Clinical trials: Lead Exposure
Environmental Exposures, Child Development
HOME Study (Health Outcomes and Measures of the Environment Study)
The goal of the HOME Study is to quantify the impact of low-level fetal and early childhood exposures to environmental toxicants including lead, mercury, and other metals, pesticides, polychlorinated biphenyls (PCBs), persistent…
- Conditions
- Environmental Exposures, Child Development, Lead and Injury Reduction
- Trial name
- NCT00129324
- Testing
- Lead Hazard Control Intervention, Injury Hazard Control Intervention
- Where
- United States
- Volunteers
- 468 people
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Lead Poisoning
Early Exposure to Lead and Adolescent Development
This prospective cohort study examines the role of prenatal and early postnatal lead exposure on the neuropsychological status and social adjustment of adolescents enrolled in the Cincinnati Lead Study.
- Trial name
- NCT00011674
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Asthma, Allergy
National Survey of Lead and Allergen Hazards in Housing
We propose to conduct a scientifically valid, descriptive survey to measure the prevalence and levels of lead in dust, soil, and paint, and the prevalence and levels of various indoor allergens in floor and bedding dust in the…
- Trial name
- NCT00339573
- Where
- United States
- Volunteers
- 831 people
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Lead Exposure
G-PUR® for Reduced Lead Bioavailability
This is a prospective, randomized, placebo-controlled, double blind, parallel-arm study in a two-staged approach that will assess the effect of two different doses of G-PUR® on enteral lead absorption in healthy adults using a…
- Trial name
- NCT04138693
- Testing
- G-PUR® 2x 2.0 g oral suspension, G-PUR® 1x 2.0 g oral suspension
- Where
- Austria
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Glock Health, Science and Research GmbH
Opioid-use Disorder, Addiction
Competitive Revision for CLARO: Collaboration Leading to Addiction Treatment and Recovery From Other Stresses
The purpose of this study is to develop and then test an enhanced version of the parent study's collaborative care intervention for co-occurring disorders (CC-COD) to reduce the risk of suicide and overdose among individuals with…
- Conditions
- Opioid-use Disorder, Addiction, Depression, Post Traumatic Stress Disorder
- Trial name
- NCT04634279
- Testing
- Collaborative care Plus
- Where
- 12 sites in United States
- Volunteers
- 68 people
- Sponsor
- RAND
Osteoporosis
Lead Exposure, Genetics, and Osteoporosis Epidemiology
This study's primary objective is to assess the effects of environmental lead exposures and genetic risk factors on the development of osteoporosis in middle-aged women.
- Trial name
- NCT00013637
- Where
- United States
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Diabetic Nephropathies, Diabetes Mellitus, Type II
Environmental Exposure to Lead and Progressive Renal Insufficiency in Type II Diabetic Nephropathy
Background The relationship between long-term heavy lead exposure and chronic interstitial nephropathy is well recognized in the previous literatures.
- Trial name
- NCT00237952
- Testing
- EDTA chelating agents
- Where
- 2 sites in China
- Sponsor
- Chang Gung Memorial Hospital
Lead, Toxicology
Potential Lead Exposure Through Eating Self-harvested Wild Game
This is a clinical research protocol to determine the feasibility of assessing lead levels in hunters who use lead projectiles. This study will determine if it is possible to perform an interventional double-blind…
- Trial name
- NCT02775890
- Testing
- Eating wild game shot with lead bullets
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Nelson Marlborough Institute of Technology
Lead Exposure
Treatment of Lead-Exposed Children Trial
The Treatment of Lead-Exposed Children (TLC) clinical trial compared the effect of lead chelation with succimer to placebo therapy.
- Trial name
- NCT00342849
- Testing
- Succimer
- Where
- 4 sites in United States
- Volunteers
- 780 people
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Lead Poisoning
Bone Lead Levels and College Achievement Scores
This project studies the relationship between lead exposure and academic achievement in college students. Most studies of the neurobehavioral effects of lead have focused on performances at the low end of the distribution.
- Trial name
- NCT00014885
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Lead Poisoning
Effects of Iron and/or Zinc Supplementation in Mexican School Children Exposed to Lead
Lead is negatively linked to nutritional status, behavior and cognition in children. Despite extensive knowledge of its toxicity and efforts to reduce exposure, lead continues to be a problem in developed and developing…
- Trial name
- NCT02346188
- Testing
- Ferrous fumarate, Zinc oxide
- Where
- United States
- Volunteers
- 602 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Lead Poisoning
Early Exposure to Lead and Adult Antisocial Outcomes
Prior research indicates a link between early lead exposure and risk for delinquent behavior. In this study, we follow a large birth cohort from the Cincinnati Lead Study into early adulthood to determine whether this increased…
- Trial name
- NCT00285610
- Where
- United States
- Volunteers
- 225 people
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Blood Loss, Surgical
Observational Cohort Study of TachoSil (TC-018-IN)
The purpose of this study is to collect information, after exposure to TachoSil ®, of all thromboembolic events, immunological events and drug interactions leading to thromboembolic events or major bleeding.
- Trial name
- NCT00285623
- Testing
- Fibrinogen (human) + thrombin (human) (TachoSil)
- Where
- Denmark
- Volunteers
- 3,000 people
- Sponsor
- Nycomed
Exposure to Toxic Dust, Elevated Blood Lead Levels
Reducing Lead Dust Exposure in Older Housing
The objective of this study is to assess the effectiveness of portable air filtration (PAF) for mitigating lead dust exposures and reducing childhood blood lead levels in older housing.
- Trial name
- NCT07485608
- Testing
- portable air filtration systems
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Michigan State University
Amyotrophic Lateral Sclerosis, ALS
Exposure to Neurotoxins as Risk Factors for Amyotrophic Lateral Sclerosis
This study is a follow-up to an earlier study that examined the relationship of This study will examine whether exposure to neurotoxins, such as lead, mercury, solvents, and pesticides, can contribute to amyotrophic lateral…
- Trial name
- NCT00339976
- Where
- United States
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Radiation Exposure
Comparison Of Effective Radiation Shielding Between Rampart IC, M1128 Shield vs Conventional Apron And Shields In Clinical Interventional Procedures
Previous studies have documented that orthopedic injuries and musculoskeletal pain are a likely result of wearing heavy leaded aprons.
- Trial name
- RAMPART (NCT05347290)
- Testing
- Rampart IC, M1128, Lead Apron and Ancillary Shield, Rampart IC, M1128 and Lead Apron
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Anemia, Malnutrition
Environmental Exposure to Lead and Its Health Effects on Patients With Maintenance Hemodialysis
One thousand patients with LHD who have no history of exposure to lead will be observed for 18 months. Blood lead level(BLL), biochemical data, hemoglobin, albumin, Cr, high sensitivity C-reactive protein (HsCRP), and blood cell…
- Conditions
- Anemia, Malnutrition, Inflammation, Lead Poisoning
- Trial name
- NCT00926406
- Testing
- lead chelation therapy
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Chang Gung Memorial Hospital
Environmental Exposure; Dietary Patterns; Nutritional Epidemiology; Human Biomonitoring
Assessing Toxic Metal Exposure From Vegetarian/Vegan, Omnivorous, and Low-carb Diets in Israel.
Different dietary intake may pose various health risks as as these have different potential exposure to heavy metals, which may originate from soils, irrigation systems, infrastructure, packaging, and other environmental…
- Trial name
- NCT07235332
- Testing
- Screening
- Where
- Israel
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Lead Poisoning
RECLEAN Pilot Study
This is an exposure assessment pilot study tailored for families of construction workers living with a child. The investigators will compare home dust metal levels and resident's blood metal levels before and after an educational…
- Trial name
- RECLEAN (NCT04498845)
- Testing
- In-home assessment plan, Family educational session, Worker take home prevention training
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Boston University
Male Infertility, Testicular Diseases
Effect of Environmental Exposures on the Egg Fertilizing Ability of Human Sperm
Our data indicate that environmental exposure to the heavy metal lead are more widespread than currently appreciated and that such exposures are associated with the production of human male subfertility.
- Conditions
- Male Infertility, Testicular Diseases, Urologic and Male Genital Diseases, Lead Poisoning
- Trial name
- NCT00012480
- Where
- 3 sites in United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)