Clinical trials: Lean
Obesity
The Acute Effect of Grains of Paradise (Aframomum Melegueta) on REE
Grains of paradise (Aframomumu melegueta) (GP), also known as Guinea pepper or Alligator pepper, belongs to the Zingiberaceae family, which is native to West Africa.
- Trial name
- NCT03894137
- Testing
- Grains of Paradise (Aframomum Melegueta)
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Plexus Worldwide
Glucose Response, Insulin Response
Glucose and Insulin Responses to Test Foods
In this study, postprandial glucose and insulin responses of different foods will be measured in individuals with varying body weight.
- Trial name
- NCT01671878
- Testing
- Reference Glucose, Test Food 1 (Cereal), Test Food 2 (Biscuit)
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Mondelēz International, Inc.
Obesity
A Study to Test if Trevogrumab or Trevogrumab With Garetosmab When Taken With Semaglutide is Safe and How Well They Work in Adult Patients With Obesity for Weight Loss, Fat Loss, and Lean Mass Preservation
This study is researching experimental drugs called trevogrumab and garetosmab (called "study drugs") in combination with another drug, semaglutide (Wegovy®).
- Trial name
- COURAGE (NCT06299098)
- Testing
- Trevogrumab-Part A, Trevogrumab-Part B and Part C, Garetosmab
- Where
- 60 sites in United States, Puerto Rico
- Volunteers
- 1,005 people, healthy volunteers welcome
- Sponsor
- Regeneron Pharmaceuticals
Overweight, Healthy Subjects
First-in-human Study to Assess Safety and Tolerability of a Single Subcutaneous Dose of SAR441255 in Lean to Overweight Subjects
Primary Objective: To assess the safety and tolerability of SAR441255 after ascending single subcutaneous (SC) doses Secondary Objectives: To assess the pharmacokinetic parameters of SAR441255 in plasma after ascending single SC…
- Trial name
- NCT04521738
- Testing
- SAR441255
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Sanofi
Obesity, Type 2 Diabetes
A Three-part First-in-human Trial to Assess Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of GUB-UCN2 in Healthy Lean and Obese Participants and Participants With T2D
The trial will enroll healthy volunteers and individuals living with obesity, with and without Type 2 Diabetes. The study, with a treatment period of up to 16 weeks in selected cohorts, will investigate GUB-UCN2 as both a…
- Trial name
- NCT07702890
- Testing
- GUB-UCN2
- Where
- Germany
- Volunteers
- 188 people, healthy volunteers welcome
- Sponsor
- Gubra A/S
Diabetes Mellitus
Insulin Glulisine in Healthy Lean and Obese Subjects
Primary objective To investigate pharmacodynamic and pharmacokinetic parameters after s.c. administration of two different doses (low dose, 0.2 IU/kg and high dose, 0.4 IU/kg) of insulin glulisine across healthy subjects in 4…
- Trial name
- NCT00311077
- Testing
- Insulin Glulisine
- Volunteers
- healthy volunteers welcome
- Sponsor
- Sanofi
Type 2 Diabetes Mellitus
A Method to Evaluate Glucose-Dependent Insulin Secretion in Healthy Males (MK-0431-179)
This study will evaluate the effect of a single dose of sitagliptin on glucose dependent insulin secretion using a meal tolerance test (MTT) during a hyperglycemic clamp (HCG) procedure.
- Trial name
- NCT00888238
- Testing
- sitagliptin
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Cancer Patients With Cachexia
Evaluation of the Effects of a Mixture of Amino Acids (Amixea) on Lean Body Mass and Muscle Strengh of Patients With Unresectable Advanced Non-small Cell Lung Cancer
The primary objectives of this study are to evaluate the effects of an amino acid mixture (Amixea) on the body composition as assessed by DXA, and on QMVC as assessed by strain gauge, in advanced NSCLC patients, compared to…
- Trial name
- NCT02877966
- Testing
- Amixea
- Where
- 3 sites in Australia
- Volunteers
- healthy volunteers welcome
- Sponsor
- Helsinn Healthcare SA
The Methodology Assessment of Glucose Dependent Insulin Secretion
A Study to Compare Methodologies for Assessing Glucose-Dependent Insulin Secretion (0000-104)(COMPLETED)
This study will compare graded glucose infusion (GGI) to the hyperglycemic clamp (HGC) for assessment of glucose-dependent insulin secretion (GDIS) using exenatide as a probe.
- Trial name
- NCT00782418
- Testing
- Comparator: exenatide
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Mitochondrial Functions
Phytochemicals on "Metabolic Aging" in Older Overweight Adults
Aging is a complex and inevitable biological process that is associated with numerous chronic health conditions and the development and progression of diseases.
- Trial name
- NCT04919876
- Testing
- fruit/vegetable supplement (FVS)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Biofortis, Merieux NutriSciences
Healthy Volunteers, Overweight
A Two-Part First-In-Human Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of GUB014295
This is a two-part, single centre, double-blind (within cohorts), randomised, placebo-controlled, single (Part 1) and multiple (Part 2) ascending subcutaneous dose study in lean to overweight or obese but otherwise healthy men…
- Trial name
- NCT06144684
- Testing
- GUB014295
- Where
- United Kingdom
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- AbbVie
Healthy
Evaluation of an Oral Nutritional Supplement on Lean Body Mass in Healthy Older Subjects.
The study will evaluate the effects of oral nutritional supplements (ONS) on attenuating the lean body mass (LBM) loss that occurs after bed rest.
- Trial name
- NCT02090387
- Testing
- ONS without AN777, ONS containing AN777
- Where
- 3 sites in United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Abbott Nutrition
Lean Muscle Development, Muscular Endurance
A Clinical Trial to Evaluate the Effects of a Powder Supplement in Supporting Lean Muscle Development, Hormone-Related Wellness, Digestive Comfort, Dermatologic Health, and Overall Wellness
This study will evaluate the effects of Clean Nutra's Shelf Builder Women's Creatine Powder on lean muscle development, hormone-related wellness, digestive comfort, dermatological health, and overall wellness.
- Conditions
- Lean Muscle Development, Muscular Endurance, Hormone-Related Wellness, Digestive Comfort
- Trial name
- NCT07766395
- Testing
- Shelf Builder Women's Creatine Powder
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Clean Nutraceuticals
Insulin Resistance, Diabetes
Acute Effect of HP-211 (Axulin) on Blood Glucose and Serum Insulin Responses in Healthy Lean and Overweight Humans
Blood sugar levels are controlled by insulin, a hormone made by cells in the pancreas. After a meal, carbohydrates are broken down into glucose (blood sugar) which is absorbed from the intestine into the blood leading to a rise…
- Trial name
- NCT03135015
- Testing
- 2g capsules, 4g capsules, Water Control
- Where
- Canada
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Housey Healthcare ULC
Healthy
Study To Estimate The Relative Bioavailability of Ertugliflozin (PF-04971729, MK-8835) in Healthy Adult Participants (MK-8835-039)
The purpose of this study is to examine the rate and extent of absorption of three oral formulations of ertugliflozin (PF 04971729, MK-8835) administered in lean to obese healthy volunteers.
- Trial name
- NCT01114568
- Testing
- Ertugliflozin 10 mg tablet, Ertugliflozin OC Fast, Ertugliflozin OC Slow
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC