Clinical trials: Leakage, Anastomotic
Bile Leak, Anastomotic Leak Biliary
Factors Influencing Occurrence of Bile Leaks in Surgery
The objective of our study is to identify the factors influencing the occurrence of a biliary leak after performing surgery leading to the creation of a biliary anastomosis to any segment of the digestive tract.
- Conditions
- Bile Leak, Anastomotic Leak Biliary, Biliary Tract Fistula
- Trial name
- NCT04665427
- Testing
- bilioenteric anastomosis i
- Where
- Algeria
- Volunteers
- 108 people
- Sponsor
- University of Oran 1
Microdialysis, Ischemia
Local Metabolism of the Gastric Tube Reconstruction After Esophagectomy
Postoperative surveillance of local metabolism of the surgical reconstruction after esophagectomy by means of Microdialysis. Dialysate is collected continuously for seven postoperative Days.
- Conditions
- Microdialysis, Ischemia, Anastomotic Leakage
- Trial name
- NCT04319835
- Testing
- OnZurf Probe
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Region Skane
Esophageal Neoplasms, Constriction
Endoscopic Evaluation for Predicting the Complications Related to Gastric Conduit After Esophagectomy
Gastric conduit ischemia or anastomotic breakdown after esophagectomy with cervical esophagogastrostomy often cause severe complications, such as leakage, necrotic organs, and strictures.
- Conditions
- Esophageal Neoplasms, Constriction, Anastomotic Leak, Ischemia
- Trial name
- NCT02937389
- Testing
- Patients after esophagectomy
- Where
- Japan
- Volunteers
- 60 people
- Sponsor
- Nagasaki University
Colorectal Surgery, Colorectal Cancer
Safety and Effectiveness Evaluation of the COLO-BT as an Alternative Treatment to the Ileostomy
The purpose of this study is to evaluate the Colorectal Balloon Tube (hereinafter referred to as COLO-BT™) device, a single use, temporary intraluminal bypass device, intended to reduce contact of fecal content with an…
- Conditions
- Colorectal Surgery, Colorectal Cancer, Rectal/Anal, Ileostomy - Stoma
- Trial name
- COLO-BT (NCT05826743)
- Testing
- COLO BT™, Stoma Creation
- Where
- 3 sites in United States
- Volunteers
- 256 people, healthy volunteers welcome
- Sponsor
- JSR Medical Co., Ltd.
Anastomotic Leak
Economic Evaluation of Stream™ Platform
This Economic Evaluation study is a multi-center, two-arm, non-randomized, interventional trial. The purpose of this study is to evaluate the economic and patient outcomes of using the Stream™ Platform for early detection of…
- Trial name
- CostAL (NCT05994625)
- Testing
- Stream™ Platform, Stream™ Platform with Risk Score Omitted
- Where
- 2 sites in Canada
- Volunteers
- 215 people
- Sponsor
- FluidAI Medical
Ileostomy - Stoma, Ileostomy; Complications
Laparoscopic Surgery of Rectal Cancer and Ileostomy
Elective diverting ileostomy may reduce consequences of anastomotic failure in laparoscopic TME. Aiming to evaluate the effectiveness of elective diverting ileostomy, its impact on the incidence and clinical behavior of…
- Conditions
- Ileostomy - Stoma, Ileostomy; Complications, Leakage, Anastomotic
- Trial name
- NCT04169425
- Testing
- elective diverting ileostomy
- Volunteers
- 150 people
- Sponsor
- Campus Bio-Medico University
Anastomotic Leakage
The Relationship Between Drainage Fluid and Anastomotic Leakage After Colorectal Cancer Surgery
A prospective and analytical study on the detection of early anastomotic leakage by abdominal drainage fluid after colorectal cancer surgery. pay attention to indicators including bilirubin
- Trial name
- NCT05191602
- Testing
- drainge fluid
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Southwest Hospital, China
Anastomotic Leak, Anti-Inflammatory Agents, Non-Steroidal
Risk of NSAIDs on Anastomotic Leak for Rectal Surgery
Conflicting reports of the association between early postoperative non-steroidal anti-inflammatory drugs (NSAIDs) administration and anastomotic leak (AL) after rectal surgery have continued.
- Trial name
- NCT06155175
- Testing
- NSAIDs
- Where
- China
- Volunteers
- 1,969 people
- Sponsor
- Third Military Medical University
Esophageal Squamous Cell Carcinoma
PPIO-005 The Relationship Between Different Nutritional Pathways and Tumor Outcomes After Minimally Invasive Esophagectomy
As there is no consensus to date on the optimal postoperative nutritional support route for patients undergoing minimally invasive esophagectomy, the purpose of this study is to assess whether there is a potential advantage to…
- Trial name
- NCT06192212
- Where
- China
- Volunteers
- 577 people
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Postoperative Complications
Probiotics in the Prevention of Complications After Colorectal Surgery
Based on the need of large-scale, trials to explore the use of probiotics to reduce post-operative complication rate, a randomized controlled trial is designed to investigate the impact of a probiotics treatment protocol on…
- Trial name
- NCT02313519
- Testing
- Probiotics
- Volunteers
- 164 people
- Sponsor
- Evangelos J. Giamarellos-Bourboulis, M.D.
Pancreatic Fistula, Pancreas Neoplasm
Biodegradable Pancreatic Stents for the Prevention of Postoperative Pancreatic Fistula After Cephalic Pancreaticoduodenectomy
Background: postoperative pancreatic fistula (POPF) remains the most important morbidity after pancreaticoduodenectomy (PD). There is no consensual technique for pancreatic reconstruction and many surgeons use a transanastomotic…
- Conditions
- Pancreatic Fistula, Pancreas Neoplasm, Stent Disintegration, Pancreatic Cancer
- Trial name
- NCT04783831
- Testing
- Biodegradable stent
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Hospital Universitario Virgen de la Arrixaca
Colorectal Neoplasms, Anastomotic Leak
Anastomotic Leakage and Enhanced Recovery Pathways After Colorectal Surgery
Prospective observational multicenter study on the influence of adherence to enhanced recovery pathways on early outcomes (anastomotic leakage, morbidity, mortality, readmission, reoperation rates and length of postoperative…
- Conditions
- Colorectal Neoplasms, Anastomotic Leak, Surgery--Complications
- Trial name
- iCral2 (NCT03771456)
- Testing
- Colorectal resections
- Where
- 41 sites in Italy
- Volunteers
- 1,748 people
- Sponsor
- Ospedale C & G Mazzoni
Anastomotic Leak, Rectal Cancer
Serial Endoscopic Surveillance & Direct Topical Antibiotics to Define the Role of Microbes in Anastomotic Healing
Rationale: The surgical complication of intestinal anastomotic leak remains a clear and present danger to patients despite advances in surgical technique and ever more powerful antibiotics.
- Trial name
- SES-DTA (NCT02682485)
- Testing
- Cipro, metronidazole, neomycin combo, Serial Endoscopic Surveillance, Saline
- Sponsor
- University of Chicago
Rectal Cancer, Sigmoid Cancer
Adaptive Anastomosis for Anterior Resection in Sigmoid and Proximal Rectal Cancer or Premalignant Lesions
Background: Anastomotic leakage (AL) after colorectal surgery remains a significant challenge, associated with increased morbidity, mortality, poor oncological outcomes, and reduced quality of life.
- Conditions
- Rectal Cancer, Sigmoid Cancer, Premalignant Lesion, Colorectal Cancer
- Trial name
- ADAPT (NCT07056374)
- Testing
- C-REX RectoAid Cath
- Where
- Netherlands
- Volunteers
- 165 people
- Sponsor
- Amsterdam UMC, location VUmc
Anastomotic Leakage
Anastomotic Leakage Following Laparoscopic Resection for Rectal Cancer
Anastomotic leak (AL) is a breakdown of a suture line in a surgical anastomosis with a subsequent leakage of the luminal content.
- Trial name
- NCT02718729
- Testing
- Laparoscopic resection for rectal cancer
- Where
- 2 sites in Egypt, Italy
- Volunteers
- 59 people
- Sponsor
- Mansoura University
Esophageal Cancer, Gastroesophageal Junction Cancer
Study of Porcine Fibrin Sealant in Preventing Cervical Anastomotic Leakage for Esophageal or Junctional Carcinoma.
The primary objective is to evaluate the efficacy and assess the role of Porcine Fibrin Sealant (Bioseal®) in preventing cervical anastomotic leakage after esophagectomy in the patients with resectable thoracic esophageal cancer…
- Conditions
- Esophageal Cancer, Gastroesophageal Junction Cancer, Anastomotic Leak
- Trial name
- PLACE020 (NCT03529266)
- Testing
- Porcine Fibrin Sealant (PFS), Surgery
- Where
- China
- Volunteers
- 57 people
- Sponsor
- Sun Yat-sen University
Complication, Anastomotic Leak
Prediction of Abdominal Complications After GastroEnterological Surgery
The aim of this multi-centered study is to understand the epidemiology of infectious complications after gastrointestinal surgery in China.
- Conditions
- Complication, Anastomotic Leak, Gastrointestinal Cancer
- Trial name
- PACAGE (NCT03828266)
- Testing
- No intervention
- Where
- 19 sites in China
- Volunteers
- 4,000 people
- Sponsor
- Peking University
Esophagus Cancer, Gastric Cancer
Predictive Model to Early Diagnosis of Anastomotic Leak After Esophagectomy and Gastrectomy.
The PROFUGO study (PRedictive Model for the early diagnosis of anastomotic leak after esophagectomy and gastrectomy) is proposed as a prospective and multicenter study at spanish national level that aims to develop, with the help…
- Conditions
- Esophagus Cancer, Gastric Cancer, Leak, Anastomotic, Complication
- Trial name
- PROFUGO (NCT05390684)
- Testing
- audit of complications, prospective data collection
- Where
- Spain
- Volunteers
- 800 people
- Sponsor
- Hospital Universitario La Fe
Esophageal Neoplasms, Esophagostomy Complication
Tissue Oxygen Saturation for Esophagectomy
Tissue oxygen saturation monitoring was a useful indicator of blood flow insufficiency in the gastric tube leading to anastomotic leakage during radical esophagectomy.
- Conditions
- Esophageal Neoplasms, Esophagostomy Complication, Anastomotic Leak, Oxygen Deficiency
- Trial name
- NCT04973046
- Where
- Japan
- Volunteers
- 18 people
- Sponsor
- Shizuoka Cancer Center
Colo-rectal Cancer, Colonic Neoplasms Malignant
The Use of Indocyanine Green Near-infrared Fluorescence for Bowel Perfusion Quantitative Assessment in Order to Prevent Anastomotic Leakage in Colorectal Surgery
Anastomotic leakage (AL) is a serious complication after surgery for colon cancer, leading to a significant increase in mortality.Intraoperative fluorescence imaging using indocyanine green has proven to be a feasible and…
- Trial name
- ICG-NIRF (NCT06845306)
- Testing
- ICG-guided bowel perfusion assessment, Conventional Bowel Anastomosis group
- Where
- Russia
- Volunteers
- 1,268 people
- Sponsor
- Vadim Kuznetsov