Clinical trials: Learning Disorders, open to volunteers
Neovascular Glaucoma
Study to Learn More About Safety of Aflibercept Injection in Japanese Patients With Neovascular Glaucoma (NVG)
This is a prospective, observational, multi-center and post-authorization safety study that includes patients with a diagnosis of Neovascular Glaucoma. The investigator will have made the decision to use Eylea for treatment.
- Trial name
- NCT04519619
- Testing
- Aflibercept (Eylea, BAY86-5321)
- Where
- Japan
- Volunteers
- 480 people
- Sponsor
- Bayer
Problem Behavior, Developmental Delay
Problem Behavior Assessment and Intervention in IDEA Part C Services
The purpose of this study is to evaluate the effect of function-based assessment and intervention to reduce problem behavior in children with developmental disability or delay in the context of IDEA Part C services.
- Conditions
- Problem Behavior, Developmental Delay, Developmental Disability
- Trial name
- NCT06771284
- Testing
- Function-based assessment and intervention
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Nevada, Las Vegas
Mild Cognitive Impairment (MCI), Cognitive Training
Cognitive Training and Neuroplasticity in Mild Cognitive Impairment: COGIT-2 Trial
Effective, clinically meaningful treatments are lacking for patients with mild cognitive impairment (MCI), which is associated with increased risk of transition to dementia.
- Trial name
- COGIT-2 (NCT06601933)
- Testing
- Cognitive Training
- Where
- 4 sites in United States
- Volunteers
- 240 people
- Sponsor
- Columbia University
Age-Related Macular Degeneration
Deciphering AMD by Deep Phenotyping and Machine Learning- Prospective Study - SUMMIT (Part 2)
We will conduct a prospective, non-interventional roll-over extension of the PINNACLE study (Deciphering AMD by deep phenotyping and machine learning).
- Trial name
- NCT06682455
- Where
- 8 sites in Austria, United Kingdom
- Volunteers
- 300 people
- Sponsor
- University of Southampton
Lung Cancer (Diagnosis), COPD (Chronic Obstructive Pulmonary Disease)
Risk-Based Lung Cancer Detection in COPD Patients
The goal of the interventional study is to evaluate whether risk-based stratification using the PLCOm2012 model and a machine learning (ML) model can identify patients with chronic obstructive pulmonary disease (COPD) who are at…
- Trial name
- ELUCID (NCT07848815)
- Testing
- Risk-based prediction models
- Where
- Denmark
- Volunteers
- 1,000 people
- Sponsor
- Vejle Hospital
Type II Endoleak, Abdominal Aortic Aneurysm Enlargement
Deep-learning Predictors of Abdominal Aortic Aneurysm Enlargement in Type II Endoleaks After Endovascular Aortic Repair: The RADAR Study
Background and rationale: Abdominal aortic aneurysm (AAA) is a weakening and enlargement of the main artery in the abdomen. Endovascular aneurysm repair (EVAR) is a minimally invasive treatment used to repair an AAA.
- Trial name
- RADAR (NCT07783126)
- Testing
- Artificial intelligence model analyzing preoperative CT angiography
- Volunteers
- 1,250 people
- Sponsor
- Ente Ospedaliero Cantonale, Bellinzona
Hepatocellular Carcinoma (HCC)
STRATHEP: AI-Driven Treatment Stratification for Advanced Hepatocellular Carcinoma
STRATHEP develops and validates a multimodal AI model to predict treatment response in advanced hepatocellular carcinoma. By integrating digital pathology and MRI radiomics, the project identifies patients likely to benefit from…
- Trial name
- STRATHEP (NCT07863258)
- Where
- 5 sites in Belgium
- Volunteers
- 280 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Benign Prostate Hypertrophy(BPH)
Orientation Video Training Administered at Different Times to Patients Undergoing Prostate Surgery on Postoperative Pain and Anxiety (Video Training)
This study aims to evaluate the effect of operating room orientation video education delivered at different time points on postoperative pain and state anxiety in patients undergoing surgery for benign prostatic hyperplasia.
- Trial name
- NCT07778355
- Testing
- Operating Room Orientation Video Education, Routine Preoperative Information
- Where
- Turkey (Türkiye)
- Volunteers
- 126 people
- Sponsor
- Ondokuz Mayıs University
COPD (Chronic Obstructive Pulmonary Disease)
Respiratory Rehabilitation and Sleep Quality in COPD Patients
COPD affects 5 to 8% of the population in France. The disease consists of inflammation of the large and small airways causing permanent obstruction of the airways and symptoms such as dyspnea, cough and sputum that worsens over…
- Trial name
- REARSOM/BPCO (NCT06677268)
- Testing
- Rehabilitation
- Where
- 4 sites in France
- Volunteers
- 90 people
- Sponsor
- University Hospital, Rouen
Anxiety Disorders
Online Parent Education for Child Anxiety
The investigators are doing this research to test whether parents of children ages 2-7 can better manage their child's anxiety by completing a brief, online, self-guided parent education program.
- Trial name
- NCT07153250
- Testing
- Project EMPOWER, Being Brave Parent Education, Sharing Feelings
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Massachusetts General Hospital
Anxiety Disorders and Symptoms, Depressive Symptoms
Using Machine Learning to Optimize User Engagement and Clinical Response to Digital Mental Health Interventions
Digital mental health interventions are a cost-effective and efficient approach to expanding the accessibility and impact of psychological treatments; however, little guidance exists for selecting the most effective program for a…
- Trial name
- NCT05567640
- Testing
- The Unified Protocol for Transdiagnostic Treatment of Emotional Disorders (UP), Space for depression, Space for resilience
- Where
- United States
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- Boston University Charles River Campus
HCC
Neoadjuvant Therapy in Patients With Resectable HCC Screened by a Multimodal Deep Learning Model
Primary liver cancer is one of the most common malignant tumors in the world, and about 80%~90% of primary liver cancers are pathologically characterized as hepatocellular carcinoma (HCC).
- Trial name
- NCT06420440
- Testing
- Hepatic arterial infusion chemotherapy, Lenvatinib, Tislelizumab
- Where
- 2 sites in China
- Volunteers
- 160 people
- Sponsor
- Chen Xiaoping
Heart Disease, Electrocardiograph
DigitHeart Echo Study
Eligible patients will be interviewed by research staff to explain the trial design and rationale. Written informed consent will be obtained from patients who voluntarily agree to participate.
- Conditions
- Heart Disease, Electrocardiograph, Echocardiography
- Trial name
- DigitHeart-SHD (NCT07558109)
- Testing
- echocardiography
- Where
- Hong Kong
- Volunteers
- 478 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Down Syndrome
How Simplified Language Affects Comprehension and Learning in Young Children With Down Syndrome
The long-term study goal is to experimentally evaluate the components (and likely active ingredients) of early language interventions for young children with Down syndrome (DS).
- Trial name
- NCT06951516
- Testing
- Linguistic simplification
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Michigan State University
Diabetes Mellitus, Type 2
Family Model DSME in FBOs in the RMI
Health disparities in the Republic of the Marshall Islands are striking, with extremely high rates of type 2 diabetes. Documented prevalence of type 2 diabetes in the Marshall Islands ranges from 20%-50%.This is significantly…
- Trial name
- NCT05502016
- Testing
- Family Model Diabetes Self-Management Education and Support, Family Model Diabetes Self-Management Education and Support (Wait-list)
- Where
- United States
- Volunteers
- 288 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Hepatocellular Carcinoma (HCC), Artificial Intelligent
Construction and Clinical Validation of a Predictive Model for Postoperative Adjuvant Therapy in Hepatocellular Carcinoma Based on Whole-Slide Digital Pathological Images and Deep Learning
Hepatocellular carcinoma (HCC) is a high-mortality global malignancy with a heavy disease burden in China. Although curative surgical resection improves survival for early-stage HCC patients, the 5-year postoperative recurrence…
- Conditions
- Hepatocellular Carcinoma (HCC), Artificial Intelligent, Adjuvant Chemoradiotherapy, TACE
- Trial name
- NCT07417800
- Testing
- AI adjuvant therapy
- Where
- China
- Volunteers
- 11,000 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Stroke, Dyslexia, Acquired
Neurofeedback Intervention for Reading Deficits in Subacute Stroke
The overall goal of this project is to advance a biologically-based approach to treatment of reading disorders after stroke, which will expand the limits of cognitive rehabilitation.
- Trial name
- ReadingNFB (NCT04875936)
- Testing
- Motor Imagery and Real-Time fMRI Neurofeedback
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Kessler Foundation
Stroke, CVA (Cerebrovascular Accident)
Cognition and Motor Learning Post-stroke
This project seeks to determine how post-stroke cognitive impairment moderates motor learning during walking in older adults with chronic stroke and identify brain structural markers that mediate this relationship.
- Trial name
- NCT04829071
- Testing
- Explicit motor learning, Implicit motor learning
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- University of Southern California
Hemophilic Arthropathy, Chronic Pain
Multicomponent Pain Self-Management in Adults With Haemophilic Arthropathy
Background: Haemophilic arthropathy is associated with chronic pain, functional limitation and impaired quality of life. Pain interference may also be influenced by cognitive, emotional and behavioural factors.
- Conditions
- Hemophilic Arthropathy, Chronic Pain, Hemophilia A, Hemophilia B
- Trial name
- NCT07860632
- Testing
- Multicomponent pain self-management programme
- Where
- Spain
- Volunteers
- 70 people
- Sponsor
- Investigación en Hemofilia y Fisioterapia
Breast Carcinoma
Research on the Whole-Process Intelligent Diagnosis and Treatment of Digital Breast Tomosynthesis Based on Deep Learning
This study aims to construct a multi-task deep learning model system to mine deep features in DBT images, so as to achieve accurate detection of breast lesions, differential diagnosis of benign and malignant (especially for the…
- Trial name
- NCT07605195
- Testing
- To explore the value of digital breast tomosynthesis based on deep learning in the diagnosis of breast cancer
- Volunteers
- 5,000 people
- Sponsor
- Yunnan Cancer Hospital
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