Clinical trials: Latent Tuberculosis
Latent Tuberculosis Infection
Screening for Latent Tuberculosis in Healthcare Workers With Quantiferon-Gold Assay: A Cost-Effectiveness Analysis
The ministry of health in Israel requires all health-care workers to undergo screening for latent Tuberculosis infection (LTBI) prior to starting work. This is based on the Mantoux skin test, which is notoriously unreliable.
- Trial name
- NCT00449345
- Testing
- Blood test for Quantiferon-GOLD assay
- Where
- Israel
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Assuta Hospital Systems
Diabetes Mellitus, Tuberculin (Skin Test) Positive
Efficacy, Security, Adherence, Tolerability and Cost Effectiveness of Latent TB Treatment in Patients With TB/DM2 (TBL)
Researchers will evaluate the efficacy, toxicity, adherence and cost effectiveness of treatment with isoniazid or rifampicin in patients with diabetes mellitus type two (DM2) and latent TB (LTB).
- Trial name
- TBL (NCT03278483)
- Testing
- Isoniazid 300 mg Oral Tablet, Rifampin 600 mg Oral Tablet
- Where
- Mexico
- Volunteers
- 396 people
- Sponsor
- Instituto Nacional de Salud Publica, Mexico
Chronic Liver Disease, Liver Transplantation
Comparison of Quantiferon-TB Gold Assay With Tuberculin Skin Testing in Patients With Chronic Liver Disease
The purpose of the study is to estimate the usefulness of the QuantiFERON®-TB Gold test for the diagnosis of latent tuberculosis infection in liver transplant candidates by correlating the test results with risk factors for LTBI
- Conditions
- Chronic Liver Disease, Liver Transplantation, Tuberculosis
- Trial name
- NCT00402402
- Testing
- Tuberculin skin test, Quantiferon-TB Gold assay
- Where
- Canada
- Volunteers
- 300 people
- Sponsor
- University Health Network, Toronto
Tuberculosis
Effects of Vitamin D Supplementation on Antimycobacterial Immunity
The purpose of this study is to determine how vitamin D supplementation (ergocalciferol) affects the immune response to mycobacterial infection.
- Trial name
- NCT00157066
- Testing
- Ergocalciferol
- Where
- United Kingdom
- Volunteers
- 230 people
- Sponsor
- Barts & The London NHS Trust
Tuberculosis, Tuberculosis, Pulmonary
A Systemic Screening for TB Disease in High-risk Groups in Barcelona
The purpose of this screening study is to identify and screen vulnerable population in Barcelona for active pulmonary tuberculosis
- Trial name
- SYS-TB-S (NCT06706596)
- Testing
- Screening for TB symptoms, Chest X-ray
- Where
- Spain
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Fundació Institut Germans Trias i Pujol
TB - Tuberculosis, HIV - Human Immunodeficiency Virus
Integrating Tuberculosis Treatment Into Community Pharmacies to Improve TB/HIV Outcomes in Uganda
Community pharmacies (CPs) have emerged as promising differentiated service delivery models for refilling antiretroviral therapy (ART) among people with human immunodeficiency virus (HIV).
- Trial name
- NCT07840651
- Testing
- The intervention is TB treatment delivery via community pharmacies for people with TB/HIV, Control Arm - standard of care
- Where
- 2 sites in Uganda
- Volunteers
- 124 people
- Sponsor
- Makerere University
Adverse Reaction to Drug, 3HP
Clinical Analysis of Safety in Latent Tuberculosis Infection Prophylaxis Treatment
The treatment of latent TB with 3HP is an important issue for the prevention of active TB. However, significant proportion of subjects receiving 3HP had adverse reaction.
- Trial name
- NCT04655794
- Testing
- 3HP
- Where
- Taiwan
- Volunteers
- 500 people
- Sponsor
- Chang Gung Memorial Hospital
Latent Tuberculosis Infection
Diagnosis of Tuberculosis Infection in Health Care Workers Using Ex-vivo Interferon-gamma Assay
The present study was to evaluate the usefulness of a whole-blood interferon-r release assays (IGRAs) as diagnostic tool of the latent tuberculosis infection for healthcare workers.
- Trial name
- NCT01007396
- Testing
- 1-step tuberculin skin test (TST) and blood sampling
- Where
- South Korea
- Volunteers
- 322 people
- Sponsor
- Samsung Medical Center
Pregnancy Related, Tuberculosis Infection
Effects of Tuberculosis Infection on Development and Function of the Placenta
The goal of this observational study is to understand how tuberculosis (TB) infection impacts the function and development of the placenta, and whether TB infection can contribute to pregnancy-related disorders through effects on…
- Conditions
- Pregnancy Related, Tuberculosis Infection, Placenta Diseases
- Trial name
- NCT06352970
- Testing
- TB infection
- Where
- Ethiopia
- Volunteers
- 500 people
- Sponsor
- Lund University
Tuberculosis Infection
Immunization With BCG Vaccine to Prevent Tuberculosis Infection
The purpose of this research is to find out if a single dose of pre-travel vaccination with BCG can lessen tuberculosis (TB) infection by producing an immune response when given to adults traveling to countries with a high or…
- Trial name
- TIPI (NCT04453293)
- Testing
- BCG (Tokyo 172) vaccine
- Where
- 7 sites in United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Tuberculosis
Short-Course Isoniazid and Rifampin Compared With Isoniazid for Latent Tuberculosis Infection
The objective of the study was to compare the compliance and the side effects of a short course to treatment of latent tuberculosis infection during 3 months(isoniazid plus rifampin)group I, with the standard course for 6…
- Trial name
- NCT00397709
- Testing
- I ( isoniazid), II (isoniazid + rifampin )
- Where
- Spain
- Volunteers
- 228 people
- Sponsor
- Hospital Virgen de la Luz
Tuberculosis Infection, HIV Infections
Computer Aided Screening for Tuberculosis in Low Resource Environments
People living with HIV (PLHIV) who require admission to hospital in WHO Africa region have poor outcomes. TB is very common in this group, but can be difficult to diagnose.
- Trial name
- CASTLE (NCT04545164)
- Testing
- CAD4TB, FujiLAM
- Where
- Malawi
- Volunteers
- 498 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Latent Tuberculosis
Trial of Vitamin D Supplementation in Cape Town Primary Schoolchildren
The investigators will conduct a n=5,400 Phase 3, double-blind, individually randomised placebo-controlled clinical trial of 5 years' duration in primary schools in City of Cape Town Metropolitan Municipality, Western Cape…
- Trial name
- ViDiKids (NCT02880982)
- Testing
- Cholecalciferol
- Where
- South Africa
- Volunteers
- 1,743 people, healthy volunteers welcome
- Sponsor
- Queen Mary University of London
HIV Infected Population With Latent Tuberculosis
Impact of Once-Weekly Rifapentine and Isoniazid on the Steady State Pharmacokinetics of Dolutegravir and Darunavir Boosted With Cobicistat in Healthy Volunteers
People with human immunodeficiency virus (HIV) often take several medicines to control HIV. Dolutegravir and darunavir boosted with cobicistat are HIV medicines that people may take.
- Trial name
- NCT02771249
- Testing
- rifapentene (RPT), darunavir/cobicistat (DRV/c), Isoniazid (INH)
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
To Compare the Serum Apoptosis-associated Markers Between Patients With Active TB and Patients With LTBI, To Evaluate the Efficiency of Apoptosis-associated Markers to Differentiate Potential of Active TB From LTBI
The Role of Apoptosis Associated Markers in Pathogenesis of Pulmonary Tuberculosis
To compare the serum apoptosis-associated markers between patients with active TB and patients with LTBI To evaluate the efficiency of apoptosis-associated markers to differentiate potential of active TB from LTBI
- Trial name
- NCT01676155
- Where
- Taiwan
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Diabetes Mellitus, Latent Tuberculosis Infection
Prospective Quality Improvement Project for High-Risk Diabetes Patients
Diabetes is the most important comorbidity of tuberculosis patients in Taiwan, and 1/4 of tuberculosis patients also It is a diabetic patient, and the treatment of latent tuberculosis infection is currently an important policy of…
- Conditions
- Diabetes Mellitus, Latent Tuberculosis Infection, Continuous Glucose Monitoring, Quality of Life
- Trial name
- NCT06472609
- Testing
- enhanced interactive education
- Where
- Taiwan
- Volunteers
- 149 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University WanFang Hospital
Tuberculosis
Diagnosis of Latent Tuberculosis(TB) Infection in Health Care Workers Using TST and Whole Blood Interferon-γ Assay
The investigators think that the health care workers who contact frequently with active tuberculosis patients have more increased prevalence of LTBI compared with those who don't.
- Trial name
- NCT00962793
- Sponsor
- Yonsei University
HIV Infections, Tuberculosis
Preventive Treatment Against Tuberculosis (TB) in Patients With Human Immunodeficiency Virus (HIV) Infection and Confirmed Latent Tuberculous Infection
To evaluate and compare the safety and effectiveness of a one-year course of isoniazid (INH) versus a two-month course of rifampin plus pyrazinamide for the prevention of reactivation tuberculosis in individuals infected with…
- Trial name
- NCT00000638
- Testing
- Isoniazid, Pyrazinamide, Pyridoxine hydrochloride
- Where
- 76 sites in United States, Puerto Rico
- Volunteers
- 2,000 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)