Clinical trials: Late Life Mood Disorder
Major Depressive Disorder, Apathy
Targeting Network Dysfunction in Apathy of Late-life Depression Using Digital Therapeutics
The goal of this randomized controlled trial is to evaluate the potential of a customized digital cognitive training intervention to target aspects of brain function in apathy of late-life depression and reduce symptoms of apathy…
- Trial name
- NCT05877885
- Testing
- Targeted Cognitive Training Intervention, General Cognitive Training Intervention
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- AdventHealth
Major Depressive Disorder, Late Life Depression
SSIPP vs. PST vs. WLC
The COVID-19 pandemic and continued lockdown measures have led to social isolation that is likely disproportionately affecting community-dwelling seniors.
- Trial name
- NCT04887350
- Testing
- Student-Senior Isolation Prevention Partnership (SSIPP), Problem Solving Therapy (PST).
- Where
- Canada
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Unipolar Depression
The Effects of Sleep Deprivation on Antidepressant Response
This study will use positron emission tomography (PET) to examine the effect of sleep deprivation on brain function.
- Trial name
- NCT00178074
- Testing
- total sleep deprivation, PET imaging
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Depressive Disorder
Depressed Mood Improvement Through Nicotine Dosing 3
Deficits in cognitive control are core features of late-life depression (LLD), contributing both to emotion dysregulation and problems with inhibiting irrelevant information, conflict detection, and working memory.
- Trial name
- DepMIND3 (NCT05746273)
- Testing
- Transdermal Nicotine Patch
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Vanderbilt University Medical Center
Major Depressive Disorder, Dysthymia
L-DOPA vs. Placebo for Depression and Psychomotor Slowing in Older Adults
Individuals with Late Life Depression (LLD) often have cognitive problems, particularly problems with memory, attention, and problem solving, all of which contribute to antidepressant non-response.
- Conditions
- Major Depressive Disorder, Dysthymia, Depression
- Trial name
- NCT03761030
- Testing
- L-DOPA
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- New York State Psychiatric Institute
Treatment Resistant Depression, Refractory Depression
Ketamine for Older Adults Pilot
This pilot study will assess the safety and feasibility of intravenous (IV) ketamine in older adults with Treatment-Resistant Depression (TRD).
- Conditions
- Treatment Resistant Depression, Refractory Depression, Therapy-Resistant Depression, Late Life Depression
- Trial name
- NCT04504175
- Testing
- Ketamine
- Where
- 5 sites in United States, Canada
- Volunteers
- 25 people
- Sponsor
- Washington University School of Medicine
Major Depressive Disorder
Frontal Hypoperfusion Effects on Antidepressant Outcomes in Late-Life Depression
The long-term goal of this line of research is to determine if decreased vascular reactivity and frontal hypoperfusion is associated with poor response antidepressants.
- Trial name
- NCT01896934
- Testing
- Sertraline
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Vanderbilt University
Depression, Hypertension
Effects of Cerebral Hypoperfusion and Its Reversal on Late-Life Depression
This pilot proposal will test the hypothesis that altered cerebral vessel reactivity and cerebral hypoperfusion (decreased blood flow to the brain) is a core mechanism underlying the relationship between vascular disease and…
- Trial name
- NCT01794455
- Testing
- Sertraline, Candesartan
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Vanderbilt University
Major Depressive Disorder
Effectiveness of Buddhist Monks in Providing Cognitive Behavior Therapy
This research is to study the effectiveness of cognitive behavioral therapy-CBT and Psychotherapy by trained buddhist monks. There are generally accepted that both cognitive and Buddhist concepts are related.
- Trial name
- Add-CBT (NCT01706731)
- Testing
- Treatment as usual, Cognitive-behavioral therapy
- Where
- Thailand
- Volunteers
- 62 people
- Sponsor
- Chiang Mai University
Major Depressive Disorder, Depression
Incomplete Response in Late-Life Depression: Getting to Remission With Buprenorphine
The Investigators are conducting a research study to learn about the safety and benefit of using a medication called buprenorphine for patient with difficult to treat depression .
- Trial name
- (IRLGREY-B) (NCT02263248)
- Testing
- venlafaxine, buprenorphine
- Where
- Canada
- Volunteers
- 56 people
- Sponsor
- Centre for Addiction and Mental Health
Major Depressive Disorder
A Study Comparing the Efficacy and Safety of Duloxetine and Placebo for the Treatment of Depression in Elderly Patients
The purpose of this study is to compare the efficacy and safety of duloxetine 60 mg once daily to placebo on depression in elderly patients (greater than or equal to 65 years of age).
- Trial name
- NCT00406848
- Testing
- duloxetine hydrochloride
- Where
- 33 sites in United States, France and 2 more
- Volunteers
- 370 people
- Sponsor
- Eli Lilly and Company
Late Life Depression, Cognitive Decline
Dopaminergic Dysfunction in Late-Life Depression
Late-Life Depression (LLD), or depression in older adults, often presents with motivational deficits, deficits in performance in cognitive domains including processing speed and executive dysfunction, and mobility impairments.
- Conditions
- Late Life Depression, Cognitive Decline, Depressive Disorder, Treatment-Resistant, Levodopa
- Trial name
- D3 (NCT04469959)
- Testing
- L-Dopa
- Where
- 2 sites in United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Major Depression
Conventional Bilateral rTMS vs. Bilateral Theta Burst Stimulation for Late-Life Depression
This trial will compare conventional sequential bilateral rTMS to a bilateral theta burst stimulation protocol. The right and left dorsolateral prefrontal cortices will be the site of stimulation in both treatment conditions.
- Trial name
- NCT02998580
- Testing
- LFR followed by HFL, cTBS followed by iTBS
- Where
- Canada
- Volunteers
- 163 people
- Sponsor
- Centre for Addiction and Mental Health
Depression
Buprenorphine for Late-Life Treatment Resistant Depression
The goals of this pilot study are to gather data about the safety and clinical effect of low-dose buprenorphine in older adults with treatment resistant depression.
- Trial name
- BUILD (NCT01071538)
- Testing
- Buprenorphine
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Pittsburgh
Major Depressive Disorder
Automatic Self Transcending Meditation Versus Treatment as Usual
Depression is a leading contributor to global burden of disease. Antidepressants do not provide adequate response for many patients.
- Trial name
- NCT02149810
- Testing
- Automatic Self Transcending Meditation
- Where
- Canada
- Volunteers
- 95 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Major Depressive Disorder
Neural Mechanisms of Monoaminergic Engagement in Late-life Depression Treatment Response (NEMO)
The Department of Psychiatry at the University of Pittsburgh is conducting a research study to learn about the changes that occur in the brain when individuals suffer from and then are treated for depression.
- Trial name
- NEMO (NCT03128021)
- Testing
- Escitalopram Pill, Levomilnacipran Pill
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- Howard Aizenstein
Major Depression, Late Life Depression (LLD)
Characterizing Cognitive Decline in Late Life Depression: The ADNI Depression Project
The purpose of this research study is to characterize the mechanisms contributing to cognitive impairment and accelerated cognitive decline in Late Life Depression (LLD).
- Trial name
- ADNI-D (NCT02434393)
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- University of Southern California
Treatment Resistant Depressive Disorder
Ketamine for Treatment Resistant Late-Life Depression
The purpose of this study is to examine the effectiveness of a single infusion of ketamine (KET), to determine which dose is optimal 7 days after infusion using Bayesian Adaptive Randomization, and to learn about how ketamine…
- Trial name
- NCT02556606
- Testing
- Ketamine, Midazolam
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- VA Office of Research and Development
Major Depressive Disorder, Depression
Anti-INFLammatory to Address Mood and Endothelial Dysfunction (INFLAMED)
The objective of this clinical trial is to evaluate whether an anti-inflammatory medication, pentoxifylline, reduces depressive symptoms and improves artery function.
- Conditions
- Major Depressive Disorder, Depression, Depressive Symptoms, Cardiovascular Disease (CVD)
- Trial name
- INFLAMED (NCT01625845)
- Testing
- Pentoxifylline, Standard Treatment
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Indiana University
Major Depression
Comparing Engage to PST for Late Life Depression
This is a non-inferiority trial of Engage, a new intervention for late-life depression, and problem solving therapy (PST). Patient participants will be randomized to either Engage or PST and receive 9 weeks of either…
- Trial name
- Engage (NCT02086201)
- Testing
- Problem Solving Therapy, Engage
- Where
- 2 sites in United States
- Volunteers
- 262 people
- Sponsor
- University of Washington