Clinical trials: Larynx Disease
Recurrent Hypopharyngeal Squamous Cell Carcinoma, Recurrent Laryngeal Squamous Cell Carcinoma
Soy Isoflavones in Preventing Head and Neck Cancer Recurrence in Patients With Stage I-IV Head and Neck Cancer Undergoing Surgery
This phase II clinical trial studies how well soy isoflavones work in preventing head and neck cancer in patients with stage I-IV head and neck cancer undergoing surgery.
- Conditions
- Recurrent Hypopharyngeal Squamous Cell Carcinoma, Recurrent Laryngeal Squamous Cell Carcinoma, Recurrent Laryngeal Verrucous Carcinoma, Recurrent Lip and Oral Cavity Squamous Cell Carcinoma
- Trial name
- NCT02007200
- Testing
- Laboratory Biomarker Analysis, Soy Isoflavones, Survey Administration
- Where
- 3 sites in United States
- Volunteers
- 55 people
- Sponsor
- National Cancer Institute (NCI)
Head and Neck Cancer
A Phase II Study of Pemetrexed Plus Gemcitabine for Metastatic/Recurrent Head and Neck Cancer (HNSCC)
The purpose of this study is to determine if the combination of 2 chemotherapy drugs called pemetrexed and gemcitabine might be effective treatment for head and neck squamous cell cancer.
- Trial name
- NCT00589667
- Testing
- Pemetrexed plus Gemcitabine
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Hearing Disorder, Oral Mucosal Disease
Biospecimen Procurement for Head and Neck Disorders
Background: Researchers want to learn more about head and neck disorders. Understanding these disorders could help them find better treatments. To do this, they are collecting tissue samples for research.
- Conditions
- Hearing Disorder, Oral Mucosal Disease, Pharyngeal Neoplasm, Head and Neck Neoplasms
- Trial name
- NCT03429036
- Where
- 9 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- National Cancer Institute (NCI)
Oxygen Inhalation Therapy Endoscopy
Comparison of Two Ventilation Methods During Endoscopy of the Pharynx, Larynx and Oesophagus
Around 15,000 ENT cancers are diagnosed each year in France. The majority of these cancers will at one time or another require an Endoscopy of the Pharynx, Larynx and Esophagus (Endo-PLE or suspension laryngoscopy).
- Trial name
- OPTIGO (NCT07004699)
- Testing
- Laryngoscopy, High-flow oxygen therapy
- Where
- 3 sites in France
- Volunteers
- 610 people
- Sponsor
- Poitiers University Hospital
Difficult Airway, Ventilation
Different Techniques for Insertion of the ProSeal Laryngeal Mask Airway in Patients With Difficult Airway
The ProSeal laryngeal mask airway (PLMA) is a new laryngeal mask device with a modified cuff to improve the seal and a drain tube to prevent aspiration and gastric insufflation.
- Trial name
- NCT00500916
- Testing
- ProSeal LMA
- Where
- Austria
- Sponsor
- Medical University Innsbruck
Paradoxical Vocal Fold Motion, Vocal Cord Dysfunction
Biofeedback vs Laryngeal Control Therapy in Management of Paradoxical Vocal Fold Motion
Paradoxical Vocal Fold Motion (PVFM) is a condition where vocal cords adduct (move toward another) instead of abduct (move away from one another) during inspiration, thus causing shortness of breath.
- Trial name
- NCT05770518
- Testing
- Biofeedback, Laryngeal control therapy (LCT)
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Washington University School of Medicine
Thyroidectomy, Paralysis of Vocal Cords
Performance of Ultrasound in the Early Diagnosis of Vocal Cords Paralysis
Thyroid and parathyroid surgery concerns around 50 000 patients a year in France. One of its main complications is paralysis of vocal cords, and the consequences can be serious.
- Trial name
- PECV (NCT03727217)
- Testing
- Pre and postoperative ultrasound
- Where
- France
- Volunteers
- 113 people
- Sponsor
- Lille Catholic University
Thyroid Diseases, Recurrent Laryngeal Nerve Injury
Endotracheal Tube Versus Transcartilage Needle Electrodes for Nerve Monitoring in Thyroid Surgery
Intraoperative neuromonitoring of the recurrent laryngeal nerve during thyroidectomy is most commonly performed with surface electrodes embedded in the endotracheal tube (ETT).
- Conditions
- Thyroid Diseases, Recurrent Laryngeal Nerve Injury, Vocal Cord Paralysis, Thyroid Nodule
- Trial name
- TRANSCOMP (NCT07902349)
- Testing
- Transcartilage needle electrode recording, Endotracheal tube surface electrode recording
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Marmara University
Respiratory Failure
Performance of Baccalaureate Nursing Students in Insertion of Laryngeal Mask: a Trial in Mannequins
The purpose of this study is to compare if there difference in acquisition of knowledge and skills in airway management to baccalaureate nursing students submitted to different learning strategies: exhibition-dialogued class and…
- Trial name
- LMANURSING (NCT01659268)
- Testing
- Simulation class, Exhibition-dialogued class
- Where
- Brazil
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Larynx Disease, Gastroesophageal Reflux
Esophageal and Laryngeal Tissue Changes in Patients Suspected of Having Laryngopharyngeal Reflux
The purpose of the study is to determine whether patients with suspected Laryngopharyngeal reflux have inflammation and ultrastructural injury on their laryngeal biopsies.
- Trial name
- biopsy I (NCT00373997)
- Testing
- Esophageal and Laryngeal biopsies, egd with biopsy
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Vanderbilt University
Intracranial Pressure Increase
The Effect of a Laryngeal Mask Airway on Optic Nerve Sheath Diameter
The goal of this observational trial is to study the effect of a laryngeal airway mask on the optic nerve sheath diameter, as a surrogate for intracranial pressure.
- Trial name
- ONSD laryngeal (NCT06403592)
- Testing
- optic nerve sheath diamater
- Where
- Netherlands
- Volunteers
- 230 people
- Sponsor
- Erasmus Medical Center
Lip and Oral Cavity Cancer, Head and Neck Cancer
ONYX-015 With Cisplatin and Fluorouracil in Treating Patients With Advanced Head and Neck Cancer
RATIONALE: A specially modified virus called ONYX-015 may be able to kill tumor cells while leaving normal cells undamaged. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or…
- Conditions
- Lip and Oral Cavity Cancer, Head and Neck Cancer, Oropharyngeal Cancer
- Trial name
- NCT00006106
- Testing
- cisplatin, fluorouracil, ONYX-015
- Where
- 2 sites in United States
- Sponsor
- National Cancer Institute (NCI)
Head and Neck Cancer
FDG-PET/CT in Assessing the Tumor and Planning Neck Surgery in Patients With Newly Diagnosed H&N Cancer
RATIONALE: Diagnostic procedures, such as fludeoxyglucose F 18-PET/CT scan, may help doctors find head and neck cancer and find out how far the disease has spread. It may also help doctors plan the best treatment.
- Trial name
- ACRIN6685 (NCT00983697)
- Testing
- therapeutic conventional surgery, fludeoxyglucose F 18
- Where
- 12 sites in United States, China
- Volunteers
- 292 people
- Sponsor
- American College of Radiology Imaging Network
Head and Neck Cancer
Cisplatin Plus Epinephrine in Treating Patients With Recurrent or Refractory Head and Neck Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Trial name
- NCT00002659
- Testing
- cisplatin-e therapeutic implant
- Where
- 28 sites in United States, Canada
- Volunteers
- 120 people
- Sponsor
- Matrix Pharmaceutical
Larynx Cancer
Functional Voice and Speech Outcomes Following Surgical Voice Restorations: A Comparison of Pharyngeal Construction Approaches
The purpose of this study is to evaluate the nature and quality of speech after removal of the voice box and all or part of the swallowing tube.
- Trial name
- NCT00600223
- Testing
- questionnaires and standardized, digital voice recording
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Oropharyngeal Cancer, Hypopharyngeal Cancer
A Phase II Study In Patients With Advanced Head And Neck Cancer Of Standard Chemoradiation And Add-On Cetuximab
Sixty patients with advanced squamous cell carcinomas of the head and neck will be enrolled in this study. Patients are treated with standard chemoradiation in combination with concurrent add-on cetuximab.
- Conditions
- Oropharyngeal Cancer, Hypopharyngeal Cancer, Laryngeal Cancer
- Trial name
- NCT01435252
- Testing
- Cetuximab
- Where
- Switzerland
- Volunteers
- 68 people
- Sponsor
- University of Zurich
Head and Neck Cancer, Lung Cancer
Paclitaxel and Cisplatin Plus Radiation Therapy Followed by Filgrastim in Treating Patients With Recurrent Head and Neck Cancer or Lung Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells.
- Trial name
- NCT00021333
- Testing
- filgrastim, cisplatin, paclitaxel
- Where
- 18 sites in United States
- Volunteers
- 29 people
- Sponsor
- Fox Chase Cancer Center
Head and Neck Cancer
A Clinical Study to Investigate the Efficacy of Tigilanol Tiglate Directly in Head and Neck Cancer
A Phase II, open label, single arm study to assess the efficacy of intratumoural tigilanol tiglate in various head and neck solid malignancies.
- Trial name
- NCT05608876
- Testing
- Tigilanol Tiglate
- Where
- 7 sites in Australia, United Kingdom
- Volunteers
- 15 people
- Sponsor
- QBiotics Group Limited
Head and Neck Carcinoma, Head and Neck Carcinoma of Unknown Primary
Intensity Modulated Proton or X-Ray Therapy After Surgery for Treatment of Head and Neck Cancer, the HEADLIGHT Study
This clinical trial studies how well intensity modulated proton therapy (IMPT) or intensity modulated X-ray (radiation) therapy (IMRT) works after surgery in treating patients with head and neck cancer.
- Conditions
- Head and Neck Carcinoma, Head and Neck Carcinoma of Unknown Primary, Hypopharyngeal Carcinoma, Laryngeal Carcinoma
- Trial name
- NCT05075980
- Testing
- Cisplatin, Intensity-Modulated Proton Therapy, Quality-of-Life Assessment
- Where
- 9 sites in United States
- Volunteers
- 174 people
- Sponsor
- Mayo Clinic
Laryngomalacia
Laryngomalacia Study
Noisy breathing is commonly caused by a floppy voicebox which is a condition called laryngomalacia. The cause of laryngomalacia is not fully understood, but some studies have suggested that it could be due to acid escaping from…
- Trial name
- NCT01782560
- Testing
- Omeprazole
- Where
- Canada
- Sponsor
- Children's & Women's Health Centre of British Columbia