Clinical trials: Larynx
Unilateral Vocal Cord Paralysis
Non-phonatory Exercises in Patients with Unilateral Vocal Fold Paralysis Post-thyroidectomy
Thyroidectomy is the most common iatrogenic cause of vocal fold paralysis. Patients complain of hoarseness caused by incomplete glottic closure and have effort to raise vocal intensity with consequent elevation of the larynx…
- Trial name
- ENFP (NCT05963165)
- Testing
- Non-phonatory exercises
- Where
- Italy
- Volunteers
- 56 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Pain, Postoperative, Cancer of Larynx
Efficacy of Adding Dexmedetomidine in Ultrasound-guided Intermediate Cervical Plexus Block for Thyroidectomy Surgery
The cervical plexus block (CPB) is one such block used to provide effective anesthesia and analgesia for surgery in the head and neck region.
- Trial name
- NCT05814744
- Testing
- dexmedetomidine, bupivacaine 0.25%, Thyroidectomy Surgery
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- National Cancer Institute, Egypt
Postoperative Pulmonary Complications
Postoperative Pulmonary Complications After Use of Supraglottic Airway Devices and Neuromuscular Blockade
SupAIR is an international, multicenter, randomized controlled trial investigating whether airway management and neuromuscular blockade during general anesthesia influence postoperative pulmonary complications.
- Trial name
- SupAIR (NCT07829094)
- Testing
- Airway management strategy, Initiation of neuromuscular blockade (NMB), Deep versus moderate neuromuscular blockade (NMB)
- Volunteers
- 6,800 people
- Sponsor
- University Hospital Ulm
Larynx Cancer
Evaluation of a Web-based Decision Aid Tool for Larynx Cancer (T3/T4) Patients.
Patients diagnosed with T3/T4 laryngeal cancer in general have several treatment options available, including total laryngectomy and/or (chemo-) radition.
- Trial name
- LaDecA (NCT03292341)
- Testing
- Interviews, Treatmentchoice Decisional Tool, Questionnaires
- Where
- Netherlands
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Maastricht Radiation Oncology
Laryngeal Disease
Role of Ultrasound in Laryngeal Lesions
The aim of the study is to assess the efficiency and limitations of ultrasound in detecting and characterizing laryngeal anatomy and study of some laryngeal disorders and their ultrasonographic appearance.
- Trial name
- NCT03450694
- Testing
- ultrasound
- Volunteers
- 50 people
- Sponsor
- Assiut University
Airway Reactivity
Preoperative Use of Montelukast Sodium
Supraglottic airway equipment used during anaesthesia application can lead to airway reactivity or even larynx spasm in sensitive children.
- Trial name
- NCT02494466
- Testing
- montelukast sodium
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Umraniye Education and Research Hospital
Head and Neck Cancer
Gene Therapy in Treating Patients With Advanced Head and Neck Cancer
RATIONALE: Gene therapy may kill cancer cells by inhibiting a gene that promotes the development and growth of cancer. PURPOSE: Phase I trial to study the effectiveness of gene therapy in treating patients who have advanced head…
- Trial name
- NCT00009841
- Testing
- EGFR antisense DNA, growth factor antagonist therapy, DC-cholesterol liposome
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of Pittsburgh
Malignant Neoplasm of Thyroid Gland
Trial on Intraoperative Neuromonitoring (IONM) in Thyroid Cancer Surgery.
Scientific objectives: Primary objective: To assess if the use of IONM can decrease the rates of temporary RLN palsy after thyroid cancer surgery Secondary objectives: To assess if the use of IONM can decrease permanent RLN palsy…
- Trial name
- ACTION (NCT04842994)
- Testing
- IONM tube
- Where
- India
- Volunteers
- 448 people
- Sponsor
- Tata Memorial Hospital
Head and Neck Cancer
S0216, Combination Chemotherapy and RT in Treating Patients With Stage III or Stage IV Head and Neck Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells.
- Trial name
- NCT00054054
- Testing
- cisplatin, docetaxel, fluorouracil
- Where
- 95 sites in United States, Canada
- Sponsor
- SWOG Cancer Research Network
Head and Neck Cancer
Chemotherapy and Radiation Therapy (RT) With or Without Vandetanib in Treating Patients With High-Risk Stage III or Stage IV Head and Neck Cancer
RATIONALE: Drugs used in chemotherapy, such as cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00720083
- Testing
- cisplatin, vandetanib, radiation therapy
- Where
- 63 sites in United States
- Volunteers
- 34 people
- Sponsor
- Radiation Therapy Oncology Group
Laryseal Pro and Ambu Aura Gain as Conduits for Fiberoptic Endotracheal Intubation
A Comparative Study Between Laryseal Pro Extraglottic Device and Ambu Aura Gain Laryngeal Mask as a Conduit for Fiberoptic Tracheal Intubation in Pediatric Population
This study aims to compare between Laryseal Pro and Ambu Aura Gain extraglottic devices as conduits for fiberoptic endotracheal intubation regarding time of endotracheal intubation in pediatric population.
- Trial name
- NCT06945029
- Testing
- Ambu Aura Gain, Laryseal Pro
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Cairo University
Cancer
Suberoylanilide Hydroxamic Acid in Treating Patients With Advanced Cancer
RATIONALE: Suberoylanilide hydroxamic acid may stop the growth of cancer cells by blocking the enzymes necessary for cancer cell growth.
- Trial name
- NCT00045006
- Testing
- vorinostat
- Where
- United States
- Sponsor
- Memorial Sloan Kettering Cancer Center
Spasmodic Dysphonia, Adductor Spasmodic Dysphonia
Assessment of Laryngopharyngeal Sensation in Adductor Spasmodic Dysphonia
Study investigators have completed a study testing laryngopharyngeal sensation at specific laryngopharyngeal subsites using a novel buckling force aesthesiometer in a series of 22 healthy adults at this institution.
- Conditions
- Spasmodic Dysphonia, Adductor Spasmodic Dysphonia, Voice Disorders
- Trial name
- SDTT (NCT05158179)
- Testing
- Sensation testing
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of California, San Francisco
General Anesthesia
The Optimal Time to Put Laryngeal Mask Airway in the Mouth Under General Anesthesia
Laryngeal mask airway (LMA) is routinely used for some patients who have surgery under general anesthesia. LMA is placed in the mouth and allow the anesthesia to be given without having to put a breathing tube in the throat.
- Trial name
- LMA (NCT00972491)
- Testing
- Insertion of Laryngeal Mask Airway
- Where
- United States
- Volunteers
- 198 people
- Sponsor
- Tufts Medical Center
Gastric Cancer, Hepatic Carcinoma
Laryngopharyngeal Injury After Endotracheal Intubation Under General Anesthesia
This study retrospectively analyzed patients who underwent tracheal intubation under general anesthesia at the First Affiliated Hospital of Zhejiang University School of Medicine between October 1, 2015, and September 30, 2025…
- Conditions
- Gastric Cancer, Hepatic Carcinoma, Pulmonary Carcinoma, Pancreatic Carcinoma
- Trial name
- NCT07359586
- Where
- 2 sites in China
- Volunteers
- 1,200 people
- Sponsor
- Zhejiang University
Anesthesia, Children, Only
Sevoflurane and Laryngeal Mask Airway Versus Propofol Infusion and Facemask for EUA in Children
The goal of this clinical trial is to find out the optimal technique of anesthesia for eye examination in children. The main question it aims to answer is: Is propofol infusion and simple oxygen facemask associated with earlier…
- Trial name
- NCT06656455
- Testing
- sevoflurane via LMA, Propofol with oxygen via simple mask
- Where
- Lebanon
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- American University of Beirut Medical Center
Aspiration Pneumonia, Tracheostomy Complication
Intra-laryngeal Implant for Treatment of Chronic Aspirations
This study evaluates the medical device Newbreez LD is designed to protect the lower airways from saliva, liquids and food aspirations in tracheotomized patients suffering from chronic aspirations that require specific care and…
- Trial name
- NCT03325725
- Testing
- NewBreez LD intra-laryngeal implant
- Where
- 2 sites in France
- Sponsor
- ProTiP Medical
Laryngeal Cancer, Hypopharyngeal Cancer
Induction Chemotherapy and Toripalimab Followed by Radiotherapy in Unresectable Laryngeal/Hypopharyngeal Carcinoma
The aim of this study is to define whether combination of induction chemotherapy and PD-1 inhibitor (Toripalimab) followed by radiotherapy improve progression-free survival, for patients with unresectable laryngeal/hypopharyngeal…
- Trial name
- NCT05420597
- Testing
- Toripalimab
- Where
- China
- Volunteers
- 61 people
- Sponsor
- Fudan University
Desflurane Anesthesia
Desflurane in Children With Laryngeal Mask Airway
The purpose of this study is to characterize the airway responses to desflurane during maintenance of and emergence from anesthesia in children whose airways were supported with laryngeal mask airways (LMAs).
- Trial name
- NCT02470442
- Testing
- Sevoflurane/Desflurane, Sevoflurane
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Seoul National University Hospital
Adverse Anesthesia Outcome
Comparison of Direct Laryngoscopy With Blind Intubation Via Intubating Laryngeal Mask Airway
Control the airways by endotracheal intubation is an important part of treatment for a trauma casualty. The use of the Laryngeal Mask Airway for fast control of the airway is known for many years.
- Trial name
- NCT02884869
- Testing
- Intubating Laryngeal Mask
- Volunteers
- 60 people
- Sponsor
- Bnai Zion Medical Center