Clinical trials: Late Life Depression
Depressive Disorder, Major
NMDA Modulation in Major Depressive Disorder in Late- Life
Major depressive disorder (MDD) is a complex and multi-factorial disorder. Most of the current antidepressants are based upon the monoamine hypothesis which cannot fully explain the etiology of depression.
- Trial name
- NCT03414931
- Testing
- NMDA, Sertraline
- Where
- 2 sites in Taiwan
- Volunteers
- 136 people
- Sponsor
- Chang Gung Memorial Hospital
Late Life Depression
A Breathing-Based Meditation Intervention for Patients With Treatment Resistant Late Life Depression
Late-life depression affects 2-8% of seniors and causes high rates of caregiver distress and risk of suicide. To exacerbate the problem, antidepressants, the cornerstone of therapy, are resistant in 55-80% of this population.
- Trial name
- NCT03368560
- Testing
- Sudarshan Kriya Yoga
- Volunteers
- healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Late Life Depression, Cognitive Decline
Dopaminergic Dysfunction in Late-Life Depression
Late-Life Depression (LLD), or depression in older adults, often presents with motivational deficits, deficits in performance in cognitive domains including processing speed and executive dysfunction, and mobility impairments.
- Conditions
- Late Life Depression, Cognitive Decline, Depressive Disorder, Treatment-Resistant, Levodopa
- Trial name
- D3 (NCT04469959)
- Testing
- L-Dopa
- Where
- 2 sites in United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Symptoms of Depression, Symptoms of Anxiety
Mindfulness-Based Cognitive Therapy for Depression and Anxiety
About 10-20% of older patients in primary care suffer from symptoms of depression and/or anxiety. Depression and anxiety are associated with higher rates of cognitive decline, lower quality of life, increased medical comorbidity…
- Trial name
- NCT02777905
- Testing
- Mindfulness Based Cognitive Therapy
- Where
- 2 sites in Canada
- Volunteers
- 100 people
- Sponsor
- Lady Davis Institute
Major Depressive Disorder, Depression
Buprenorphine Used With Treatment Resistant Depression in Older Adults
The investigators are conducting a research study to learn about the safety and benefit of using a medication called buprenorphine for patients with difficult to treat depression.
- Trial name
- IRLGreyB (NCT02181231)
- Testing
- venlafaxine XR, buprenorphine
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Washington University School of Medicine
Depression
A Randomized Sham-Controlled Study of H-Coil Repetitive Transcranial Magnetic Stimulation for Treatment-Resistant Late-Life Depression
The purpose of the study is to explore the efficacy and safety of H-Coil rTMS in comparison to a sham H-Coil rTMS in older patients with treatment-resistant major depressive disorder.Subjects will be randomized to receive H1-Coil…
- Trial name
- NCT01760681
- Testing
- H- Coil DTMS
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Shalvata Mental Health Center
Depression
Primary Prevention of Major Depression in Later Life
The Institute of Medicine has called for studies of "indicated" preventive interventions to reduce the incidence of mental illness in persons already symptomatic but not yet presenting with fully developed clinical syndromes.
- Trial name
- NCT00326677
- Testing
- Problem Solving Therapy, Dietary Education
- Where
- 2 sites in United States
- Volunteers
- 306 people
- Sponsor
- University of Maryland, College Park
Loneliness, Well-Being, Psychological
A Randomized Controlled Trial of Robotic Support for Enhanced Later Life (RoSELL)
The purpose of this study is to compare the efficacy of a personalized, co-designed robot interaction against a standardized, fixed robot interaction for reducing loneliness, depression, as well as improving self-agency and…
- Conditions
- Loneliness, Well-Being, Psychological, Depression - Major Depressive Disorder
- Trial name
- RoSELL (NCT07102017)
- Testing
- Co-Design LOVOT Intervention, Standard LOVOT Intervention
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Depression, Suicidal Ideation
Social Connections and Late Life Suicide
With the long-term goal of improving interventions for late-life suicide, the purpose of this study is to examine whether a mechanism by which behavioral interventions reduce risk for late-life suicide is by increasing social…
- Trial name
- NCT02188485
- Testing
- ENGAGE
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- University of Rochester
Late Life Depression
One-Year Trajectory of Cognitive Changes in Patients With Late-life Depression in the Short Term
The purpose of this study was to investigate the one-year trajectory of cognitive change in elderly patients with depression, to explore the transfer characteristics and transfer rules of various states of cognitive impairment in…
- Trial name
- NCT06447428
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Fujian Medical University
Major Depressive Disorder
Deep rTMS for Treatment-Resistant Late-life Depression
In this study, the investigators will be examining the effects of the deep repetitive transcranial magnetic stimulation (rTMS) using the H1 coil in patients over the age of 60 who have been unable to tolerate or failed to respond…
- Trial name
- rTMS (NCT01860157)
- Testing
- Brainsway H1-Coil Deep TMS System
- Where
- Canada
- Volunteers
- 58 people
- Sponsor
- Centre for Addiction and Mental Health
Major Depressive Disorder
Biomarkers for Outcomes In Late-life Depression (BOLD)
Major depressive disorder (MDD) is a common psychiatric illness with high cost to society and individual patients. One reason for the high cost is that most patients endure lengthy and ultimately unsuccessful empiric…
- Trial name
- BOLD (NCT01082237)
- Testing
- Escitalopram
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of California, Los Angeles
Late Life Depression
Chronic Anergic Depression IDentification - Magnetic Resonance Imaging Exploration in the Elderly of Traits Related to Onset
Depression in the elderly, or "late life depression" (LLD), is often considered to be homogeneous, legitimizing standardized treatment.
- Trial name
- CAnD'ID-METRO (NCT06663891)
- Testing
- Functional MRI with EEG per MRI
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Strasbourg, France
Major Depressive Disorder
LEPR Polymorphism Weight Gain by Mirtazapine in Late Life Depression
Patients with an episode of depression in late life prescribed mirtazapine recruited from a clinical sample will be monitored for weight and receive a blood test during their usual course of treatment to determine polymorphisms…
- Trial name
- NCT01601002
- Testing
- Mirtazapine
- Where
- Canada
- Volunteers
- 19 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Depression in Old Age
High-definition Transcranial Direct Current Stimulation (HD-tDCS) in Late-life Depression (LLD)
To determine the efficacy of a 2-week daily programme (10 sessions) of HD-tDCS to augment antidepressant therapy in subjects with late-life depression who had residual depressive symptoms despite adequate dosage and duration of…
- Trial name
- NCT05322863
- Testing
- High-definition Transcranial Direct Current Stimulation
- Where
- Hong Kong
- Volunteers
- 58 people
- Sponsor
- The University of Hong Kong
Depressive Disorder
Depressed Mood Improvement Through Nicotine Dosing 3
Deficits in cognitive control are core features of late-life depression (LLD), contributing both to emotion dysregulation and problems with inhibiting irrelevant information, conflict detection, and working memory.
- Trial name
- DepMIND3 (NCT05746273)
- Testing
- Transdermal Nicotine Patch
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Vanderbilt University Medical Center
Major Depressive Disorder
Gait, Depression, and Mind-body Therapy in Seniors
Falls are the leading cause of injury---related hospitalization and death in the elderly. As such, fear of falling (FOF) is common among senior populations and often leads to activity avoidance, social isolation, and reduced…
- Trial name
- NCT02283541
- Testing
- Automatic self-transcending meditation
- Where
- Canada
- Volunteers
- 27 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Depression, Dementia
Antidepressant Medication Plus Donepezil for Treating Late-life Depression
This study will determine the effectiveness of combining escitalopram, venlafaxine, or duloxetine with donepezil, a medication used in Alzheimer's disease, in improving memory, concentration, attention, and problem solving…
- Trial name
- NCT00177671
- Testing
- Escitalopram, Donepezil, Venlafaxine
- Where
- United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Major Depressive Disorder, Late Life Depression
SSIPP vs. PST vs. WLC
The COVID-19 pandemic and continued lockdown measures have led to social isolation that is likely disproportionately affecting community-dwelling seniors.
- Trial name
- NCT04887350
- Testing
- Student-Senior Isolation Prevention Partnership (SSIPP), Problem Solving Therapy (PST).
- Where
- Canada
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Major Depression, Dysthymic Disorder
Improving Depression Care for Elders: Coordinating Center
Purpose: To determine the effectiveness of the Improving Mood-Promoting Access to Collaborative Treatment(IMPACT) collaborative care management program for late-life depression.
- Conditions
- Major Depression, Dysthymic Disorder, Both Major Depression and Dysthymic Disorder
- Trial name
- IMPACT (NCT01561105)
- Testing
- IMPACT
- Volunteers
- 1,801 people
- Sponsor
- University of California, Los Angeles