Clinical trials: Later Life
Late-life Depression, Major Depressive Disorder
Cognitive Behavioural Therapy for the Treatment of Late Life Depression
This study addresses the unmet medical problem of insufficient treatment of late life depression (LLD). Compared with depression in early adulthood, treatment options of LLD are limited.
- Conditions
- Late-life Depression, Major Depressive Disorder, Major Depressive Episode, Major Depressive Disorder, Recurrent
- Trial name
- CBTlate (NCT03735576)
- Testing
- Psychotherapy, Questionnaires, Magnetic Resonance Imaging
- Where
- 7 sites in Germany
- Volunteers
- 250 people
- Sponsor
- University of Cologne
Bipolar Disorder
Treatment of Geriatric Bipolar Mood Disorders: A Pilot Study
The purpose of this study is to collect pilot data on the feasibility of recruiting, eliciting informed consent, assessing, treating, and following patients aged 60 and older with bipolar mood disorders.
- Trial name
- NCT00177567
- Testing
- lithium carbonate, Depakote-ER, risperidone
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- University of Pittsburgh
Anxiety Disorders
Relaxation Treatment for Anxiety in Adults Aged 60 or Older
The PI developed a self-directed program to treat late-life anxiety called Breathing, Relaxation, and Education for Anxiety Treatment in the Home Environment (BREATHE).
- Trial name
- BREATHE (NCT02429778)
- Testing
- Diaphragmatic Breathing, Progressive Muscle Relaxation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Palo Alto Veterans Institute for Research
Depression
Psychotherapy for Late Life Depression
This randomized pilot study will test the feasibility of a behavioral intervention for late life depression. Enrolled participants will receive 9 weeks of a specialized form of psychotherapy we call "ENGAGE" or standard of care…
- Trial name
- ENGAGE-II (NCT01698255)
- Testing
- ENGAGE, Standard of Care Psychotherapy
- Where
- 2 sites in United States
- Volunteers
- 48 people
- Sponsor
- Weill Medical College of Cornell University
Depressive Symptoms, Caregiver Burden
Caregiver Stress and Sleep Study
The purpose of this research study is to better understand how stress, sleep and activity might impact caregivers' mood and brain health.
- Trial name
- CARES (NCT05219955)
- Testing
- Morning Action Plan Execution, Activity Strategy-based Session with Therapist, Attention-based Session with Therapist
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Major Depressive Disorder
A Study Comparing the Efficacy and Safety of Duloxetine and Placebo for the Treatment of Depression in Elderly Patients
The purpose of this study is to compare the efficacy and safety of duloxetine 60 mg once daily to placebo on depression in elderly patients (greater than or equal to 65 years of age).
- Trial name
- NCT00406848
- Testing
- duloxetine hydrochloride
- Where
- 33 sites in United States, France and 2 more
- Volunteers
- 370 people
- Sponsor
- Eli Lilly and Company
Depression in Old Age
Fitness for Brain Optimization for Late-Life Depression
Cognitive impairment and brain abnormalities are common and persist after depression remission in those with Late Life Depression (LLD), compounding dementia risk in both individuals with acute and remitted LLD (rLLD).
- Trial name
- FIT BOLD (NCT04670510)
- Testing
- On-site AE, At-home AE, Social Engagement (SE)
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of Pittsburgh
Child Care
Providing Grandchild Care in Later Life
Grandchild care is a modern global phenomenon arising from increased life expectancy , and, correlated with the rest of the world, the Turkish Statistical Institute's report on aging states that the prevalence of grandchild…
- Trial name
- NCT07501260
- Testing
- Providing grandchild care in old age reduces frailty, depression, and self-care neglect in geriatric outpatients.in Geriatric Outpatients"
- Where
- Turkey (Türkiye)
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Mersin University
Suicide, Bereavement
Risk and Resilience to Suicide Following Late-Life Spousal Bereavement
The purpose of the RISE study is to examine how the 24-hour rhythm of sleep and social activity relate to mood and suicidal ideation among older adults that recently lost a spouse or life partner.
- Trial name
- RISE (NCT06191484)
- Testing
- WELL Behavioral Probe
- Where
- United States
- Volunteers
- 169 people
- Sponsor
- University of Pittsburgh
Depression
Examining the Feasibility and Effectiveness of Case Manager Delivered Problem Solving Therapy on Late Life Depression
This study seeks to determine the feasibility and efficacy of a Problem Solving Therapy intervention for the treatment of late life depression (LLD).
- Trial name
- NCT02505178
- Testing
- Problem Solving Therapy
- Where
- Canada
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Late-Life Depression
Fish Oil Supplementation in Late-life Depression
To investigate whether fish oil supplementation, compared to placebo (olive oil), could have better effects on depression course and cognitive function in older people with major depression.
- Trial name
- NCT01235533
- Testing
- N-3 polyunsaturated fatty acids
- Where
- 2 sites in Taiwan
- Volunteers
- 89 people
- Sponsor
- Taipei City Psychiatric Center, Taiwan
Female, Late Life Depression
Central Glutathione Levels in Women With Late Life Depression: a Cross Sectional Pilot Feasibility Study
Female participants with an episode of late-life depression (LLD) and age-matched control participants with no history of mental disorder will attend a one hour Magnetic Resonance Imaging (MRI).
- Trial name
- NCT02757833
- Testing
- A 3 Tesla MRI scanner (Siemens, Erlangen Germany), will be used to measure levels of GSH in the brain.
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Depression in Old Age, Psychotherapy
Engage for Late-Life Depression and Comorbid Executive Dysfunction
Although there are an increasing number of mental health treatment adaptations for older adults, there are still a number of factors to consider when making these adaptations.
- Conditions
- Depression in Old Age, Psychotherapy, Mild Cognitive Impairment, Executive Dysfunction
- Trial name
- NCT05356611
- Testing
- Engage
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Nevada, Las Vegas
Generalized Anxiety Disorder
Cognitive Behavior Treatment of Older Adults With Generalized Anxiety Disorder in Primary Care
The purpose of this study is to determine whether cognitive behavior treatment (CBT) can be delivered effectively by providers of different expertise levels in adults age 60 and older in a primary care setting.
- Trial name
- NCT00765219
- Testing
- CBT, Usual Care
- Where
- United States
- Volunteers
- 222 people
- Sponsor
- Baylor College of Medicine
Schizophrenia, Schizoaffective Disorder
Anticholinergic Deprescription in Schizophrenia
In this study, the investigators will examine whether a deprescription of unnecessary anticholinergic drugs (benztropine or trihexyphenidyl) can augment quality of life, functioning, and neurocognition in individuals who with…
- Trial name
- NCT06562608
- Testing
- Anticholinergic Deprescription, No Anticholinergic Deprescription
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Deepak K. Sarpal, M.D.
Disability Physical
The Turkish Version of the Late Life Function and Disability Instrument
The aim of this study is to investigate the Turkish validity and reliability of the Late Life Function and Disability Instrument (LLFDI) and to provide a measurement tool for researchers who wish to work in this field within the…
- Trial name
- NCT06858085
- Testing
- Turkish Version of the Late Life Function and Disability Instrument
- Where
- Turkey (Türkiye)
- Volunteers
- 216 people
- Sponsor
- Okan University
Major Depressive Disorder
Frontal Hypoperfusion Effects on Antidepressant Outcomes in Late-Life Depression
The long-term goal of this line of research is to determine if decreased vascular reactivity and frontal hypoperfusion is associated with poor response antidepressants.
- Trial name
- NCT01896934
- Testing
- Sertraline
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Vanderbilt University
Vaginal Disease
Post Marketing Follow Up Study To Evaluate Performance Safety Quality of Menopausal Transition Women Treated With Ainara
The objective of the present PMCF study with a 6 month follow up period is to identify potential new and unknown risks associated with longer term use of Ainara® and (considering the duration of symptoms in GSM) to collect…
- Trial name
- NCT04362371
- Testing
- Ainara
- Where
- Romania
- Volunteers
- 73 people
- Sponsor
- Italfarmaco
Depression
Clemastine for Improving White Matter and Boosting Antidepressant Response in Late-life Depression
The goal of this study is to find out if the antihistamine, clemastine, can make the white matter in the brain better in older adults with depression.
- Trial name
- CLIMB (NCT06591091)
- Testing
- Clemastine Fumarate
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Illinois at Chicago
Memory Impairment, Executive Dysfunction
The Effects of Playing High School Football on Later Life Cognitive Functioning and Mental Health
The purpose of this study is to assess the effect of playing high school football on later in life cognitive functioning and mental health.
- Conditions
- Memory Impairment, Executive Dysfunction, Depression
- Trial name
- NCT02833129
- Volunteers
- 3,904 people
- Sponsor
- University of Pennsylvania