Clinical trials: Lean
Obesity, Overweight
A Study to Investigate Weight Management With Bimagrumab (LY3985863) and Tirzepatide (LY3298176), Alone or in Combination, in Adults With Obesity or Overweight
The main purpose of this study is to evaluate the efficacy and safety of Bimagrumab and Tirzepatide, alone or in combination, in adults with obesity or overweight, with at least one obesity related comorbidity, without Type 2…
- Trial name
- NCT06643728
- Testing
- Bimagrumab, Tirzepatide
- Where
- 12 sites in United States
- Volunteers
- 252 people
- Sponsor
- Eli Lilly and Company
Obesity, Glucose Intolerance
Prevalence of Carbohydrate Intolerance in Lean and Obese Children
The prevalence of obesity in children is reaching epidemic proportions. Excess adiposity is more than just a cosmetic problem, having substantial metabolic consequences.
- Conditions
- Obesity, Glucose Intolerance, Diabetes, Acanthosis Nigricans
- Trial name
- NCT00000112
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Center for Research Resources (NCRR)
Obesity
Sequential Therapy Anti-obesitY Medication With Muscle Preservation for Weight Loss and MaintEnance: A PragmAtic Randomized CoNtrolled Trial (STAY-LEAN Trial)
This is a prospective, pragmatic, 21 month, single-center, randomized, 2-phased, open-label, parallel-group trial comparing the use of enhanced lifestyle changes (ELC) in two different therapy: sequential vs continuation of AOM.
- Trial name
- STAY-LEAN (NCT06854614)
- Testing
- Comprehensive weight loss, Enhanced lifestyle changes, Tirzepatide
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- The Cleveland Clinic
Obesity, Type 2 Diabetes Mellitus
Brown Adipose Tissue and Body Mass Index
In this study the investigators aim to investigate whether the sympathetic stimulation of BAT, as assessed with a 123I-metaiodobenzylguanidine single-photon emission computed tomography computed tomography scan, differs between…
- Trial name
- NCT02173834
- Testing
- 18F- fluorodeoxyglucose-positron emission tomography Computed Tomography scan and 123I-metaiodobenzylguanidine-single-photon emission computed tomography scan
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Spondylarthropathy, Sarcopenia
Sarcopenia in Axial and Peripheral Spondyloarthropathies
Spondylarthropathies (SpA) are among the most common chronic inflammatory rheumatisms in adults, responsible for a muscular loss or sarcopenia which can be very disabling, not much documented in the literature, and not yet…
- Trial name
- SASPAR (NCT03319264)
- Testing
- Dynamometry exam, Walking test, DXA measurement
- Where
- France
- Volunteers
- 106 people
- Sponsor
- Hospices Civils de Lyon
The Null Hypothesis is That Food Rheology Will Have no Effect on These Indices, The Alternate Hypothesis is That Increased Mechanical Stimulation Will Result in Stronger Satiation/Satiety and Reduced Energy Intake
Effects of Gum Chewing on Appetite and Digestion
One obvious property difference between energy-yielding beverages and solid foods is the oral mechanical processing required to prepare the two food forms for swallowing.
- Conditions
- The Null Hypothesis is That Food Rheology Will Have no Effect on These Indices, The Alternate Hypothesis is That Increased Mechanical Stimulation Will Result in Stronger Satiation/Satiety and Reduced Energy Intake, It is Hypothesized That the Effects of Mastication Will be Less Evident in Obese Compared to Lean Individuals
- Trial name
- NCT01070212
- Testing
- soft gum, firm gum, no gum
- Where
- 2 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Purdue University
Lean Muscle Development, Muscular Endurance
A Clinical Trial to Evaluate the Effects of a Powder Supplement in Supporting Lean Muscle Development, Hormone-Related Wellness, Digestive Comfort, Dermatologic Health, and Overall Wellness
This study will evaluate the effects of Clean Nutra's Shelf Builder Women's Creatine Powder on lean muscle development, hormone-related wellness, digestive comfort, dermatological health, and overall wellness.
- Conditions
- Lean Muscle Development, Muscular Endurance, Hormone-Related Wellness, Digestive Comfort
- Trial name
- NCT07766395
- Testing
- Shelf Builder Women's Creatine Powder
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Clean Nutraceuticals
Type 2 Diabetes Mellitus
Effects of Short-term Intensive Insulin Therapy in Newly Diagnosed Type 2 Diabetes Patients
It is well known that Long-term hyperglycemia (also known as glucose toxicity) contribute to impairment in islet β-cell function and development of insulin resistance.
- Trial name
- NCT01588743
- Testing
- insulin aspart
- Volunteers
- 130 people
- Sponsor
- Li Guangwei
Obesity & Overweight, Diabetes (DM)
Determination of Resistance Training Status for Patients on Glucagon-Like Peptide-1 Receptor Agonists
This study examines how adults who take a GLP-1 receptor agonist medication (such as semaglutide [Ozempic, Wegovy, Rybelsus], liraglutide [Saxenda, Victoza], or tirzepatide [Mounjaro, Zepbound]) perform resistance (strength)…
- Trial name
- NCT07702461
- Testing
- Glucagon-Like Peptide-1 Agonist (GLP-1)
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Ohio State University
Healthy Aging
Protein-Distinct Macronutrient-Equivalent Diet 2
The central hypothesis is that the addition of minimally processed lean pork to a healthy plant-forward low ultra-processed diet will enhance nutrient adequacy, promote muscular fitness, and maintain metabolic functions for…
- Trial name
- PRODMED2 (NCT05581953)
- Testing
- Omnivorous, No meat
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- South Dakota State University
Diabetes Mellitus, Type 2
Targeting Beta-cell Failure in Lean Patients With Type 2 Diabetes
The majority of people with type 2 diabetes (T2D) are overweight, and while weight gain is a major contributor to diabetes, a minority of patients with T2D are not overweight or obese.
- Trial name
- Lean-DM (NCT04657939)
- Testing
- Liraglutide, Pioglitazone
- Where
- United Kingdom
- Volunteers
- 57 people
- Sponsor
- University of Leeds
Hyperandrogenism
Effects of Androgen Administration on Inflammation in Normal Women
The hypothesis of this study is that DHEA administration to increase male hormone in healthy normal-weight young women to levels present in women with Polycystic Ovary Syndrome will cause an inflammatory response in white blood…
- Trial name
- NCT01753037
- Testing
- Dehydroepiandrosterone (DHEA)
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Ulcerative Colitis
Effects of WB-EMS in Ulcerative Colitis Patients
The purpose of this study is to determine the effect of 12 weeks of WB-EMS either applicated passive in a supine resting position or active during slight movements compared with a non-training control group on body composition…
- Trial name
- NCT02144129
- Testing
- active Whole Body Electromyostimulation, Passive WB-EMS, WB-EMS application
- Where
- Germany
- Sponsor
- University of Erlangen-Nürnberg Medical School
Weight Loss
Effect of Moderate Weight Loss in Metabolically Abnormal Lean Subjects
Obesity is associated with a constellation of cardiometabolic abnormalities (including insulin resistance, elevated blood pressure and dyslipidemia) that are risk factors for diabetes and cardiovascular disease.
- Trial name
- MAL (NCT02452567)
- Testing
- Moderate (8-10%) diet-induced weight loss
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Healthy
Health Beneficial Effects of Krill Oil and Lean and Fatty Fish
Intake of omega-3 (n-3) polyunsaturated fatty acids (PUFAs) from fish oil and fish are associated with significant health benefits in risk of cardiovascular disease.
- Trial name
- NCT02568228
- Testing
- Krill oil, Lean and fatty fish
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Oslo Metropolitan University
Colorectal Cancer
Effect of EPA on Aerobic Performance, Muscle, and Quality of Life in Colorectal Cancer Surgery Patients
Primary Aim is to test the Hypothesis: Nutritional supplementation with 960mg EPA three times a day positively affects muscle function and mass (assessed by muscle biopsies, assays of cellular aerobic function and DEXA scan) and…
- Trial name
- EPA-colo (NCT01320319)
- Testing
- Experimental: Nutritional Supplementation with EPA
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- University of Nottingham
Healthy
The Effect of Dairy on Bone Mass and Body Composition in 4th-8th Grade Boys and Girls
Building stronger bones during pubertal growth could reduce lifelong fracture risk. This project is an 18 month dairy intervention study for overweight and healthy weight 4th-8th grade boys and girls.
- Trial name
- B3 (NCT00635583)
- Testing
- Increased Dairy Consumption
- Where
- 2 sites in United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Purdue University
Metastatic Solid Malignancies, Locally Advanced Solid Malignancies
Effects of LBM and PPIs on Pharmacokinetics and Safety of Regorafenib (BAY 73-4506) in Cancer Patients
The FDA and Health Canada have approved regorafenib at a daily dose of 160mg for the treatment of metastatic colorectal cancer and gastrointestinal stromal cancer; however, the 160 mg dose is not well tolerated by patients…
- Trial name
- NCT02439723
- Testing
- Regorafenib
- Where
- Canada
- Sponsor
- AHS Cancer Control Alberta
Undernutrition
The Comparison of Handgrip Strength, Lean Mass, and Blood Pressure in Primary School Children Aged 8-10 Years Old With Undernutrition and Normal Nutritional Status
Undernutrition occurs in 900 million individuals globally, so it is a very important health problem because it contributes to high mortality rates, especially in children.
- Trial name
- NCT05952479
- Where
- Indonesia
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Universitas Airlangga
Body Composition Changes
Magnesium Supplementation on Body Composition
The goal of this interventional clinical trial is to learn if the supplementation of magnesium can affect body composition in physically active individuals between the ages of 18 and 30.
- Trial name
- NCT06703099
- Testing
- Magnesium Supplementation
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Nova Southeastern University