Clinical trials: Later Life
Ovarian Cancer
NIraparib and Quality of LifE is a Longitudinal Study Evaluating in Real Life the Tolerability of Niraparib.
This is a longitudinal, national, open, multi-centre phase IV study which will recruit up to 141 patients with ovarian cancer in late relapse treated with niraparib according to the labelling In France.
- Trial name
- NiQoLe (NCT03752216)
- Testing
- Niraparib
- Where
- 30 sites in France
- Volunteers
- 141 people
- Sponsor
- ARCAGY/ GINECO GROUP
Depression
Sleep Deprivation Plus Paroxetine for Treating Major Depression in Elderly Individuals
This study will determine the effectiveness of total sleep deprivation (TSD) for one night plus paroxetine versus either TSD plus placebo or paroxetine alone in inducing rapid symptom resolution of major depression in the elderly.
- Trial name
- NCT00178035
- Testing
- paroxetine, One night of Total Sleep Deprivation
- Where
- United States
- Volunteers
- 158 people
- Sponsor
- University of Pittsburgh
Primary Insomnia, Depression
Paroxetine in the Treatment of Chronic Primary Insomnia
The goal of the study is to examine the role of paroxetine, an antidepressant medication, in the acute and continuation treatment of insomnia.
- Trial name
- NCT00178048
- Testing
- paroxetine
- Where
- 2 sites in United States
- Volunteers
- 66 people
- Sponsor
- University of Pittsburgh
Alcoholism, Depression
Treating Alcohol Use In Older Adults With Depression
The purpose of this study is to test the efficacy combining a treatment for depression with a treatment for alcohol dependence.
- Trial name
- NCT00018824
- Testing
- NALTREXONE
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- US Department of Veterans Affairs
Basic Life Support
Early or Late Booster for Basic Life Support?
Attrition of skills after basic life support (BLS) training is common. Psychology studies have established that for basic memory recall tasks, spaced learning strategies improve retention.
- Trial name
- NCT02998723
- Testing
- Early Booster Teaching, Late Booster Teaching
- Where
- Canada
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Ottawa Hospital Research Institute
Late Life Depression
TBS,TMS, Suicidal Ideation, Magnetic Resonance Imaging, Dorsolateral Prefrontal Cortex, Ventrolateral Prefrontal Cortex
Transcranial magnetic stimulation (TMS) is a noninvasive brain stimulation technique, its approved therapeutic indication is high-frequency stimulation to the left dorsolateral prefrontal cortex (DLPFC) for treatment resistant.
- Trial name
- NCT05010915
- Testing
- Transcranial magnetic stimulation
- Where
- Taiwan
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Late Life Treatment Resistant Depression, Depression - Major Depressive Disorder
The BAARD Study : Evaluating a Computerized Approach to Treatment Selection in Older Adults With Treatment Resistant Depression.
The goal of this clinical trial is to test whether a personalized approach to treatment selection improves symptoms in older adults with treatment-resistant depression.
- Conditions
- Late Life Treatment Resistant Depression, Depression - Major Depressive Disorder, Treatment Resistant Depression
- Trial name
- BAARD (NCT07810738)
- Testing
- Aripiprazole Augmentation, Bupropion Augmentation
- Where
- 3 sites in United States, Canada
- Volunteers
- 300 people
- Sponsor
- Washington University School of Medicine
Cognition, Depression
To Enhance Cognition in Late Life Depression Using Transcranial Direct Current Stimulation
Late Life Depression (LLD) is a serious health problem which not only causes depressed mood but also results in impairments in memory and attention.
- Trial name
- NCT02212366
- Testing
- Active TDCS
- Where
- Canada
- Volunteers
- 36 people
- Sponsor
- Centre for Addiction and Mental Health
Bipolar Disorder
Bipolar Disorder in Late Life
The purpose of this study is to look at certain structural changes in the brain in people with bipolar disorder or those with a history of Bipolar disorder.
- Trial name
- BPD (NCT00787930)
- Testing
- Valproic Acid
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Duke University
Cancer, Cancer in Pregnancy
ProspectiveFemaleAYA - Late Effects of Cancer Therapies on Gonadal Function, Fertility, Efficiency of Fertility Preservation Procedures and Pregnancy Outcomes
In the past two decades, the evidence-based knowledge on the prevalence and risk factors for gonads impairment, including infertility, following cancer and numerous cancer treatment regimen has significantly increased.
- Conditions
- Cancer, Cancer in Pregnancy, Infertility, In Vitro Fertilisation (IVF) Treatment
- Trial name
- FemFertilAYA (NCT07622420)
- Volunteers
- 3,000 people
- Sponsor
- Karolinska Institutet
Late-life Depression, Treatment-resistant Depression
SSM vs HEP in Late-Life Depression
The investigators will conduct a randomized controlled trial (RCT), comparing SSM (n=96) versus HEP (n=96) in 192 LLD participants stratified by site and presence of treatment resistant late life depression (TR-LLD).
- Trial name
- NCT03564041
- Testing
- Sahaj Samadhi Meditation (SSM), Health Enhancement Program (HEP)
- Where
- Canada
- Volunteers
- 95 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Alzheimer Dementia (AD), Dementia
Clinical Risk Score Prediction for Risk of Dementia Among Late-life Population With Depression
The goal of this observational study is to learn about the ability of a point risk score prediction model, developed using electronic medical record data, to predict the risk of progression from geriatric depression to dementia…
- Conditions
- Alzheimer Dementia (AD), Dementia, Late Life Depression (LLD), Risk Scores
- Trial name
- NCT07676851
- Testing
- No Intervention: Observational Cohort
- Where
- China
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Nanchang University
Depression
Vascular Augmentation of Late-life Unremitted Depression (VALUeD)
Depression has a high occurrence and causes other problems in older people, two thirds of these patients will not have a lessening in their condition from routine treatment medication.
- Trial name
- VALUeD (NCT01557153)
- Testing
- Amlodipine
- Where
- United Kingdom
- Volunteers
- 80 people
- Sponsor
- Gateshead Health NHS Foundation Trust
Perimenopause, Postmenopause
Effects of a Dietary Supplement in Women With Late Perimenopause or Early Postmenopause
This study will evaluate the effects of a plant extract-based dietary supplement on menopausal symptoms and health indicators in women with late perimenopause or early postmenopause.
- Conditions
- Perimenopause, Postmenopause, Hot Flashes
- Trial name
- NCT07863973
- Testing
- Plant Extract-Based Dietary Supplement
- Where
- Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Alicante
Late Life Depression (LLD), Depression - Major Depressive Disorder
tDCS for Late-Life Depression
The purpose of this research study is to determine the effectiveness of Transcranial direct current stimulation (tDCS) therapy in the treatment of participants with Late-life depression (LLD).
- Trial name
- NCT07657234
- Testing
- High-intensity (6 mA) transcranial direct current stimulation (tDCS)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Andre Russowsky Brunoni
Mild Cognitive Impairment
Rosiglitazone Effects on Cognition for Adults in Later Life
The purpose of this study is to determine the effects of the insulin-sensitizing medication rosiglitazone on attention and memory skills in older adults with mild cognitive impairment (MCI).
- Trial name
- RECALL (NCT00242593)
- Testing
- Rosiglitazone
- Where
- 3 sites in United States
- Volunteers
- 120 people
- Sponsor
- University of Washington
Major Depressive Disorder
Measuring Psychomotor Response to L-DOPA Challenge As a Biomarker for Outcomes in Late-Life Depression: a Pilot Feasibility Trial
Background Adults over the age of 60 with symptoms of major depressive disorder are said to have late-life depression (LLD), a condition that usually decreases a person's quality of life and is associated with other risks like…
- Trial name
- LLDOPA (NCT06626152)
- Testing
- Apo-levocarb
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University of British Columbia
Late-Life Depression
Effects of Specific Amino Acid Supplementation and Lifestyle Factors on Brain Ageing
The aim of this clinical trial is to investigate the effects of L-serine supplementation on cognitive decline and psychosocial functioning in older adults with late-life depression (LLD).
- Trial name
- AAAgeing (NCT07497347)
- Testing
- L-serine supplementation
- Where
- Italy
- Volunteers
- 84 people
- Sponsor
- IRCCS Centro San Giovanni di Dio Fatebenefratelli