Clinical trials: Lasers
Refractive Surgery
Analysis of Ocular Surface Microbiota in Dry Eye Patients After Femtosecond Laser-assisted In-situ Keratomileusis (FS-LASIK)
By using 16S rRNA sequencing technology to analyze the changes in ocular surface microbiota before and after surgery, as well as the impact of changes in ocular surface microbiota on FS-LASIK induced DES, new treatment ideas are…
- Trial name
- NCT06448468
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Nanchang University
Intumescent Cataract
Femtosecond Laser Assisted Cataract Surgery in Intumescent Cataracts
The purpose of the study is to compare femtosecond laser-assisted capsulotomy to manual capsulorhexis in patients with intumescent cataracts. An intumescent cataract is defined as a cataract with a pressurized capsular bag.
- Trial name
- NCT02403206
- Testing
- Femtosecond laser, Continuous Curvilinear Capsulorhexis (CCC)
- Volunteers
- 406 people
- Sponsor
- Alcon, a Novartis Company
Irritable Bowel Syndrome, Food Allergy
Endomicroscopic Evaluation of Food-induced Gastrointestinal Mucosal Alteration
The overarching goal of this study is to establish a first ever registry in the U.S. to collect outcomes data to evaluate changes in the gastrointestinal (GI) mucosa following direct food application utilizing Confocal Laser…
- Trial name
- NCT06792838
- Testing
- Confocal Laser Endomicroscopy
- Volunteers
- 200 people
- Sponsor
- Cook Children's Health Care System
Muscle Fatigue (C23.888.592.612.612), Delayed Onset Muscle Soreness (DOMS)
Photobiomodulation on NMES-Induced Muscle Fatigue and Damage
Neuromuscular electrical stimulation (NMES) is effective for strength training and rehabilitation, but non-selective motor unit recruitment often induces rapid fatigue, discomfort, and muscle damage.
- Conditions
- Muscle Fatigue (C23.888.592.612.612), Delayed Onset Muscle Soreness (DOMS), Muscle Damage, Photobiomodulation (PBM)
- Trial name
- NCT07790016
- Testing
- Photobiomodulation Therapy (PBMT)
- Where
- Brazil
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Federal University of Rio Grande do Sul
Pulp Necroses
Histopathological Evaluation of the Periodontal Ligament Subjected to Laser Ablation.
Laser Ablation therapy (LA) using an 810nm diode laser and Indocyanine Green (ICG) solution, which efficiently absorbs laser energy and increases the effectiveness of tissue removal.
- Trial name
- NCT06173648
- Testing
- Laser and ICG solution.
- Where
- Brazil
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- CAO Group, Inc.
Peri-implant Mucositis
Diode Laser Added to Non-Surgical Treatment for Peri-Implant Mucositis
This randomized controlled clinical trial evaluated the clinical and biological effects of adjunctive diode laser therapy in the non-surgical treatment of peri-implant mucositis.
- Trial name
- NCT07886593
- Testing
- Conventional Non-Surgical Treatment, Adjunctive Diode Laser Therapy
- Where
- Spain
- Volunteers
- 206 people
- Sponsor
- Universidad Europea de Valencia
Pupillary Block After DMEK, Laser Iridotomy / Surgical Iridectomy
Impact of Iridotomy/Iridectomy Size on Postoperative Pupillary Block and Dysphotopsia Following DMEK
Descemet membrane endothelial keratoplasty (DMEK) is the standard surgical treatment for corneal endothelial disorders. A postoperative pupillary block may occur despite routine preoperative laser iridotomy or intraoperative…
- Conditions
- Pupillary Block After DMEK, Laser Iridotomy / Surgical Iridectomy, Dysphotopsia, Descemet Membrane Endothelial Keratoplasty (DMEK)
- Trial name
- NCT07577635
- Testing
- Anterior Segment Optical Coherence Tomography (AS-OCT), Dysphotopsia Questionnaire
- Volunteers
- 100 people
- Sponsor
- University of Leipzig
Gingival Recession
Effect of Hyaluronic-acid on the Healing After Free Gingival Graft
This study evaluated the effect of topical hyaluronic acid (HA) application on free gingival graft (FGG) donor and recipient sites during the early wound healing period with laser Doppler flowmetry (LDF) and to investigate the…
- Trial name
- NCT03871218
- Testing
- Hyaluronic acid group
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Gazi University
Decayed Teeth
Laser Activation in Reducing Pain During and After Root Canal Treatment for Painful Lower Molar Teeth.
Effectiveness of lasers in reducing pain during and after root canal treatment for mandibular molar teeth affected with acute irreversible pulpitis.
- Trial name
- NCT04735120
- Testing
- iLASE DIODE LASERS
- Where
- India
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- CSI College of Dental Sciences and Research, Madurai
Malnutrition, Child
Use of Low-level Laser Therapy on Children Aged One to Five Years With Energy-protein Malnutrition
Malnutrition is a clinical-social disease caused by multiple prenatal, intrauterine and postnatal factors as well as social, political and cultural determinants (distal causes).
- Trial name
- NCT03355313
- Testing
- Low level Light therapy
- Where
- 2 sites in Brazil
- Volunteers
- 50 people
- Sponsor
- University of Nove de Julho
Urinary Stress Incontinence
Study Comparing the Use of Laser and of Kinesiotherapy for the Treatment of Female Stress Urinary Incontinence
The purpose of this study is compare the effect of laser and of kinesiotherapy in the treatment of women with stress urinary incontinence
- Trial name
- NCT03301142
- Testing
- Laser, kinesiotherapy
- Where
- 2 sites in Brazil
- Volunteers
- 40 people
- Sponsor
- University of Sao Paulo General Hospital
Oral Lichen Planus
Different Treatment Modalities for Oral Lichen Plan
The goal of applications of Low-Level Laser and Topical Steroid in the Management of Oral Lichen Planus is to learn if intervention can by relieve pain, decreasing inflammation, and facilitating tissue healing in20 patients who…
- Trial name
- NCT06681090
- Testing
- 0.1% topical triamcinolone Acetonide preparation "Kenacourt-A Orabase", 980 nm diode laser
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Al-Azhar University
Glaucoma
Laser Dosage in MicroPulse TransScleral CycloPhotocoagulation
This is a prospective study to evaluate the clinical outcome of varying doses of Micropulse TransScleral CycloPhotocoagulation (MP-TSCPC) laser in patients with glaucoma.
- Trial name
- NCT04709679
- Testing
- MicroPulse TransScleral CycloPhotoCoagulation
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- State University of New York at Buffalo
Knee Arthropathy
Laser + Cryo-thermal Therapy Following Total Knee Replacement Surgery
Objective To investigate the effectiveness of the use of the QMD Helios Laser device in association with standard rehabilitation therapy in reducing inflammatory symptoms in patients following total knee replacement.
- Trial name
- NCT04183673
- Testing
- Laser therapy-cryo thermal therapy, Usual care
- Where
- Italy
- Volunteers
- 68 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Chronic Periodontitis
Combined Use of Er:YAG and Nd:YAG Laser
The aim of the present study was to compare the effectiveness of combined Er:YAG and Nd:YAG laser therapy to that of scaling and root planning with hand instruments in nonsurgical treatment of chronic periodontitis.
- Trial name
- NCT02851823
- Testing
- Periodontal curettes, Er-YAG+Nd-YAG lasers
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Izmir Katip Celebi University
Wound, Diabetic Foot
Effect of the Use of Low Intensity Therapeutic LASER
Diabetes mellitus consists of a heterogeneous group of metabolic disorders that have hyperglycemia in common, resulting from defects in insulin action, insulin secretion, or both.
- Conditions
- Wound, Diabetic Foot, LTBI
- Trial name
- NCT05530486
- Testing
- CC, LG1, LG2
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- Federal University of Piaui
Hailey Hailey Disease
M. Hailey-Hailey: hSPCA1 Expression and Skin Structure Upon Laser Therapy
Hailey-Hailey disease is a genetic acantholytic dermatosis characterized by continuous erosion of the skin that results in a burning, painful sensation and restricts the patient in daily life.
- Trial name
- NCT03849989
- Testing
- Skin biopsy
- Where
- Netherlands
- Volunteers
- 11 people
- Sponsor
- Maastricht University Medical Center
Acne Scars - Mixed Atrophic and Hypertrophic
Performance of PicoWayTM Picosecond Fractional Laser for Acne Scars
Open-label, prospective study. Up to 60 healthy adult volunteers seeking facial acne scars treatment, males or females of 18 to 75 years of age, from up to 3 investigational sites.
- Trial name
- NCT02592993
- Testing
- PicoWay device
- Where
- 3 sites in United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Syneron Medical
Periodontal Disease, Periodontal Pockets
Adjunctive Diode Laser Therapy in Non-Surgical Periodontal Therapy
The goal of this clinical trial is to evaluate the efficacy of adjunctive application of diode laser to mechanical, non-surgical root surface debridement in patients attending periodontal office.
- Conditions
- Periodontal Disease, Periodontal Pockets, Periodontal Attachment Loss
- Trial name
- NCT07446127
- Testing
- LASER assisted SRP, RsD
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Tel Aviv University
Dentin Hypersensitivity
Evaluation of Biomimetic Mineralization Plus Soft Laser Irradiation in Dentin Hypersensitivity Management
Randomized clinical trial to investigate the efficacy of diode laser , Biomimetic mineralization desensitizing agents Curodont D'Senz (CS) gel both in combination and alone, and the efficacy of bifluoride 10 (5 % sodium fluoride)…
- Trial name
- Rct (NCT06829277)
- Testing
- Sodium fluoride varnish, Curodont De Senz, Curodont De Senz plus laser irradiation
- Where
- Egypt
- Volunteers
- 84 people
- Sponsor
- MTI University
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