Clinical trials: Late-Life Depression, open to volunteers
Late Life Depression (LLD), Depression - Major Depressive Disorder
tDCS for Late-Life Depression
The purpose of this research study is to determine the effectiveness of Transcranial direct current stimulation (tDCS) therapy in the treatment of participants with Late-life depression (LLD).
- Trial name
- NCT07657234
- Testing
- High-intensity (6 mA) transcranial direct current stimulation (tDCS)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Andre Russowsky Brunoni
Late Life Depression (LLD), Depression - Major Depressive Disorder
Accelerated vs. Conventional Theta Burst Stimulation for Late-life Depression
The purpose of this trial is to compare the treatment efficacy (improvement in depressive symptoms) of accelerated TBS protocol (where participants receive multiple TBS treatments daily) to conventional TBS protocol (where…
- Conditions
- Late Life Depression (LLD), Depression - Major Depressive Disorder, Depressive Disorder, Treatment-Resistant, Mood Disorders
- Trial name
- ACT-LLD (NCT06854367)
- Testing
- TBS
- Where
- 2 sites in Canada
- Volunteers
- 280 people
- Sponsor
- Centre for Addiction and Mental Health
Late Life Depression (LLD)
The Leuven Longitudinal Late-Life Depression Study
The goal of this observational study is to learn about the long-term effects of late-life depression (LLD) in adults aged 60 and older. LLD is depression that begins for the first time later in life.
- Trial name
- L4D (NCT07768098)
- Where
- Belgium
- Volunteers
- 178 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Late-Life Adults, Late-Life Prodromal Depression
Effects of Mindfulness or Brain Stimulation Intervention for Late-life Adults in Taiwan Urban and Rural Areas
This randomized controlled trial will examine the effects of mindfulness-based interventions and brain stimulation interventions on cognitive function and psychological well-being in older adults.
- Conditions
- Late-Life Adults, Late-Life Prodromal Depression, Late-Life Depression, Mindfulness
- Trial name
- PredictNPI (NCT07186023)
- Testing
- MBSR, MBWC, MBCI
- Where
- 2 sites in Taiwan
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- National Health Research Institutes, Taiwan
Treatment Resistant Depression (TRD), Late Life Depression (LLD)
Lumateperone for Late-Life Depression
The purpose of this research study is to examine how well a medication called lumateperone (Caplyta) works to relieve depression in older adults with treatment-resistant depression. Lumateperone (Caplyta) is approved by the U.S.
- Conditions
- Treatment Resistant Depression (TRD), Late Life Depression (LLD), Depression / Major Depressive Disorder
- Trial name
- IRL Grey-C (NCT07623135)
- Testing
- Lumateperone
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Eric Lenze
Late Life Treatment Resistant Depression, Depression - Major Depressive Disorder
The BAARD Study : Evaluating a Computerized Approach to Treatment Selection in Older Adults With Treatment Resistant Depression.
The goal of this clinical trial is to test whether a personalized approach to treatment selection improves symptoms in older adults with treatment-resistant depression.
- Conditions
- Late Life Treatment Resistant Depression, Depression - Major Depressive Disorder, Treatment Resistant Depression
- Trial name
- BAARD (NCT07810738)
- Testing
- Aripiprazole Augmentation, Bupropion Augmentation
- Where
- 3 sites in United States, Canada
- Volunteers
- 300 people
- Sponsor
- Washington University School of Medicine
Breast Neoplasms, Quality of Life
Breast Cancer and Resilience in Couple
This is a prospective pilot study examining the couple's dyadic attitudes from diagnosis to 24 months later when one member is affected by illness and the adaptive strategies the couple employs when stressful events occur.
- Trial name
- resilience (NCT06875414)
- Testing
- Nursing care model
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Regina Elena Cancer Institute
Depression, Suicidal Ideation
Brain Changes During Social Reward Psychotherapy for Mid- and Late-Life Suicidality
The investigators hypothesized that during the 9-week course of Engage \& Connect treatment there will be an increase in brain functions of the Positive Valence System which in turn will lead to reduction in suicidality.
- Conditions
- Depression, Suicidal Ideation, Major Depressive Disorder, Depressive Disorder
- Trial name
- NCT05925322
- Testing
- "Engage & Connect" Psychotherapy, Symptom Review and Psychoeducation (SRP)
- Where
- United States
- Volunteers
- 128 people
- Sponsor
- Weill Medical College of Cornell University
Depressive Symptoms, Caregiver Burden
Caregiver Stress and Sleep Study
The purpose of this research study is to better understand how stress, sleep and activity might impact caregivers' mood and brain health.
- Trial name
- CARES (NCT05219955)
- Testing
- Morning Action Plan Execution, Activity Strategy-based Session with Therapist, Attention-based Session with Therapist
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Alzheimer Dementia (AD), Dementia
Clinical Risk Score Prediction for Risk of Dementia Among Late-life Population With Depression
The goal of this observational study is to learn about the ability of a point risk score prediction model, developed using electronic medical record data, to predict the risk of progression from geriatric depression to dementia…
- Conditions
- Alzheimer Dementia (AD), Dementia, Late Life Depression (LLD), Risk Scores
- Trial name
- NCT07676851
- Testing
- No Intervention: Observational Cohort
- Where
- China
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Nanchang University
Major Depressive Disorder, Apathy
Targeting Network Dysfunction in Apathy of Late-life Depression Using Digital Therapeutics
The goal of this randomized controlled trial is to evaluate the potential of a customized digital cognitive training intervention to target aspects of brain function in apathy of late-life depression and reduce symptoms of apathy…
- Trial name
- NCT05877885
- Testing
- Targeted Cognitive Training Intervention, General Cognitive Training Intervention
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- AdventHealth
Suicide, Bereavement
Risk and Resilience to Suicide Following Late-Life Spousal Bereavement
The purpose of the RISE study is to examine how the 24-hour rhythm of sleep and social activity relate to mood and suicidal ideation among older adults that recently lost a spouse or life partner.
- Trial name
- RISE (NCT06191484)
- Testing
- WELL Behavioral Probe
- Where
- United States
- Volunteers
- 169 people
- Sponsor
- University of Pittsburgh
Depression
Clemastine for Improving White Matter and Boosting Antidepressant Response in Late-life Depression
The goal of this study is to find out if the antihistamine, clemastine, can make the white matter in the brain better in older adults with depression.
- Trial name
- CLIMB (NCT06591091)
- Testing
- Clemastine Fumarate
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Illinois Chicago
Major Depression, Late Life Depression (LLD)
Characterizing Cognitive Decline in Late Life Depression: The ADNI Depression Project
The purpose of this research study is to characterize the mechanisms contributing to cognitive impairment and accelerated cognitive decline in Late Life Depression (LLD).
- Trial name
- ADNI-D (NCT02434393)
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- University of Southern California
Late-Life Depression
Effects of Specific Amino Acid Supplementation and Lifestyle Factors on Brain Ageing
The aim of this clinical trial is to investigate the effects of L-serine supplementation on cognitive decline and psychosocial functioning in older adults with late-life depression (LLD).
- Trial name
- AAAgeing (NCT07497347)
- Testing
- L-serine supplementation
- Where
- Italy
- Volunteers
- 84 people
- Sponsor
- IRCCS Centro San Giovanni di Dio Fatebenefratelli
Anxiety Disorders, Anxiety Depression
Exposure Therapy for Late-life Anxiety
The primary objective is to evaluate the (cost-)effectiveness of exposure therapy (ET) delivered by trained mental health nurses (MHNs) in terms of anxiety symptoms and quality of life for late life anxiety disorders in primary…
- Trial name
- DeFEAD65+ (NCT06770517)
- Testing
- Exposure therapy, Usual Care
- Where
- Netherlands
- Volunteers
- 170 people
- Sponsor
- ProPersona
Late-Life Depression, Anhedonia
Investigating the Efficacy and Mechanisms of Individualized tACS Targeting Anhedonia in Late-Life Depression
This project focuses on clinical translational research into personalized transcranial alternating current stimulation (tACS) for treating anhedonia in late-life depression (LLD).
- Trial name
- NCT07637773
- Testing
- Transcranial Alternating Current Stimulation (tACS)
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Jie Li
Late Life Depression
Chronic Anergic Depression IDentification - Magnetic Resonance Imaging Exploration in the Elderly of Traits Related to Onset
Depression in the elderly, or "late life depression" (LLD), is often considered to be homogeneous, legitimizing standardized treatment.
- Trial name
- CAnD'ID-METRO (NCT06663891)
- Testing
- Functional MRI with EEG per MRI
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Strasbourg, France