion Validation Study
Acute ischemic stroke (AIS) is a treatable disease if patients can be transported and treated at stroke centers. MindRhythm, Inc (sponsor) has developed an investigational medical device that is designed for prehospital field use…
- Trial name
- NCT05719272
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- MindRhythm, Inc.
Acute Ischemic Stroke
Intravenous Tirofiban After Bridging Therapy for Acute Stroke With Atherosclerotic Large Artery Occlusion
The investigators propose to assess the efficacy and safety of intravenous tirofiban after bridging therapy (endovascular therapy [EVT] following intravenous Tenecteplase) for acute ischemic stroke due to intracranial…
- Trial name
- RESCUE-AS (NCT07335107)
- Testing
- Intravenous Tirofiban, Standard Medical Therapy
- Where
- China
- Volunteers
- 564 people
- Sponsor
- Beijing Tiantan Hospital
Acute Ischemic Stroke
Biomarkers to Predict Hemorrhage and Outcomes After Endovascular Treatment in Patients With Acute Large Vessel Occlusion
The main aim of the biomarkers to predict Hemorrhagic transformation(HT) after endovascular treatment in Acute Ischemic Stroke Patients. The study has three main parts.
- Trial name
- NCT03915834
- Testing
- Endovascular treatment
- Where
- 2 sites in China
- Volunteers
- 300 people
- Sponsor
- Capital Medical University
Acute Ischemic Stroke
Randomized Study of Bailout Intracranial Angioplasty Following Thrombectomy for Acute Large Vessel Occlusion
Unfavorable outcomes were associated with failed thrombectomy of acute large vessel occlusions (LVO). The failed thrombectomy rate was 12-41% reported in multiple randomized controlled trials (RCT).
- Trial name
- ANGEL-REBOOT (NCT05122286)
- Testing
- Bailout angioplasty, Standard therapy
- Where
- China
- Volunteers
- 348 people
- Sponsor
- Beijing Tiantan Hospital