Clinical trials: Late Radiation Injury
Lung Cancer (Non-Small Cell), Radiation
Early Prophylactic Versus Late Salvage Recombinant Human Endostatin in Managing Radiosurgery-Induced Brain Injury for NSCLC Brain Metastases
Primary Purpose:To preliminarily evaluate the efficacy and safety of recombinant human endostatin (Endostar) in the early prophylactic cohort (Cohort A) and late salvage cohort (Cohort B) for radiation-induced brain injury after…
- Conditions
- Lung Cancer (Non-Small Cell), Radiation, Brain Injury, Brain Edema
- Trial name
- NCT07841106
- Testing
- Recombinant Human Endostatin (Endostar)
- Volunteers
- 49 people
- Sponsor
- Jiangmen Central Hospital
Abnormalities, Radiation-Induced
Optical Coherence Tomography for Monitoring Late Oral Radiation Toxicity After Radiotherapy of Head and Neck Cancer Patients
Radiation therapy of the head and neck cancer patients causes late oral radiation complications such as xerostomia (dry mouth) or mucosal atrophy.
- Trial name
- NCT01692600
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Late Radiation Injury, Chronic Pain
HBOT Late Radiation Tissue Injury
Background: Radiotherapy is a common treatment for many malignancies. Radiation-related complications developing months or years after radiation treatment are known as late radiation tissue injury (LRTI) and are estimated to…
- Trial name
- NCT02425215
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University Health Network, Toronto
Merkel Carcinoma, Radiotherapy Side Effect
Prediction of Appearance of Late Cutaneous Side Effects After RadioTherapy
Search for blood predictive marker (s) for cutaneous radiosensitivity
- Trial name
- PAESCART (NCT03060226)
- Testing
- blood sample
- Where
- France
- Volunteers
- 18 people
- Sponsor
- Centre Francois Baclesse
Radiotherapy Side Effect, Xerostomia Due to Radiotherapy
Prevalence of Late Xerostomia and Hyposalivation with Associated Risk Factors in Survivors of Head and Neck Cancer After Radiotherapy: a Multi-centric Cross-sectional Study
The study titled "Prevalence of Late Xerostomia and Hyposalivation with Associated Risk Factors in Survivors of Head and Neck Cancer After Radiotherapy" is a multi-centric cross-sectional study conducted in Egypt.
- Conditions
- Radiotherapy Side Effect, Xerostomia Due to Radiotherapy, Xerostomia Due to Radiotherapy (Disorder)
- Trial name
- NCT06851572
- Where
- Egypt
- Volunteers
- 260 people
- Sponsor
- Ain Shams University
Radiation Injury, Breast Cancer
Breast Cancer Lung Late Effects
Through improved early detection and treatment, the number of long term breast cancer survivors continues to increase. There are now 2.8 million breast cancer survivors in the U.S.
- Trial name
- BELLE (NCT02725840)
- Testing
- Proton beam radiation therapy., X-ray based radiation therapy, Computed Tomography (CT) Scan
- Where
- 2 sites in United States
- Volunteers
- 41 people
- Sponsor
- University of Florida
Radiation Proctitis, Gastrointestinal Hemorrhage
A Study of Chlorophyllin or Placebo With Standard Treatment for Late Radiation Induced Luminal Gastrointestinal Tract Bleeding
This multicenter, randomized, double-blind, placebo-controlled Phase III clinical trial will evaluate whether oral sodium copper chlorophyllin (CHL) is effective and safe for treating late radiation-induced gastrointestinal (GI)…
- Conditions
- Radiation Proctitis, Gastrointestinal Hemorrhage, Radiation Injuries
- Trial name
- NCT07837713
- Testing
- Chlorophyllin, Sodium Copper Complex
- Where
- India
- Volunteers
- 200 people
- Sponsor
- Tata Memorial Centre
Wounds and Injuries
The Use of Pentoxifylline and Vitamin E in the Treatment of Late Radiation Related Injuries
Patients with radiation induced injuries experience significant pain and negative effects on quality of life. Currently, no standard therapy for these patients exists, with some patients treated symptomatically, and others…
- Trial name
- NCT00188552
- Testing
- pentoxifylline, α-Tocopherol
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University Health Network, Toronto
Cardiac Toxicity, Unspecified Childhood Solid Tumor, Protocol Specific
Enalapril in Treating Heart Damage Patients Who Received Anthracycline Chemotherapy for Childhood Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Chemoprotective drugs, such as enalapril, may protect normal cells from the toxic effects of chemotherapy.
- Trial name
- NCT00003070
- Testing
- enalapril maleate, quality-of-life assessment
- Where
- 61 sites in United States, Canada and 1 more
- Volunteers
- 13 people
- Sponsor
- Children's Oncology Group
Radiation-induced Intestinal Injury
Prediction of Radiation-induced Late Intestinal Injury
Our team has constructed a prediction model based on the phase separation level of DNA repair factors (MRNIP、NONO、NOP53) to predict radiation-induced late intestinal injury (RLII) and verified the predictive efficacy of the…
- Trial name
- RLII (NCT05749510)
- Testing
- NCRT+TME
- Volunteers
- 200 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University