Clinical trials: Leak, Anastomotic
Intestinal Anastomotic Leak, Intestinal Perforations
Endosponge Vacuum Therapy (E-VAC) Registry of Intestinal Anastomotic Leaks and Perforations
The purpose of this registry is to collect data on the clinical use of endoluminal vacuum (E-Vac) therapy to treat both upper and lower intestinal leaks and perforations.
- Trial name
- NCT02477930
- Testing
- No interventions are done
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Baylor Research Institute
Anastomosis, Leaking
Study With Dehisgel Used in Adult Patients Undergoing Colorectal Anastomosis
A two-phase, multicenter, open-label, "first-in-human" prospective study evaluating the product's safety and efficacy in a pivotal phase.
- Trial name
- NCT07490080
- Where
- Czechia
- Volunteers
- 20 people
- Sponsor
- Contipro Pharma a.s.
Type 2 Diabetes Mellitus (T2DM), Obesity & Overweight
The Transit Bipartition With the Use of a Metallic Anastomosis Clip and Circular Fundocorporeal Gastroplication
This study evaluates a new surgical device - the Metallic Anastomotic Clip (MAC) - for performing a laparoscopic bypass gastroenteroanastomosis with entero-enteric anastomosis (transit bipartition / "dual-path" procedure) in…
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Obesity & Overweight, Marginal Ulcer (Peptic) or Erosion, Leakage, Anastomotic
- Trial name
- MACBIPARTFCG (NCT07495020)
- Testing
- Laparoscopic transit bipartition with Metallic Anastomotic Clip and Circular Fundocorporeal Gastroplication, Laparoscopic transit bipartition (gastroenteroanastomosis and entero-enteric anastomosis) use the Metallic Anastomotic Clip and with sleeve gastrectomy, laparoscopic duodenal transit bipartition using the Metallic Anastomotic Clip with circular fundocorporeal gastroplication without gastrectomy
- Where
- Kazakhstan
- Volunteers
- 90 people
- Sponsor
- The Society of Bariatric and Metabolic Surgeons of Kazakhstan
Anastomotic Leakage in Colon Surgery
Predictive Value of Procalcitonin, CRP, Drain Fluid Culture, Il-6 and Tnf-α in Anastomotic Leakage
Evaluating predictive value of serum procalcitonin, C-Reactive Protein, drain IL-6 and TNF-alpha for anastomotic leakage in post-operative period.
- Trial name
- NCT02361918
- Testing
- Colon surgery
- Volunteers
- 50 people
- Sponsor
- Istanbul University
Crohn Disease
Post-operative CRP Trend After Ileocolic Resection in Crohn's Disease Patients.
Our aim is to analyze C-Reactive Protein trends during the post-operative course in Crohn's Disease patients having undergone ileocolic resection and primary anastomosis, for the purpose of anastomotic leak early diagnosis.
- Trial name
- NCT04739579
- Testing
- C-Reactive Protein
- Where
- France
- Volunteers
- 59 people
- Sponsor
- Central Hospital, Nancy, France
Colorectal Anastomosis Leak
Impact of Oxygen Saturation Levels on Anastomotic Leakage and Postoperative Complications in Colorectal Surgery
The aim of the present study was to evaluate the association between postoperative oxygen saturation levels and surgical complications, with particular emphasis on anastomotic leakage, in patients undergoing elective colorectal…
- Trial name
- NCT07534618
- Where
- Turkey (Türkiye)
- Volunteers
- 174 people
- Sponsor
- Yasir Musa Kesgin
Obesity, Obesity, Morbid
Endoscopic Metabolic and Bariatric Therapies
This is a prospective collection of data from adult patients who have had an endoscopic metabolic and bariatric endoscopy procedure (EMBT) for primary or revision surgical procedures for obesity.
- Conditions
- Obesity, Obesity, Morbid, Obesity Associated Disorder, Bariatric Surgery Candidate
- Trial name
- EMBTs (NCT05725967)
- Testing
- Primary Obesity Endoscopic Procedures, Endoscopic Revision of Bariatric Surgical Procedures, Bariatric Surgery Procedures
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- Christopher C. Thompson, MD, MSc
Cancer
Peritoneal Microdialysis in Patients Undergoing Low Anterior Resection for Rectum Cancer
Anastomotic leakage is a serious complication after LAR with high morbidity and mortality rates. Early diagnosis and treatment is mandatory.
- Trial name
- NCT01062334
- Testing
- Peritoneal Microdialysis, CT-scan, leakage scoring
- Where
- 2 sites in Denmark
- Volunteers
- 150 people
- Sponsor
- Odense University Hospital
Esophageal Neoplasms, Constriction
Endoscopic Evaluation for Predicting the Complications Related to Gastric Conduit After Esophagectomy
Gastric conduit ischemia or anastomotic breakdown after esophagectomy with cervical esophagogastrostomy often cause severe complications, such as leakage, necrotic organs, and strictures.
- Conditions
- Esophageal Neoplasms, Constriction, Anastomotic Leak, Ischemia
- Trial name
- NCT02937389
- Testing
- Patients after esophagectomy
- Where
- Japan
- Volunteers
- 60 people
- Sponsor
- Nagasaki University
Rectal Cancer
Transanual Tube Placement in Low Anterior Resection (LAR) for Rectal Cancer
The purpose of this study is to evaluate the effectiveness of transanual tube placement in low anterior resection (LAR) for rectal cancer in preventing anastomotic leakage.
- Trial name
- NCT02905968
- Testing
- transanual tube placement
- Where
- China
- Volunteers
- 520 people
- Sponsor
- Fudan University
Anastomosis; Complications, Colon Disease
Computed Tomography vs. Endoscopy Study
Patients undergoing elective surgery for left-sided colon resection are asked to participate in this study: Every patient undergoes two types of examinations (endoscopy, CT scan) on day 3, 4 or 5 postoperatively.
- Conditions
- Anastomosis; Complications, Colon Disease, Leak, Anastomotic
- Trial name
- NCT03148054
- Testing
- Computer Tomography and Endoscopy
- Where
- Switzerland
- Volunteers
- 416 people
- Sponsor
- Spital Limmattal Schlieren
Rectal Cancer, Anastomotic Leak
CRP-guided Transanal Drainage Removal After Rectal Surgery
Transanal drainage tube (TDT) has the benefit of reducing intraluminal pressure after rectal surgery and may provide ideal regional environment for anastomotic healing.
- Trial name
- NCT05502354
- Testing
- removal of transanal drainage tube
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Qilu Hospital of Shandong University
Anastomotic Leak Esophagus
Endoscopic Negative Pressure Therapy After Oncological Gastrectomies
Background and study aims: Management of esophago-jejunal anastomotic leackages (EJAL) after gastric resections is challenging. Endoscopic negative pressure therapy (ENPT) is an emerging effective tool for treatment of…
- Trial name
- NCT04362605
- Testing
- Endoscopic Negative Pressure Therapy
- Where
- Germany
- Volunteers
- 8 people
- Sponsor
- University Hospital Tuebingen
Anastomotic Leak Rectum
Impact of Obsidian ® ASG on Anastomotic Healing
The use of regenerative medicine in colorectal surgery constitutes an entirely new therapeutic principle. The aim of this new therapeutic approach is to reduce the anastomotic leak rate and minimise morbidity and mortality.
- Trial name
- NCT04386148
- Testing
- Obsidian ASG®
- Where
- Austria
- Volunteers
- 270 people
- Sponsor
- Kepler University Hospital
Rectal Neoplasms
Defunctioning Cannula Ileostomy After Lower Anterior Resection of Rectal Cancer
Most surgeons suggest the use of fecal diverting to address the high morbidity and mortality associated with anastomotic leakage (AL) in patients with high risk factors on AL who are undergoing anterior resections.
- Trial name
- NCT01980238
- Testing
- cannula ileostomy, loop ileostomy, LAR
- Where
- China
- Volunteers
- 300 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Colorectal Cancer
Gut Microbiota, Anastomotic Leak and Colorectal Cancer
This is a prospective study evaluating the relation between the gut microbiota composition, intestinal healing after colorectal surgery and colorectal cancer behavior.
- Trial name
- NCT04071964
- Where
- Canada
- Volunteers
- 300 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Colorectal Cancer, Gastrointestinal Complications
J-Pouch Colorectal Anastomosis or Straight Colorectal Anastomosis in Treating Patients With Rectal Cancer Who Have Undergone Surgery to Remove the Tumor
RATIONALE: It is not yet known whether a J-pouch colorectal anastomosis is more effective than a straight colorectal anastomosis in treating patients with rectal cancer who have undergone surgery to remove the tumor.
- Conditions
- Colorectal Cancer, Gastrointestinal Complications, Perioperative/Postoperative Complications
- Trial name
- NCT01110798
- Testing
- intraoperative complication management/prevention, assessment of therapy complications, gastrointestinal complications management/prevention
- Where
- 4 sites in Italy
- Volunteers
- 600 people
- Sponsor
- Azienda Ospedaliera di Padova
Anastomotic Leak
PREDICS Study: PCT Reveals Early Dehiscence in Colorectal Surgery
Procalcitonin (PCT) is a biomarker used to monitor serious bacterial infections and guide antibiotic therapy. Anastomotic leak (AL) after colorectal surgery is a severe complication associated with relevant short and long-term…
- Trial name
- PREDICS (NCT01817647)
- Testing
- Colorectal surgery
- Where
- Italy
- Volunteers
- 504 people
- Sponsor
- University of Roma La Sapienza
Anastomotic Leak Esophagus
Anastomotic Leaks in Esophageal Squamous Cell Carcinoma Patients After Trimodal Therapy
To investigate the clinical factors and preoperative treatment to the future anastomotic location of cervical esophagus that were correlated with anastomotic leaks in esophageal squamous cell carcinoma patients undergoing…
- Trial name
- NCT06556355
- Testing
- neoadjuvant chemoradiation and McKeown esophagectomy
- Where
- China
- Volunteers
- 218 people
- Sponsor
- Qiaoqiao Li
Rectal Cancer Patients, Rectal Cancer Surgery
FLuorescent Angiography in REduction of Anastomotic Leak in Rectal Cancer Surgery
The goal of this clinical trial is to find out whether using a special green dye called indocyanine green (ICG) during minimally invasive rectal cancer surgery can help surgeons assess blood flow to the bowel and reduce leakage…
- Conditions
- Rectal Cancer Patients, Rectal Cancer Surgery, Colorectal Cancer, Anastomotic Leak Rectum
- Trial name
- FLARE (NCT07899125)
- Testing
- Indocyanine Green Fluorescence Angiography, Standard Surgical Perfusion Assessment
- Where
- India
- Volunteers
- 610 people
- Sponsor
- Basavatarakam Indo American Cancer Hospital & Research Institute